Clinical trials: Silicosis
Silicosis, Silicotic Fibrosis (Massive) of Lung
Silicosis Treatment, Action, Screening and Surveillance in Rwanda Trials
Silicosis is the most prevalent occupational lung disease in low- and middle-income countries (LMICs) with "tens of millions" estimated to suffer from the disease according to the World Health Organization (WHO).
- Trial name
- STARSS (NCT05538299)
- Testing
- questionnaire, KAP
- Where
- Rwanda
- Volunteers
- 995 people
- Sponsor
- Samuel Hatfield
Silicosis
Using Silica 12CH to Mitigate the Effects and Symptoms of Silicosis in Brazil
This clinical study aims to address a research and clinical treatment gap related to individuals with symptoms of Silicosis resulting from quartzite mining work.
- Trial name
- HOHM (NCT06011785)
- Testing
- Silica 12CH
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- HOHM Foundation
Silicosis
The SHIELD Whole Lung Lavage Study
An observational cohort study that will assess the efficacy of Whole Lung Lavage in workers with silicosis or silica-induced bronchitis.
- Trial name
- SHIELD (NCT05402176)
- Testing
- Whole Lung Lavage
- Where
- 4 sites in Australia
- Volunteers
- 30 people
- Sponsor
- The University of Queensland
Silicosis
The SHIELD Study-silicosis
An observational cohort study to derive biomarkers which are able to more accurately diagnose silicosis, as well as predict disease progression, assess response to treatment, and hasten therapeutic discovery.
- Trial name
- NCT05546944
- Where
- Australia
- Volunteers
- 120 people
- Sponsor
- The University of Queensland
Silicosis, Tuberculosis
Silicosis and Silicotuberculosis Among Small Scale Gemstone Miners in Northern Tanzania
Artisanal, small-scale mining (ASM) is a large and essential component of the world's economy. Despite attendant risks, there is little research into risks to the health of artisanal miners.
- Conditions
- Silicosis, Tuberculosis, Silicosis; With Tuberculosis
- Trial name
- SilicoTB (NCT06403800)
- Testing
- No intervention
- Where
- Tanzania
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- National Heart and Lung Institute
Silicosis, Tuberculosis
Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention
Tuberculosis (TB) remains the most important infectious disease in the world. Preventive treatment plays an important role in successful control of TB.
- Trial name
- NCT02430259
- Testing
- Weekly INH / RRT given by DOT
- Where
- China
- Volunteers
- 566 people
- Sponsor
- Huashan Hospital
Chronic and Accelerated Silicosis
Safety of Stem Cells Intrabronchial Instillation for Silicosis
The aim of this study was to analyze the safety, pulmonary function, and quality of life data of patients with silicosis treated with intrabronchial instillation of bone marrow derived mononuclear cells (BMDMC, 2x107) through…
- Trial name
- SilicStemCell (NCT01239862)
- Testing
- Autologous cell transplantation
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Silicosis
Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis
The aim of this study was to analyze the safety, pulmonary function, and imaging changes of patients with silicosis treated with autologous bone marrow stromal cells with modification by hepatocyte growth factor.
- Trial name
- NCT01977131
- Testing
- Cells
- Volunteers
- 10 people
- Sponsor
- Wei Yu
Silicosis
DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone)
Silicosis is well-known occupational disease caused by free crystalline silica (silicon dioxide) and is marked by inflammation and pulmonary fibrosis.
- Trial name
- NCT01329003
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Lung Diseases, Obstructive, Asbestosis
Specialized Center of Research in Occupational and Immunologic Lung Disease
The overall objective of the Center was to develop a scientific data base for the control and prevention of acute and chronic lung injury caused by the inhalation of a variety of agents in the workplace and in the environment.
- Conditions
- Lung Diseases, Obstructive, Asbestosis, Silicosis, Pneumoconiosis
- Trial name
- NCT00005280
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
COPD, Interstitial Pneumonia
Perioperative Risk Factors Related to the Prognosis of Lung Transplantation: A Retrospective Study
This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results.
- Conditions
- COPD, Interstitial Pneumonia, Bronchiectasis, Respiratory Failure
- Trial name
- NCT06922916
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Zhejiang University
Pneumoconiosis Coal, Asbestosis
The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial
Prospective clinical pilot study for subjects diagnosed with Occupational Progressive Pneumoconiosis. Subjects will be treated with Nintedanib 150mg twice daily for 3 years.
- Conditions
- Pneumoconiosis Coal, Asbestosis, Silicosis
- Trial name
- NiPPs (NCT04161014)
- Testing
- Nintedanib 150 MG [Ofev]
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Holdsworth House Medical Practice
Silicosis, Progressive Massive Fibrosis
Pirfenidone for the Reduction of Metabolic, Inflammatory and Fibrogenic Activity in Complicated Silicosis
Silicosis is one of the leading causes of occupational respiratory disease worldwide. It is due to inhalation of respirable crystalline silica and can lead to progressive massive fibrosis (PMF), respiratory failure, and death.
- Conditions
- Silicosis, Progressive Massive Fibrosis, Complicated Silicosis
- Trial name
- NCT05118256
- Testing
- Pirfenidone Oral Tablet
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Instituto de investigación e innovación biomédica de Cádiz
Silicosis
Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone)
Silicosis is well-known occupational disease caused by free crystalline silica (silicon dioxide) and is marked by inflammation and pulmonary fibrosis.
- Trial name
- NCT01338064
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Silicosis Tuberculosis
Short Course Rifapentine and Isoniazid for the Preventive Treatment of Tuberculosis(SCRIPT-TB)
Tuberculosis (TB) remains the most important infectious disease in the world. Preventive treatment plays an important role in successful control of TB.
- Trial name
- TB (NCT03900858)
- Testing
- Isoniazid；Rifapentine
- Where
- China
- Volunteers
- 566 people
- Sponsor
- Huashan Hospital
Silicosis
Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis
Silicosis is a chronic and incurable occupational disease that can progress independent of the end of exposure. Recent works suggest that the Forced Oscillation Technique (FOT) may help to improve our understanding of the changes…
- Trial name
- NCT01725971
- Where
- Brazil
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Silicosis, Pneumoconiosis; Silica
Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma
Silicosis, a preventable yet irreversible occupational lung disease, has an insidious onset with a latency period for diagnosis extending beyond 10 years from the initial exposure.
- Trial name
- NCT04205708
- Testing
- Tuberculosis test, Chest X-ray, Pulmonary Function Test
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- University of Oklahoma
Silicosis
Reducing Silica Exposure Among Brick Kiln Workers in Nepal
Inhaling respirable silica increases the risk for silicosis, an incurable and debilitating lung disease. In South Asia, one high-risk industry is brick manufacturing, where more than 4 million manual laborers mold bricks by hand.
- Trial name
- NCT06090370
- Testing
- N95 Respirator, Protective Eyewear, Baseline Survey
- Where
- 3 sites in United States, Nepal
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
TB - Tuberculosis, Silicosis
KAP TB in Senior Management Officials of Companies With Increased Silica Exposure
The study was designed as a descriptive cross-sectional survey conducted between February and October 2022. Senior management officials were targeted because of their role in workplace policy and oversight.
- Conditions
- TB - Tuberculosis, Silicosis, Occupational Exposure, Occupational Health
- Trial name
- KAP TB (NCT07749872)
- Where
- Zambia
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Silicosis
Comprehensive Risk Assessment of People With Silicosis: A Population-based Study
Objectives: This study aims to explore the risk profiles among people with silicosis in Hong Kong underpinned by the Pittsburgh Mind-Body Center model.
- Trial name
- NCT02794701
- Testing
- People with silicosis
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Chinese University of Hong Kong