Clinical trials: Simvastatin
Diabetes, Dyslipidemia
The Effects of Hypolipemic and Antidiabetic Treatment on Cytokines
The study is planned to show whether combined hypolipemic and antidiabetic therapy with various daily dosages influence the fasting plasma glucose, insulin sensitivity and proinflammatory cytokines in diabetic and dyslipidemic…
- Conditions
- Diabetes, Dyslipidemia, Inflammation, Cytokines
- Trial name
- MSF (NCT01101204)
- Testing
- Metformin 1000mg, simvastatin 10mg and fenofibrate 100mg
- Where
- Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Alzheimer's Disease
GSK2647544 RD, DDI in Healthy Young and Elderly Volunteers
GSK2647544 is an orally available, selective inhibitor of Lp PLA2 that is being developed for the treatment of Alzheimer's disease.
- Trial name
- NCT01978327
- Testing
- GSK2647544, drug-drug interaction
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pain
Effects of Simvastatin in the Prevention of Pain Experienced After Tooth Extraction
Atraumatic extraction of maxillary premolar teeth (on the Right, left side) was done; Subsequently, the patients were randomly divided into two equal groups: A group (Extraction + filled with a Simvastatin solution impregnated…
- Trial name
- NCT04406883
- Testing
- Extraction + filled with Simvastatin solution impregnated gelatin sponge
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Healthy
Effect of Simvastatin Withdrawal on Ocular Endothelial Function
Statins are drugs representing the most commonly prescribed medication for the treatment of hypercholesterolemia. In a recently published study, discontinuation of statin therapy in patients after acute myocardial infarction was…
- Trial name
- NCT02533141
- Testing
- Dynamic Vessel Analyzer (DVA), Laser Doppler Velocimetry (LDV), Simvastatin
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Chronic Periodontitis Wth Diabetes Mellitus
Comparative Evaluation Of 1.2% Atorvastatin and 1.2% Simvastatin Gel Local Drug Delivery And Redelivery In Chronic Periodontitis Subjects With Diabetes Mellitus: A Randomized Controlled Clinical Trial.
Statins are specific competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, known for its hypolipidemic actions, possessing biologically significant anti-inflammatory and antioxidant properties…
- Trial name
- NCT03745300
- Testing
- ATORVASTATIN, SIMVASTATIN
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Myopathy
Maintenance of Muscle Mass in Older People: the Negative Impact of Statin Therapy
A major contributor to frailty and immobility in the elderly is the age related loss of muscle mass (sarcopenia). Cardiovascular disease (CVD) is the leading cause of mortality in the elderly, with high blood cholesterol and…
- Trial name
- NCT01047163
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Dental Caries Extending to Pulp, Dental Implant Failed
Effect of Local Application of Simvastatin Versus Bone Powder on Implant Bone Changes
This study is conducted A- To investigate that PRF loaded with osteopromotive pharmacological drug can be a great aid in implant rehabilitation, and whether it could be a replacement for the other high price bone graft materials…
- Trial name
- NCT06016218
- Testing
- Simvastatin
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Dimensional Changes, Bone Density
Topic Simvastatin for Bone Regeneration
The goal of this clinical trial is to evaluate the efficacy of topical application of simvastatin in bone regeneration in the maxillae, in the reduction of dimensional bone changes, using mandibular third molar surgery as a model…
- Trial name
- SM (NCT07031778)
- Testing
- Simvastatin, Simvastatin 10 mg
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Healthy
A Study of LY3526318 in Healthy Male Japanese Participants
This is a study of LY3526318 in healthy male Japanese. The main purposes of this study are to: Assess how safe and well tolerated LY3526318 is when given by mouth. Measure how LY3526318 affects the kidney and the liver.
- Trial name
- NCT05580250
- Testing
- LY3526318, Iohexol, Simvastatin
- Where
- Japan
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
HIV Infections, HIV Seronegativity
The Effect of Efavirenz and Nelfinavir on the Blood Levels of Certain Lipid-Lowering Drugs
The purpose of this study is to find out whether certain anti-HIV drugs (efavirenz [EFV] and nelfinavir [NFV]) affect the amount of certain fat-lowering drugs (atorvastatin, pravastatin, and simvastatin) in the blood.
- Conditions
- HIV Infections, HIV Seronegativity, Lipodystrophy
- Trial name
- NCT00017758
- Testing
- Pravastatin sodium, Simvastatin, Atorvastatin calcium
- Where
- 10 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ridge Splitting, Simvastatin
The Effect of Simvastatin With Guided Bone Regeneration in Ridge Splitting and Simultaneously Implantation
Ridge split augmentation technique, with immediate implant placement, reduces the time of the treatment and the time of the final prosthetic reconstruction. Furthermore, compression of the bone increases its density.
- Conditions
- Ridge Splitting, Simvastatin, Immediate Implant
- Trial name
- NCT05020405
- Testing
- Immediate implant placement and ARS with GBR and SMV, Immediate implant placement and ARS with GBR
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Healthy
Drug Interaction Study of MGL-3196 With Rosuvastatin and Simvastatin
The purpose of this study is to determine whether MGL-3196 alters the pharmacokinetics of rosuvastatin and/or simvastatin in healthy male subjects and female subjects not of child-bearing potential.
- Trial name
- NCT02542969
- Testing
- Simvastatin, Rosuvastatin, MGL-3196
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Madrigal Pharmaceuticals, Inc.
Healthy
Pharmacokinetic and Safety Study of Cenicriviroc and HMG-CoA Reductase Inhibitors, Caffeine and Digoxin
This is a Phase 1, Open-Label, 3-Period, Single-sequence, Drug-drug Interaction Study in Healthy Subjects to Assess the Effect of Cenicriviroc on the Pharmacokinetics (PK) of HMG-CoA Reductase Inhibitors [Rosuvastatin (ROS)…
- Trial name
- NCT02685462
- Testing
- Rosuvastatin, Atorvastatin, Simvastatin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Tobira Therapeutics, Inc.
Healthy
A Study to Assess the Effects of Canagliflozin (JNJ-28431754) on the Pharmacokinetics, Pharmacodynamics, and Safety of Simvastatin in Healthy Volunteers
The purpose of this study is to determine how multiple doses of canagliflozin (JNJ-28431754) affect the pharmacokinetics (ie, how the body affects the drug) and pharmacodynamics (ie, how the drug affects the body) of a single…
- Trial name
- NCT01821027
- Testing
- Simvastatin, Canagliflozin (JNJ-28431754)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Dyslipidemia, Healthy Volunteers
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TAP311 in Healthy Subjects and Dyslipidemic Patients
This study will assess the safety, tolerability, and effect of TAP311 on blood lipids in healthy subjects and in patients who have dyslipidemia.
- Trial name
- NCT01487460
- Testing
- TAP311
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Three Wall Intrabony Defects in Chronic Periodontitis
Platelet Rich Fibrin Combined With Simvastatin for Treatment of Intrabony Defect in Chronic Periodontitis
The purpose of the present study was to investigate the efficacy of autologous Platelet rich fibrin (PRF) or PRF and Simvastatin (SMV) with open flap debridement (OFD) in the treatment of three wall intrabony defects in…
- Trial name
- NCT02120872
- Testing
- Platelet rich fibrin and simvastatin, Platelet rich fibrin, Open Flap Debridement alone
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Oxidative Stress, Diabetic Polyneuropathy
Statins for Oxidative Stress and Mitochondrial Function in Diabetic Polyneuropathy
Aims: To evaluate the effect of ezetimibe/simvastatin and rosuvastatin on oxidative stress and mitochondrial function in patients with DPN.
- Trial name
- NCT02129231
- Testing
- calcined magnesia, Ezetimibe/simvastatin, Rosuvastatin
- Where
- Mexico
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Hypercholesterolemia, Hyperlipidemia
Assessment of Interaction Between Vytorin and Niaspan in Healthy Subjects (P04955AM2)
This is a single-center, randomized, open-label, 3-period, 3-treatment multiple-dose crossover study designed to assess the interaction between VYTORIN® (Ezetimibe and Simvastatin) and NIASPAN® (Niacin Extended-Release Tablets)…
- Trial name
- NCT00652431
- Testing
- Vytorin + Niaspan, Vytorin, Niaspan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Choroideremia
The Short-term Effects of Simvastatin on the Vision of Males Affected by Choroideremia
Primary objective: To examine the short-term effects of of simvastatin on the vision on males with choroideremia, evaluated by full-field scotopic threshold testing.
- Trial name
- NCT01654562
- Testing
- Simvastatin
- Where
- Canada
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Hypercholesterolemia
Effect of Ezetimibe on Platelet Aggregation and LDL Tendency to Peroxidation
The aim of our study is to Estimate the reduction of LDL by ezetimibe in hypercholesterolemic patients on simvastatin.Investigate the effect of LDL lowering by ezetimibe on platelet activity and LDL tendency to peroxidation in…
- Trial name
- NCT00466401
- Testing
- Simvastatin, Ezetimibe
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital