Clinical trials: Simvastatin
Healthy Subjects
A Study to Evaluate the DDI of DBPR108 With Metformin,Glibenclamide,Valsartan, or Simvastatin in Healthy Subjects
This is a four-part, single-center, open-label, single-sequence crossover phase I clinical study to characterize the Drug-Drug Interaction (DDI) potential of DBPR108 at steady-state with Metformin hydrochloride, Glibenclamide…
- Trial name
- NCT04859452
- Testing
- DBPR108 tablets, Metformin hydrochloride tablets, Glibenclamide tablets
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Oxidative Stress
SIMOX - Induction of Oxidative Stress
The purpose of the study is to investigate if use of simvastatin is associated with the level of oxidative stress in humans. The association is examined by comparing changes in oxidative stress in a group treated with simvastatin…
- Trial name
- SIMOX (NCT02256254)
- Testing
- Simvastatin
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy
Bioequivalence Study of Simvastatin Tablets, 80 mg of Dr. Reddy's Under Fed Conditions
The purpose of this study is to compare the single dose bioavailability of Simvastatin 80 mg tablets with Zocor® 80 mg tablets of MercK \& Co.
- Trial name
- NCT01167933
- Testing
- Simvastatin
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Autogenous Tooth Bone Graft, Immediate Implant Placement
Immediately Placed Implants Using Simvastatin and Autogenous Tooth Graft Combination in Periodontally Compromised Sites
Recently, autogenous tooth graft (ATG) made from compromised teeth was applied in bone defects and resulted in a good clinical efficacy.(6) Moreover, it is more accepted by patients to use extracted teeth as a bone graft…
- Conditions
- Autogenous Tooth Bone Graft, Immediate Implant Placement, Simvastatin
- Trial name
- NCT04992416
- Testing
- immediate implant placement with ATBG and SMV, immediate implant placement with ATBG
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Healthy Participants
A Pharmacokinetic Interaction Study Between TMC435, Atorvastatin and Simvastatin in Healthy Participants
The purpose of this study is to evaluate effects of steady-state concentrations (constant concentration of medication in the blood) of TMC435 on the single dose pharmacokinetics (what the body does to the medication) of…
- Trial name
- NCT01689623
- Testing
- TMC435, Atorvastatin, Simvastatin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Inflammation, Atherosclerosis
Anti-inflammatory Effects of Simvastatin
The purpose of this research study is to determine which of the two ingredients of Vytorin (Simvastatin or Ezetimibe) is responsible for the anti-inflammatory effects of Vytorin
- Conditions
- Inflammation, Atherosclerosis, Hypercholesterolemia
- Trial name
- NCT04638400
- Testing
- Simvastatin 40mg, Ezetimibe 10mg
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- paresh Dandona
Healthy
PRC-4016 (Icosabutate) Phase I Drug-drug Interaction Study
The aim of the study is to evaluate the effect of PRC-4016 at steady state on the pharmacokinetics (PK) of cytochrome P450 (CYP) 3A substrates (midazolam, simvastatin), a CYP2C9 substrate (omeprazole) and a CYP2C19 substrate…
- Trial name
- NCT02367937
- Testing
- PRC-4016 (icosabutate)
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pronova BioPharma
Healthy Volunteers
A Study of Baricitinib and Simvastatin in Healthy Participants
The purposes of this study are to determine the effects of baricitinib on the time it takes to remove simvastatin from the body and to look at how well-tolerated and safe baricitinib is when given alone and in combination with…
- Trial name
- NCT01960140
- Testing
- Baricitinib, Simvastatin
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy Volunteer
Bioequivalence Study of Simvastatin 40 mg Film-coated Tablets in Healthy Thai Volunteers
The goal of this bioequivalence study is to determine and compare the rate and extent of absorption and to evaluate safety of test and reference formulations.
- Trial name
- NCT06178640
- Testing
- Simvastatin 40 mg film-coated tablet, Zocor 40 mg film-coated tablet
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- International Bio service
Diabetes Mellitus, Type 2
A Study to Investigate the Interaction of GSK1292263 With Rosuvastatin and Simvastatin in Healthy Subjects
This study is a Phase I, open-label, single-sequence drug interaction study to evaluate the effect of repeated doses of GSK1292263 on the pharmacokinetics of rosuvastatin and simvastatin in healthy adult subjects.
- Trial name
- NCT01101568
- Testing
- Simvastatin, Rosuvastatin, GSK1292263
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Periodontitis
Curcumin-Simvastatin-EDTA in the Treatment of Periodontitis
Among the root conditioning materials is the Ethylenediaminetetraacetic acid (EDTA). EDTA exposes the collagen fibers on dentin surfaces and also enhances early cell colonization.
- Trial name
- NCT04044417
- Testing
- currettage, curcumin simvastatin paste, EDTA root conditioning
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Peri-implant Mucositis
Use of Topical Subgingival Application of Simvastatin Gel in the Treatment of Peri-Implant Mucositis
This study seeks to test the recently discovered anti-inflammatory action of statins on inflamed mucosa surrounding dental implants. Hypothesis: The application of 1.2% simvastatin gel will decrease peri-implant inflammation.
- Trial name
- NCT03400475
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ahmed Mohamed Mahrous
Tooth, Deciduous
3Mixstatin ,Tri-Antibiotic Mix & Simvastatin in the Treatment of Primary Molars
The aim of this study is to determine whether the success rate of pulp therapy undergone on primary molars with signs and symptoms of odontogenic infection that may render them indicated for extraction will improve with the use…
- Trial name
- NCT03585751
- Testing
- Pulpectomy for primary molars + triple antibiotic mix, Pulpectomy for primary molars + 3mixstatin, Pulpectomy for primary molars + simvastatin
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Pain
To Explore The Potential For PF-04531083 To Effect The Blood Concentrations Of Simvastatin And Its Main Acid Metabolite Following Co-Administration Of Both Medications
The purpose of this study is to quantify the effect of multiple doses of PF-04531083 on the pharmacokinetics (PK) of co-administered single dose simvastatin.
- Trial name
- NCT01103739
- Testing
- PF-04531083, simvastatin
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Infection, Human Immunodeficiency Virus
A Drug Interaction Study Between Simvastatin, Atorvastatin, Rosuvastatin, and GSK2248761 in Healthy Subjects.
This study is a Phase I, open-label, single-sequence drug interaction study to evaluate the effect of repeated doses of GSK2248761 on the pharmacokinetics of simvastatin, atorvastatin, and rosuvastatin in healthy adult subjects.
- Trial name
- NCT01138072
- Testing
- GSK2248761, Simvastatin, Atorvastatin
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
Drug-drug Interaction of Empagliflozin (BI 10773) and Simvastatin
The objective of the study is to investigate the drug-drug interaction potential between BI 10773 and simvastatin.
- Trial name
- NCT01304329
- Testing
- BI 10773, simvastatin
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
PCOS, Insulin Resistance
Effects of Simvastatin and Micronized Trans-resveratrol Treatment on Polycystic Ovary Syndrome (PCOS) Patients
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age. Hyperandrogenism is the central feature of PCOS.
- Trial name
- NCT02766803
- Testing
- Simvastatin and micronized trans-resveratrol
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Type 2 Diabetes Mellitus
Pharmacokinetic Drug Interaction Study of Dapagliflozin and Valsartan or Simvastatin in Healthy Subjects
Phase A - To assess the effect of simvastatin on the pharmacokinetics (PK) of dapagliflozin and to determine the effect of dapagliflozin on the PK of simvastatin, when simvastatin and dapagliflozin are coadministered in healthy…
- Trial name
- NCT00839683
- Testing
- simvastatin, Dapagliflozin, valsartan
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hypercholesterolemia, Myopathy
DNA Diagnostic System for Statin Safety and Efficacy
Lipitor®, Zocor®, and Crestor® are statin drugs commonly taken to lower cholesterol and prevent heart disease. Statins lower cholesterol by different amounts in different patients and sometimes statins cause muscle pain, cramps…
- Trial name
- SIM (NCT00767130)
- Where
- 3 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Genomas, Inc
Healthy
Pharmacokinetics of Simvastatin and Its Metabolite Simvastatin Acid With and Without Concomitant Administration of Telmisartan in Healthy Subjects
To assess the pharmacokinetics of simvastatin and simvastatin acid with/without concomitant administration of telmisartan
- Trial name
- NCT02187536
- Testing
- Telmisartan, Simvastatin
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim