Clinical trials: Single Coronary Vessel Disease
Coronary Artery Disease
Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia
Binodenoson (an experimental drug) and adenosine (an FDA-approved drug that is currently used by doctors) are used to increase blood flow to the heart just like when a person exercises on a treadmill.
- Trial name
- VISION-305 (NCT00944970)
- Testing
- binodenoson, adenosine
- Volunteers
- 578 people
- Sponsor
- Pfizer
Coronary Artery Disease
Antiplatelet Effects of Ticagrelor Versus Clopidogrel in American Indian Patients
Assess the pharmacodynamic effect of ticagrelor vs. Clopidogrel in American Indian patients with stable coronary artery disease.
- Trial name
- NCT01706510
- Testing
- Ticagrelor, Clopidogrel
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Rapid City Regional Hospital, Inc
ST-elevation Myocardial Infarction
Evaluation of Myocardial Reperfusion After Primary PCI in Patients With High Platelet Reactivity Treated by Cangrelor or Not
This study aims to evaluate the impact on myocardial reperfusion and residual thrombotic burden of adding Cangrelor -a potent and immediate P2Y12 inhibitor- to ticagrelor in primary PCI patients with high on ticagrelor platelet…
- Trial name
- ERMIT (NCT04927949)
- Testing
- cangrelor perfusion during PCI, standard PCI
- Where
- France
- Volunteers
- 128 people
- Sponsor
- University Hospital, Caen
Coronary Artery Disease
Comparison of Cardiac Computed Tomographic Angiography (CTA) to Tc-99m Single Photon Emission Computed Tomography (SPECT)
Cardiovascular disease and ischemic heart disease is the #1 killer in Canada. Currently, Cardiac invasive catheterization angiography (CICA) is the gold standard for the assessment of the arteries in the heart.
- Trial name
- NCT00449943
- Testing
- Computed Tomographic Angiography, Myocardial Perfusion Imaging Scan
- Where
- Canada
- Volunteers
- 107 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Single-ventricle, Fontan Circulation
Venous Compression in Fontan
The aim of this study is to investigate whether venous compression garments increase exercise stroke volume in patients with Fontan circulation. To address this aim, we will test the following hypotheses: 1.
- Trial name
- NCT07220226
- Testing
- Lower extremity compression garments, Without compression garments
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Coronary Artery Disease
Study of the Orsiro Drug Eluting Stent System
The purpose of this study is to compare the BIOTRONIK Orsiro Drug Eluting Stent System with the Abbott Xience Prime™ Drug Eluting Stent System with respect to in-stent Late Lumen Loss in a non-inferiority study in de novo…
- Trial name
- BIOFLOW-II (NCT01356888)
- Testing
- Percutaneous Coronary Intervention (Abbott Laboratories - Xience Prime DES), Percutaneous Coronary Intervention (Orsiro DES)
- Where
- 24 sites in Austria, France and 6 more
- Volunteers
- 452 people
- Sponsor
- Biotronik AG
Arterial Hypertension, Heart Rhythm Disorders
Screening for Cardiac and Cardiac-associated Pathology Using Single-channel Electrocardiogram
It is a prospective, controlled, single-center, observational, non-randomized study. The study is planned to include at least 4000 patients 18 years old and older in the training sample and 1000 patients over 18 years old in the…
- Conditions
- Arterial Hypertension, Heart Rhythm Disorders, Valvular Heart Diseases, Heart Failure
- Trial name
- NCT07396792
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Coronary Artery Disease
Phase 3 Imaging and Safety Study of AI-700 in Patients With Suspected Coronary Artery Disease Undergoing SPECT Imaging
This study was designed to evaluate the ability of AI-700-enhanced rest-stress echocardiography to detect coronary artery disease (CAD) in patients with suspected ischemic heart disease who are indicated for single-photon…
- Trial name
- NCT00156793
- Testing
- AI-700 contrast-enhanced echocardiography
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Acusphere
Coronary Artery Disease, Coronary Stent Restenosis
A Phase 1b Study Evaluating RESTEN-MP in Subjects With Focal de Novo Stenosis
The process of re-narrowing of a coronary artery following a revascularization procedure such as angioplasty, begins at the time of the procedure.
- Trial name
- NCT00244647
- Testing
- RESTEN-MP
- Volunteers
- 40 people
- Sponsor
- Sarepta Therapeutics, Inc.
Abdominal Aorta Aneurysm, Abdominal Aorta Atheroma
Impact of Intra- and Postoperative Continuous Infusion of Lidocaine on Analgesia in Vascular Anaesthesia
The aim of the study is to test the effectiveness and safety of the use of lidocaine infusion in multimodal analgesic management.
- Conditions
- Abdominal Aorta Aneurysm, Abdominal Aorta Atheroma, Surgery, Pain, Postoperative
- Trial name
- NCT04691726
- Testing
- lidocaine 10mg/ml, Metamizole, Morphine
- Where
- Poland
- Volunteers
- 87 people
- Sponsor
- Łukasz Krzych
Coronary Artery Disease
Resting Full-cycle Ratio (RFR)-Guided Revascularization
The purpose of this study is to compare the clinical outcomes of a 2-year follow-up to determine whether RFR-guided coronary intervention is non-inferior to FFR-guided coronary intervention in patients with intermediate coronary…
- Trial name
- NCT06075160
- Testing
- Resting full-cycle ratio (RFR)-guided revascularization, Fractional flow ratio (FFR)-guided revascularization
- Where
- South Korea
- Volunteers
- 1,167 people
- Sponsor
- Sejong General Hospital
Myocardial Infarction
Multicentre 2x2 Factorial Randomised Study Comparing Tirofiban Versus Abciximab and SES Versus BMS in AMI
The purpose of this study is to determine which from the four combinations tirofiban+sirolimus eluting stent (SES), tirofiban+bare metal stent (BMS), abciximab+SES, abciximab+BMS is the possible gold standard treatment for…
- Trial name
- NCT00229515
- Testing
- abciximab followed by implantation of bare metal stent, abciximab and Sirolimus eluting stent, tirofiban and bare metal stent
- Where
- Italy
- Volunteers
- 744 people
- Sponsor
- Marco Valgimigli
Myocardial Infarct
Ilomedin Treatment for Patients Having Undergone Primary Percutaneous Coronary Intervention (PCI)
Acute myocardial infarct patients with STEMI (ST-elevation on ECG) whom undergo a primary percutaneous cardiac intervention will following the standard treatment , received low dose of Ilomedin and to low dose of standard…
- Trial name
- NCT01179776
- Testing
- Ilomedin, Ilomedin and standard low dose treatment
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Thrombologic ApS
Acute Coronary Syndrome
Pre-hospital Rule-out of Acute Coronary Syndrome
Patients with chest pain suspected for non ST-segment elevation acute coronary syndrome (NSTE-ACS) are routinely transferred to the emergency department (ED).
- Trial name
- ARTICA (NCT05466591)
- Testing
- Pre-hospital rule-out strategy
- Where
- Netherlands
- Volunteers
- 866 people
- Sponsor
- Radboud University Medical Center
Endothelial Dysfunction, Acute Myocardial Infarction (AMI)
Validation of Cor-IS Impedance Spectroscopy Against Ultrasound Flow-Mediated Dilation
This prospective observational study evaluated the Cor-IS bioelectrical impedance spectroscopy technique for the assessment of endothelial function by comparison with ultrasound-based brachial artery flow-mediated dilation (FMD).
- Conditions
- Endothelial Dysfunction, Acute Myocardial Infarction (AMI), Cardiovascular Risk Factors (e.g., Hypertension), Flow Mediated Dilation
- Trial name
- NCT07882550
- Testing
- Cor-IS FMD, Ultrasound FMD
- Where
- Greece
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Coronary Disease, Fatty Acids, Unsaturated
123I-BMIPP SPECT Analysis for Decreasing Cardiac Events in Hemodialysis Patients
The aim of this multi-center study is to determine the applicability of BMIPP to diagnosing cardiac disease and to predicting the outcome of patients on hemodialysis.
- Conditions
- Coronary Disease, Fatty Acids, Unsaturated, Radioisotopes, Hemodialysis
- Trial name
- B-SAFE (NCT00586950)
- Where
- Japan
- Volunteers
- 1,000 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Coronary Artery Disease
ARTDIVA Study : First in Man Safety Evaluation of the ART18Z Bioresorbable Stent
This prospective, multicentre, open labeled, single arm, first in man interventional investigation aims to evaluate the safety of the ART18Z bioresorbable stent for the treatment of patients with single de novo lesion of a native…
- Trial name
- NCT01761578
- Testing
- ART18Z Bioresorbable stent
- Where
- 5 sites in France
- Volunteers
- 30 people
- Sponsor
- Arterial Remodeling Technologies
ST Segment Elevation Myocardial Infarction (STEMI), Allogeneic Mesenchymal Bone Marrow Cells
A Study of Allogeneic Mesenchymal Bone Marrow Cells in Subjects With ST Segment Elevation Myocardial Infarction (STEMI)
The purpose of this study is to assess the safety and tolerability of human allogeneic mesenchymal bone marrow cells (aMBMC) administered intravenously to subjects with ST Segment Elevation Myocardial Infarction (STEMI).
- Trial name
- NCT01770613
- Testing
- Stem cells
- Where
- 2 sites in United States
- Sponsor
- Stemedica Cell Technologies, Inc.
Coronary Artery Disease
Remimazolam Besylate and Propofol Sedation on Hemodynamic for Coronary Artery Bypass Graft Patients
In the immediate postoperative period following cardiac surgery, many patients require short-term sedation until cardiovascular and respiratory stability has been achieved and weaning from artificial ventilation can be started.
- Trial name
- NCT06496165
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 338 people
- Sponsor
- Shanghai Zhongshan Hospital
ST-segment Elevation Myocardial Infarction
Phase 2 Study to Evaluate the Efficacy, Safety and PK of Intravenous Single Injection LC28-0126 Immediately Before PCI in STEMI Patients
Evaluate the efficacy, Safety and Pharmacokinetics of Intravenous single injection LC28-0126 immediately before PCI (Percutaneous Coronary Intervention) in Patients with STEMI (ST-segment Elevation Myocardial Infarction)
- Trial name
- NCT02070471
- Testing
- LC28-0126 Dose A, LC28-0126 Dose B, LC28-0126 Dose C
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- LG Life Sciences