Clinical trials: Single Dose
Malignant Melanoma, Neoplasms
A Pharmacokinetics Study to Investigate the Effect of Ketoconazole on Vemurafenib in Patients With BRAFV600 Mutation-Positive Metastatic Melanoma
This open-label, multi-center, three-period, one sequence study will investigate the effect of ketoconazole on the pharmacokinetics of vemurafenib in patients with unresectable BRAFV600-mutation positive metastatic melanoma or…
- Trial name
- NCT01765556
- Testing
- ketoconazole, vemurafenib
- Sponsor
- Hoffmann-La Roche
Alzheimer Disease, Cognition Disorder
Study to Evaluate the Effects of Single Ascending Oral Doses of ACD856 on Safety, Tolerability and Pharmacokinetics
The SAD design of the study is based on the aim to study safety, tolerability and PK of selected doses of ACD856 in a limited number of healthy volunteers. ACD856 will be administered orally.
- Trial name
- NCT05077631
- Testing
- ACD856, ACD856 (fed cohort)
- Where
- Sweden
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- AlzeCure Pharma
Osteoarthritis, Knee
Study of Safety, Tolerability and Pharmacokinetics of LNA043 in Japanese Osteoarthritis Participants
The objective of this study was to determine the safety, tolerability and pharmacokinetics after single ascending dose of LNA043 in Japanese participants with osteoarthritis of the knee.
- Trial name
- NCT04564053
- Testing
- LNA043
- Where
- 2 sites in Japan
- Volunteers
- 12 people
- Sponsor
- Novartis Pharmaceuticals
Healthy
Study to Evaluate Safety, Tolerability and Pharmacokinetics of ASC42 in Chinese Healthy Subjects
This is a Phase I Randomized, Double-Blind, Placebo-Controlled, Dose Escalation, Single Center Bridging Study to Evaluate Safety, Tolerability and Pharmacokinetics of ASC42 in Chinese Healthy Subjects.
- Trial name
- NCT04965337
- Testing
- ASC42
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ascletis Pharmaceuticals Co., Ltd.
Acute Pain
Efficacy, Tolerability, Safety, and Pharmacokinetic Study of DFN-15
Efficacy, Tolerability, Safety and Pharmacokinetic Study of DFN-15 in Post-Surgical Dental Pain.
- Trial name
- NCT03554772
- Testing
- DFN-15 (Celecoxib Oral Solution) 62.5 mg, DFN-15 (Celecoxib Oral Solution) 125 mg, DFN-15 (Celecoxib Oral Solution) 250 mg
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Pain
Dose Proportionality and Food Effect of Morphine Sulfate
Establish the dose proportionality of the 15 mg and 30 mg morphine sulfate tablets and to examine the effect of food on absorption from the 30 mg tablet.
- Trial name
- NCT00994539
- Testing
- morphine sulfate
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Healthy Volunteers
The Purpose of the Study is to Evaluate the Safety, Tolerability and Pharmacokinetics of Single-ascending and Multiple-ascending Doses of GIM-407
This study is for the evaluation of the safety, tolerability, PK, PD, and biomarker activity of GIM-407 in healthy volunteers in the absence of any disease-related or potentially confounding factors.
- Trial name
- NCT06536101
- Testing
- GIM-407
- Where
- Australia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Georgiamune Inc
Healthy Volunteers
A PET Study Following a Single Oral Dose of ITI-333 in Healthy Subjects
This is an open-label, single-dose study of up to 4 dose levels of ITI-333 in healthy male and female subjects. Each cohort will enroll 6 subjects.
- Trial name
- NCT05470101
- Testing
- ITI-333
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Intra-Cellular Therapies, Inc.
Pregnancy
Estriol and Trimegestone Dose-response Trial With Single Dose Application of Vaginal Rings
This clinical trial is performed as proof of pharmacological action investigation by demonstration of ovulation inhibition (dose-response study) under treatment with three Test vaginal rings releasing varying doses of estriol…
- Trial name
- NCT03343912
- Testing
- Estriol 0.400 mg/day and Trimegestone 0.06 mg/day, Estriol 0.300 mg/day and Trimegestone 0.12 mg/day, Estriol 0.200 mg/day and Trimegestone 0.18 mg/day
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Galeno Desenvolvimento de Pesquisas Clínicas
Healthy
Bioavailability of Telmisartan/Amlodipine Fixed Dose Combination in Healthy Male and Female Volunteers
Study to investigate the effect of food intake on the bioavailability of a fixed dose combination of 80 mg telmisartan / 10 mg amlodipine following a high fat breakfast
- Trial name
- NCT02259777
- Testing
- Telmisartan/Amlodipine, high fat, high caloric meal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
Safety, Tolerability and Pharmacokinetics of Eptinezumab in Healthy Chinese Subjects
The purpose of the study is to investigate how the body absorbs and get rid of eptinezumab when given directly into a vein in Chinese subjects.
- Trial name
- NCT05045781
- Testing
- Eptinezumab
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Healthy Participants
A Study to Assess the Relative Bioavailability of Brensocatib Pediatric Oral Solution to Oral Tablets in Healthy Participants
The primary purpose of this study is to determine the relative bioavailability of brensocatib between the pediatric oral solution and oral tablets in healthy participants.
- Trial name
- INS1007 (NCT06344728)
- Testing
- Brensocatib Oral Solution, Brensocatib Oral Tablet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Insmed Incorporated
Healthy
A Study of LY3537031 in Healthy Participants
The main purpose of this study is to evaluate the safety and tolerability of LY3537031 in healthy participants. The blood tests will be performed to check how much LY3537031 gets into the bloodstream, how long the body takes to…
- Trial name
- NCT04648865
- Testing
- LY3537031
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Muscular Atrophy, Spinal
A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of a Single Oral Dose of Risdiplam Compared to Matched Healthy Participants With Normal Hepatic Function
This is a multi-center, open-label, non-randomized, parallel-group, 2-part study to evaluate the effect of hepatic impairment on the PK and safety and tolerability of a single oral dose of risdiplam compared to matched healthy…
- Trial name
- NCT03920865
- Testing
- Risdiplam
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Healthy
Safety and Pharmacokinetic Comparison of Co-administration and a Combination Drug of Rosuvastatin and Olmesartan in Healthy Male Volunteers
This study investigates safety and pharmacokinetic comparison of DWJ1276, a combination drug of Rosuvastatin and Olmesartan (test formulation), and co-administration of Rosuvastatin and Olmesartan (reference formulation) for…
- Trial name
- NCT01823900
- Testing
- Test formulation, Reference formulation
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Severance Hospital
Infection, Human Immunodeficiency Virus
A Study to Investigate the Pharmacokinetics, Safety and Tolerability of GSK1349572 (Dolutegravir, DTG) in Healthy Japanese Subjects
This study is a Phase 1, open label, non-randomized, single dose study to determine pharmacokinetics, safety and tolerability of doultegravir (DTG) following 50 mg single oral administration in healthy Japanese subjects.
- Trial name
- NCT01332565
- Testing
- GSK1349572
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Thromboembolic Disorders
A Trial to Learn How a New Liquid Form of Rivaroxaban Behaves and How Safe it is Compared to the Current Tablet Form of Rivaroxaban in Healthy Male Participants
Researchers were looking for another way to treat people with a blood clot in their veins. Before a treatment can be approved for people to take, researchers do clinical trials to better understand its safety and how it behaves.
- Trial name
- NCT04720092
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bayer
Tobacco Dependence
Single-dose Nicotine Pharmacokinetics With Three Oral Nicotine Replacement Products. A Study in Healthy Smokers.
Single-dose nicotine pharmacokinetics with three oral nicotine replacement products.
- Trial name
- NCT01234792
- Testing
- 6 mg Experimental nicotine gum, 4 mg Nicotine Gum/, 2 mg Nicotine Gum
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- McNeil AB
Healthy
A Study to Learn More About the Study Medicine PF-07264660 in Healthy Chinese Adult Participants
The purpose of this study is to learn if the study medicine (called PF-07264660) is safe and how it is processed in healthy Chinese participants. This study is seeking participants who: are between 18 to 65 years of age.
- Trial name
- NCT06712082
- Testing
- PF-07264660
- Where
- 2 sites in China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
A Study to Evaluate the Pharmacokinetics and Safety Between HCP2201 and Co-administration of Each Component in Healty Male Volunteers
The purpose of this study is to evaluate the pharmacokinetic characteristics and safety between HCP2201 and co-administration of each component in fasting condition in healthy male volunteers.
- Trial name
- NCT05737082
- Testing
- HCP2201, RLD2205, RLD2206
- Where
- South Korea
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
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