Clinical trials: Single Lung Ventilation
COVID-19
Safety and Immunogenicity Study in Adults of AZD1222 and rAd26-S Administered as Heterologous Prime Boost Regimen for the Prevention of Coronavirus Disease 2019 (COVID-19)
This is a Phase I/II, parallel group, single blinded (participant blinded), randomised study assessing the immunogenicity and safety of AZD1222 and rAd26-S administered as heterologous prime-boost in alternating order in 2 study…
- Trial name
- NCT04760730
- Testing
- AZD1222, rAd26-S
- Where
- United Arab Emirates
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- R-Pharm
Anesthesia Time
Single Lumen Intubation and Heart-Lung Machine (HLM) Mode Ventilation
In this trial, we aimed to compare anesthetic outcomes of single lumen intubation with Heart-Lung Machine mode ventilation versus double lumen intubation study in endoscopic thoracic sympathetic blockade.
- Trial name
- NCT05791045
- Testing
- single vs double
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Biruni University
COPD
Effect of a New Combination Bronchodilator on Exercise in GOLD Stage II Moderate COPD
Preliminary information from our laboratory indicated that even patients with milder chronic obstructive pulmonary disease (COPD) can have significant physiological derangements which become more pronounced during exercise…
- Trial name
- NCT01491802
- Testing
- LAMA/LABA, LAMA
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Queen's University
One-Lung Ventilation, Postoperative Complications
Driving Pressure and Postoperative Pulmonary Complications in Thoracic Surgery
Pulmonary complications are the most common complication in thoracic surgery and the leading cause of mortality.Therefore, lung protection is utmost important, and protective ventilation is strongly recommended in thoracic…
- Conditions
- One-Lung Ventilation, Postoperative Complications, Driving Pressure, Postoperative Pulmonary Complication
- Trial name
- NCT04260451
- Testing
- ventilation
- Where
- South Korea
- Volunteers
- 1,300 people
- Sponsor
- Samsung Medical Center
Lung Diseases, Dyspnea
Effects of Transcutaneous Nerve Electrostimulation (TENS) of Acupuncture Points on Pulmonary Function and Dyspnea Symptoms in Patients With Pulmonary Nodules
The ancient use of acupuncture as a treatment modality of traditional Chinese medicine has also been proven effective in Western medicine.
- Conditions
- Lung Diseases, Dyspnea, Acupuncture
- Trial name
- LUNG TENS (NCT04051398)
- Testing
- transcutaneous nerve electrostimulation (TENS) of acupuncture points
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital Santa Marcelina
Bronchopulmonary Dysplasia
Ultrasound Assessment of Diaphragmatic Function in Infants With BPD
Preterm infants have high and prolonged exposure to positive pressure ventilation, which contributes to acute lung injury and the development of bronchopulmonary dysplasia (BPD).
- Trial name
- NCT04941963
- Testing
- Chest ultrasound
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Mount Sinai Hospital, Canada
Double-Lumen Tube Placement, One-Lung Ventilation
Examination of Double-Lumen Tube Placement by Functional Electrical Impedance Tomography
The purpose of this study is to determine whether functional electrical impedance tomography is suitable for examination of double-lumen tube placement compared with fibreoptic evaluation.
- Trial name
- NCT00486616
- Testing
- electrical impedance tomography, double-lumen tube placement
- Where
- Germany
- Sponsor
- University Hospital Freiburg
Lung Cancer
Effect of Optimal Positive End-Expiratory Pressure on Oxygenation and Intrapulmonary Shunt During One-lung Ventilation
To observe the effect of compliance guided an optimal Positive End-Expiratory Pressure（PEEP）on arterial oxygenation and intrapulmonary shunt during one-lung ventilation(OLV)，and discuss the lung protective effect of optimal PEEP…
- Trial name
- NCT03804398
- Testing
- compliance guided an optimal Positive End-Expiratory Pressure, PEEP level of 5 cmH2O
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Fujian Medical University Union Hospital
One-lung Ventilation (OLV), Video-assisted Thoracis Surgery (VATS)
Comparison of Different Ventilation Modes in Video-Assisted Thoracoscopic Lung Resection
One-lung ventilation (OLV) is required for video-assisted thoracoscopic surgery (VATS) lung resection, but it exposes the dependent lung to atelectasis, high driving pressures, and oxidative stress, and is associated with…
- Trial name
- OLV-VENT (NCT07866170)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Respiratory Disorders, Asthma and Rhinitis
Bioequivalence of GW483100 10 Milligram (mg) Tablets in Healthy Subjects Under Fasting Conditions
This study is conducted to determine whether the test product (GW483100 10 mg containing montelukast sodium equivalent to 10 mg of montelukast) is bioequivalent to the reference montelukast sodium 10 mg tablets (innovator…
- Trial name
- NCT02658422
- Testing
- Test Montelukast, Reference Montelukast
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Myopathy
Efficacy and Tolerance of AVAPS Mode in Myotonic Dystrophy
Myotonic dystrophy type 1 is a myopathy with complex respiratory pattern and at risk to develop respiratory failure. Classical mode of ventilation are sometimes not tolerated or ineffective in this population.
- Trial name
- NCT01530841
- Testing
- Nocturnal ventilation
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
One-Lung Ventilation, Thoracic Surgery
Dexmedetomidine Improved Oxygenation and Reduced Shunt in One-Lung Ventilation at High-Risk Pediatric Thoracic Surgery
Children with high anesthetic risk who underwent Thoracic surgery with OLV (one lung ventilation) technique during general anesthesia were divided into two groups.
- Trial name
- NCT06505772
- Testing
- Dexmedetomidine, Normal saline
- Where
- Syria
- Volunteers
- 78 people
- Sponsor
- Damascus University
COPD, One Lung Ventilation
Effects of Dexmedetomidine on Respiratory Mechanics and Oxygenation During One Lung Ventilation With Chronic Obstructive Lung Disease
COPD is often associated with the airflow limitation and the pulmonary hyperinflation. During the one-lung ventilation (OLV), COPD patients' physiologic dead space increases and hypercapnia may develop.
- Trial name
- NCT02185430
- Testing
- saline infusion, dexmedetomidine infusion
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Unrecognized Condition
Titration of Inspired Oxygen to Decrease the Incidence of Postoperative Pulmonary Complications
Lung cancer is with the highest incidence rate and mortality among people over 60 years old in China. Postoperative pulmonary complications (PPCs) is the most common complication after pneumonectomy, which has a significant…
- Trial name
- NCT06243146
- Testing
- Titration of Inspired Oxygen
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Sichuan Provincial People's Hospital
Fluid Response
Pulse Pressure Variations as Index of Preload Dependency During Thoracic Surgery
Background: calculation of the pulse pressure variation (PPV) has repeatedly been shown to be a reliable predictor of fluid responsiveness in mechanically ventilated patients.
- Trial name
- NCT01329146
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Lille
One-lung Ventilation
Nomogram for Prediction of Alveolo-arterial Gradient During One-lung Ventilation
The cause of hypoxia during one-lung ventilation is a common anaesthetic problem seen during thoracic surgery and is associated with increased fraction of shunted blood.
- Trial name
- NCT06376123
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
End of Life, Respiratory Failure
Feasibility of the Comfort Measures Only Time Out (CMOT)
Nearly 25% of Americans die in intensive care units (ICUs). Most deaths in ICUs are expected and involve the removal of ventilator support, or palliative withdrawal of mechanical ventilation (WMV).
- Conditions
- End of Life, Respiratory Failure, Ventilatory Failure, Coma
- Trial name
- NCT05861323
- Testing
- Comfort Measures Only Time out (CMOT)
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Beth Israel Deaconess Medical Center
Thoracic Surgery, One-lung Ventilation
Individualized PEEP in Thoracic Surgery
Intraoperative protective ventilation with low tidal volumes (TV), positive end-expiratory pressure (PEEP) and possibly lung recruitment maneuvers (RMs) reduces postoperative pulmonary complications.
- Conditions
- Thoracic Surgery, One-lung Ventilation, Respiratory Mechanics, Artificial Respiration
- Trial name
- NCT04740151
- Testing
- Best PEEP, Standard PEEP
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Trieste
End-stage Lung Disease
Perioperative Recovery Outcomes With a Spontaneous Breathing Strategy in Severely Underweight Lung Transplant Recipients
The goal of this prospective, multicenter, single-arm clinical study is to learn whether a spontaneous breathing-preserving perioperative management strategy can improve recovery and is safe in lung transplant recipients with…
- Trial name
- NCT07384572
- Testing
- Lung transplantation that preserves spontaneous breathing function
- Volunteers
- 56 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
One Lung Ventilation
Comparison of Three Methods of PEEP Titration During One Lung Ventilation in Prone Position
One-lung ventilation and prone positioning during thoracoscopic esophagectomy is associated with pulmonary complications so lung protection is strongly recommended.
- Trial name
- NCT05851612
- Testing
- constant PEEP, Driving pressure guided PEEP, oxygenation method guided PEEP
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Mansoura University