Clinical trials: Single Nucleotide Polymorphism
Rhabdomyolysis, Myopathy
The Association of Genetic Polymorphisms With Statin-Induced Myopathy.
To observe not only the distribution of single nucleotide polymorphism in genes related with pharmacodynamic and pharmacokinetics alteration of statins but also to analyze the correlation between these SNPs and the incidence of…
- Trial name
- NCT00549029
- Testing
- DNA
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Athletic Performance
Stool Microbiome, Pathogens, and Infectious Agents Among Olympic and Elite Athletes
This research is being done to investigate fecal microbiome and metabolome as well as serum analytes and single nucleotide polymorphisms in Olympic athletes in comparison with other elite athletes.
- Trial name
- TRMC-Bio (NCT02818413)
- Testing
- Biospecimen collection and questionnaires
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Congenital Heart Disease
Genetics of Congenital Heart Disease
Congenital heart disease (CHD) is the most common type of birth defect but the cause for the majority of cardiac birth defects remains unknown.
- Trial name
- NCT01192048
- Testing
- Blood Sample Collection
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Hypercholesterolemia, Myopathy
DNA Diagnostic System for Statin Safety and Efficacy
Lipitor®, Zocor®, and Crestor® are statin drugs commonly taken to lower cholesterol and prevent heart disease. Statins lower cholesterol by different amounts in different patients and sometimes statins cause muscle pain, cramps…
- Trial name
- SIM (NCT00767130)
- Where
- 3 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Genomas, Inc
Immune Thrombocytopenic Purpura
" Effect of Single-nucleotide Polymorphism of CD40 Gene rs1883832 C/T on the Risk of Immune Thrombocytopenic Purpura "
Immune thrombocytopenia is an acquired autoimmune disease, in which platelets are opsonized by auto-antibodies and destroyed by phagocytic cells .Genetic polymorphisms in the immune mediators have been suggested to play a pivotal…
- Trial name
- NCT05585944
- Testing
- Genotyping of rs1883832C/T related single-nucleotide polymorphism
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Metalloproteinase SNPs -1575 G/A MMP-2, 836 A/G MMP-9 and -77 A/G MMP-13 and Risk for Developing Knee Osteoarthritis in Greek Population
Association of Single Nucleotide Polymorphisms (SNPs) in Metalloproteinases (MMPs) Genes With the Risk of Primary Knee Osteoarthritis in Greek Population.
Does the presence of gene polymorphisms -1575G / A in the MMP-2 gene, 836A / G in the MMP-9 gene and -77A / G in the MMP-13 gene, affect the risk of developing idiopathic knee osteoarthritis in the Greek population?
- Trial name
- NCT04463290
- Testing
- No intervention, Patients selection based on clinical symptoms and radiological imaging
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Mammography
Single Nucleotide Polymorphism (SNP) Panels and Risk Assessment in Women Undergoing Mammography
The primary objective is to compare the predicted lifetime risk values produced by SNP panel assessment to the risk values produced by the prediction models that are most commonly used.
- Trial name
- NCT01124019
- Where
- United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Genetics, Skin Aging
Relationship of Skin Related SNP to Topical Skin Care Product
Demonstrate the relationship between single nucleotide polymorphisms (SNP) and response to a topical skin care product.
- Trial name
- NCT03446079
- Testing
- Topical Anti Aging Cream
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- HelicalCodeMD
Skin Cancer
TLR4 Polymorphisms and Risk of Skin Cancer
Toll-like receptors (TLRs) play a key role in the innate immune system. Toll-like receptor-4 (TLR4) in particular, appears to play a role in susceptibility to cancer.
- Trial name
- NCT03122366
- Testing
- Detection of single nucleotide polymorphisms (SNP)
- Where
- United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Metformin, Organic Cation Transporter 2
A Pharmacokinetic Evaluation of Metformin in Relation to the Polymorphism A270S in Healthy Caucasian Volunteers
The aim of the study is to evaluate the pharmacokinetics of metformin in healthy Caucasians volunteers with and without the polymorphism A270S in OCT2,thus the study hypothesis is that renal clearance of metformin is affected in…
- Conditions
- Metformin, Organic Cation Transporter 2, Polymorphism,Single Nucleotide
- Trial name
- NCT01237522
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
NAFLD, Fatty Liver
A Nutrigenetic Intervention in MASLD
The study is designed as a 12-week randomized controlled dietary intervention in individuals who had been diagnosed with NAFLD in the last 6 months and whose body mass index is above 25 at the time of participation in the…
- Trial name
- NCT06220695
- Testing
- Dietary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Atopy, Allergic Disease
Use Cord Blood Single Nucleotide Polymorphism to Predict the Later Development of Atopy and Allergy
The aim of our study was firstly to detect in cord bloods the polymorphism of genes related to atopy and allergic diseases and to examine their mutual interaction and their associations with cord blood IgE and cytokines.
- Trial name
- NCT00444327
- Where
- 2 sites in Taiwan
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
Healthy
Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)
The objective of this study is to evaluate the association between the evolution of plasma CPK levels and genetic polymorphisms, both before the muscle-damaging exercise and at three post-exercise time points.
- Trial name
- POLYGENDOMUS (NCT06740136)
- Testing
- Exercise
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Lille University
Phantom Limb
Study to Identify the Genetic Variations Associated With Phantom Limb Pain
The purpose of this study is to determine if there is a genetic component to phantom limb pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and phantom limb pain group.
- Trial name
- NCT01462448
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 726 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Primary Ovarian Insufficiency, Cardiovascular Diseases
Associations of Combinations of Single-nucleotide Polymorphisms in Women With Premature Ovarian Failure
Research objective. To study the associations between combinations of single nucleotide polymorphisms and behavioural risk factors with non-communicable diseases and adverse outcomes in women with premature ovarian failure.
- Conditions
- Primary Ovarian Insufficiency, Cardiovascular Diseases, Menopause, Premature, Coronary Disease
- Trial name
- NCT04943354
- Testing
- Taking a person's venous blood
- Where
- Russia
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Ryazan State Medical University
ITP - Immune Thrombocytopenia
"Cytotoxic T Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Single-nucleotide Polymorphism in Primary Immune Thrombocytopenic Purpura in Children"
the investigators aim in this study to investigate the potential association of single gene polymorphisms of CTLA-4 (SNPs; rs: 3087243) using real-time PCR in children with primary ITP.
- Trial name
- ITP (NCT07014904)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Single Nucleotide Polymorphism
Folate Gene Polymorphisms and Cellular Folate Speciation Pilot Study
This pilot study is designed to investigate differences in folate-related genes (single nucleotide polymorphisms) and their relationship to the species of folate present on red blood cells.
- Trial name
- FolGene (NCT00975364)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Single-nucleotide Polymorphism (SNP) for Glaucoma
Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients
A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.
- Trial name
- NCT01025024
- Testing
- SNP analysis of the DNA
- Where
- South Korea
- Volunteers
- 1,224 people, healthy volunteers welcome
- Sponsor
- Chungnam National University