Clinical trials: Skeletal Age Maturation
Achondroplasia
A Clinical Trial to Evaluate the Safety and Efficacy of BMN 111 in Infants and Young Children With Achondroplasia
Study 111-206 is a Phase 2 randomized, double-blind, placebo-controlled clinical trial of BMN 111 in infants and young children with a diagnosis of achondroplasia.
- Trial name
- NCT03583697
- Testing
- BMN 111
- Where
- 16 sites in United States, Australia and 2 more
- Volunteers
- 75 people
- Sponsor
- BioMarin Pharmaceutical
Inactivity, Physical, Aging
Oral 'Breath Test' to Measure Anabolic Sensitivity to a Protein Meal Across the Age and Physical Activity Spectrum
The purpose of this study is to determine how anabolic sensitivity, in response to the ingestion of a liquid protein meal, differs across the lifespan, between biological sexes, and with varying physical activity levels.
- Conditions
- Inactivity, Physical, Aging, Healthy Aging, Growth & Development
- Trial name
- NFRF (NCT06744491)
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Bone Development
Bone Age of Chinese Child (BACC)
The bone age of the hand and wrist will be assessed with X-rays in more than 20,000 healthy children age 3-18 years old recruited in 28 sites from 14 province.The bone mineral density (BMD) will be measured as well.
- Trial name
- BACC (NCT04197557)
- Where
- China
- Volunteers
- 20,166 people, healthy volunteers welcome
- Sponsor
- Beijing Jishuitan Hospital
Adolescence, Bone Maturation
Age Estimation of Adolescents for Legal Purposes
Economic globalisation has been associated with a rise of cross-border migration in Europe. In France, courts commonly demand appropriate medical tests aimed at age estimations of supposed minors without documentation.
- Trial name
- AGE-ADO (NCT01577498)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Growth Hormone Deficiency (GHD), Growth Hormone Deficiency in Children
GB06 Phase III Trial for Pediatric Growth Hormone Deficiency
This study aims to evaluate the efficacy and safety of GB06 (a biosimilar of Norditropin®FlexProTM from Novo Nordisk) for the treatment of growth disorders caused by growth hormone deficiency (GHD) in children.
- Conditions
- Growth Hormone Deficiency (GHD), Growth Hormone Deficiency in Children, Growth Hormone Deficiency, Pediatric
- Trial name
- NCT07553351
- Testing
- GB06, Norditropin®FlexProTM
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Kexing Biopharm Co., Ltd.
Bone Aging, Osteoporosis Diagnosis
Automated Bone Age Estimation From Noncontrast Abdominal CT Using Deep Learning
This study is a retrospective analysis that uses abdominal CT scans, which were originally taken for other medical reasons, to estimate bone age.
- Trial name
- NCT07162168
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Slipped Capital Femoral Epiphysis
Evaluation of Skeletal Maturity for Slipped Capital Femoral Epiphysis
This study is being done for two reasons: 1) to evaluate growth problems in the hip in patients with Slipped Capital Femoral Epiphysis (SCFE) as they continue to grow into adults, and 2) to help doctors determine which patients…
- Trial name
- NCT01220882
- Testing
- Radiographic skeletal age assessment
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rutgers, The State University of New Jersey
Achondroplasia
A Study to Evaluate the Efficacy and Safety of Infigratinib in Children and Adolescents With Achondroplasia
This is a Phase 3, multicenter, double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of infigratinib in children and adolescents with achondroplasia (ACH) who have completed at least 26 weeks of…
- Trial name
- PROPEL3 (NCT06164951)
- Testing
- Infigratinib 0.25 mg/kg/day
- Where
- 27 sites in United States, Argentina and 8 more
- Volunteers
- 114 people
- Sponsor
- QED Therapeutics, a BridgeBio company
McCune-Albright Syndrome
Arimidex in McCune Albright Syndrome
The primary objective of this study is to evaluate the safety and efficacy of anastrozole 1 mg given once daily in subjects with McCune-Albright Syndrome.
- Trial name
- NCT00055302
- Testing
- Arimidex 1 mg
- Where
- 7 sites in France, Germany and 2 more
- Volunteers
- 40 people
- Sponsor
- AstraZeneca
Frail Elderly Syndrome, Diabetes
Muscle Multi-parametric NMR Imaging Development in Aged People With Sarcopenia or Frailty Syndrome; CLINical Study
Frailty is a multideterminant syndrome in which muscle function appears to play a central role. Muscle function depends on brain control, nutrition and perfusion.
- Trial name
- MIDAS (NCT04238494)
- Testing
- Nuclear magnetic resonance (NMR)
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Bone Diseases, Developmental
Developing a COMputerised Bone Age Tool
The Greulich and Pyle technique (G\&P) is that most commonly used to assess bone age in children, particularly in the context of suspected skeletal dysplasia.
- Trial name
- COMBAT1 (NCT02617901)
- Testing
- Left hand DXA
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Skeletal Age Maturation
BASIC Study: Bone Age Study In Children
This study will see if the introduction of a hand outline on the Xray plate on which the child rests their hand will improve the quality of the Xray and reduce exposure to additional radiation by not having xrays repeated.
- Trial name
- BASIC (NCT04216914)
- Testing
- Hand outline
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Hip Dislocation, Congenital, Hip Dysplasia, Congenital, Nonsyndromic
Global Hip Dysplasia Registry
Developmental dysplasia of the hip (DDH) is the most common hip condition affecting infants and children. DDH represents a spectrum of issues affecting the hip joint - a "ball-and-socket" joint.
- Conditions
- Hip Dislocation, Congenital, Hip Dysplasia, Congenital, Nonsyndromic, Congenital Dysplasia of the Hip, Congenital Hip Dislocation
- Trial name
- GHDR (NCT04117685)
- Testing
- Observational
- Where
- Canada
- Volunteers
- 5,000 people
- Sponsor
- University of British Columbia
Short Stature, Growth Disorders
Bone Age Assessment in Children Using Ultrasound Compared to Wrist X-ray
Bone age assessment in children is based on the interpretation of hand x-ray scans according to Greulich and Pyle (GP) standard atlas and frequently used for evaluating growth and puberty in children and adolescents.
- Trial name
- NCT03123003
- Testing
- SonicBone Ultrasound, Wrist X-ray
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Scoliosis; Adolescence, Bone Diseases
Thumb Ossification Composite Index (TOCI) to Predict Skeletal Maturity and Curve Progression in AIS
Accurate skeletal maturity assessment is important for prediction of curve progression and clinical management of adolescent idiopathic scoliosis (AIS) including bracing decision and counseling for prognosis.
- Conditions
- Scoliosis; Adolescence, Bone Diseases, Bone Growth Abnormal
- Trial name
- TOCI (NCT03904914)
- Testing
- TOCI
- Where
- Hong Kong
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong