Clinical trials: Skeletal Disorders
Type 2 Diabetes
Regulation of Tissue Lipolysis by Insulin in Type 2 Diabetes
Inadequate suppression of intramuscular and adipose tissue lipolysis, and consequent excessive delivery of fatty acids to ectopic tissues (e.g.
- Trial name
- NCT01680133
- Testing
- Hyperinsulinemic euglycemic clamp
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Heart Failure
Impact of Heart Failure on Calcium Homeostasis and Mitochondrial Function in Human Skeletal Muscle
The aim of this project is to investigate the impact of heart failure (HF) on calcium homeostasis, mitochondrial function and oxidative stress in human skeletal muscle, before and after exercise training.
- Trial name
- Calcicard (NCT01014611)
- Where
- France
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Obesity, Skeletal Muscle
Anti-Inflammatory Milk Matrix
Obesity is pro-inflammatory, impairs metabolism, and physically limiting. Specifically, muscle in obese persons does not synthesize proteins normally. This further increases metabolic and physical dysfunction.
- Conditions
- Obesity, Skeletal Muscle, Inflammation
- Trial name
- AIMM (NCT04216004)
- Testing
- Controlled-Feeding Intervention, Non-dairy beverage, Full-fat milk
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Obesity, Type 2 Diabetes
Changes of Biomarkers in Response to Training and Antioxidant Treatment
The aim of the study is to compare the effects of an intensive 4 weeks exercise training program with or without additional treatment with antioxidants.
- Trial name
- NCT00638560
- Testing
- Vitamin C, Vitamin E, Antioxidant treatment
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Metabolic Dysfunction-associated Steatotic Liver Disease
Targeting the Skeletal Muscle to Treat Metabolic Dysfunction-associated Steatotic Liver Disease
Muscle changes including myosteatosis are reported as highly prevalent in metabolic dysfunction-associated steatotic liver disease (MASLD). Recent studies highlighted a link between muscle fat content and liver disease severity.
- Trial name
- MYO-MASLD (NCT06506513)
- Testing
- High-intensity interval training, Moderate intensity exercise training, Low intensity exercise training
- Where
- 2 sites in Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Heart Failure
Oral Nitrite for Older Heart Failure Patients
Studies have demonstrated nitrite therapy increases adenosine triphosphate (ATP) synthesis in skeletal muscle mitochondria concomitant with reduced whole-body oxygen cost during steady state exercise.
- Trial name
- ONTx+HF (NCT02457260)
- Testing
- 14 N Sodium Nitrite
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Gladwin, Mark, MD
Hyperglycemia, Normoglycemia
Skeletal Muscles, Myokines and Glucose Metabolism MYOGLU
Normal glucose uptake and metabolism in skeletal muscles are essential to keep blood glucose within normal range and hence, insulin resistance (possibly mediated by inflammatory processes) in skeletal muscle is a major pathogenic…
- Conditions
- Hyperglycemia, Normoglycemia, Myokine
- Trial name
- MyoGlu (NCT01803568)
- Testing
- Exercise
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Malocclusion, Angle Class II, Division 1
Pharyngeal Airway Dimensions With Twinblock Versus Myobrace Appliances in Developing Skeletal Class II Patients
The goal of this clinical trial is to compare the pharyngeal airway changes after treatment with Myobrace and after treatment with Twinblock in developing skeletal Class II patients.
- Trial name
- NCT05610150
- Testing
- Myobrace Functional Appliance, Twin Block
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Stroke, Immobilization
Characterization of Skeletal Muscle Using Magnetic Resonance Elastography (MRE)
The goal of this proposal is two-fold: (1) to further develop and validate a technology, magnetic resonance elastography (MRE), for quantitatively imaging mechanical properties and tension distribution in muscle and (2) to apply…
- Conditions
- Stroke, Immobilization, Myofacial Pain, Hyperthyroid Myopathy
- Trial name
- NCT00588432
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Occupational Diseases, Work Related Upper Limb Disorder
ARPE Training for Manual Handling Workers: A Quasi-Experimental Study on Ergonomic Knowledge and Practice
The goal of this study is to evaluate whether an Augmented Reality-based ergonomic training module (ARPE) can improve ergonomic knowledge, self-prevention, and self-evaluation practices among adult manual material handling (MMH)…
- Trial name
- ARPE;MMH (NCT06993298)
- Testing
- Augmented Reality Ergonomics Training (ARPE), Conventional Ergonomics Training
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Universiti Teknologi Mara
Muscle Weakness, Osteoporosis, Postmenopausal
Assessing the Effect of Shatavari Supplementation on Bone and Skeletal Muscle Health in Healthy Postmenopausal Women
Shatavari is a plant that grows in Nepal, Sri Lanka, India and the Himalayas and its root has long been used in Ayurvedic medicine.
- Trial name
- NCT05025917
- Testing
- Shatavari, Magnesium stearate
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Sarcopenia, Dietary Exposure
Impact of Diet on the Gut-Muscle Axis in Older Adults
Muscle health declines during aging. One factor that may impact muscle health is the community of bacteria that live in our intestines, but studies aimed at improving muscle health by targeting the gut in older adults are sparse.
- Conditions
- Sarcopenia, Dietary Exposure, Microbial Colonization
- Trial name
- NCT05549622
- Testing
- Low-soluble fiber diet, High-soluble fiber diet
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Tufts University
Osteoporosis, Inflammation
Synbiotic to Attenuate Resorption of the Skeleton
This randomized, double blind, placebo controlled clinical trial will test the efficacy of a probiotic/prebiotic combination ("synbiotic") on the skeleton in older women.
- Conditions
- Osteoporosis, Inflammation, Aging
- Trial name
- STARS (NCT06389539)
- Testing
- SBD111 medical food
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Barth Syndrome
Heart and Muscle Metabolism in Barth Syndrome
Barth syndrome (BTHS) is an X-linked disorder caused by abnormal cardiolipin metabolism and is characterized by skeletal and cardiomyopathy and high mortality rates.
- Trial name
- NCT01625663
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Duke University
Sarcopenia, Frailty
Protein and Skeletal Muscle in Older Twins: Role of the Gut Microbiome
Research Question: Does the gut microbiome contribute to muscle anabolic resistance to protein supplementation in older adults? Background: Loss of muscle occurs with age and skeletal muscle in older adults can display anabolic…
- Conditions
- Sarcopenia, Frailty, Age-Related Sarcopenia
- Trial name
- PROMOTe (NCT04309292)
- Testing
- Prebiotic food supplement, Protein supplement
- Where
- United Kingdom
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- King's College London
HEALTHY
Biological Aging of Skeletal Muscles in Humans
Aging affects almost all the tissues and physiological functions, and skeletal muscle is the most affected organ. The progressive decline of the weight and the muscular function linked to the aging contributes to the lack of…
- Trial name
- BioAge (NCT02675192)
- Testing
- Proof cohort : muscular assessment
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Insulin Sensitivity
Acute Effects of an Oral Fat Load on Skeletal Muscle and Hepatic Insulin Sensitivity
The development of type 2 diabetes is based on a combination of insulin resistance and beta cell dysfunction. In the last years, elevated FFA were recognized as a key players in the pathogenesis of insulin resistance and type 2…
- Trial name
- FLAME (NCT01736202)
- Testing
- fat orally
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Elderly, Sarcopenia
Human Muscle Gene Expression Profiles in Young and Old Men
To reach the goals of living longer in better medical conditions, many countries reach the same conclusion: new strategies have to be developed to avoid, or at least limit, the effects of age; this requires a better knowledge of…
- Trial name
- CERA (NCT00725166)
- Testing
- Skeletal muscle aging
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Aging, Obesity
Resistance Exercise Training in the Older Population With Obesity
Background: Aging leads to an alteration in the immune response, characterized by a chronic inflammatory state, and a progressive decrease in muscle quantity and quality, a situation that increases in women and in the presence of…
- Trial name
- RETOPO (NCT06367296)
- Testing
- Prolonged resistance exercise training
- Where
- 2 sites in Chile
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universidad de La Frontera
Class II Malocclusion, Division 1
Treatment Effects of Herbst Appliance in Skeletal Class II Cases During Prepubertal and Postpubertal Periods
The study was directed to compare the treatment outcomes of subjects with Class II malocclusion who were treated with Herbst appliance before and after puberty.
- Trial name
- NCT04518865
- Testing
- Herbst appliance
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University