Clinical trials: Skeletal Disorders
Masseter, Ultrasonography
Masseter Muscle Thickness and Craniofacial Skeletal Patterns
Facial morphology is influenced by hard and soft tissues, including bone and muscle. While numerous factors can lead to changes in bone tissue, soft tissues such as muscle also have an important influence.
- Conditions
- Masseter, Ultrasonography, Malocclusions, Cephalometry
- Trial name
- NCT06870084
- Testing
- Ultrasonography, Lateral cephalometric radiography, Facial photograph
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Genetic Skeletal Diseases, Skeletal Dysplasia
Decoding the Genetic Landscape of Skeletal Diseases
This 5-year project aims to (1) search for genetic causes for yet unsolved congenital skeletal disorders (GSDs); (2) study consequences of the newly identified pathogenic variants in cells and in transgenic mice, (3) summarize…
- Conditions
- Genetic Skeletal Diseases, Skeletal Dysplasia, Molecular Causes, Skeletal Disorder
- Trial name
- SKDLAND (NCT05876416)
- Where
- Sweden
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Muscle Composition, Sarcopenia
Effects of Increased, Egg-Based Protein Intake on Muscle Composition,
This study is designed to assess the effect of a diet-controlled nutrition program utilizing an egg-based higher protein diet on muscle composition and size, and indices of metabolic health and markers of systemic inflammation in…
- Conditions
- Muscle Composition, Sarcopenia, Hypertrophy, Inflammation
- Trial name
- S25 (NCT01396915)
- Testing
- Dietary Protein Intake
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Purdue University
Sarcopenia
Morphological and Functional Biomarkers of Skeletal Muscle Adaptations in Sarcopenia
Sarcopenia is an age-related condition characterized by progressive loss of skeletal muscle mass, muscle strength, and physical performance.
- Trial name
- EXEDOS (NCT07692308)
- Testing
- Digitally delivered home-based exercise intervention, General physical activity recommendations
- Where
- Italy
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Iron Deficiency
Iron Status and Human Metabolism
Iron deficiency is common in cardiorespiratory diseases and appears to contribute to a worse outcome. This human physiology study will examine the extent to which human skeletal muscle metabolism and exercise physiology are…
- Trial name
- NCT02308449
- Testing
- Ferric carboxymaltose
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy, Skeletal Muscle Atrophy
Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse
Skeletal muscle plays a critical role in supporting human health. Beyond its role in providing the force to move, skeletal muscle accounts for a large proportion of metabolic rate, glucose disposal, and amino acid storage.
- Conditions
- Healthy, Skeletal Muscle Atrophy, Skeletal Muscle Hypertrophy
- Trial name
- NCT06350591
- Testing
- Immobilization, Resistance training
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Queen's University
Aging, Sarcopenia
Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health
What are the effects of resistance exercise (RE) alone or RE plus low intensity physical activity (LPA) breaks in sedentary time (ST) on skeletal muscle health in older adults? What are the effects of resistance exercise (RE)…
- Conditions
- Aging, Sarcopenia, Disability Physical, Cardiovascular Diseases
- Trial name
- REALPA (NCT03771417)
- Testing
- Exercise Intervention
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Louisiana State University and A&M College
Overweight and Obesity
High Intensity Interval Training and Skeletal Muscle Insulin Sensitivity
This human intervention study will test if 12 weeks of supervised HIIT-based intervention improves skeletal muscle NOGD capacity in obese subjects.
- Trial name
- NCT03405545
- Testing
- High-intenstiy interval training
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Cachexia, Neoplasms
Cancer-associated Muscle Mass - Molecular Factors and Exercise Mechanisms
Muscle mass loss is a common adverse effect of cancer. Muscle mass loss occurs with or without reduction in body weight. Cancer cachexia (CC) is the involuntary loss of body weight of >5% within 6 months and it occurs in 50-80%…
- Conditions
- Cachexia, Neoplasms, Exercise, Metabolism
- Trial name
- PANACEA (NCT05307367)
- Testing
- Exercise training
- Where
- Denmark
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Class II Malocclusion
Maxillary Segmental Distalization Using Digitally Printed Appliances
Evaluation of Maxillary Segmental Distalization Using Infrazygomatic versus Palatal Digitally Printed Skeletal Anchored Appliances.
- Trial name
- NCT06511219
- Testing
- maxillary segmental distalization
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Mobile Application, Cephalometric Analysis
Accuracy of a Newly Developed Mobile Application Versus the Conventional Method of Cephalometric Analysis in the Diagnosis of Dental and Skeletal Deformities Among Pre-adolescent Patients
This study aims to evaluate the accuracy of a newly developed mobile application versus the conventional method of cephalometric analysis in the diagnosis of dental and skeletal deformities among pre-adolescent patients.
- Trial name
- NCT05070676
- Testing
- newly developed mobile application
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Cairo University
Diabetes Mellitus, Type 2, Cardiomyopathy, Dilated
Cross-over Study on Effect of Lipid Lowering by Acipimox on Cardiac and Skeletal Muscle Mitochondrial Function
Accumulation of lipid in skeletal and cardiac muscle has been associated with insulin resistance and diabetic cardiomyopathy. In skeletal muscle, lipotoxic damage has been suggested to lead to dysfunction of mitochondria.
- Trial name
- ACP (NCT00943059)
- Testing
- Acipimox, Cellulosum Mycrocryst
- Where
- Netherlands
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Inclusion Body Myositis
IBM Dietary Surveillance Study
The goal of this observational study is to understand how diet may influence the disease characteristics of inclusion body myositis (IBM).
- Trial name
- NCT07535996
- Testing
- Whole-Body Dual-Energy X-ray Absorptiometry, Anthropometry, Capillary Blood Sampling
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Manchester Metropolitan University
Sleep Deprivation, Healthy Volunteers
Effects of Sleep Privation on Sensorimotor Integration of the Upper Limb During a Manual Endurance Test in Healthy Volunteers-Physiological Study
The investigator showed that a night of sleep deprivation halved the duration of an inspiratory endurance test and that this loss of endurance could be secondary to a lack of activation of the pre-motor cortex.
- Conditions
- Sleep Deprivation, Healthy Volunteers, Skeletal Muscle
- Trial name
- NCT03404427
- Testing
- Normal sleep night, Sleepless night
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Maxillofacial Abnormalities, Jaw Abnormalities
Digital Occlusal Wafer Versus Waferless Distal Segment Repositioning for BSSO in Skeletal Mandibular Deformities
Research studies continues to attempt testing modifications to refine the treatment protocols through computer assisted design or computer-generated surgical Wafer splints, have greatly revolutionized the incorporation of digital…
- Conditions
- Maxillofacial Abnormalities, Jaw Abnormalities, Prognathism, Retrognathia
- Trial name
- NCT05151042
- Testing
- wafer-less approach, Computer Guided orthognathic surgery using occlusal wafers
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Physical Inactivity, Vascular Dysfunction
Heat Therapy During Reduced Physical Activity
The purpose of this randomized controlled trial is to determine whether daily Finnish dry sauna therapy attenuates the adverse cardiovascular, muscular, and metabolic effects of seven days of experimentally reduced physical…
- Conditions
- Physical Inactivity, Vascular Dysfunction, Skeletal Muscle Atrophy
- Trial name
- HEAT-RPA (NCT07847424)
- Testing
- Sauna, Reduced Physical Activity
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Healthy, Kidney Failure, Chronic
Phosphate Intake's Effect on the Skeletal System - Pilot
The purpose of this study is to determine the effects of different amounts of phosphorus in the diet on hormones that control phosphorus and bone health both in men who are healthy and in ones who have moderate kidney disease.
- Trial name
- NCT00187629
- Testing
- dietary phosphorus
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Glycogen Storage Disease, McArdle Disease
Carbon-13 Magnetic Resonance Spectroscopy in Glycogen Storage Diseases
The project will use carbon-13 magnetic resonance spectroscopy to assess whether high glycogen levels in skeletal muscle of patients with Glycogen Storage Diseases is a prelude for muscle damage.
- Conditions
- Glycogen Storage Disease, McArdle Disease, Pompe Disease (Late-onset)
- Trial name
- NCT04929002
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Skeletal Muscle Protein Synthesis in Elderly, Protein Kinetics
Effect of Low Intensity Exercise and Protein Intake on Skeletal Muscle Protein Synthesis in Elderly
Maintenance of skeletal muscle mass is crucial during lifespan to retain health and functional autonomy. Sarcopenia, being the loss of muscle mass during aging, is a well-known phenomenon in the elderly and a major challenge…
- Conditions
- Skeletal Muscle Protein Synthesis in Elderly, Protein Kinetics, Sarcopenia
- Trial name
- NCT01640145
- Testing
- Protein, Exercise
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Muscle Atrophy
The Effects of 17β-estradiol on Skeletal Muscle
The maintenance of skeletal muscle mass and function is critical for healthy aging. Muscle loss with disuse, termed muscle disuse muscle atrophy, leads to impaired functional capacity, the onset of insulin resistance, as well as…
- Trial name
- NCT03069781
- Testing
- 17β-estradiol, Polycose
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University