Clinical trials: Skeletal Muscle Atrophy
HEALTHY
Biological Aging of Skeletal Muscles in Humans
Aging affects almost all the tissues and physiological functions, and skeletal muscle is the most affected organ. The progressive decline of the weight and the muscular function linked to the aging contributes to the lack of…
- Trial name
- BioAge (NCT02675192)
- Testing
- Proof cohort : muscular assessment
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Chronic Obstructive Pulmonary Disease (COPD), Muscle Atrophy
The Effect of Two Weeks of Voluntary Reduced Physical Activity in Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD) is the most common pulmonary disease, responsible for considerable morbidity and mortality and is the third leading cause of death worldwide.
- Trial name
- NCT02221804
- Testing
- 14 days of voluntary step count reduction to no more than 1500 steps/day.
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Sarcopenia, Muscle Loss
Counteracting Age-related Loss of Skeletal Muscle Mass
Up to approximately 205 (dependent on drop-out rate) healthy elderly individuals (at least 65 years old) are recruited as subjects.
- Trial name
- CALM (NCT02034760)
- Testing
- Heavy Resistance Training, Light Intensity Training, Protein Whey
- Where
- Denmark
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Sedentary Behavior, Aging
Oral 'Breath Test' to Measure Anabolic Sensitivity in Young and Older Adults at Different Activity Levels
Recent work in the investigators laboratory has examined the ability of a non-invasive 13CO2 breath-test to assess differences in amino acid oxidation rates and net balance in young healthy males following protein feeding and…
- Conditions
- Sedentary Behavior, Aging, Sarcopenia, Amino Acids
- Trial name
- ARBT (NCT05216809)
- Testing
- Habitual Physical Activity, Step-Reduction
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Muscle Injury, Muscle Atrophy
Ultrasound Measurements Hamstring Muscles Thickness
No previous studies have compared the association between muscle thickness (MT) and muscle cross-sectional area (CSA) in healthy volunteers.
- Trial name
- NCT02958254
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Valencia
Old Age; Atrophy, Inflammatory Response
Effects of Parmigiano Reggiano on Skeletal Muscle Damage in Older Adults
Aging is associated with the loss of muscle mass and function (sarcopenia) and reduced tissue regenerative capacity. Eccentric exercise (ECC) is a model of RET that can be used with the elderly, due to the ability of the muscle…
- Conditions
- Old Age; Atrophy, Inflammatory Response, Muscle Soreness
- Trial name
- NCT04872374
- Testing
- Parmigiano Reggiano, Whey Protein
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Padova
Sarcopenia
Skeletal Muscle Inflammation, Oxidative Stress and DNA Repair in Age-Related Sarcopenia
The purpose of this research study is to investigate how and why the loss of muscle mass occurs with aging. Tissue collected from young subjects will be compared to previously collected tissue from elderly subjects, as well as…
- Trial name
- NCT02116166
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Florida
Haematological Cancer, Healthy
Pulsed Electromagnetic Fields in Preventing Physical Deconditioning in Patients Undergoing Prolonged Hospitalization
The goal of this clinical trial is to examine if pulsed electromagnetic fields (PEMF) can prevent or decrease physical deconditioning associated with prolonged hospitalisation and immobility of haematology patients.
- Trial name
- PEMF (NCT06744764)
- Testing
- PEMF (1mT), PEMF (0mT)
- Where
- 2 sites in Singapore
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Sarcopenia, Muscle Hypotrophy
Systemic Hormones and Muscle Protein Synthesis
This study evaluates the effect of increase in testosterone levels in older males and the effects of decrease in testosterone levels in young males on muscle protein synthesis.
- Conditions
- Sarcopenia, Muscle Hypotrophy, Muscle Atrophy
- Trial name
- NCT03054168
- Testing
- Sustanon 250, Zoladex
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sarcopenia
A Study of the Intervention Effect of a Hybrid Exercise Program on Elderly With Sarcopenia
Sarcopenia is a geriatric condition characterized by a progressive decrease in skeletal muscle content and loss of muscle function.
- Trial name
- NCT05694117
- Testing
- self-determine sequence exercise program, resistance training, Taichi exercise and resistance training
- Where
- China
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- Northeast Normal University
Sarcopenia
Blood Flow, Muscle Regeneration and Sarcopenia
Due to the rapid aging of the population, sarcopenia is among the greatest challenges facing the health care system over the next quarter century.
- Trial name
- NCT01035060
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Florida
Aging, Muscle Atrophy or Weakness
C-Protein in Fatigue and Aging
This study is investigating changes to the proteins in skeletal muscle that contribute to reduced muscle size and muscle function that occurs with aging.
- Conditions
- Aging, Muscle Atrophy or Weakness, Sarcopenia in Elderly, Sarcopenia
- Trial name
- NCT05926219
- Testing
- Fatiguing Exercise
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Muscle Atrophy
Mechanisms Underlying Local and Systemic Effects of Massage
The purpose of this study is to determine whether massage can attenuate the loss of muscle mass in humans after a short period of disuse.
- Trial name
- NCT04131712
- Testing
- Massage
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Esther Dupont-Versteegden
Knee Osteoarthristis
Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty
Total knee replacement, or arthroplasty, is the final clinical intervention available to relieve pain and functional limitations related to advanced stage knee osteoarthritis.
- Trial name
- NCT03051984
- Testing
- Neuromuscular electrical stimulation
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Gastrointestinal Neoplasms, Bronchial Carcinoma
Effect of an Antioxidant on Cancer-Cachectic Patients Undergoing Exercise Training
The purpose of the study is to tests the hypothesis, that N-acetylcysteine (a thiol-antioxidant)improves the exercise training effect on cancer patients that experience weight loss (cachexia) as assessed by muscle mass and…
- Conditions
- Gastrointestinal Neoplasms, Bronchial Carcinoma, Hodgkin Disease, Non-Hodgkin Lymphoma
- Trial name
- NCT00196885
- Testing
- N-acetylcysteine
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- German Cancer Research Center
Metastatic Cancer, Cachexia; Cancer
Cancer-Associated Muscle Atrophy and Weakness: An Investigation of Etiology
This study is designed to gain a better understanding of the mechanisms leading to muscle wasting and metabolic abnormalities in skeletal muscle of cancer patients.
- Trial name
- NCT03012139
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Anterior Cruciate Ligament Reconstruction, Muscular Atrophy
Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in Adults
Loss of skeletal muscle mass (atrophy) and strength in the lower limb are consequences of elective knee surgery as result of prolonged disuse from limb immobilization and impaired mobility, as well as pathophysiological trauma.
- Trial name
- NCT06233825
- Testing
- Omega-3 Fatty Acids and Essential Amino Acids, Safflower Oil and Non-Essential Amino Acids
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Chris McGlory, PhD
Cancer, Muscle Atrophy
Influence of Motor Proteins on Muscle Atrophy in Cancer Patients
The aim of the study is to investigate the effect of exercise in form of whole-body electromyostimulation (WB-EMS) on early tumor-induced muscular dysfunction.
- Trial name
- NCT03551990
- Testing
- whole-body electromyostimulation WB-EMS
- Where
- Germany
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Sarcopenia, Dietary Protein
Dietary Protein Quality for Skeletal Muscle Anabolism in Older Adults
Dietary proteins potently augment muscle protein synthesis. Because of poorer anabolic sensitivity with ageing, studies and guidelines recommend higher dietary protein intake for older adults.
- Conditions
- Sarcopenia, Dietary Protein, Resistance Exercise
- Trial name
- NCT05574205
- Testing
- Resistance Exercise, Protein supplementation
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Exercise Training, Skeletal Muscle
Resistance Training, Detraining, and Retraining Study 2022
The research project is aiming to examine the muscular adaptations to resistance training (RT), detraining (DT) and repeated RT (i.e. retraining).
- Conditions
- Exercise Training, Skeletal Muscle, Skeletal Muscle Atrophy
- Trial name
- TraDeRe2022 (NCT05553769)
- Testing
- Resistance training, detraining, retraining
- Where
- Finland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Jyvaskyla