Clinical trials: Skeletal Muscle Injury
Spinal Cord Injuries
Skeletal Muscle Hypertrophy and Cardio-Metabolic Benefits After Spinal Cord Injury
Spinal cord injury (SCI) is a devastating medical problem that affects thousands of civilian and military personnel in the United States.
- Trial name
- NCT02660073
- Testing
- NMES+FES, Control+FES
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- United States Department of Defense
Spinal Cord Injuries
Musculoskeletal Plasticity After Spinal Cord Injury
Patients with spinal cord injury (SCI) experience metabolic syndrome, diabetes, obesity, pressure ulcers, and cardiovascular disease at far greater rates than the general population.
- Trial name
- NCT02622295
- Testing
- Single-session electrically induced exercise, Electrically-induced exercise training
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Richard K Shields
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial
Spinal cord injury (SCI) results in lower limb muscle loss, bone loss, and high fat mass that impede the recovery of physical function, increase bone fracture risk, and worsen health and quality of life.
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Injuries, Spinal Cord, Spinal Cord Contusion
- Trial name
- TRT-SCI (NCT07742553)
- Testing
- testosterone cypionate, finasteride
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
Blood Flow Restriction Exercise for Those With SCI
Spinal cord injuries (SCI) are among the most debilitating conditions an individual can sustain with the estimates of SCI incidence in the United States at 12,000 new cases per year.
- Trial name
- NCT04889092
- Testing
- Blood Flow Restriction exercise, Traditional resistance exercise
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- VA Office of Research and Development
Traumatic Injury, Muscle Injury
Musculotendinous Tissue Unit Repair and Reinforcement (MTURR) Coordinating Center
The objective of the study is to assess mechanical strength and function in subjects undergoing Musculotendinous Tissue Unit Repair and Reinforcement (MTURR) with the use of biologic scaffolds for the restoration of both…
- Conditions
- Traumatic Injury, Muscle Injury, Tendon Injury, Soft Tissue Injury
- Trial name
- MTURR (NCT01497678)
- Testing
- Extracellular Matrix
- Where
- United States
- Sponsor
- University of Pittsburgh
Traumatic Injury, Muscle Injury
Musculotendinous Tissue Repair Unit and Reinforcement (MTURR)
The objective of the study is to assess mechanical strength and function in subjects undergoing Musculotendinous Tissue Unit Repair and Reinforcement (MTURR) with the use of biologic scaffolds for the restoration of both…
- Conditions
- Traumatic Injury, Muscle Injury, Tendon Injury, Soft Tissue Injury
- Trial name
- MTURR (NCT01292876)
- Testing
- Extracellular Matrix
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Pittsburgh
PRP, Losartan
The Effect of Combined Use of Anti-fibrotic Agent With Platelet Rich Plasma on Skeletal Muscle Healing After Acute Injuries
The aim of this comparative study is to determine whether or not LOSARTAN with its anti-fibrotic action has an added effect when administrated with platelet rich plasma injection on skeletal muscle healing and on decreasing the…
- Conditions
- PRP, Losartan, Muscle Injury, Sport Injury
- Trial name
- NCT05827484
- Testing
- Autologous platelets rich plasma, Autologous platelets rich plasma + oral LOSARTAN administration
- Volunteers
- 20 people
- Sponsor
- Mostafa Hassanein, Msc
Muscle Strain, Multiple Sites
Nutritional Strategies After Muscle Strain Injuries
Muscle strain injuries are a particularly frequent type of sports injury in soccer, athletics, badminton/ tennis and cross-fit fitness, thereby affecting a broad range of popular leisure time activities.
- Trial name
- NCT04100161
- Testing
- Protein supplementation, Carbohydrate supplementation, Active rehabilitation
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Disuse Osteoporosis, Atrophy, Disuse
Activity Dependent Rehabilitation Model to Improve Bone and Muscle Outcomes
For many after spinal cord injury (SCI) there is immobilization, muscle atrophy, bone loss, fracture risk during transferring (or falls), and the risk of secondary complications, and increase in attendance care and cost.
- Conditions
- Disuse Osteoporosis, Atrophy, Disuse, Nervous System, Structural; Marker
- Trial name
- NCT02309983
- Testing
- Electrical Stimulation, Stand Retraining with Body Weight Support (BWS)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Kessler Foundation
Type 2 Diabetes
Study to Weigh the Effect of Exercise Training on BONE (SWEET-BONE) Quality and Strength in Type 2 Diabetes
Type 2 diabetes mellitus (T2DM) is associated with increased fracture risk despite normal to increased bone mass, thus suggesting poor bone quality.
- Trial name
- SWEET-BONE (NCT02421393)
- Testing
- supervised exercise training
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Metabolic Fitness Association, Italy
Hip Fractures, Muscular Atrophy
Effects of Exercise on Markers of Inflammation in Skeletal Muscle in Elderly Hip Fracture Patients
Decreased skeletal muscle mass is a prevalent condition among the elderly, and an important cause of disability and functional decline.
- Trial name
- NCT00006194
- Testing
- Exercise
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Critical Illness, Acute Kidney Injury
Skeletal Muscle Wasting and Renal Dysfunction After Critical Illness Trauma - Outcomes Study
This study aims to determine changes in kidney function during and after critical illness, comparing conventional creatinine based methods with the gold standard to accurately establish the presence of new or worsened chronic…
- Conditions
- Critical Illness, Acute Kidney Injury, Muscle Loss, Major Trauma
- Trial name
- KRATOS (NCT03736005)
- Testing
- Exposure of significant critical illness
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Queen Mary University of London
Femoral Shaft Fracture, Tibial Shaft Fracture
MAGIK for Femoral/Tibial Shaft Fractures
The purpose of this phase 2 randomized control trial will be to evaluate the effect of glucose-insulin-potassium (GIK) therapy in the setting of lower extremity trauma to reduce short- and long-term muscle damage, acute…
- Trial name
- MAGIK (NCT05627479)
- Testing
- GIK solution, Isotonic Normal Saline Solution
- Where
- United States
- Sponsor
- NYU Langone Health
Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation
Aloe Vera Ointment Application and Skeletal Muscle Recovery
Aloe vera, sometimes described as pharmaceutical aloe, is a flowering succulent plant with many therapeutic properties such as wound and burn wound healing, treatment of diabetes and reduction of blood lipid profile.
- Conditions
- Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation, Performance
- Trial name
- NCT03934762
- Testing
- Natural Aloe Vera, Aloe vera soup
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Plus Finasteride Treatment After Spinal Cord Injury
The purpose of this study is to determine whether testosterone plus finasteride treatment will improve musculoskeletal health, neuromuscular function, body composition, and metabolic health in hypogonadal men who have experienced…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injuries
- Trial name
- NCT02248701
- Testing
- Testosterone Enanthate, Finasteride
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Anterior Cruciate Ligament Reconstruction
Prevention of Skeletal Muscle Adaptations to Traumatic Knee Injury and Surgery
Traumatic knee injury is common and highly debilitating. Surgical reconstruction/repair improves knee biomechanics and function, but neuromuscular dysfunction persist for years despite rehabilitation, hindering resumption of…
- Trial name
- NCT02945553
- Testing
- Neuromuscular electrical stimulation, Microstimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Vermont
Skeletal Muscle Damage, Skeletal Muscle Performance
NAC Supplementation and Skeletal Muscle Performance
In this investigation the investigators utilized NAC administration to foster GSH availability during an 8-day period following eccentric exercise-induced muscle damage in order to test our hypotheses: i) antioxidant…
- Conditions
- Skeletal Muscle Damage, Skeletal Muscle Performance, Intgracellular Signaling in Skeletal Muscle, Inflammatory Status
- Trial name
- NCT01778309
- Testing
- n-acetylcysteine supplementation
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Muscle Strain, Multiple Sites, Inflammation
Optimal Treatment of Acute Skeletal Muscle Injury
Acute muscle strain injuries occur both during sports, in leisure time activities and during manual occupation and represent a major clinical challenge and has societal economic costs.
- Trial name
- NCT06274151
- Testing
- Naproxen 500 Mg, Rehabilitation
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Breast Cancer, Metastatic Breast Cancer
Nicotinamide Riboside and Prevention of Cancer Therapy Related Cardiac Dysfunction in Breast Cancer Patients
Breast cancer is the most common form of cancer in women. Modern breast cancer treatments have led to increased survival, but at the same time, increased risk for cardiotoxicity and development of heart failure.
- Conditions
- Breast Cancer, Metastatic Breast Cancer, Cancer Therapy-Related Cardiac Dysfunction, Cardiotoxicity
- Trial name
- NARNIA (NCT05732051)
- Testing
- Nicotinamide Riboside
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital, Akershus
Spinal Cord Injuries
The Effect of FES and Therapeutic Exercise on SCI Patients Skeletal Muscles, Sitting Balance, Posture and Quality of Life
Aim of the current study is to evaluate the effect functional electrical stimulation and therapeutic exercise on traumatic spinal cord injured participants'skeletal muscle characteristics, sitting balance, lung function and…
- Trial name
- NCT03517787
- Testing
- FES+TE, TE, REF-FES+TE
- Where
- Estonia
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Tartu University Hospital