Clinical trials: Skeletal Muscle Physiology
Sarcopenia
Effect of Exercise and Protein Supplementation on Muscle Function in Patients With Hemodialysis
Sarcopenia can be easily observed in patients with hemodialysis. However, there were few studies on the precise concept and diagnostic criteria for sarcopenia in patients with hemodialysis.
- Trial name
- NCT04927208
- Testing
- exercise and nutritional support
- Where
- South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Chungnam National University Hospital
Heart Failure With Preserved Ejection Fraction (HFPEF)
Effects of a Multicomponent Training Program on Cardiac Function, Skeletal Muscle Metabolism, Functional Capacity, and Quality of Life in Patients With HFpEF: SENSORFIT-4HEART Study
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with increasing incidence and poor prognosis, accounting for up to 50% of heart failure cases.
- Trial name
- SENSORFIT-4HEA (NCT07251361)
- Testing
- Supervised training
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universidad Pública de Navarra
Muscular Atrophy
Two Weeks of Reduced Activity and Skeletal Muscle Health in Older Men
Muscle size declines at around 0.5-1% per year after 50 years of age, with muscle strength declining up to twice as fast as muscle size.
- Trial name
- NCT02495727
- Testing
- Step-reduction, Pre-training, Exercise snacking
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Bath
Inclusion Body Myositis
IBM Dietary Surveillance Study
The goal of this observational study is to understand how diet may influence the disease characteristics of inclusion body myositis (IBM).
- Trial name
- NCT07535996
- Testing
- Whole-Body Dual-Energy X-ray Absorptiometry, Anthropometry, Capillary Blood Sampling
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Manchester Metropolitan University
Overweight and Obesity
GRK-Biased Activation Via β2-Adrenergic Receptors in Human Skeletal Muscle
This longitudinal mechanistic physiological study examines biased β2-adrenergic receptor (β2-AR) signaling in human skeletal muscle, with emphasis on G protein-coupled receptor kinase (GRK)-mediated pathways.
- Trial name
- GAIN (NCT07421024)
- Testing
- ATR-258
- Where
- Denmark
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Healthy
Effect of a Nutritional Supplement on Muscle Recovery
The aim is to develop a food supplement drink that supports muscle health by combining specific fatty acids, which can positively affect metabolic and inflammation processes that are important for muscle health.
- Trial name
- RECOVER (NCT07586839)
- Testing
- Control drink, Vegan supplement containing caprylic acid and omega-3 fatty acids
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Chronic Kidney Diseases
Skeletal Muscle Oxygenation in Patients With Chronic Kidney Disease Stage 2, 3 and 4
Endothelial dysfunction occurs early in chronic kidney disease (CKD) and is associated with target organ damage, progression of renal injury, cardiovascular events, and mortality.
- Trial name
- NCT05250167
- Where
- Greece
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Heart Failure
Impact of Heart Failure on Calcium Homeostasis and Mitochondrial Function in Human Skeletal Muscle
The aim of this project is to investigate the impact of heart failure (HF) on calcium homeostasis, mitochondrial function and oxidative stress in human skeletal muscle, before and after exercise training.
- Trial name
- Calcicard (NCT01014611)
- Where
- France
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Aging, Sarcopenia
Peanut Protein Supplementation to Augment Muscle Growth and Improve Markers of Muscle Quality and Health in Older Adults
This study will evaluate the adaptations in skeletal muscle that occur in response to 10 weeks of weight training with or without peanut protein supplementation in older adult men and women.
- Trial name
- NCT04015479
- Testing
- Peanut Protein Powder, Full body resistance training
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Auburn University
Sarcopenia
Effect of Carnitine Supplementation and Resistance Training on Skeletal Muscle Function
The primary aim of the current research project is to explore whether nutritional supplementation and resistance training might be combined to produce synergistic effects in the prevention of muscle loss during aging.
- Trial name
- NCT03907592
- Testing
- L-carnitine supplementation, Leucine supplementation, Resistance training
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Congenital Heart Disease, Single Ventricle
Cardiovascular, Pulmonary and Skeletal Muscle Evaluation Postoperative in Fontan Patients: Effects of Exercise Training
Introduction: The Fontan operation is the surgical treatment in most patients with either anatomic or functional single ventricles.
- Conditions
- Congenital Heart Disease, Single Ventricle, Univentricular Heart
- Trial name
- NCT02283255
- Testing
- Aerobic Exercise Training, Inspiratory Muscle Training, No Exercise Training
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Low Skeletal Muscle Mas
High- and Moderate-Intensity Inspiratory Muscle Training on Diaphragm Ultrasound Parameters, Cognition, and Mental Health
Low skeletal muscle mass during young adulthood may impair diaphragm function, cognition, sleep, and psychological well-being. Inspiratory muscle training (IMT) has been shown to improve respiratory muscle performance; however…
- Trial name
- NCT07757139
- Testing
- High-Intensity IMT, Moderate-Intensity IMT
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Immobilization, Tonic, Physical Activity
Vascular Health With Immobilization and Exercise Training
The study includes healthy young habitually active subjects. All subjects are subjected to two weeks of immobilization of one leg followed by four weeks of training of both legs.
- Trial name
- NCT03054376
- Testing
- Immobilization, Training with non immobilized leg, Exercise training with both legs
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Iron Deficiency
Effects of Iron Supplementation on Skeletal Muscle Properties in Females With Suboptimal Iron Storage
The goal of this clinical trial is to learn whether oral iron supplementation will increase skeletal muscle iron storage and its effects on exercise capacity in females with suboptimal iron status.
- Trial name
- MyoIRON (NCT07084298)
- Testing
- Oral iron supplement
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Muscle Loss
Carnitine Supplementation and Skeletal Muscle Mass
The primary aim of the current research project is to investigate the effect of carnitine supplementation on muscle strength and body composition.
- Trial name
- ROM (NCT05009641)
- Testing
- L-carnitine
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Skeletal Muscle Mitochondrial Dysfunction in the Elderly
A Phase 2 Study to Evaluate the Impact of MTP-131 (Bendavia™) on Skeletal Muscle Function in Elderly
This was a Phase 2, randomized, double-blind, placebo-controlled study, enrolling 41 elderly subjects with previous evidence of mitochondrial dysfunction to evaluate whether the administration of MTP-131 (elamipretide) will…
- Trial name
- MOTION (NCT02245620)
- Testing
- Elamipretide
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Stealth BioTherapeutics Inc.
Chronic Obstructive Pulmonary Disease
Non Invasive Ventilation on Peripheral Muscle Function and Aerobic Performance
Background: Non-invasive ventilation (NIV) reduces respiratory load and demands on peripheral muscles. Methods: This study aims to evaluate the acute effects of bi-level NIV on peripheral muscle function during isokinetic…
- Trial name
- NIV (NCT05417503)
- Testing
- Non-invasive ventilation bi-level
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
ICU Acquired Weakness, Sepsis
ICU Combined Assessment of Cardio-Respiratory Exercise
This study aims to investigate how sepsis and critical illness can impair the cardiovascular system and microcirculation in intensive care unit (ICU) patients, which can lead to long-lasting muscle weakness/dysfunction or…
- Conditions
- ICU Acquired Weakness, Sepsis, Shock, Critical Illness
- Trial name
- ICU-CARE (NCT06193980)
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Manitoba
Impaired Mitochondrial Function, Muscle Performance
Increasing Mitochondrial Function on Skeletal Muscle Performance in Older Men
As people grow older skeletal muscle gradually becomes smaller and weaker, causing reduced mobility and quality of life. To understand and reverse this negative process investigators need to find new ways of improving the ability…
- Trial name
- Rejuvenate (NCT02792621)
- Testing
- Acipimox
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Sarcopenia, Physical Fitness
Swedish Physical Activity and Fitness Longitudinal Study
Aging means loss of strength, which can affect the ability to lead an active life and be independent. Physical activity can counteract the loss of strength to some extent, but individual differences are large and the mechanisms…
- Conditions
- Sarcopenia, Physical Fitness, Muscle Strength, Dynapenia
- Trial name
- SPAF (NCT06496204)
- Where
- Sweden
- Volunteers
- 429 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet