Clinical trials: Skin Absorption
Anti-Psychotic, Management of Manifestations of Psychotic Disorders
Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride
Cycle Pharmaceuticals Ltd. (Cycle) is developing an oral tablet formulation of Chlorpromazine Hydrochloride and intends to conduct bioequivalence trials to demonstrate its similarity to the RLD.
- Conditions
- Anti-Psychotic, Management of Manifestations of Psychotic Disorders, Treatment of Schizophrenia, Control Nausea and Vomiting
- Trial name
- NCT02943213
- Testing
- Chlorpromazine Hydrochloride
- Where
- South Africa
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cycle Pharmaceuticals Ltd.
Leishmaniasis
Safety and Drug Absorption of Orally Administered Oleylphosphocholine (OlPC) in Healthy Adults
The goal of this interventional study is to assess the safety and tolerability of OlPC and to characterize the pharmacokinetics (PK) of OlPC following single, ascending doses administered orally in healthy-fed subjects.
- Trial name
- NCT06124144
- Testing
- Oleylphosphocholine
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Health Adult Subjects
An Early-stage Clinical Trial to Evaluate the Safety, Absorption, and Disposition of YR001 Ointment Following Topical Application on the Skin of Healthy Chinese Subjects
The goal of this clinical trial is to evaluate the safety, local tolerability, and pharmacokinetic (PK) profile of YR001 Topical Ointment in healthy Chinese participants.
- Trial name
- NCT07673458
- Testing
- PA032, Vehicle Ointment
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hangzhou Yirui Pharmaceutical Technology Co., Ltd
Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis
A Study to Assess the Mass Balance Recovery (Absorption, Distribution, Metabolism and Excretion) of [14C]CCX168 in Healthy Participants
The primary objective of this study is to perform mass balance following a single oral dose of [14C]CCX168 in healthy adult male participants.
- Trial name
- NCT06004960
- Testing
- [14C]CCX168
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Amgen
Healthy
Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers
RATIONALE: Lorazepam, diphenhydramine hydrochloride, and haloperidol gel, when absorbed into the skin, may be an effective treatment for nausea and vomiting.PURPOSE: This clinical trial studies lorazepam, diphenhydramine…
- Trial name
- NCT01204255
- Testing
- lorazepam, diphenhydramine hydrochloride, haloperidol
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Melasma
Stem Cell Derived Exosomes in the Treatment of Melasma and Its Percutaneous Penetration
Melasma is a refractory skin disease due to its complex pathogenesis and difficult treatment. Studies have found that human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) could serve as a novel cell-free…
- Trial name
- NCT06221787
- Testing
- 1565 nm non-ablative fractional laser combined with normal saline, microneedles combined with hUCMSC-Exos, 1565 nm non-ablative fractional laser combined with hUCMSC-Exos
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Smoking Cessation
A Study Evaluating The Absorption Of Varenicline Into The Body From A Varenicline Solution And A Varenicline Patch Applied To The Skin
To evaluate the absorption, safety, and tolerability of a varenicline solution and a varenicline patch applied to the skin.
- Trial name
- NCT00774605
- Testing
- Varenicline free base solution, Varenicline free base patch
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Vaccination, Skin Absorption
Microneedle Patch Study in Healthy Infants/Young Children
Microneedles can be prepared as a low-cost patch that is simple for patients to apply for vaccine delivery targeting the many antigen-presenting cells present in the skin.
- Trial name
- NCT03207763
- Testing
- Microneedle Formulation 1, Microneedle Formulation 2
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Emory University
Hereditary Angioedema
Study to Determine How BCX4161 is Metabolized and Eliminated by the Body
The purpose of the study is to assess the extent that radioactive dose of BCX4161 taken by mouth ends up in the urine, feces and expired air.
- Trial name
- NCT02218294
- Testing
- BCX4161
- Where
- United Kingdom
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- BioCryst Pharmaceuticals
Rheumatoid Arthritis (RA)
A Study of Human Substance Balance and Biotransformation of [14C]SHR0302
The study is being conducted to evaluate the absorption, metabolism and excretion of [14C]SHR0302 in healthy Chinese adult male subjects.
- Trial name
- NCT05047341
- Testing
- SHR0302、[14C]SHR0302
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Lupus Erythematosus, Systemic
Evaluation of the Influence of Food Regimen on Oshadi D Absorption
The study will be a non-randomized, open label, single dose, placebo control, single center, and single arm study in healthy subjects.
- Trial name
- NCT01327352
- Testing
- Oshadi D
- Where
- Israel
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Oshadi Drug Administration
Alzheimer's Disease, Huntington's Disease
A Study Evaluating The Absorption Of Dimebon Into The Body From A Dimebon Solution Applied To The Skin
To estimate the absorption, safety, and tolerability of a dimebon transdermal solution relative to the dimebon immediate release oral formulation.
- Trial name
- NCT00990613
- Testing
- Dimebon IR, Dimebon Transdermal
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Pfizer
Nutritional Deficiency
Zinc Bioavailability From Amaranth-enriched Maize Tortillas
Young children in Guatemala are at risk for nutrient deficiencies due to plant-based diets and poor sanitation. Stunting, frequent diarrhea, and respiratory infections are common.
- Trial name
- NCT02208609
- Testing
- Day 1: Maize Tortillas with 20% Amaranth, Day 2 Maize Tortillas without 20% Amaranth
- Where
- 2 sites in United States, Guatemala
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Smoking Cessation
A Study Evaluating The Absorption Of Varenicline Into The Body From A Varenicline Patch Applied To The Skin
This study will evaluate the single-dose pharmacokinetics, safety, and tolerability of a varenicline patch applied to the skin.
- Trial name
- NCT01013454
- Testing
- varenicline free base patch
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Biological Availability, Skin Absorption
A Study to Investigate the Bioavailability and Skin Absorption of CBD and THC From GT4 Technology in Healthy Adults
The bioavailability of cannabinoids differs greatly for different routes of administration. When applied topically to the skin, they are absorbed through the skin or hair follicles while interacting with receptors to provide…
- Conditions
- Biological Availability, Skin Absorption, CBD, THC
- Trial name
- NCT05121506
- Testing
- CBD and THC with GT4 technology
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Gefion Canada Inc.
Breast Cancer, Healthy Volunteers
Study to Determine Absorption, Metabolism, and Excretion of [14C]-SAR439859, and to Assess Absolute Oral Bioavailability of Amcenestrant (SAR439859), in Healthy Post-menopausal Women
Primary Objectives: To assess the excretion balance after oral and IV administration of [14C]-SAR439859 To assess PK of total radioactivity, [14C] -SAR439859 and its metabolite (M7) after IV administration of [14C]-SAR439859 and…
- Trial name
- NCT04940026
- Testing
- amcenestrant, [14C]-SAR439859 microtracer, [14C]-SAR439859
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Sanofi
Nutritional Deficiency
Absorption of Zinc (Zn) From Zn-biofortified and Zn-fortified Maize in Young Zambian Children Between 24-36 Months
The objective of this study is to compare the quantity of Zn absorbed from an accurately weighed quantity (~100 g) of minimally milled control maize (~15 µg Zn/g maize), from biofortified maize (~30 µg Zn/g) and from the same…
- Trial name
- HPZM (NCT02208635)
- Testing
- Biofortified Maize, Fortified Maize, Control Maize
- Where
- 2 sites in United States, Zambia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Psoriasis
Assessment of Gut Absorption of Experimental Medication BMS-986165 in Healthy Males
The purpose of this study is to evaluate sites of gut absorption of BMS-986165 in males
- Trial name
- NCT03873415
- Testing
- BMS-986165
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Smoking Cessation
A Study Evaluating the Absorption Of Varenicline Through The Skin Following Once Daily Application Of A Patch For 14 Days
This study will evaluate the steady-state pharmacokinetics, safety and tolerability of a varenicline patch applied once daily to the skin for 14 days.
- Trial name
- NCT01234142
- Testing
- varenicline free base patch
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pfizer
Rosacea, Erythematotelangiectatic
Metronidazole SC Penetrance With Moisturizers
Topical metronidazole is a widely used first line treatment for erythemotelangiectatic and inflammatory rosacea. Commonly, a moisturizer is also used to restore the skin barrier and reduce inflammation.
- Trial name
- NCT06434519
- Testing
- Metronidazole cream, Cetaphil moisturizer, CeraVe moisturizer
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Duke University