Clinical trials: Skin Barrier Dysfunction, active
Skin Barrier to Water Loss, Microbial Colonization
Oral Lactobacillus Reuteri for Skin Barrier Dysfunction in Obesity
This clinical trial aims to evaluate the safety and efficacy of oral Lactobacillus reuteri supplementation for treating obesity-induced skin barrier impairment in individuals aged 18-40 with a BMI ≥30.
- Trial name
- NCT07512050
- Testing
- Oral Lactobacillus reuteri group, Oral administration of inactive Lactobacillus reuteri group
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shenzhen People's Hospital
Psoriasis, Atopic Dermatitis
Novel Skin Barrier Product Versus Petrolatum for Skin Barrier Dysfunction
The goal of this clinical trial is to learn if a novel barrier topical product works to treat barrier dysfunction in adults. It will also learn about the safety of the novel barrier topical product.
- Conditions
- Psoriasis, Atopic Dermatitis, Xerosis, Contact Dermatitis
- Trial name
- NCT07183423
- Testing
- Novel barrier repair topical product, Petrolatum
- Where
- Philippines
- Volunteers
- 26 people
- Sponsor
- Makati Medical Center
Allergic, Inflammatory
THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins
Background: Allergic and inflammatory conditions have been increasing over the years. Many factors may play a role in this. Every day, people are exposed to pollution and chemicals in our foods, clothing, and all of the cleaning…
- Trial name
- NCT07271381
- Testing
- Environmental Exposures, Control Exposures
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Skin Barrier Dysfunction, Healthy Volunteers
Effect of FPP on Cutaneous Barrier Integrity
This pilot study will test how Fermented Papaya Preparation (FPP) impacts overall TEWL of areas that commonly display diminished barrier function, such as the skin from face, arms, and hands.
- Trial name
- FPP OSATO (NCT07725835)
- Testing
- Fermented Papaya Preparation (FPP)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Atopic Dermatitis
Evaluation of a Non-Invasive Device for Early Detection of Atopic Dermatitis Flares
This study will collect skin measurements from people with atopic dermatitis (AD) using the investigational Nevisense Go device.
- Trial name
- Detect-AD (NCT07645820)
- Testing
- Nevisense electrical impedance spectroscopy
- Where
- 13 sites in United States
- Volunteers
- 450 people
- Sponsor
- Castle Biosciences Incorporated
Autosomal Recessive Congenital Ichthyosis, Skin Barrier Dysfunction
Cholesterol Cream vs Urea Cream for Skin Barrier and Quality of Life in Ichthyosis
This study looks at whether a cream containing 10% cholesterol works better than a cream containing 10% urea for people with autosomal recessive congenital ichthyosis (ARCI), a rare inherited skin condition that causes dry…
- Conditions
- Autosomal Recessive Congenital Ichthyosis, Skin Barrier Dysfunction, Ichthyosis Inherited
- Trial name
- CURE-ARCI (NCT07689435)
- Testing
- 10% Cholesterol Cream, 10% Urea cream
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Institute of Dermatology, Thailand