Clinical trials: Skin Diseases, Bacterial
Tinea Pedis, Athlete's Foot
Multicenter Study of the Safety and Efficacy of NAFT-500 in Tinea Pedis
A research study to compare the safety and effectiveness of an investigational medication called NAFT-500 to placebo, when used in subjects with tinea pedis (athlete's foot).
- Trial name
- NCT00750139
- Testing
- NAFT-500, Naftin 1%
- Where
- 17 sites in United States
- Volunteers
- 707 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
Onychomycosis
Human Factors Testing for OTC Use of the Erchonia® LunulaLaser
Human factors validation testing to assess the intended user's ability to correctly, safely, and effectively set-up, activate and operate the LunulaLaser™ OTC, to administer a treatment to a suitably qualified client, and to…
- Trial name
- NCT05626270
- Testing
- LunulaLaser OTC
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Erchonia Corporation
Helminthiasis, Tinea Capitis
Design and Clinical Evaluation of a School Meal With Deworming Properties
Intestinal parasites (IP) are among the world's neglected tropical diseases. Morbidity due to IPs is greatest in school-age children who typically have the highest burden of infection.
- Conditions
- Helminthiasis, Tinea Capitis, Anemia
- Trial name
- NCT02725255
- Testing
- Ujiplus, Albendazole, uji
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Kenya Medical Research Institute
Buruli Ulcer, Mycobacterium Ulcerans
BURULICO Drug Trial Study Protocol: RCT SR8/SR4+CR4, GHANA
The standard for treatment Buruli ulcer disease (BUD) used to be surgery but the WHO now advises streptomycin (S, 15 mg/kg daily, intramuscularly) and rifampicin (R,10 mg/kg daily) along with surgery.
- Trial name
- BURULICO (NCT00321178)
- Testing
- SR4 - switch to CR4
- Where
- 2 sites in Ghana
- Volunteers
- 151 people
- Sponsor
- University Medical Center Groningen
Hidradenitis Suppurativa
Treatment of Hidradenitis Suppurativa With Eth 755nm Alexandrite Laser
Patients with bilateral hidradenitis in the axilla, groin and/or inframammary will be treated on one side with the Alexandrite hair removal laser. The other side will serve as the control.
- Trial name
- NCT03054155
- Testing
- Alexandrite Laser
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Hidradenitis Suppurativa
A Study of Zasocitinib in Adults With Hidradenitis Suppurativa
Hidradenitis Suppurativa (HS) is a skin condition that causes deep, painful bumps on the skin. These bumps usually appear in an area where the skin rubs together.
- Trial name
- NCT07244263
- Testing
- Zasocitinib (Dose A)
- Where
- 49 sites in United States, Australia and 6 more
- Volunteers
- 90 people
- Sponsor
- Takeda
Rheumatic Fever, Sydenham Chorea
TREAT-SC: Early, Short Course Oral Dexamethasone for the Treatment of Sydenham Chorea in Children
The purpose of this study is to find out whether an early three-day course of an oral steroid medication (dexamethasone) can improve the physical and mental recovery and wellbeing for children with Sydenham's chorea.
- Trial name
- TREAT-SC (NCT06259006)
- Testing
- Dexamethasone Oral
- Where
- 17 sites in Australia, New Zealand
- Volunteers
- 80 people
- Sponsor
- Starship Child Health, Te Toka Tumai Auckland
Onychomycosis
Efficacy Study of LIQUICURE™ to Treat Toe Nail Fungus
There is a major clinical need for an inexpensive topically-applied product that can inhibit the growth of the dermatophytes that cause nail fungus.
- Trial name
- CT001 (NCT00960089)
- Testing
- LIQUICURE
- Where
- 4 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Chesson Laboratory Associates, Inc
Lyme Disease
Direct Diagnosis of Disseminated Lyme Borreliosis.
Lyme borreliosis is a bacterial multisystemic infection transmitted by an Ixodes tick. It affects the skin, the joint and the brain.
- Trial name
- DIALYD (NCT04719962)
- Testing
- Targeted proteomics in skin +/- cerebrospinal or synovial fluid to diagnose disseminated Lyme disease
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Strasbourg, France
Onychomycosis
Erbium-doped Yttrium Aluminium Garnet Laser(Er:Yag)Associated With Amorolfine Lacquer in the Treatment of Onychomycosis
The study aims to investigate the effectiveness of a single application of Er:YAG laser to the nail plate in increasing the efficacy of the amorolfine lacquer used in the treatment of onychomycosis (fungal infection of nails)…
- Trial name
- NCT01528813
- Testing
- Er:YAG laser + amorolfine lacquer, Amorolfine lacquer
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Brasilia University Hospital
Erythema Chronicum Migrans
Comparison of Doxycycline and Cefuroxime Axetil in Erythema Migrans
A European, prospective clinical trial in which doxycycline and cefuroxime axetil were compared in the treatment of adult patients with erythema migrans included a control group to address this question.
- Trial name
- NCT03584919
- Testing
- doxycycline, Cefuroxime Axetil 500Mg Tab, control subjects
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Hidradenitis Suppurativa
Negative Pressure Wound Therapy With Instillation for Treatment of Hidradenitis Suppurativa
The current surgical management for severe Hidradenitis suppurativa (HS) involves wide excision of affected skin, resulting in a large soft tissue defect.
- Trial name
- HIDRA (NCT04325607)
- Testing
- Excision of HS followed by NPWTi, Excision of HS followed by NPWT
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Tinea Pedis
Efficacy and Safety of Terbinafine Film Forming Solution in Patients With Tinea Pedis
This study will compare the efficacy and safety of a single dose of terbinafine film forming solution 1% with a single dose of placebo film forming solution in the treatment of tinea pedis.
- Trial name
- NCT01433107
- Testing
- Terbinafine
- Where
- 6 sites in China
- Volunteers
- 290 people
- Sponsor
- Novartis
Foot Dermatoses
Antifungal Activity of Loceryl Nail Lacquer in Combination With a Cosmetic Varnish
The main objective is to compare efficacy, in terms of antifungal activity of Loceryl Nail Lacquer associated with a Cosmetic Varnish and Loceryl Nail Lacquer alone, in the treatment of mild to moderate toenail Distal Subungual…
- Trial name
- COOL (NCT02321098)
- Testing
- Loceryl NL + Cosmetic varnish, Loceryl NL 12 weeks, Loceryl NL 15 months
- Where
- Iceland
- Volunteers
- 50 people
- Sponsor
- Galderma R&D
Hidradenitis Suppurativa (HS)
Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib
Rollover study for participants from predetermined, Incyte-sponsored parent clinical trials of povorcitinib.
- Trial name
- STOP-LTR (NCT06855498)
- Testing
- povorcitinib
- Where
- 306 sites in United States, Argentina and 18 more
- Volunteers
- 600 people
- Sponsor
- Incyte Corporation
Fatigue, Inflammatory Rheumatism
Guided Self-Management Intervention Targeting Fatigue in Rheumatic Inflammatory Diseases
Fatigue is common and debilitating in rheumatic inflammatory diseases as for other chronical medical conditions. The purpose of this study is to develope and evaluate a cognitive behavioural intervention targeting fatigue.
- Trial name
- NCT03216616
- Testing
- Cognitive Behavioural Therapy
- Volunteers
- 40 people
- Sponsor
- Diakonhjemmet Hospital
Hidradenitis Suppurativa (HS)
A Study Evaluating BFB759 in Moderate to Severe Hidradenitis Suppurativa
This is a double-blind, placebo-controlled study where subjects are participating for approximately 36 to 40 weeks. The study compares how well BFB759 works and how safe it is compared with a placebo.
- Trial name
- COMPASS 2-HS (NCT07287644)
- Testing
- BFB759
- Where
- 64 sites in United States, Bulgaria and 5 more
- Volunteers
- 210 people
- Sponsor
- Bluefin Biomedicine, Inc.
Blastomycosis
Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Blastomycosis Dermatitidis Infection in Patients Not Infected With HIV and Complications Associated With Blastomycosis Dermatitidis Infection
Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or…
- Trial name
- NCT00001702
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- National Cancer Institute (NCI)
Skin and Connective Tissue Diseases, Neglected Tropical Diseases
Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers
Skin-related Neglected Tropical Diseases (Skin NTDs) affect about 1.8 billion people worldwide, particularly in poor and rural communities where healthcare access is limited.
- Conditions
- Skin and Connective Tissue Diseases, Neglected Tropical Diseases, Leprosy, Buruli Ulcer
- Trial name
- SkincAIr (NCT07506967)
- Testing
- A mobile app with AI functionality for diagnosing skin-related NTDs
- Where
- 5 sites in Democratic Republic of the Congo, Ethiopia and 3 more
- Volunteers
- 2,420 people
- Sponsor
- Kenya Medical Research Institute
Rheumatic Heart Disease, Rheumatic Fever
The Genetic Basis of Acquired Heart Disease in Africa
Background: An acquired heart disease is one that a person gets after they are born. Two of these are rheumatic heart disease (RHD) and endomyocardial fibrosis (EMF).
- Conditions
- Rheumatic Heart Disease, Rheumatic Fever, Endomyocardial Fibrosis, Acquired Heart Disease
- Trial name
- NCT02124109
- Where
- 2 sites in Nigeria, Uganda
- Volunteers
- 736 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)