Clinical trials: Skin Diseases, Papulosquamous
Psoriasis, Eczema
A Real-world Study of Deucravacitinib in the Treatment of Moderate to Severe Plaque Psoriasis With Eczematous Features
Emerging evidence indicates that psoriasis and eczema can coexist in the same patient, with reported co-prevalence rates ranging from 0.17% to 20%, suggesting that these conditions may represent a disease spectrum-referred to as…
- Conditions
- Psoriasis, Eczema, JAK Inhibitor
- Trial name
- NCT06999941
- Testing
- Deucravacitinib 6mg po qd
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xi Tan
Psoriasis
Combining Topical Corticosteroid and LCD Treatment for Localized Plaque Psoriasis
This is a 12 week bilateral study, consisting of 6 weeks of treatment and 6 weeks of follow-up. The purpose of the study is to compare the safety and effectiveness of combining and then following a high potency topical…
- Trial name
- NCT00769184
- Testing
- Corticosteroid, LCD
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NeoStrata Company, Inc.
Psoriasis
A Study of IBI112 in Chinese Patients With Psoriasis Who Were Previously Treated With Biologics
This is a multicenter, open-label study aim to evaluate the efficacy and safety of IBI112 in Chinese participants with plaque psoriasis who were treated with biologics and switched to IBI112.
- Trial name
- NCT05970978
- Testing
- regular treatment, Intensive treatment
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Arthritis, Psoriatic
A Study of Apremilast Use and Effectiveness in Patients With Psoriatic Arthritis in The Netherlands
This is a multicenter, prospective, non-interventional, observational single arm study. 100 patients will be recruited in the Netherlands over a one year period.
- Trial name
- REWARD (NCT02875184)
- Where
- 21 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Amgen
Arthritis, Psoriatic, Arthritis, Rheumatoid
Fertility Study of Women With Chronic Inflammatory Rheumatism
Etiopathogenesis of Chronic inflammatory rheumatisms (CIR) includes genetic, autoimmune and environmental factors. Their impact on the quality of life is important, leading to a sometimes severe disability.
- Conditions
- Arthritis, Psoriatic, Arthritis, Rheumatoid, Ankylosing Spondylitis, Chronic Juvenile Arthritis
- Trial name
- FERTIRHUM (NCT03452735)
- Testing
- Questionnaire about fertility
- Where
- France
- Volunteers
- 2,900 people
- Sponsor
- University Hospital, Toulouse
Psoriasis, Coronary Artery Disease
Premature Coronary Artery Disease (CAD) in Severe Psoriasis
The purpose of this study is to compare the prevalence and severity of CAD (coronary artery disease) in patients with and without severe psoriasis, otherwise matched for cardiovascular risk factors.
- Trial name
- NCT00893126
- Testing
- CCTA Scan (Coronary CT Angiogram)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Psoriasis
Transitioning From Cyclosporine to Alefacept in Psoriasis
The purpose of this study is to devise a safe and effective method for transitioning patients from cyclosporine to alefacept.
- Trial name
- NCT00143806
- Testing
- Transitioning patients from cyclosporine to alefacept
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Psoriasis
A First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Intravenous (IV) Dose of GSK2831781 in Healthy Volunteers and Patients With Plaque Psoriasis
This study is a phase I, randomised, double blind (sponsor unblinded), placebo-controlled, single ascending dose study GSK2831781 administered by IV.
- Trial name
- NCT02195349
- Testing
- GSK2831781
- Where
- 3 sites in Germany, United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Infectious Disease, Chronic Skin Disease
Relationships Among Inflammation, Physical and Mental Health in Subjects With Chronic Inflammatory Physical Diseases.
The prevalence of common mental disorders is high in patients with chronic inflammatory physical diseases(e.g., autoimmune or infectious diseases).
- Conditions
- Chronic Infectious Disease, Chronic Skin Disease, Mental Disorders, Psoriasis
- Trial name
- InflaMent (NCT05125458)
- Where
- Italy
- Volunteers
- 93 people
- Sponsor
- University of Campania Luigi Vanvitelli
Parapsoriasis
A Phase 4 Study of Efficacy and Safety of Apremilast in Subjects With Moderate Plaque Psoriasis.
This study will evaluate the clinical efficacy, the patients quality of life, and safety of oral apremilast 30 mg twice daily (BID) compared to placebo, in adult patients with moderate plaque psoriasis during the 16 week Placebo…
- Trial name
- UNVEIL (NCT02425826)
- Testing
- Apremilast
- Where
- 26 sites in United States
- Volunteers
- 221 people
- Sponsor
- Amgen
Rheumatoid Arthritis, Psoriatic Arthritis
A Study to Test the Design, Functionality, and Ergonomic Features of the Autoinjector
The main purpose of this study is to evaluate how well the autoinjector works in a group of people who are likely to use the autoinjector for injecting their medicine in the future.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Psoriasis
- Trial name
- NCT00643526
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- Centocor, Inc.
Psoriasis, Inflammatory Bowel Diseases
On the Impact of Therapeutic Tumor Necrosis Factor-alpha Inhibition on Anogenital Human Papillomavirus Infection
In this prospective, open, controlled, cross-sectional observational study patients with psoriasis or IBD, who received either anti-TNF-alpha inhibitors or alternates (purine-, folic acid analogues, phototherapy, fumaric ester…
- Trial name
- NCT02376478
- Testing
- TNF-alpha inhibitors, Alternative/no medication, Purine/folic acid analogues
- Volunteers
- 222 people
- Sponsor
- Medical University of Vienna
Pruritus, Psoriasis
Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Plaque Psoriasis
Study of the efficacy, safety, and tolerability of serlopitant for the treatment of pruritus in adults with plaque psoriasis
- Trial name
- NCT03343639
- Testing
- 5 mg Serlopitant Tablets
- Where
- 39 sites in United States
- Volunteers
- 204 people
- Sponsor
- Vyne Therapeutics Inc.
Psoriasis, Systemic Inflammation
Anti-Inflammatory Effects of Time-Restricted Feeding
Background: Time-restricted feeding (TRF) means that a person eats only during certain hours of the day. In other studies, researchers have found that fasting can improve immune system function in healthy people.
- Trial name
- NCT04728165
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Psoriasis Vulgaris
Therapeutic Drug Monitoring of Ixekizumab in Psoriasis Patients
Biologics, such as ixekizumab, are currently the most effective treatment option for patients with moderate-to-severe psoriasis.
- Trial name
- BIOLOPTIM-IXE (NCT04083612)
- Testing
- Venapuncture, Patient questionnaires
- Where
- 7 sites in Belgium
- Volunteers
- 49 people
- Sponsor
- University Hospital, Ghent
Psoriatic Arthritis
PsA Secukinumab XCT Structural Progression Study
Psoriatic arthritis is related with chronic inflammation and progressive radiographic damages, and it in turn lead to disability and loss in function-ability.
- Trial name
- NCT03623867
- Testing
- Secukinumab
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Oral Lichen Planus
A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus
A phase 2 randomized, placebo-controlled, double-blind trial of a two week course of curcuminoids in oral lichen planus will be conducted.
- Trial name
- NCT00525421
- Testing
- Curcuminoids
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nita Chainani Wu
Generalized Pustular Psoriasis
CorEvitas Generalized Pustular Psoriasis (GPP) Drug Safety and Effectiveness Registry
Prospective, observational registry for subjects with GPP under the care of a dermatology investigator.Approximately 200 subjects and 75 clinical sites in North America will be recruited to participate with no defined upper limit…
- Trial name
- NCT06100991
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CorEvitas
Seborrheic Dermatitis
A 4 Week Study of Elidel (Pimecrolimus) for the Treatment of Seborrheic Dermatitis
This is an exploratory study to determine effectiveness of Elidel for the treatment of seborrheic dermatitis
- Trial name
- NCT00403559
- Testing
- Elidel, Ketoconazole Cream
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Dermatology Specialists Research
Arthritis, Psoriatic
Guselkumab in Active Psoriatic Arthritis Participants With Inadequate Response/Intolerance to One Prior Anti-TNF Alpha Agent
The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) and inadequate response (IR) and/or intolerance to a prior anti-tumor necrosis factor (TNF) by…
- Trial name
- SOLSTICE (NCT04936308)
- Testing
- Guselkumab
- Where
- 169 sites in United States, Argentina and 12 more
- Volunteers
- 453 people
- Sponsor
- Janssen Research & Development, LLC
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