Clinical trials: Skin Flaps
Breast Reconstruction, Breast Cancer
Comparison of PEAK PlasmaBlade™ to Conventional Diathermy in Abdominal Based Free Flap Breast Reconstruction
Electrosurgery allows for dissection with simultaneous haemostasis. One of its disadvantages is that the heat production can cause injury to the surrounding tissue which may result in wound healing problems and an increased rate…
- Trial name
- NCT04350411
- Testing
- Conventional diathermy, PEAK PlasmaBlade™
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- Anglia Ruskin University
Breast Cancer, Surgery
LIMBO : Breast Reconstruction by Lipomodeling Alone or With Flap: Evaluation in Franche-Comté
The Limbo study is a retrospective descriptive study which aims to establish the current state of breast reconstruction surgery at the Besançon University Hospital and Hôpital Nord Franche-Comté, between October 2017 and December…
- Trial name
- LIMBO (NCT06101732)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Breast Cancer, Mastectomy
Post-Operative Outcomes of Low Thermal Dissection vs. Traditional Electrosurgery
Low thermal dissection devices have been introduced as a tool to improve surgical outcomes. PlasmaBlade, a low thermal dissection device, has shown to be associated with effective cutting, and significantly lower temperature than…
- Conditions
- Breast Cancer, Mastectomy, Perfusion; Complications, Hemostasis
- Trial name
- NCT03711916
- Testing
- PlasmaBlade 3.0S
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Wound Healing
Basement Membrane Regeneration for Wound Repair
This study is a prospective, multicenter, real-world observational study. It aims to evaluate the effectiveness and safety of autologous basement membrane regeneration technology (epidermal basal cell suspension prepared using a…
- Trial name
- NCT07551284
- Testing
- Autologous Epidermal Basal Cell Suspension
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Knee Joint Prosthesis Infection, Flap Necrosis
The Contributions of the Multidisciplinary Management of Prosthesis Knee Infections in a Reference Center: A Retrospective Study About 52 Cases.Skin Coverage in a Reference Center: A Retrospective Study About 52 Cases
Acute and chronic infection of knee joint prosthesis can have several outcomes, the most feared of which is trans-femoral amputation.
- Conditions
- Knee Joint Prosthesis Infection, Flap Necrosis, Skin Graft Complications
- Trial name
- NCT05367726
- Testing
- patients having had skin coverage of the knee
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer
The Effects of Indocyanine Green Angiography (IGA) on Deep Inferior Epigastric Artery Perforator (DIEP) Flap Design and Post-Operative Fat Necrosis
The aim of this study is to prospectively evaluate the effect of intra-operative Indocyanine green angiography (IGA) on both flap design and rate of post-operative fat necrosis in patients undergoing autologous breast…
- Trial name
- SPY (NCT02144961)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Breast Neoplasms, Ischemia-Reperfusion Injury
DIEP Flap Breast Reconstruction: Perioperative Biomarkers and Outcomes
Brief Summary This observational study will follow patients who undergo DIEP flap breast reconstruction to better understand a common surgical challenge called ischemia-reperfusion (I/R) injury.
- Conditions
- Breast Neoplasms, Ischemia-Reperfusion Injury, Postoperative Complications, Wound Healing
- Trial name
- NCT07263347
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hubei Cancer Hospital
Post Traumatic Skin Defect in Leg and Foot
Use of Perforator Flaps for Leg and Foot Reconstruction
Perforator vessels are those where the source artery is deep and the branch that carries blood to the fasciocutaneous tissues passes through the overlying deep fascia.
- Trial name
- NCT03269864
- Testing
- perforator flaps
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Breast Cancer, Wound Dehiscence, Surgical
ciNPT in Autologous DIEP Flap Breast Reconstruction
In women who undergo mastectomy for the treatment of breast cancer, autologous reconstruction using the deep inferior epigastric perforator (DIEP) flap is a common surgical procedure that aims to restore both the appearance and…
- Trial name
- NCT05907941
- Testing
- ciNPT, Conventional Tape Dressings, DIEP Breast Reconstruction
- Volunteers
- 114 people
- Sponsor
- McMaster University
Breast Cancer
Reconstructions With Back Donor Site Flaps and Validation of Quality of Life Scales
The latissimus dorsi flap is the oldest and most used technique for breast reconstruction. Nonetheless, there are few studies evaluation the long-term effect of harvesting one of the muscles of the back.
- Trial name
- NCT04526561
- Testing
- Latissimus dorsi flap, Thoracodorsal artery perforator flap to breast, Deep inferior epigastric perforator flap
- Where
- Sweden
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Pressure Ulcer
Fluid Immersion Simulation (FIS) System Versus Air Fluidized Bed (AFB) System for Pressure Ulcers
The primary objective is to compare the efficacy of the FIS on closure rate to the AFB after 2 weeks of operative debridement and closure.
- Trial name
- NCT03522714
- Testing
- Fluid Immersion Simulation System, Air Fluidized Bed System
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Breast Cancer
Post-op Outcomes of Enhanced Energy Delivery Dissection for Mastectomy With Immediate Breast Reconstruction
Principal Investigator: Sheldon Feldman, MD Co-Principal Investigator: Mohamad Sebai, MD Department of Surgery, Montefiore Medical Center - Einstein College of Medicine Title Pilot Study: Post-operative outcomes of enhanced…
- Trial name
- NCT03627442
- Testing
- Mastectomy with PhotonBlade, Mastectomy with Bovie
- Volunteers
- 15 people
- Sponsor
- Invuity, Inc.
Oncoplastic Breast Surgery, Breast Cancer
Aesthetic Outcomes of Oncoplastic Breast Surgery for Breast Cancer in the Upper Inner Quadrant
Oncoplastic breast surgery, combining oncological resection with plastic surgical techniques, has emerged as an important surgical strategy to optimize conventional breast-conserving surgery.
- Conditions
- Oncoplastic Breast Surgery, Breast Cancer, Aesthetic Outcomes
- Trial name
- NCT05179304
- Testing
- Oncoplastic technique with a droplet-shaped glandular flap
- Where
- China
- Volunteers
- 109 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Bone Diseases, Infectious
Pressure Ulcer-associated Osteomyelitis: Evaluation of a Two-stage Surgical Strategy With Prolonged Antimicrobial Therapy
Pressure ulcer represents a frequent clinical condition in patient with spinal cord injury or after prolonged Intensive Care Unit (ICU) stay.
- Trial name
- NCT03010293
- Where
- France
- Volunteers
- 61 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer, Physiotherapy
Evaluation of the Impact of Pre-habilitation Using Physiotherapy and Mechanical Stimulation on Shoulder Pain and Mobility in Patients Undergoing Breast Reconstruction Using a Latissimus Dorsi Flap
Each year in France, nearly 59,000 new cases of breast cancer are diagnosed, and approximately 22,000 mastectomies are performed. Among these patients, 30% choose to undergo breast reconstruction.
- Conditions
- Breast Cancer, Physiotherapy, Breast Reconstruction, Latissimus Dorsi Flap
- Trial name
- PREHAB KINELGD (NCT07418060)
- Testing
- Prehabilitation with physiotherapy including mechanostimulation, No Prehabilitation with physiotherapy including mechanostimulation
- Where
- 2 sites in France
- Volunteers
- 96 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Acquired Breast Deformity, Breast Cancer
Endoscopic Assisted Latissimus Dorsi Musculocutaneous Flap for Breast Reconstruction
This prospective single-arm case series evaluates the feasibility, safety, and clinical outcomes of endoscopic-assisted latissimus dorsi musculocutaneous flap harvest for breast reconstruction.
- Conditions
- Acquired Breast Deformity, Breast Cancer, Post Burn Breast Deformities
- Trial name
- NCT07691294
- Testing
- Endoscopic-Assisted Latissimus Dorsi Musculocutaneous Flap Harvest
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Kasr El Aini Hospital
Breast Cancer
Functional Evaluation After Breast Reconstruction With a Minimally Invasive Latissimus Dorsi Flap Following Radical Surgery for Breast Cancer.
This study will quantify the muscle function after breast reconstruction using a minimally invasive latissimus dorsi flap. The proposed measures (clinical, isokinetic, electrophysiology, function and quality of life…
- Trial name
- BREAST (NCT05278741)
- Testing
- Surgery for unilateral breast reconstruction
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Centre Georges Francois Leclerc
Breast Cancer, Wound Complication
The Risk of Postoperative Wound Complications Following the Use of Negative Pressure Wound Therapy in Patients Undergoing Mastectomy
To evaluate the risk of postoperative wound complications following the use of Avelle negative pressure wound therapy in patients undergoing mastectomy and flap fixation, which might serve as a basis for a randomized controlled…
- Conditions
- Breast Cancer, Wound Complication, Wound Infection, Wound Dehiscence
- Trial name
- ALEX (NCT03942575)
- Testing
- Negative pressure wound therapy
- Where
- Netherlands
- Volunteers
- 162 people
- Sponsor
- Zuyderland Medisch Centrum
Surgical Incision, Surgical Site Infection
Comparison of the Classical Median Sternotomy Skin Incision with the Paramedian Flap Skin Incision
The goal of this observational study is to determine the effects of a flap-shaped paramedian skin incision on protection from mediastinal infections, wound healing, and scar formation in open heart surgery performed through the…
- Conditions
- Surgical Incision, Surgical Site Infection, Keloid Scar Following Surgery
- Trial name
- NCT06725472
- Testing
- Open Heart Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ataturk University
Breast Cancer
Primary Radiotherapy And DIEP flAp Reconstruction Trial
Many women with breast cancer now live for decades after their breast cancer treatment. In view of this, modern breast reconstruction surgery after mastectomy for breast cancer aims to reproduce as natural a breast shape as…
- Trial name
- PRADA (NCT02771938)
- Testing
- Radiotherapy before surgery
- Where
- United Kingdom
- Volunteers
- 33 people
- Sponsor
- Royal Marsden NHS Foundation Trust