Clinical trials: Skin Infection
Verruca Vulgaris, Common Warts
Exploratory Study of Efficacy and Safety of Ingenol Mebutate 0.05% Gel for Common Warts on the Hands.
The purpose of this study is to determine if ingenol mebutate 0.05% gel is safe and effective in treating common warts on the hands.
- Trial name
- NCT02748902
- Testing
- ingenol mebutate 0.05% gel
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Neal D. Bhatia, MD
Merkel Cell Carcinoma, Neuroendocrine Carcinoma of the Skin
Neoadjuvant Lenvatinib Plus Pembrolizumab in Merkel Cell Carcinoma
This is a single arm trial of participants with Merkel cell carcinoma receiving a combination of lenvatinib plus pembrolizumab.
- Conditions
- Merkel Cell Carcinoma, Neuroendocrine Carcinoma of the Skin, Trabecular Carcinoma of the Skin
- Trial name
- NCT04869137
- Testing
- Lenvatinib Oral Product, Pembrolizumab
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Invasive Fungal Infections, Invasive Aspergillosis
Validation of an Index of Neutropenia (D-index) in Febrile Neutropenic Cancer Patients
The main objective of this study is to test prospectively the performance of an algorithm stratified by an index based on neutrophil counts in association with galactomannan assay and image tests to start an antifungal early…
- Conditions
- Invasive Fungal Infections, Invasive Aspergillosis, Invasive Fusariosis
- Trial name
- Dindexval (NCT00982540)
- Testing
- caspofungin as preemptive antifungal therapy
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Otitis Media, Suppurative Chronic, Cholesteatoma
Chronic Suppurative Otitis Media Microbiology
This study is planned to reveal the microbiological agents and drug sensitivities to these agents in patients diagnosed with chronic suppurative otitis media who complain of ear discharge.
- Conditions
- Otitis Media, Suppurative Chronic, Cholesteatoma, Microbial Colonization
- Trial name
- NCT06424704
- Testing
- Microbiological culture
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Selcuk University
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome
Efficacy and Safety of Thalidomide for Pediatric PFAPA Syndrome
The goal of this clinical trial is to evaluate the efficacy and safety of thalidomide in the treatment of children with Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis (PFAPA) syndrome.
- Trial name
- NCT07476625
- Testing
- Thalidomide (50mg), Colchicine
- Volunteers
- 106 people
- Sponsor
- Wenjie Zheng
Leishmaniasis, Cutaneous
Miltefosine Plus IL Pentamidine for Bolivian CL
Bolivian cutaneous leishmaniasis due to Leishmania braziliensis was treated with the combination of miltefosine (150 mg/day for 28 days) plus intralesional pentamidine (120 ug/mm2 lesion area on days 1, 3, and 5).
- Trial name
- NCT03445897
- Testing
- miltefosine plus intralesional pentamidine
- Volunteers
- 50 people
- Sponsor
- Jonathan Berman
Cancer, Healthy
Collection and Distribution of Biospecimens for Novel Research Uses
iSpecimen aims to create a clinical partner network of hospitals, laboratories, academic institutions, and other healthcare organizations ("institutions") capable of providing researchers and educators ("researchers") with…
- Conditions
- Cancer, Healthy, Gastrointestinal Complication, Autoimmune Diseases
- Trial name
- NCT03848962
- Where
- 2 sites in United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- iSpecimen Inc
Cutaneous Leishmaniasis
WR 279,396 Open Label Treatment Protocol in Tunisia
The U.S. Army has recently completed a Phase 3 clinical trial in Tunisia. This is an open-label single site trial designed to expand our safety database and capture additional efficacy (final clinical cure rate of an index…
- Trial name
- NCT01494350
- Testing
- WR 279,396 topical cream
- Where
- Tunisia
- Volunteers
- 50 people
- Sponsor
- U.S. Army Medical Research and Development Command
Onychomycosis
Diode Laser and Photodynamic Therapy Vs. Ciclopirox.
The main objective of this study is to compare the efficacy of treatment of onychomycosis by: diode laser combined with photodynamic therapy, and topical treatment with Ciclopirox Hydroxypropyl Chitosan (HPCH) Nail Lacquer.
- Trial name
- Laser (NCT05809297)
- Testing
- Diode laser combined with photodynamic-red laser therapy by RapidoPodia Laser Diodo®, Ciclopirox Hydroxypropyl Chitosan (HPCH) Nail Lacquer
- Volunteers
- 26 people
- Sponsor
- Universidad Complutense de Madrid
Diabetic Foot, Diabetic Foot Ulcer
Adjunctive Phototherapy Treatment of Infected Diabetic Ulcers
The key purpose of this study is to determine and understand the safety and effectiveness of blue light phototherapy in the treatment and healing of infected diabetic wounds, as well as determining if this treatment is capable of…
- Conditions
- Diabetic Foot, Diabetic Foot Ulcer, Diabetes, Diabetes Mellitus
- Trial name
- NCT04285710
- Testing
- Phototherapy, Debridement Surgery and Wound Dressing
- Where
- United States
- Sponsor
- Boston Medical Center
Hidradenitis Suppurativa
Therapeutic Effect of Methalazine on 27 Cases of Suppurative Hidradenitis
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory relapsing disease involving the axillae, breast ,groin and anogenital regions. The therapies of the disease are diverse, including medication and surgery.
- Trial name
- NCT06568224
- Testing
- Mesalazine
- Where
- China
- Volunteers
- 27 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Herpes
Hsv 1 and 2 Gowey Protocol Versus Placebo
This study will compare efficacy of versabase gel with 20% sarracenia purpurea versus placebo applied every 3-4 hours to herpes lesions.
- Trial name
- NCT01477879
- Testing
- Versabase gel with sarracenia purpurea 20% liquid extract
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Naturopaths International
Onychomycosis
Absorption and Systemic Study of AN2690 in Patients With Moderate to Severe Onychomycosis (ADME I)
The purpose of the study is to determine the absorption, systemic pharmacokinetics and accumulation in the nail of AN2690 during a 28 day period of daily application of a 7.5% solution of AN2690 to all 10 toenails of up to 25…
- Trial name
- NCT00680160
- Testing
- AN2690
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Pfizer
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma
In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors
This phase I trial evaluates the safety and effectiveness of in situ immunomodulation with CDX-301, radiotherapy, CDX-1140 and Poly-ICLC (Cohort A) and these with intravenous (IV) pembrolizumab and subcutaneous (SC) tocilizumab…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Prognostic Stage IV Breast Cancer AJCC v8, Unresectable Breast Carcinoma
- Trial name
- NCT04616248
- Testing
- Anti-CD40 Agonist Monoclonal Antibody CDX-1140, Poly ICLC, Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Southern California
Hidradenitis Suppurativa
A Randomized Controlled Trial Evaluating the Efficacy of Intralesional Triamcinolone in Hidradenitis Suppurativa.
Purpose: To evaluate the effectiveness of intralesional triamcinolone for the treatment of hidradenitis suppurativa (HS) Participants: Patients diagnosed with Hidradenitis Suppurativa that have active inflammatory HS lesions.
- Trial name
- NCT02781818
- Testing
- Triamcinolone Acetonide 10mg/mL, Triamcinolone Acetonide 40mg/mL, Normal Saline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Surgical Site Infection
Skin Staples vs Polypropylene in Elective Laparotomy
Surgical site infection (SSI) is one of the most common postoperative complications following elective laparotomy and contributes significantly to patient morbidity, prolonged hospital stay, and increased healthcare costs.
- Trial name
- NCT07781878
- Testing
- Skin staples, Polypropylene skin suture
- Where
- Pakistan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
MRSA
Community-Assoc. S. Aureus Colonization and Recurrent Infection in Pts With Uncomplicated S. Aureus Skin Abscesses
Infections due to S. aureus are a major healthcare burden. Currently there is not an effective way to prevent S. aureus infection.
- Trial name
- CIRCUS (NCT02690415)
- Testing
- Antibiotics Given, Antibiotics not given
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Southern Illinois University
Solid Tumor, Lymphoma
Safety and Efficacy of p53 Gene Therapy Combined With Immune Checkpoint Inhibitors in Solid Tumors.
This is a single arm Phase 2 study of the combination of adenoviral p53 (Ad-p53) gene therapy administered intra-tumorally with approved immune checkpoint inhibitors in patients with recurrent or metastatic cancers.
- Trial name
- NCT03544723
- Testing
- Ad-p53
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- MultiVir, Inc.
Impetigo, Folliculitis
Twice Daily Altabax Application for the Treatment of Uncomplicated Soft Tissue Infection
The purpose of this study is to document the clinical and bacteriological efficacy of retapamulin in the treatment of subjects with bacterial infections, including impetigo, folliculitis, and minor soft tissue infections…
- Conditions
- Impetigo, Folliculitis, Secondarily Infected Eczema, Minor Soft Tissue Infections
- Trial name
- NCT01126268
- Testing
- Retapamulin (Altabax)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- The University of Texas Health Science Center, Houston
WHIM, Warts
Base-Edited Hematopoietic Stem/Progenitor Cell Gene Therapy for Treatment of CXCR4-WHIM
Background: Warts, hypogammaglobulinemia, infections and myelokathexis syndrome (WHIMs) is a rare disorder that affects the immune system. People with WHIMs can have severe infections all over their body.
- Conditions
- WHIM, Warts, Hypogammaglobulinemia, Immunodeficiency
- Trial name
- NCT07775313
- Testing
- Busulfan, Palifermin, Plerixafor
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.