Clinical trials: Skin Infections, Bacterial
Superficial Mycoses, Dermatomycoses
A Clinical Study to Evaluate the Pharmacokinetics of Lozanoc and Sporanox in Korean Healthy Male Volunteers
Study Objectives: To evaluate the pharmacokinetics (PK) of orally administered Lozanoc under fasted and fed condition in healthy male subjects To compare the pharmacokinetics (PK) of orally administered Lozanoc and Sporanox under…
- Conditions
- Superficial Mycoses, Dermatomycoses, Candidiasis, Histoplasmosis
- Trial name
- NCT02493738
- Testing
- Lozanoc 50mg, Sporanox 100mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Rheumatoid Arthritis, Systemic Lupus
Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease
The overall objective of this project is to study the influence of modern anti-inflammatory treatments in established inflammatory rheumatic diseases (IRD) on antibody response elicited by pneumococcal vaccination using 13-valent…
- Conditions
- Rheumatoid Arthritis, Systemic Lupus, Sjögren Syndrome, Systemic Vasculitis
- Trial name
- IPS-BOOSTER (NCT03762824)
- Testing
- 13-valent pneumococcal conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Region Skane
Hyperthermia
Infrared Bioeffect System for the Treatment of Onychomycosis
Onychomycosis is a common nail plate infection caused by dermatophytes, non-dermatophytic molds, and yeasts. The disease is difficult to achieve self-healing and predisposed to secondary bacterial infections.
- Trial name
- NCT06036654
- Testing
- infrared thermotherapy instrument
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gao Xinghua
Staphylococcus Aureus
Staphylococcus Aureus Toxoids Phase 1-2 Vaccine Trial
This study involves the use of investigational vaccines. A vaccine is a medicine that causes the body to make antibodies. Antibodies help destroy foreign substances that enter the body.
- Trial name
- NCT01011335
- Testing
- Monovalent rAT, Monovalent rLukS-PV, Bivalent rLukS-PV / rAT
- Where
- 2 sites in United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Hidradenitis Suppurativa
Treatment of Hidradenitis Suppurativa With Eth 755nm Alexandrite Laser
Patients with bilateral hidradenitis in the axilla, groin and/or inframammary will be treated on one side with the Alexandrite hair removal laser. The other side will serve as the control.
- Trial name
- NCT03054155
- Testing
- Alexandrite Laser
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Dermatophytoses, Skin Lesion
Use of Essential Oils as Natural Therapies
Mycosis is defined as a fungal infection caused by the implantation of etiological agents that compromises the dermis and subcutaneous tissue.
- Trial name
- NCT05777525
- Testing
- application of cream "La Chinata"
- Where
- Spain
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Extremadura
Skin Diseases, Infectious
Effective Antibiotic Treatment of MRSA
To evaluate the effective duration (in days) to clinical improvement of outpatient antibiotic regimens in the treatment of superficial abscesses caused by MRSA in patients that present to the emergency department.
- Trial name
- NCT00388310
- Testing
- Culture
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Hidradenitis Suppurativa (HS)
The Role of Host-microbiota Interplay in Hidradenitis Suppurativa Pathogenesis
Hidradenitis Suppurativa (HS) is a chronic disabling inflammatory skin disorder associated with the development of painful and purulent lesions of the folds (armpits, inguinal folds, sub-mammary glands).
- Trial name
- VERIMMUNE (NCT05735925)
- Testing
- Skin Swab & Skin Biopsies & Blood Sample
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Association pour la Recherche Clinique et Immunologique
Yaws
Evaluation of an Intensive 3-round MDA Strategy Towards Yaws Eradication
The current principle of yaws eradication (the Morges strategy) is based on single round mass drug administration (MDA) of azithromycin (AZI) called total community treatment (TCT) followed by targeted treatment of active cases…
- Trial name
- NCT03490123
- Testing
- R1-Total community treatment with azithromycin, R2-Total community treatment with azithromycin, R3-Total community treatment with azithromycin
- Where
- Papua New Guinea
- Volunteers
- 56,000 people, healthy volunteers welcome
- Sponsor
- Lihir Medical Centre
Antifungal Agents
Bioequivalence (BE) Study of Test Griseofulvin 500 Milligram (mg) Tablets Versus Reference and Dose Proportionality Study of Test Griseofulvin 250 mg and 500 mg Tablets Under Fed Conditions
Griseofulvin is an antifungal agent used in treatment of Dermatophytosis caused by Microsporum spp. (species), Trichophyton spp., Epidermophyton spp., where topical therapy is considered inappropriate or has failed.
- Trial name
- NCT04318535
- Testing
- Griseofulvin 500 mg, Griseofulvin 250 mg, Reference Griseofulvin 500 mg
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tinea Pedis
Nitric Oxide Releasing Solution (NORS) Footbath to Treat Athlete's Foot
The purpose of this study is to determine the fungicidal efficacy of nitric oxide releasing solution footbath and it's effect on the clinical signs and symptoms associated with Tinea Pedis
- Trial name
- NCT02871011
- Testing
- Nitric Oxide, Water
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nitric Solutions Inc.
Tinea Versicolor
Ketoconazole Foam 2% for the Treatment of Versicolor
Ten adult patients age 19 and older with a clinical diagnosis of tinea versicolor, as well as a positive Potassium Hydroxide (KOH) using calcofluor.
- Trial name
- NCT00830388
- Testing
- Ketoconazole 2% Foam
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Boni Elewski, MD
Tuberculosis, Skin Tests
Tolerability and Reactogenicity Trial of the Recombinant Tuberculosis Allergen in Healthy Volunteers
Primary objective of the trial is to study the safety and tolerability of the Recombinant tuberculosis allergen in standard dilution in healthy volunteers after a single dose.
- Trial name
- NCT05398562
- Testing
- Mycobacterial recombinant allergens 0.1 μg, Mycobacterial recombinant allergens 0.2 μg
- Where
- Russia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- St. Petersburg Research Institute of Vaccines and Sera
Rheumatic Heart Disease
Effectiveness of Edutainment-Based Interventions in Increasing Knowledge of Rheumatic Fever and Rheumatic Heart Disease Among School-Going Children in Nepal: Study Protocol for Colors to Save Hearts Quasi-Experimental Pretest-Posttest Study
Background: Acute rheumatic fever (ARF) and its sequela, rheumatic heart disease (RHD), remain significant public health concerns in low- and middle-income countries, including Nepal.
- Trial name
- NCT07065474
- Testing
- education material
- Where
- Nepal
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Kathmandu Institute of Child Health
Tinea Cruris, Jock Itch
Multicenter Study of the Safety and Efficacy of NAFT-500 in Tinea Cruris
A research study to compare the safety and effectiveness of an investigational medication called NAFT-500 to placebo (no active treatment), when used in subjects with tinea cruris, also known as jock itch.
- Trial name
- NCT00750152
- Testing
- NAFT-500
- Where
- 20 sites in United States, Puerto Rico
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
Hidradenitis Suppurativa, Mediterranean Diet
Nutritional Status and Hidradenitis Suppurativa (Acne Inversa)
Hidradenitis suppurativa (HS) is a chronic inflammatory, debilitating skin disorder. The exacerbating factors of HS include nutrition and adiposity.
- Conditions
- Hidradenitis Suppurativa, Mediterranean Diet, Body Composition, Vitamin D Deficiency
- Trial name
- NutriHidra (NCT03683238)
- Testing
- Mediterranean Diet
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Federico II University
Latent Tuberculosis
Latent Tuberculosis in Second Generation Immigrants From High Risk Countries Compare to Low-risk Young Israeli Adults
The aim of study is to evaluate the prevalence of latent TB in second generation immigrants from countries with high incidence of tuberculosis (above 20 of 100,000) compare to the control native Israelis without a family member…
- Trial name
- NCT02073669
- Testing
- Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA)
- Where
- 2 sites in Israel
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Hidradenitis Suppurativa
Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa Patients
The objective is to investigate ex vivo the inflammatory response in hidradenitis suppurativa (HS) (activation of an inflammasome, role of pro-inflammatory cytokines) in the skin of patients treated surgically for this disease.
- Trial name
- NCT02833909
- Testing
- surgery
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Tinea Pedis, Athlete's Foot
Once a Day Topical Treatment for Athlete's Foot Fungus Inbetween the Toes in Males and Females
The topical cream, Sertaconazole (Ertaczo), has been FDA approved for the treatment of athlete's foot using twice a day dosing for 4 weeks.
- Conditions
- Tinea Pedis, Athlete's Foot, Foot Fungus, Ringworm
- Trial name
- NCT00856596
- Testing
- Sertaconazole nitrate cream 2%
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jamaica Hospital Medical Center