Clinical trials: Skin Infections (Acne)
Infection, Bacterial
Efficacy of Surgical Diathermy in Eradicating Cutibacterium Acnes From Surgical Skin Incision During Shoulder Arthroplasty
Periprosthetic infection following shoulder arthroplasty is a devastating complication. Diagnosing and treating periprosthetic shoulder infection poses a significant challenge.
- Trial name
- Electrocautery (NCT04608916)
- Testing
- Using surgical diathermy to make skin incision, Using scalpel blade to make skin incision
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Missouri-Columbia
Hidradenitis Suppurativa
An Alternative Dose Interval Study in Participants With Hidradenitis Suppurativa Receiving Brodalumab
Phase 0 Study of an alternative dosing interval of Brodalumab in patients with moderate to severe Hidradenitis Suppurativa to identify biomarkers of disease activity and clinical response.
- Trial name
- NCT04249713
- Testing
- Brodalumab
- Where
- United States
- Sponsor
- Rockefeller University
Hidradenitis Suppurativa (HS), Hidradenitis Suppurativa (Acne Inversa)
Comparison of the Clinical Efficacy and Safety of Topical and Subcutaneous Injection of Secukinumab in HS
Secukinumab is currently approved in Europe, US and China for the treatment of moderate to severe HS as a biologic agent targeting IL-17A.Two phase III clinical trials (SUNSHINE and SUNRISE) showed that 300 mg s.c.
- Conditions
- Hidradenitis Suppurativa (HS), Hidradenitis Suppurativa (Acne Inversa), Secukinumab
- Trial name
- NCT07261072
- Testing
- Topical injection of Secukinmab, Subcutaneous injection of Secukinumab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College
Hidradenitis Suppurativa (HS)
1726-nm Laser for Acne Inversa (Hidradenitis Suppurativa)
Hidradenitis suppurativa (HS) is a long-lasting skin condition that causes painful lumps, abscesses, and tunnels in areas such as the armpits and groin.
- Trial name
- WMCREI (NCT07155239)
- Testing
- AviClear Lase Treatment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wynn Medical Center
Hidradenitis Suppurativa (HS)
A Study to Evaluate the Efficacy and Safety of Povorcitinib (INCB054707) in Participants With Moderate to Severe Hidradenitis Suppurativa (HS)
The purpose of this study is to evaluate the efficacy and safety of Povorcitinib (INCB054707) in participants with moderate to severe Hidradenitis Suppurativa (HS) over a 12-week placebo-controlled period, followed by a 42-week…
- Trial name
- STOP-HS2 (NCT05620836)
- Testing
- Povorcitinib
- Where
- 101 sites in United States, Australia and 9 more
- Volunteers
- 619 people
- Sponsor
- Incyte Corporation
Skin Infections (Acne)
Bioequivalence Study for an Isotretinoin
The objective of this study was to confirm if two formulations of isotretionin (capsules) are bioequivalent. Test product was Oratane® 20 mg (Laboratorios Dermatológicos Darier) and reference product Roaccutan® 20 mg (Productos…
- Trial name
- NCT01863615
- Testing
- Isotretinoin 40 mg
- Where
- Mexico
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hidradenitis Suppurativa, Acne Inversa
A Study to Evaluate the Efficacy, Safety and Tolerability of Bermekimab in Patients With Hidradenitis Suppurativa
This study further evaluates the efficacy of bermekimab in treating moderate to severe hidradenitis suppurativa in adults. 1/3 of patients will receive weekly injections of bermekimab, 1/3 will receive alternating every other…
- Conditions
- Hidradenitis Suppurativa, Acne Inversa, Suppurative Hidradenitis
- Trial name
- NCT04019041
- Testing
- bermekimab
- Where
- 33 sites in United States
- Volunteers
- 153 people
- Sponsor
- Janssen Research & Development, LLC
Hidradenitis Suppurativa (HS), Hidradenitis Suppurativa (Acne Inversa)
Global Healthcare Study on Hidradenitis Suppurativa
The Global Healthcare Study on Hidradenitis Suppurativa (GHSHS) is an international, multicenter observational study hosted by the University of Zurich (UZH) investigating healthcare access, treatment patterns, disease severity…
- Trial name
- GHSHS (NCT07659769)
- Where
- Switzerland
- Volunteers
- 9,600 people
- Sponsor
- Julia Tatjana Maul
Propionibacterium Infection
Antimicrobial Prophylaxis for Skin Colonization With Propionibacterium Acnes in Primary Open Shoulder Surgery
INESS Antibiotic Prophylaxis in Orthopedic Guide recommends the use of Cefazolin at induction for all orthopaedic procedure with implantation of internal fixation device. With the increasing rate of identified P.
- Trial name
- PAPA (NCT02996656)
- Testing
- Cefazolin, Ceftriaxone
- Where
- Canada
- Volunteers
- 88 people
- Sponsor
- Université de Montréal
Hidradenitis Suppurativa, Acne Inversa
Evaluation of Safety and Efficacy of Avacopan in Subjects With Moderate to Severe Hidradenitis Suppurativa (AURORA)
Phase 2 study of Avacopan in Subjects with Moderate to Severe Hidradenitis Suppurativa
- Trial name
- NCT03852472
- Testing
- Avacopan
- Where
- 91 sites in United States
- Volunteers
- 435 people
- Sponsor
- Amgen
Propionibacterium Infection
Does the Addition of Hydrogen Peroxide to Chlorhexidine Skin Prep to Treat P. Acnes in the Shoulder
This is a prospective, randomized controlled trial to evaluate the ability of hydrogen peroxide preparation in addition to chlorhexidine to decrease the colonization of Propionibacterium acnes(a bacteria commonly found in the…
- Trial name
- NCT03656588
- Testing
- a. Standard iodine scrub, 3% hydrogen peroxide prep, follow by ChloraPrep (2% chlorhexidine gluconate and 70% isopropyl alcohol, Iodine scrub and ChloraPrep alone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rothman Institute Orthopaedics
Hidradenitis Suppurativa (HS), Hidradenitis Suppurativa (Acne Inversa)
Efficacy and Safety of Secukinumab in Conjunction With Surgery in Moderate to Severe Hidradenitis Suppurativa
This study aims to retrospectively analyze the efficacy and safety of secukinumab combined with surgery in treating moderate to severe HS in real-world clinical practice, providing clinical practioners with real-world evidence in…
- Conditions
- Hidradenitis Suppurativa (HS), Hidradenitis Suppurativa (Acne Inversa), Secukinumab
- Trial name
- NCT06926192
- Testing
- Surgery combined with secukinumab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College
Wounds, Hidradenitis Suppurativa
Wound Etiology and Healing Study
The purpose of the WE-HEAL Study is to help researchers use human tissue samples and health records to study the reasons why some patients heal quickly and some have problems healing wounds.
- Conditions
- Wounds, Hidradenitis Suppurativa, Hidradenitis, Acne Inversa
- Trial name
- WE-HEAL (NCT01352078)
- Where
- United States
- Volunteers
- 743 people
- Sponsor
- George Washington University
Acne Vulgaris, Vitamin D Deficiency
Impact of COVID-19 Vaccination on Serum 25-hydroxyvitamin D Level
Vitamin D plays a pivotal but still not well understood role in the immune response to coronavirus disease (COVID-19) infection and vaccination.
- Conditions
- Acne Vulgaris, Vitamin D Deficiency, COVID-19
- Trial name
- NCT05398939
- Testing
- Blood test and skin evaluation
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Hidradenitis Suppurativa (Acne Inversa)
Efficacy, Safety, and Pharmacokinetics Study of CJM112 in Hidradenitis Suppurativa Patients
This is a randomized, double blind, multicenter study in patients with moderate to severe chronic hidradenitis suppurativa in parallel groups, to determine the efficacy and safety of multiple doses of CJM112 in comparison to…
- Trial name
- NCT02421172
- Testing
- CJM112
- Where
- 16 sites in United States, Denmark and 3 more
- Volunteers
- 66 people
- Sponsor
- Novartis Pharmaceuticals
Hidradenitis Suppurativa, Acne Inversa
Anifrolumab for Hidradenitis Suppurativa
This clinical trial aims to study if a drug called anifrolumab works to treat Hidradenitis Suppurativa (HS) as well as its effect in quality of life before and after treatment.
- Conditions
- Hidradenitis Suppurativa, Acne Inversa, Hidradenitis
- Trial name
- NCT06374212
- Testing
- Anifrolumab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of North Carolina, Chapel Hill
Actinic Keratosis, Acne/Rosacea
Using a Cold Atmospheric Plasma Device to Treat Skin Disorders
This study examines the efficacy of a non-thermal, atmospheric plasma device in the treatment of skin disorders
- Conditions
- Actinic Keratosis, Acne/Rosacea, Verruca Plana, Tinea
- Trial name
- NCT02759900
- Testing
- Non-thermal, atmospheric plasma to treat skin lesions and acne, Indirect non-thermal, atmospheric plasma to treat hair loss and acne
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Skin Center Dermatology Group
Acne Vulgaris, Gingivitis and Periodontal Diseases
Retinoic Acid Therapy and Regulation of Salivary and Serum IL-1β, IL-8 and MCP-1 Levels
This prospective cohort study analysed the effects of systemic retinoic acid use on periodontal status, salivary flow rate (SFR), and salivary and serum levels of interleukin (IL)-1β, IL-8 and monocyte chemoattractant protein…
- Conditions
- Acne Vulgaris, Gingivitis and Periodontal Diseases, Saliva Collection, Inflammation Biomarkers
- Trial name
- NCT06879795
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medipol University
Hidradenitis Suppurativa (HS)
A Study Evaluating BFB759 in Moderate to Severe Hidradenitis Suppurativa
This is a double-blind, placebo-controlled study where subjects are participating for approximately 36 to 40 weeks. The study compares how well BFB759 works and how safe it is compared with a placebo.
- Trial name
- COMPASS 2-HS (NCT07287644)
- Testing
- BFB759
- Where
- 64 sites in United States, Bulgaria and 5 more
- Volunteers
- 210 people
- Sponsor
- Bluefin Biomedicine, Inc.
Helicobacter Pylori Infection, Acne Vulgaris
Prevalence of H.Pylori in Patients With Acne Vulgaris Acne Vulgaris
The objective of the study is to investigate prevalence of H.Pylori infection among acne vulgaris patients.
- Trial name
- NCT03411733
- Testing
- Blood and stool samples collection
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University