Clinical trials: Skin Inflammation
Skin Inflammation, Cosmetic Skin
35 kDa Hyaluronan Fragment (HA35) Reduces Chronic Inflammation of Skin
To explore the clinical effect and safety of 35 kDa hyaluronic acid fragment ( HA35 ) combined with negative pressure microneedle technology in improving skin problems.
- Trial name
- NCT06387212
- Testing
- 35 kDa hyaluronan fragment HA35 injection
- Where
- Mongolia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nakhia Impex LLC
Inflammation, Skin Inflammation
Skin Barrier Function and Inflammation in Aging: The BIA Study
This is a randomized, investigator-blinded, self-controlled pilot study of the physiologic response to topical moisturizers among older adults with dry skin.
- Conditions
- Inflammation, Skin Inflammation, Aging
- Trial name
- BIA (NCT06750653)
- Testing
- CeraVe Moisturizing Cream, Vaseline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Respiratory Disease, Inflammation
Partners in Children's Health (CSN): A Randomized Trial of an Attachment Based Intervention
The goal of this randomized controlled trial is to evaluate the impacts of an attachment-based intervention (Attachment Biobehavioral Catch-Up (ABC) and Home Book-of-the-Week (HBOW) program on emerging health outcomes (i.e.…
- Conditions
- Respiratory Disease, Inflammation, Insufficient Sleep, Digestive Disease
- Trial name
- NCT06002685
- Testing
- Attachment and Biobehavioral Catch-Up, Home-Based Book-of-the-Week
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Pediatric Cancer, CNS Tumor, Childhood
Preventative Skin Care for Children Undergoing Targeted CNS Tumor Therapy
This research study is examining a preventive skin care regimen for children diagnosed with a brain tumor and receiving anti-cancer therapy with a MEK, Pan-RAF, or BRAF inhibitor.
- Conditions
- Pediatric Cancer, CNS Tumor, Childhood, Skin Inflammation
- Trial name
- NCT04479514
- Testing
- Warm Baths or Showers, Moisturizer, SPF 30 or Higher Suncreen
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Dana-Farber Cancer Institute
Skin Inflammation, Allergic Contact Dermatitis
Using a Contact Dermatitis Model With Biologic Medications to Study Skin Inflammation
The purpose of this study is to answer: how do inflammation and anti-inflammatory skin therapies work in the skin? Inflammation is a protective response from the body's immune system to injury, disease, or irritation.
- Trial name
- NCT05535738
- Testing
- Squaric Acid Dibutyl Ester, Known patch test allergens, Dupilumab
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Wei-Che Ko
Skin Inflammation, Immunosenescence
Skin Inflammation in (Peri)Menopause: A Probiotic Intervention Proof of Concept Trial
This study will explore whether a daily probiotic drink containing Lactobacillus casei Shirota (LcS) can help improve immune function and reduce inflammation in women going through the menopausal transition.
- Conditions
- Skin Inflammation, Immunosenescence, Inflammation, Skin Health
- Trial name
- SIPPI (NCT07341087)
- Testing
- Lactobacillus casei Shirota (LcS) Probiotic Drink, Skimmed Milk Control Drink
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College London
Melanoma (Skin Cancer)
IMmune checkPoint Inhibitor Related gonAdal toxiCiTy in Premenopausal Women and Men With Melanoma
This study aims to capture information regarding the effect of immune checkpoint inhibitor (ICI) treatment for melanoma on reproductive organ function and sex hormone levels.
- Trial name
- IMPACT (NCT07138222)
- Where
- 6 sites in Australia
- Volunteers
- 80 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Skin Manifestations
New Regenerative Approach for Dermal Renovation (Karisma)
Purpose/Objectives of the Study: Regenerative medicine, as well as aesthetic plastic surgery and dermatology field persistently seeks innovative, minimally invasive interventions to enhance skin quality and mitigate signs of…
- Trial name
- Karisma (NCT06152718)
- Testing
- Karisma
- Where
- 2 sites in Italy, Serbia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Down Syndrome, Alopecia Areata
Tofacitinib for Immune Skin Conditions in Down Syndrome
People with Down syndrome (DS) display widespread immune dysregulation, including several immune skin conditions. This study hypothesizes that pharmacological inhibition of the increased interferon (IFN) signaling seen in DS is…
- Conditions
- Down Syndrome, Alopecia Areata, Atopic Dermatitis / Eczema, Hidradenitis Suppurativa
- Trial name
- NCT04246372
- Testing
- Tofacitinib
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Colorado, Denver
Hidradenitis Suppurativa (HS), Skin Inflammation
Molecular Evaluation of TAAR1 and JAK/STAT Pathway in Hidradenitis Suppurativa
This observational translational study aims to investigate gene and protein expression in lesional and perilesional skin of patients with Hidradenitis Suppurativa (HS) compared to controls.
- Trial name
- NCT07278011
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Trakya University
Liposuction, Bruising
EFFECTS OF TRANEXAMIC ACID IN TUMESCENT SOLUTION FOR LIPOSUCTION PROCEDURES
The goal of this trial is to evaluate the effect of adding Tranexamic Acid (TXA) to the tumescent solution used in arm liposuction on postoperative outcomes.
- Conditions
- Liposuction, Bruising, Inflammation, Skin Condition
- Trial name
- ARMTXA (NCT06648265)
- Testing
- Tranexamic Acid (Topical), Tumescent solution with dilute lidocaine and epinephrine
- Where
- Colombia
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Total Definer Research Group
Skin Inflammation, Skin Melanoma
Effects of Ultraviolet B Exposure Using a Ultraviolet Skin Care Device on Vitamin D Production and Immune Response in Healthy Adults
Vitamin D regulates various physiological functions, including calcium homeostasis, bone health, and potentially reducing cancer risks.
- Trial name
- NCT06625918
- Testing
- Ultraviolet B exposure to produce vitamin D synthesis
- Where
- South Korea
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Wonju Severance Christian Hospital
Inflammation; Skin, Psoriasis
Pleiotropic Role of TRPV1 in Psoriasis Inflammation
Widely expressed in the sensory nerve endings of the skin, Transient Receptor Potential Vanilloid 1 (TRPV1) is a receptor that plays an important role in the perception of pain and pruritus but also in skin inflammation…
- Trial name
- TRIP (NCT04848194)
- Testing
- skin biopsy and blood sampling
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Brest
Psoriasis, Inflammation
A Herbal Compound for Psoriasis
The goal of this interventional clinical trial study is to compare ZAX.1400.P03 and placebo in Psoriasis patients. The main question it aims to answer is: Can treatment with ZAX.1400.P03 for 3 weeks improve clinical signs of skin…
- Conditions
- Psoriasis, Inflammation, Skin Diseases
- Trial name
- NCT06301997
- Testing
- ZAX.1400.P03
- Where
- Iran
- Volunteers
- 104 people
- Sponsor
- Fasa University of Medical Sciences
Skin Inflammation
Skin IaM: An Exploratory Clinical Trial to Evaluate Changes in Skin Appearance, Colour, and/or Texture Following the Induction of a Local Inflammatory Skin Response
This trial will test the feasibility of various imaging devices to detect local skin inflammation prior to clinical manifestation.
- Trial name
- NCT03192280
- Testing
- Leukotriene B4, FLIR One, SCIO
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Surgery, Skin Cancer
A Randomized Controlled Trial Comparing Sutures vs Staples for High Tension Closures
The study aims to compare outcomes in patient comfort, cosmetic appearance, and complication rates between sutures and staples in high tension areas for closures of skin cancers excised in a dermatology clinic.
- Conditions
- Surgery, Skin Cancer, Suture; Complications, Infection or Inflammation
- Trial name
- NCT06638736
- Testing
- Wound Closure with sutures vs staples
- Where
- United States
- Sponsor
- University of Kansas Medical Center
Psoriasis, Aging
Effects of Tildrakizumab on Epigenetic Age
Design: Single-center open-label clinical trial. Objective: Evaluate if tildrakizumab reverses peripheral blood leukocyte DNA methylation (epigenetic aging) observed in chronic psoriasis. Number of subjects: 30.
- Conditions
- Psoriasis, Aging, Epigenetic Disorder, Inflammation; Skin
- Trial name
- NCT05110313
- Testing
- TILDRAKIZUMAB
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Carlos Wambier
Skin Inflammation
Broccoli Seed Extract and Skin Health
The primary objective of this study is to examine the influence of 4-weeks ingestion of TrueBroc®, (broccoli seed extract, BSE) with mustard seed powder (MSP) on improving skin health by evaluating skin physiological and…
- Trial name
- NCT05745636
- Testing
- Broccoli, mustard, vitamin C
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Eczema, Atopic, Inflammation; Skin
Nutrients-fortified Egg Consumption on Eczema Condition in Individuals With Eczema
The study aims to assess the effects of daily consumption of nutrients-fortified eggs on eczema condition in individuals with eczema.
- Conditions
- Eczema, Atopic, Inflammation; Skin, Eczema, Hypersensitivity
- Trial name
- NCT05913791
- Testing
- Nutrients-fortified egg, Regular egg
- Where
- Singapore
- Volunteers
- 41 people
- Sponsor
- National University of Singapore
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin