Clinical trials: Skin Irritation
Erythema, Sensitisation
50 Human Subject Repeat Insult Patch Test
Consumer products or raw materials designed for consistent reapplication to areas of the skin may, under proper conditions, prove to be contact sensitizers or irritants in certain individuals.
- Trial name
- HRIPT (NCT04498676)
- Testing
- CB-0002B
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CAGE Bio Inc.
Skin Irritation
Patch Test Skin Irritation/Sensitization of Cetaphil Restoraderm Skin Restoring Body Wash
Determine if Cetaphil Restoraderm Skin Restoring Body Wash proves to be a contact sensitizer or irritant in certain individuals.
- Trial name
- NCT01892410
- Testing
- Cetaphil Restoraderm Skin Restoring Body Wash
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Osteoporosis, Postmenopausal
A Multiple-Dose Study to Evaluate Skin Irritation and Sensitization of Teriparatide Administered Transdermally in Healthy Postmenopausal Women
This study is a Phase 1, multi-center, 2-part, subject- and investigator-blind, randomized, placebo-controlled, multiple dose study of transdermal teriparatide (80-µg dose) in healthy postmenopausal women.
- Trial name
- NCT01250145
- Testing
- LY333334
- Where
- 5 sites in United States, Germany and 1 more
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Psoriasis Vulgaris
Skin Irritation of LEO 90100 Foam (Calcipotriol Hydrate Plus Betamethasone Dipropionate) in Healthy Japanese Subjects
This trial is looking at whether the LEO 90100 foam causes irritation of the skin in healthy Japanese male adults without psoriasis.
- Trial name
- NCT03442244
- Testing
- LEO 90100 foam, Vehicle of LEO 90100 foam
- Where
- Japan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Alopecia Areata, Alopecia
Efficacy of Hair Transplantation Compared With Hypodermic Needle Irritation in Alopecia Areata
The purpose of this study is to look at the safety, as well as the efficacy of hair transplantation compared with irritation with hypodermic needles in the treatment of subjects with refractory alopecia areata.
- Conditions
- Alopecia Areata, Alopecia, Balding
- Trial name
- NCT01385839
- Testing
- Hair transplantation, Hypodermic needle irritation
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Diaper Dermatitis
BM Collection From NICU Infants for Composition
The primary objective of this study is to collect feces from premature infants over a five weeks period to characterize its composition.
- Trial name
- NCT02570698
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Kimberly-Clark Corporation
Skin Care
A Photoxicity and Photoallergy Study of a Developmental Face Cream, Serum and Lotion
The purpose of this study is to demonstrate the absence of sensitisation and irritation potential of a product when applied to the skin and exposed to ultraviolet (UV) radiation.
- Trial name
- NCT04006795
- Testing
- Serum, Lotion, Cream
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Major Depressive Disorder (MDD)
A Study to Assess the Skin Irritation and Sensitization of Selegiline TDS in Healthy Subjects
The two products used in this study are transdermal patches that contain selegiline. The test drug is the Selegiline Transdermal Delivery System (TDS). The comparator drug is the EMSAM® TDS.
- Trial name
- NCT07452692
- Testing
- Selegiline Transdermal Delivery System
- Where
- 3 sites in Bulgaria
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.
Healthy
Cumulative Irritation Test of PAC-14028 in Healthy Volunteers
The purpose of this study is to determine the cumulative irritation potential of the products listed by the Sponsor.
- Trial name
- NCT01638117
- Testing
- PAC14028-Vehicle, PAC14028-0.1, PAC14028-0.3
- Where
- South Korea
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Amorepacific Corporation
Pain, Healthy Volunteers
A Study to Learn About Whether BAYH006689 Causes Skin Irritation When Applied as a Topical Gel in Healthy Participants
Researchers are looking for a better way to treat muscle and joint pains. Researchers have seen that medicines which help reduce pain and inflammation could be safer when applied directly to the skin, called topical application…
- Trial name
- NCT06511973
- Testing
- Naproxen (BAYH006689), A solution of 0.9% Saline, A solution of 0.2% SLS
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bayer
Borderline Personality Disorder
Clinical Research Study to Evaluate Selegiline in the Treatment of Borderline Personality Disorder
Selegiline is superior to placebo in improving psychological and physical functioning in patients with Borderline Personality Disorder.
- Trial name
- NCT01912391
- Testing
- Selegiline
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mood and Anxiety Research, Inc
Skin Irritancy Potential
A 96-hour Patch Test Study Using Healthy Human Volunteers to Assess the Skin Irritation Potential of 11 Topically Applied Formulations
This study is an evaluation of the irritation potential of 9 test products and 2 control materials applied to the backs of at least 44 volunteer human subjects over the course of a 96-hour period to determine and compare…
- Trial name
- NCT04942496
- Testing
- Chlorhexidine Gluconate, Hibi Universal Bathing System, 0.1% SLS
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Molnlycke Health Care AB
Acne
Addition of a Topical Steroid to a Topical Retinoid in Acne Patients
A randomized, split-face, placebo-controlled, double-blind, single-center clinical trial comparing topical retinoid on half the face and retinoid plus topical steroid on the other half.
- Trial name
- NCT02704507
- Testing
- Triamcinolone, Tretinoin, Emollient
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Healthy, Atopic Dermatitis
A Study to Determine the Safety and Sensitizing Potential of HAT1 Topical Products Using Skin Sensitivity Patch Tests
The objective of this clinical study is to assess the irritation and sensitisation potential of HAT1 topical products after repeated patch applications to healthy human participants by following conventional Repeated Insult…
- Conditions
- Healthy, Atopic Dermatitis, Psoriasis
- Trial name
- NCT03406117
- Testing
- HAT1, Saline Solution
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Haus Bioceuticals
Healthy Adult
Human Repeat Insult Patch Test to Evaluate Skin Irritation and Sensitization in Healthy Volunteers
This study evaluates skin irritation and sensitization following repeated application of a collagen-based material in healthy adult volunteers under controlled conditions.
- Trial name
- HRIPT (NCT07473661)
- Testing
- Collagen-Based Material
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- SerenaGroup, Inc.
Skin Care
To Investigate Primary Irritation Potential of Four Skin Serum Products on Human Subjects Assessed by 24 Hour Patch Test
To assess the irritation potential of four prototype daily defense serum formulations after 24 (± 2) hours under semi-occlusive patch application to the skin of healthy volunteers.
- Trial name
- NCT03233009
- Testing
- Experimental Daily Defense Serum A, Experimental Daily Defense Serum C, Experimental Daily Defense Serum G
- Where
- 2 sites in Brazil
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Skin Manifestations
Standard TDS Irritation Study: Trained Skin Grader vs. Digital Imaging
The purpose of this study is to (1) collect trained observer scores and digital images of skin irritated by generic and RLD Lidocaine 5% delivered via TDS, and (2) assess performance of an automated system for predicting scores…
- Trial name
- TDS_TSG_DI (NCT02787356)
- Testing
- TDS Lidocaine 5%; generic, TDS Lidocaine 5%; RLD
- Volunteers
- healthy volunteers welcome
- Sponsor
- SRI International
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Sunburn
Dermal Irritation, Sensitization and Cumulative Irritation Potential of 6% Bemotrizinol
The purpose of this clinical trial is to evaluate the dermal safety of Bemotrizinol (6%).
- Trial name
- NCT05260359
- Testing
- 6% Bemotrizinol (BEMT) in a basic sunscreen oil formulation, 6% Bemotrizinol (BEMT) dispersion in petrolatum, Sunscreen oil vehicle with 10% ethanol as penetration enhancer without BEMT
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Determine Sensitivity of Skin to Cetaphil Daily Advance Ultra Hydrating Lotion
Patch Test Skin Irritation/Sensitization of Cetaphil Daily Advance Ultra Hydration Lotion
Determine if Cetaphil Daily Advance Ultra Hydrating Lotion proves to be a contact sensitizer or irritant in certain individuals.
- Trial name
- NCT01885130
- Testing
- Cetaphil Daily Advance Ultra Hydrating Lotion
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Galderma R&D