Clinical trials: Skin Microbiome
Healthy Skin
Effect of Surfactants on the Skin Microbiome
Up to 10 volunteers will be recruited to evaluate the microbial environment on their forearms. Following informed consent, bacterial swabs will be obtained at baseline from the forearms of all subjects.
- Trial name
- NCT01951391
- Testing
- Control Hand Soap, Benzalkonium Chloride Soap, Triclocarban Soap
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Atopic Dermatitis (AD)
Targeted Microbiome Transplant in Atopic Dermatitis
The purpose of this study is to examine the safety and effectiveness of a new therapy, commensal lotion containing infection fighting bacteria, on decreasing or eliminating the infection causing bacteria found on the skin of…
- Trial name
- NCT03151148
- Testing
- TMT Lotion
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Volunteers
Evaluation of Changes to Skin Microbiome With Tape-Stripped Wounds
This single center, randomized, 15-day clinical trial is being conducted to assess the changes to the skin microbiome of induced wounds on the back in approximately 35 healthy adult subjects aged 18-55 years, with Fitzpatrick…
- Trial name
- NCT03365934
- Testing
- ADHESIVE BANDAGE #1, ADHESIVE BANDAGE #2, ADHESIVE BANDAGE #3
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants
Effect of Photodynamic Treatment on Skin Microbiome. Single Center Study
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if photodynamic therapy has an effect on bacterial skin colonization and decrease number of…
- Conditions
- Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection
- Trial name
- PHOMIC (NCT04067843)
- Testing
- Photodynamic treatment
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Psoriasis
Psoriasis Microbiome and Phototherapy
The ASPIRE study is a clinical trial designed to examine the microbes (e.g., bacteria) within psoriasis skin lesions compared with normal skin.
- Trial name
- NCT02552316
- Testing
- NB-UVB Phototherapy
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Pennsylvania
Atopic Dermatitis
Validation of the Short-term Antimicrobial Action of Transplanted Bacteria
Unlike healthy control skin, the skin of patients with atopic dermatitis (AD) is frequently colonized by Staphylococcus aureus (S. aureus), putting these patients at increased risk of S. aureus skin infections.
- Trial name
- NCT01959113
- Testing
- Autologous Microbiome Transplant
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Diego
Acne, Healthy
Profiling the Skin Microbiome in Response to Altreno in Acne Patients
The study objective is to characterize the shift in the diversity and abundance of the skin microbial community at baseline and in response to Altreno monotherapy as compared to benzoyl peroxide (BPO) 2.5% leave-on gel…
- Trial name
- NCT04548349
- Testing
- Altreno, Benzoyl peroxide
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Rosacea
Evaluation of the Inhibitory Effects of Topical Ivermectin on Markers of Rosacea Specific Inflammation.
This study will assess the role of topical Ivermectin 1% cream and its effect on protease and antimicrobial peptide expression and on the skin microbiome (the microorganisms that live on the skin) in rosacea.
- Trial name
- NCT02806414
- Testing
- Ivermectin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Diego
Hidradenitis Suppurativa
Hidradenitis Suppurativa (HS) Tunneling Wounds
The purpose of this study is to look at the change in the microbiome (bacterial composition) of an HS tunneling wound and examine if treatment with an antibiofilm surfactant wound gel (ABWG) (a topical medication that will fight…
- Trial name
- NCT04648631
- Testing
- antibiofilm surfactant wound gel (ABWG)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Miami
Rheumatoid Arthritis
Effects of Administration of SCFA in Rheumatoid Arthritis Inadequate Responders
This study is a pilot, proof of concept study to determine the effects of administering an oral short-chain fatty acid (SCFA) supplement to Rheumatoid Arthritis (RA) patients with inadequate response to methotrexate (MTX).
- Trial name
- EASi-RAIR (NCT05718583)
- Testing
- Butyrate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Metastatic Melanoma
Melanoma Checkpoint and Gut Microbiome Alteration With Microbiome Intervention
This study is designed to evaluate the safety and tolerability of treatment with oral microbiome study intervention (SER-401) or matching placebo in combination with anti-programmed cell death 1 (anti-PD-1) therapy (nivolumab) in…
- Trial name
- MCGRAW (NCT03817125)
- Testing
- Vancomycin pretreatment, Nivolumab, SER-401
- Where
- 7 sites in United States
- Volunteers
- 14 people
- Sponsor
- Parker Institute for Cancer Immunotherapy
Atopic Dermatitis
Targeted Investigation of Microbiome Elimination
The purpose of this study is to examine the pharmacokinetics or survival of new product containing commensal infection fighting bacteria, on the skin of patients with Atopic Dermatitis (AD), after a single application.
- Trial name
- TIME-1 (NCT05177328)
- Testing
- S. hominis A 9 Product
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Rheumatoid Arthritis
Acupuncture Study on Rheumatoid Arthritis, Monitoring Microbiome and Blood
Acupuncture is used and recommended by the WHO for the treatment of Rheumatoid Arthritis. The molecular bases of this recommendation are not known, the investigators want to compare with the usage of high-throughput molecular…
- Trial name
- NCT01619176
- Testing
- methotrexate, non-steroidal anti-inflammatory drug (NSAID), leflunomide
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Lichen Planopilaris of Scalp, Alopecia Areata
Mechanical Intervention on the Scalp Microbiome: Setting the Stage for the Future Management of Cicatricial Alopecias
The objective of this study is to assess the effect of standardized scalp care, specifically mechanical cleansing with the Venus Glow™ Device and water, on the scalp microbiome.
- Trial name
- NCT06357169
- Testing
- Venus Glow
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants
Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-II)
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if PDT has an effect on bacterial skin colonization in order to improve skin antisepsis…
- Conditions
- Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection
- Trial name
- NCT04618276
- Testing
- Photodynamic Therapy
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Rheumatoid Arthritis, Psoriatic Arthritis
Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an inflammatory form of arthritis that causes joint pain and damage. RA attacks the lining of the joints (synovium), causing swelling that can result in aching and throbbing, and eventually deformity.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Periodontal Disease
- Trial name
- NCT01198509
- Testing
- doxycycline, vancomycin
- Where
- 2 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Breast Cancer
Gut Microbiome & Gastrointestinal Toxicities as Determinants of Response to Neoadjuvant Chemo for Advanced Breast Cancer
The purpose of this research is to test whether bacteria that normally live in the intestines play a role in fighting cancer. It is believed that the development and behavior of these immune cells may be influenced by bacteria…
- Trial name
- NCT02696759
- Testing
- Blood & Fecal Collection
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Arkansas