Clinical trials: Skin Microbiome
Rosacea
Evaluation of the Inhibitory Effects of Topical Ivermectin on Markers of Rosacea Specific Inflammation.
This study will assess the role of topical Ivermectin 1% cream and its effect on protease and antimicrobial peptide expression and on the skin microbiome (the microorganisms that live on the skin) in rosacea.
- Trial name
- NCT02806414
- Testing
- Ivermectin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Diego
Microbiota, Eczema
Infant Restore: Efficacy of Microbiome Analysis and Education
The goal of this clinical trial is to learn if a microbiome analysis, education, and recommendation program can improve gut health, reduce future health risks, and empower parents in their children's health in infants aged 0-3…
- Conditions
- Microbiota, Eczema, Microbiome, Gut Microbiome
- Trial name
- NCT06424691
- Testing
- Tailored Recommendations, Consult Call, Email Series
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Seeding Inc
Breast Cancer, Triple Negative Breast Cancer
TNBC Gut Microbiota During Neoadjuvant Treatment
The gut microbiome is made up of the microbes (such as bacteria, viruses, and other organisms too small to see with the naked eye) that live in the digestive tract and has been shown to be important in metabolizing food…
- Conditions
- Breast Cancer, Triple Negative Breast Cancer, Early Stage Triple-Negative Breast Carcinoma
- Trial name
- NCT06610097
- Testing
- Nutritional Counseling
- Where
- United States
- Sponsor
- Scripps Health
Darier Disease
Characterization of the Cytokine Profile and the Microbiome in Darier's Disease
Darier disease is a rare genetic skin disease caused by mutations in the ATP2A2 gene. Clinically, patients present with inflammatory and keratotic papules, sometimes erosive and oozing, predominating in seborrheic areas and…
- Trial name
- DARKINBIOT (NCT06614777)
- Testing
- skin biopsies and blood extraction
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Toulouse
Microbiome
Evaluation of Two Regimens, With Healthy Male and Female Babies, Ages 3-6 Months Old, Using Various Assessments.
This study is to assess the impact of two skincare regimens on the cutaneous microbiome and skin physiology of healthy male and female infants, ages 3-6 months using clinical, instrumental, D-Squame tape, microbiome and parental…
- Trial name
- Microbiome (NCT03457857)
- Testing
- Cleanser, Cleanser and Lotion
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Skin Microbiome, Graft Versus Host Disease
The Skin Microbiome in Graft Versus Host Disease
Based on the evidence on the impact of the intestinal microbiome on the Graft Versus Host Disease (GVHD) after allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT), it is hypothesized that the skin-microbiome may play a…
- Conditions
- Skin Microbiome, Graft Versus Host Disease, Graft Versus Host Disease in Skin
- Trial name
- NCT04231500
- Testing
- Skin swabs, Skin punch biopsies, additional blood sampling
- Where
- Switzerland
- Volunteers
- 74 people
- Sponsor
- University Hospital, Basel, Switzerland
Acne Vulgaris
Acne Vulgaris Related Microbiology and Serology
This will be an investigation to determine the quality of the serological immune responses against Propionibacterium acnes (P. acnes) in acne patients compared to healthy individuals.
- Trial name
- NCT04056598
- Testing
- Study of humoral immunity
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sanofi
Cosmetics Product Effects
Cosmetic Products and Facial Skin Microbiome
The skin microbiome diversity in female healthy volunteers will be studied along with cosmetic products application in 1 month period.
- Trial name
- NCT05004103
- Testing
- Cosmetic products application
- Where
- Indonesia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Ovarian Cancer, Breast Cancer
Comprehensive Outcomes for After Cancer Health
This study intends to explore feasibility, acceptability, and outcomes related to the use of a digital health coaching intervention for individuals who have completed primary therapy for cancer.
- Conditions
- Ovarian Cancer, Breast Cancer, Lung Cancer, Gastric Cancer
- Trial name
- COACH (NCT05349227)
- Testing
- Digital Health Coaching Program, Fitbit
- Where
- 7 sites in United States
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- Pack Health
Acne Vulgaris
Studying the Skin Microbiome and the Potential of a Topical Probiotic Cream for Patients With Acne
In this study the topical use of cream with live probiotic bacteria was evaluated for its efficacy in reducing acne symptoms and its effect on the skin microbiota on patients with acne.
- Trial name
- NCT03469076
- Testing
- YUN ACN Cream
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Acne Vulgaris
Effectiveness and Safety of Zingiber Officinale Transdermal Patch for Acne Vulgaris; Study of Interleukin 1 and Skin Microbiome
The goal of this clinical trial is to investigate the effectivity and safety of mild to moderate acne vulgaris therapy using Zingiber officinale 5 % transdermal patch.
- Trial name
- NCT06787222
- Testing
- tretinoin 0.025% + Z. officinale patch, tretinoin 0.025% cream
- Where
- Indonesia
- Volunteers
- 26 people
- Sponsor
- Hasanuddin University
Healthy
UVB: Skin to Gut Study
This research will explore the potential effects of Narrow-Band Ultra Violet B (NB-UVB) radiation on the intestinal microbiota composition and confirm a regulatory skin-to-gut axis during baseline conditions.
- Trial name
- NCT03962673
- Testing
- NB-UVB light exposure
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Atopic Eczema
A Pilot Study of Efficacy and Safety of SIM05 in Adults With Atopic Eczema
Atopic eczema causes significant disease burdens worldwide. Some studies reported gastrointestinal symptoms in eczema patients which could be related to gut microbiota change.
- Trial name
- NCT06230991
- Testing
- SIM05
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Xerosis
Clinical Therapeutic Potential of Novel Microbiome LP-51 on Xerosis Individual Based on Xerosis-microbiome Index
The purpose of this clinical trial is to assess the skin hydration and transepidermal water loss improvement, pruritus relief, and microbiome alteration effects of a Lactobacillus sp.
- Trial name
- NCT06706050
- Testing
- Microbiome Therapeutic LP-51
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Ho-Yeon Song
Rheumatoid Arthritis (RA)
Probiotics in Adults With Rheumatoid Arthritis
The goal of this clinical study is to collect data on the effect of probiotic administration on clinical outcomes in rheumatoid arthritis patients.
- Trial name
- NCT07304505
- Testing
- Align Extra Strength Probiotic Supplement
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ancilia Biosciences
Atopic Dermatitis
Vitamin D Treatment Effect for Atopic Dermatitis in Children
A double-blind study to evaluate the role of human microbiome and vitamin D in the development of atopic dermatitis.
- Trial name
- NCT05523986
- Testing
- Vitamin D
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Psoriatic Arthritis
The MEDIPSA Clinical Trial
The main purpose of this study is to validate the positive effect of "Omnibiotic Stress Repair" on patients with active psoriatic Arthritis.
- Trial name
- MEDIPSA (NCT04588623)
- Testing
- Omnibiotic Stress Repair (OBSR)
- Where
- Austria
- Volunteers
- 66 people
- Sponsor
- Medical University of Graz
Skin Health
The Effect of Skin Cleansers on the Skin Surface Microbiome
This study determines the effects of a single application of different antiseptic skin cleansers on the composition of the skin surface microbiome using next-generation sequencing (NGS) techniques.
- Trial name
- NCT03348917
- Testing
- 7.5% Povidone-Iodine [PVP-I], 4% chlorhexidine skin cleanser, Plain non antibacterial soap
- Where
- Singapore
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mundipharma Manufacturing Pte Ltd.
Focus: Healthy Skin Microbiome
The Effect of Surfactants on the Bacterial Composition of the Layers of the Skin
Recent research in the investigator's lab has shown that bacteria are present not only on the outer surface of our skin, but also in the deeper components as well.
- Trial name
- NCT02057055
- Testing
- Soap 300000027003, Soap 300000029240
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Diego
Rheumatoid Arthritis, Periodontitis
Dental Prophylaxis and Rheumatoid Arthritis
This study evaluates the influence of dental prophylaxis on disease activity of Rheumatoid Arthritis. In addition to standard antirheumatic therapy, recently the question has been raised whether or not there is a supplementary…
- Conditions
- Rheumatoid Arthritis, Periodontitis, Gingivitis, Dental Prophylaxis
- Trial name
- PREPARA II (NCT03087240)
- Testing
- Dental Prophylaxis
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- University Hospital Heidelberg