Clinical trials: Skin Neoplasm
Breast Cancer
Accelerated Radiation Therapy (ART) to the Breast and Nodal Stations
This protocol is for patients with newly diagnosed breast cancer with an indication for post-operative radiotherapy after neo-adjuvant chemotherapy and surgery.
- Trial name
- ART (NCT02917421)
- Testing
- Radiation
- Where
- 3 sites in United States
- Volunteers
- 88 people
- Sponsor
- Weill Medical College of Cornell University
Breast Cancer, Radiation-Induced Telangiectasias
QOL Assessment in Breast Cancer Patients With Radiation-Induced Telangiectasias Treated With the Pulsed Dye Laser
The purpose of this study is to see how the look of telangiectasias (small dilated blood vessels) on radiated breast skin when altered by the pulsed dye laser affects a patient's overall well being.
- Trial name
- NCT01803516
- Testing
- questionnaires
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Metastatic Breast Cancer
Toxicity Markers to Trastuzumab-Deruxtecan (T-DXd) In Patients With Advanced Breast Cancer
the anti-Human Epidermal Growth Factor Receptor 2 (HER2) Trastuzumab-Deruxtecan (T-DXd) has shown impressive clinical activity in pretreated patients with metastatic breast cancer (MBC) but is also associated with a…
- Trial name
- Tox-DXd (NCT07049133)
- Testing
- T-DXd toxicity marker identification
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- European Institute of Oncology
Breast Cancer
Carboplatin in EARLY Triple Negative Breast Cancer Trial (PEARLY Trial)
This is a randomized, open-label, multicenter, phase III study comparing anthracyclines followed by taxane to anthracyclines followed by taxane plus carboplatin as (neo)adjuvant therapy in patients with triple-negative breast…
- Trial name
- NCT02441933
- Testing
- taxane plus carboplatin, Taxane
- Where
- 21 sites in South Korea
- Volunteers
- 878 people
- Sponsor
- Yonsei University
Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma
CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery to Improve Treatment of Melanoma Brain Metastases
This phase I/II trial tests how well the combination of CA-4948 with pembrolizumab works to reduce the need for intracranial intervention, such as surgery, additional radiosurgery, laser therapy, or whole brain radiotherapy…
- Trial name
- NCT05669352
- Testing
- Emavusertib, Pembrolizumab, Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Mayo Clinic
Melanoma (Skin)
PET and CT Scans to Evaluate Patients With Stage III or Stage IV Melanoma
RATIONALE: Diagnostic procedures may improve the ability to detect metastatic melanoma and to determine the extent of disease. PURPOSE: Phase II trial to evaluate the effectiveness of PET and CT scans to detect metastatic disease…
- Trial name
- NCT00004152
- Testing
- iodinated contrast dye, computed tomography, positron emission tomography
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer, Endometrial Cancer
Non-Hormonal Vaginal Moisturizer in Hormone-Receptor Positive Postmenopausal Cancer Survivors Experiencing Estrogen Deprivation Symptoms on Vulvovaginal Health
The purpose of this study is to see whether it is feasible to conduct a study to determine if the use of hyaluronic acid (HLA) vaginal gel (HyaloGYN®) improves vulvovaginal health.
- Trial name
- NCT01738152
- Testing
- HLA vaginal gel (HyaloGYN®),, questionnaires
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Neoplasm Malignant Female
Interest of Touch-massage in Hospital Day Care
In spite of progresses made in the medical and nurse announcement (linked to the cancer plan), still a lot of patients fell lost, anxious, especially during the first venue at the hospital day care for their chemotherapy.
- Trial name
- TOMAS (NCT04348955)
- Testing
- Women between 18 and 70 years old with an adjuvant breast cancer histologically characterized
- Where
- 2 sites in France
- Volunteers
- 36 people
- Sponsor
- Institut Cancerologie de l'Ouest
Tracheostomy, Oral Cancer
Novel Tracheostomy Tube Fixation Device in Oral Cancer Patients
This study evaluated a novel tracheostomy tube fixation device in post-tracheostomy patients with oral cancer. After tracheostomy, conventional fixation methods may be associated with skin pressure injury, wound contamination…
- Conditions
- Tracheostomy, Oral Cancer, Post-Tracheostomy Care, Tracheostomy Complications
- Trial name
- NCT07701226
- Testing
- Novel Self-Adhesive Bidirectional Tracheostomy Tube Fixation Device, Routine Tracheostomy Care and Conventional Fixation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Breast Cancer
Late Cardiac Evaluation of the Three Arm Belgian Trial Involving Node-positive Early Breast Cancer Patients
Late Cardiac Evaluation of the Three Arm Belgian Trial A phase III randomized trial involving node-positive early breast cancer patients with a long median follow-up (~ 15 years) OBJECTIFS Primary: To compare the incidence of…
- Trial name
- NCT01554943
- Testing
- cardiac MRI
- Where
- Belgium
- Volunteers
- 73 people
- Sponsor
- Jules Bordet Institute
Salivary Gland Tumor, Urothelial Carcinoma
A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
This is a first-in-human (FIH), Phase 1 open-label, multicentre dose escalation study investigating AVA6000 monotherapy administered intravenously in patients with locally advanced (unresectable) or metastatic solid tumours that…
- Conditions
- Salivary Gland Tumor, Urothelial Carcinoma, Ovarian Carcinoma, Breast Cancer
- Trial name
- NCT04969835
- Testing
- AVA6000
- Where
- 9 sites in United States, United Kingdom
- Volunteers
- 158 people
- Sponsor
- Avacta Life Sciences Ltd
Ovarian Cancer, Hypodontia
Hypodontia and Ovarian Cancer
The purpose of this project is to examine whether the risk of developing ovarian cancer is increased in Danish women with congenital missing teeth as a result of their failure to develop (hypodontia).
- Conditions
- Ovarian Cancer, Hypodontia, Breast Cancer, Colon Cancer
- Trial name
- NCT01470235
- Where
- 2 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- University of Aarhus
Breast Neoplasm, Breast Cancer
Effect of a Clinical Nutrition Intervention Program in Breast Cancer Patients During Antineoplastic Treatment
The aim of this study is to evaluate the effect of a 6-mo individualized and specialized food-based nutrition intervention program in breast cancer patients' body composition, metabolism and antioxidant activity associated with…
- Trial name
- NCT03625635
- Testing
- Individualized food-based intervention
- Where
- Mexico
- Volunteers
- 34 people
- Sponsor
- Humberto Francisco Astiazaran Garcia, PhD
Dupuytren Contracture, Dupuytren Disease of Finger
Safety and Efficacy Study of Collagenase CNT201 Injection for Treatment of Dupuytren's Contracture
This trial is a multicenter, Phase 1/2, study to assess the safety, tolerability, efficacy, PK, and immunogenicity of CNT201 in adult participants with DC (Dupuytren's Contracture).
- Trial name
- NCT07640425
- Testing
- [Step1] CNT201 First-dose, [Step1] CNT201 Low-dose, [Step1] CNT201 Intermediate-dose
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- CONNEXT
Breast Cancer
Tumour Necrosis Factor Release in Locally Advanced Breast Cancer Patients Receiving Neoadjuvant Docetaxel
The purpose of this study is to assess the fine needle aspiration methodology in collecting sufficient tumour cells to measure tissue TNFa levels serially in human breast cancer sample receiving Taxane treatment
- Trial name
- TNFactor (NCT01539876)
- Testing
- Fine needle aspiration assessing tumour TNFa levels
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Melanoma (Skin), Unspecified Adult Solid Tumor, Protocol Specific
Vaccine Therapy in Treating Patients With Metastatic Cancer
RATIONALE: Vaccines made from a peptide may make the body build an immune response and kill tumor cells. PURPOSE: Randomized phase II trial to study the effectiveness of vaccine therapy in treating patients who have metastatic…
- Trial name
- NCT00021164
- Testing
- aldesleukin, incomplete Freund's adjuvant, telomerase: 540-548 peptide vaccine
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Breast Neoplasms
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
This study will include two groups of patients: Cohort 1 and Cohort 2. Cohort 1: will help researchers learn how a medicine called imlunestrant (LY3484356) affects a specific type of breast cancer.
- Trial name
- preEMBER (NCT07287098)
- Testing
- Imlunestrant, Goserelin, Tamoxifen 20 mg
- Where
- 87 sites in United States, Belgium and 5 more
- Volunteers
- 600 people
- Sponsor
- Eli Lilly and Company
Breast Cancer, Metastatic Cancer
Biological Therapy in Treating Women With Breast Cancer That Has Spread to the Liver
RATIONALE: Biological therapy using a gene-modified virus that can make interleukin-12 may help the body build an effective immune response to kill tumor cells.
- Trial name
- NCT00301106
- Testing
- adenovirus-mediated human interleukin-12
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Max Sung
Breast Cancer
A Dose Increase Finding Study of Doxorubicin Hydrochloride Liposome Injection for Patients With Breast Cancer
To study the maximum tolerated dose of Doxorubicin Hydrochloride Liposome Injection combination with cyclophosphamide and sequential treatment of docetaxel for patients with locally advanced breast cancer
- Trial name
- NCT03017404
- Testing
- Doxorubicin Hydrochloride Liposome Injection, Cyclophosphamide, docetaxel
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Hebei Medical University Fourth Hospital
Breast Cancer, Prostate Cancer
4-weekly Versus 12-weekly Administration of Bone-targeted Agents in Patients With Bone Metastases
The current Rethinking Clinical Trials (REaCT) trial will compare two schedules(12- vs. 4-weekly) of bone-targeting agents (BTAs) to evaluate quality of life, pain and skeletal events within the Canadian Health Care System.
- Conditions
- Breast Cancer, Prostate Cancer, Metastasis
- Trial name
- REaCT-BTA (NCT02721433)
- Testing
- Pamidronate, Denosumab, Zoledronate
- Where
- Canada
- Volunteers
- 263 people
- Sponsor
- Ottawa Hospital Research Institute