Clinical trials: Skin Physiology
Sjogren's Syndrome, Xerostomia
Pilot Study of Thalidomide to Treat Sjogren's Syndrome
This study will evaluate the safety and effectiveness of thalidomide in treating Sjogren's syndrome. In this autoimmune disease, the immune system attacks the body's tear glands and salivary glands, causing dry mouth and dry…
- Trial name
- NCT00001599
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Breast Cancer
Biomarkers and Cardiac MRI as Early Indicators of Cardiac Exposure Following Breast Radiotherapy
Radiotherapy plays an integral role in breast cancer therapy. Multiple randomized studies have demonstrated decreased local-regional recurrence rates and decreased breast-cancer mortality.
- Trial name
- NCT02496260
- Testing
- Research Cardiac MRI, Biomarkers
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Henry Ford Health System
Spinal Cord Injury, Pressure Ulcer
Low Friction Bed Sheet
Introduction: It is known that people with spinal cord injury (SCI) bear a considerably increased risk of developing pressure ulcer, whereby frictional forces and shear forces are recognized as risk factors.
- Trial name
- NCT01943201
- Testing
- new bedsheet, conventional bedsheet
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Melanoma, Non-small Cell
Evolution of the Heart Function When Monitoring Immunotherapies Anti-cancerous Inhibiting PD-1
Prospective, monocentric clinical study. Patients selected for nivolumab therapy in AP-HM for melanoma and non-small cell lung cancer will be eligible.
- Conditions
- Melanoma, Non-small Cell, Lung Cancer
- Trial name
- NCT03313544
- Testing
- Nivolumab, MRI, BLOOD SAMPLES
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Autonomic Nervous System Diseases, Sweat Gland Diseases
The Effects of Liraglutide on Sudomotor Function and Inflammation in Type 2 Diabetes
The purpose of this study is to conduct an interventional, one year, randomized, double blind, placebo-controlled trial with Liraglutide in patients with type 2 diabetes (diabetes duration of >6 months and <10 years, HbA1c <10%)…
- Conditions
- Autonomic Nervous System Diseases, Sweat Gland Diseases, Diabetic Neuropathy With Neurologic Complication
- Trial name
- NCT03426085
- Testing
- Liraglutide 6 mg Solution for Injection
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Eastern Virginia Medical School
Rheumatoid Arthritis (RA)
Mechanistic Studies of B- and T-Cell Function in RA Patients Treated With TNF Antagonists, Tocilizumab, or Abatacept
An Agency for Healthcare Research and Quality executive summary indicated that better comparative effectiveness trial designs are needed to determine the relative merits of existing versus new and expensive biologic drug…
- Trial name
- MAZERATI (NCT02353780)
- Testing
- TNF Antagonist (enbrel, humire, remicade, cimzia, symponi), Abatacept, Tocilizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dr. Larry W. Moreland
Scleroderma, Systemic
A Study in People With Systemic Sclerosis to Test Whether Avenciguat (BI 685509) Has an Effect on Lung Function and Other Systemic Sclerosis Symptoms
This study is open to adults aged 18 and older or above legal age who have systemic sclerosis. People can participate if they have a specific subtype called diffuse cutaneous systemic sclerosis.
- Trial name
- VITALISScE™ (NCT05559580)
- Testing
- Avenciguat (BI 685509)
- Where
- 168 sites in United States, Argentina and 35 more
- Volunteers
- 214 people
- Sponsor
- Boehringer Ingelheim
Glomerulonephritis, Lupus Nephritis
Cyclophosphamide and Fludarabine to Treat Lupus Nephritis
This study will test the safety and effectiveness of combination therapy with cyclophosphamide (Cytoxan) and fludarabine in treating lupus nephritis (kidney inflammation).
- Conditions
- Glomerulonephritis, Lupus Nephritis, Systemic Lupus Erythematosus
- Trial name
- NCT00001676
- Testing
- SQ Fludarabine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Malignant Melanoma
CP-675,206 In Patients With Advanced Melanoma
The purpose of this study is to assess the efficacy, safety, and tolerability of monoclonal antibody therapy using 2 regimens for the treatment of advanced melanoma
- Trial name
- NCT00086489
- Testing
- CP-675,206
- Where
- 9 sites in United States
- Volunteers
- 118 people
- Sponsor
- AstraZeneca
Hypohidrotic Ectodermal Dysplasia
Characterization of Sweat Gland Function in Patients With Recessively Inherited Hypohidrotic Ectodermal Dysplasia
Hypohidrotic ectodermal dysplasia (HED) is a complex genetic disorder characterized by lack of sweat glands, sparse hair, and missing or malformed teeth.
- Trial name
- NCT01109290
- Where
- Germany
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University Hospital Erlangen
Breast Cancer
Follow up Study of Crocin on Cardiac Function Protection in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy Based on Color Doppler Ultrasound Combined With Myocardial Zymogram
Foreign data show that: 1807 tumor patients were followed up for 7 years, 33% of them died of heart disease and 51% of them died of the tumor itself.
- Trial name
- NCT06187818
- Testing
- Crocin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Mei Zhang
Osteogenesis Imperfecta
Whole Body Vibration Training in Children With Osteogenesis Imperfecta and Limited Mobility
Children with osteogenesis imperfecta (OI) have impaired bone strength, fractures, weak muscles and limited mobility. Mild to moderate forms of OI (type 1 and 4) may benefit from muscle training that leads to secondary…
- Trial name
- NCT03029312
- Testing
- Galileo M
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Breast Cancer
Adjuvant Ovarian Suppression Plus Aromatase Inhibitor or Tamoxifen in Young Women
The objective of this study is to compare the curative effects in patients under the age of 35 with hormone receptor positive breast cancer and high recurrent risk factors including large tumor or metastatic lymph nodes…
- Trial name
- ASPAIT (NCT02914158)
- Testing
- Goserelin, Tamoxifen, Aromatase Inhibitors
- Where
- 25 sites in China
- Volunteers
- 680 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Breast Cancer, Shoulder Dysfunction
Effectiveness of a Visual Biofeedback Program Versus Conventional Physiotherapy on Shoulder Mobility, Strength, and Function in Women After Breast Cancer Surgery
This study aims to evaluate the effectiveness of a physiotherapy program incorporating visual biofeedback compared to a conventional physiotherapy program in improving shoulder function in women following breast cancer surgery.
- Trial name
- NCT07542106
- Testing
- Experimental Group: Physiotherapy + Visual Biofeedback
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Extremadura
Physiology, Skin
Study to Investigate the Effect of Superba Boost on the Skin.
Study to determine the effect of 12 weeks daily consumption of Superba Boost as compared to placebo on changes in Trans-Epidermal Water-Loss (TEWL).
- Trial name
- NCT04013945
- Testing
- Superba Boost (Active)
- Where
- Ireland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aker BioMarine Human Ingredients AS
Idiopathic Thrombocytopenic Purpura
Platelet Function in Idiopathic Thrombocytopenic Purpura (ITP) Patients With Eltrombopag
This is a single-center, prospective, controlled study with one eltrombopag treatment group and 2 control groups, one on standard steroid treatment, and another one untreated.
- Trial name
- PLATEFUN (NCT00888901)
- Testing
- eltrombopag, corticosteroids (Aprednislon)
- Volunteers
- 30 people
- Sponsor
- Ingrid Pabinger, MD
Breast Cancer
Does Scar Massage Improve Postoperative Pain and Function in Women With Breast Cancer?
All patients undergoing breast cancer surgery are left with scars which can significantly affect their physical and psychological well being.
- Trial name
- NCT00175344
- Testing
- Scar massage.
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of British Columbia
Rheumatoid Arthritis, Hand Rheumatism
Treatment of Rheumatoid Hand With Magnetotherapy
Brief Summary: Participants with rheumatoid arthritis with recommendation to physiotherapy. Created 2 study groups: 1. Kinesiotherapy with static magnetic field 2.
- Trial name
- NCT05920746
- Testing
- Kinesiotherapy with magnetotherapy
- Where
- Poland
- Volunteers
- 72 people
- Sponsor
- Jolanta Zwolińska
Metastatic Breast Cancer
Physical Activity to Maintain Quality of Life and Physical Function in Women With Metastatic Breast Cancer: a Pilot Study
Metastatic breast cancer (MBC) is an incurable disease. Maintaining optimum quality of life is a major goal of care. There is a strong body of evidence that exercise can reduce or manage fatigue, depression and insomnia in breast…
- Trial name
- NCT02682836
- Testing
- Walk with Ease
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
CYP2D6 Polymorphism
A Study to Evaluate Exemestane Tablets Combined With Ovarian Function Suppression/Ablation in Treatment of Premenopausal Breast Cancer Patients With CYP2D6*10 Mutations （STEP）
This is a multicenter, randomized, open-label, parallel, active-controlled superiority clinical study conducted in early premenopausal estrogen-receptor positive breast cancer patients with CYP2D6*10 mutations.
- Trial name
- STEP (NCT03137368)
- Testing
- Exemestane Tablets, ovarian function suppression/ablation, CYP2D6*10 gene test
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences