Clinical trials: Skin Physiology
Psoriasis
Effects of Capsaicin on the Structure, Distribution, and Function of Cutaneous Small Nerve Fibers in Psoriatic Skin
The purpose of this research study is to examine the role of nerves in the skin in psoriasis and to better understand the effects of capsaicin in psoriasis.In this study, capsaicin will be compared to a moisturizer (aquaphor…
- Trial name
- NCT00697034
- Testing
- Capsaicin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wake Forest University
Breast Cancer, Female
The Role of Myocardial SPECT in Evaluation of Irradiation-induced Changes.
Helical tomotherapy nowadays provides the most precise data on radiotherapy (RT) dose delivered to each region of the heart in left-sided breast cancer therapy, which allows greater sparing of the heart from doses associated with…
- Trial name
- NCT01758419
- Testing
- Thallium-201 Myocardial Perfusion Study
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Osteogenesis Imperfecta
Whole Body Vibration Training in Children With Osteogenesis Imperfecta and Limited Mobility
Children with osteogenesis imperfecta (OI) have impaired bone strength, fractures, weak muscles and limited mobility. Mild to moderate forms of OI (type 1 and 4) may benefit from muscle training that leads to secondary…
- Trial name
- NCT03029312
- Testing
- Galileo M
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Breast Cancer
Timing of Specific Exercise Therapy After Breast Cancer Surgery: Early Versus Delayed Initiation
This single-center, parallel-group randomized controlled trial (RCT) will compare two timings for initiating specific exercise therapy after breast cancer surgery.
- Trial name
- BEST-Timing (NCT06918184)
- Testing
- Specific Exercise Therapy
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Al Hayah University In Cairo
Rheumatoid Arthritis, Rheumatoid Arthritis (RA
Development and Evaluation of the Effectiveness of the SMART-HAND Protocol for Hand Rehabilitation in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) frequently affects the hand and wrist, resulting in pain, reduced joint stability, impaired proprioception, muscle weakness, and limitations in daily activities.
- Conditions
- Rheumatoid Arthritis, Rheumatoid Arthritis (RA, Rheumatoid Arthritis (RA) Prevention
- Trial name
- NCT07754552
- Testing
- SMART-HAND Protocol, Conventional Hand Rehabilitation, Joint Protection and Ergonomic Education
- Volunteers
- 132 people
- Sponsor
- Istanbul University - Cerrahpasa
Lupus Erythematosus, Systemic
The Role of Lipids in Immune Cell Function in SLE Patients
The overall aim of this project is to investigate the different types of immune cells found in the blood of patients with Systemic Lupus Erythematosus (SLE) and healthy donors.
- Trial name
- NCT04361734
- Testing
- Blood sampling to include Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University College, London
Albinism, Oculocutaneous Albinism
Vision Response to Dopamine Replacement
The purpose of the study is to evaluate and document physiologic and functional changes in visual performance and retinal function of patients diagnosed with albinism (a dopamine deficiency state) following a trial of oral…
- Trial name
- NCT01663935
- Testing
- Levodopa/carbidopa
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Polymyositis, Dermatomyositis
Effects of High-intensity Interval Training (HIIT) in Recent Onset Polymyositis and Dermatomyositis
Polymyositis and dermatomyositis are rare inflammatory systemic conditions. Reduced muscle function is a cardinal symptom and lung involvement is very common.
- Trial name
- HIITmyositis (NCT03324152)
- Testing
- High-intensity interval training (HIIT) - myositis, Standard low-intensity home exercise, High-intensity interval training (HIIT) - healthy
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Aging, Inflammation
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence
The MIRACLE study aims to investigate age-related mitochondrial dysfunction, mitochondrial RNA (mtRNA) release, inflammation, and cellular senescence in adult participants across three age groups.
- Conditions
- Aging, Inflammation, Healthy Ageing
- Trial name
- MIRACLE (NCT07596615)
- Testing
- Skin biopsy and venous blood sampling
- Where
- 2 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Sedentary Behavior, Sedentary Time
RISE - Reduce Sitting Time Among Breast Cancer Survivors
This 3-month study will test whether a program to reduce sitting time, for breast cancer survivors experiencing some physical limitations, can improve their physical function and other important aspects of quality of life.
- Conditions
- Sedentary Behavior, Sedentary Time, Breast Cancer
- Trial name
- NCT05260723
- Testing
- Behavioral: Sit Less
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of California, San Diego
Breast Cancer
Evaluating the Effectiveness of an Individualized Nutrition and Physical Activity Counseling Program
More than 65% of breast cancer survivors are overweight and less than one-third participate in recommended levels of physical exercise.
- Trial name
- NCT04365569
- Testing
- Nutrition and physical activity counseling program
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Case Comprehensive Cancer Center
Bariatric Surgery, Abdominoplasty
Effect of a Collagen-containing Supplement on Dermal Collagen Content in Metabolic Bariatric Surgery Patients Undergoing Corrective Aesthetic Surgery: A Randomized, Double-blind, Placebo-controlled Trial
This single-center, randomized, placebo-controlled trial evaluated whether perioperative supplementation with a collagen-based oral formulation affected dermal collagen content and postoperative outcomes in adults aged 18-65…
- Conditions
- Bariatric Surgery, Abdominoplasty, Collagen Synthesis, Skin Physiology
- Trial name
- COLLAGEN (NCT06787924)
- Testing
- Collagen hydrolyzed peptides, Starch
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Breast Cancer, Exercise
Effect of Combined Aerobic and Resisted Exercise in Breast Cancer Survivors
The purpose of this study is to evaluate the effects of a combined aerobic and resistance exercise program in breast cancer survivors.
- Conditions
- Breast Cancer, Exercise, Physical Function
- Trial name
- NCT00877188
- Testing
- exercise
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- National Taiwan University Hospital
Atopic Dermatitis
Pimecrolimus and Epidermal Barrier Function
This study seeks to investigate the role of pimecrolimus in restoring disturbed skin barrier function and reversing epidermal abnormalities found in atopic dermatitis (AD).
- Trial name
- NCT01132079
- Testing
- cream treatment
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University of Kiel
Healthy Nutrition, Pregnancy Related
Maternal Carotenoids Across Pregnancy Study
Before infants are born, they depend on their mother to provide the nutrients necessary to grow and develop, such as iron, folic acid, iodine and other vitamins and minerals.
- Trial name
- MCAPS (NCT06004479)
- Testing
- Carotenoid Intake, Serum carotenoid concentration
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Cancer-related Fatigue, Breast Cancer
Telehealth Exercise Program Evaluating Fatigue and Physical Function in Rural Cancer Survivors
This study investigates the efficacy of a telehealth exercise program designed specifically for rural cancer survivors with cancer-related fatigue (CRF).
- Conditions
- Cancer-related Fatigue, Breast Cancer, Prostate Cancer
- Trial name
- NCT07001241
- Testing
- Telehealth Exercise Program
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- University of Colorado, Denver
Arthritis, Rheumatoid
Study in Patients With Moderated to Severe Rheumatoid Arthritis Who Have Failed to Combination Therapy of Conventional Disease-modifying Antirheumatic Drugs (cDMARDs) to cDMARD Plus ANti-TNF Versus cDMARDs in Real World
This study will be conducted to observe the disease activity change of Conventional Disease Modifying Anti-Rheumatic Drugs (cDMARD) plus anti-tumour necrosis factor (anti-TNF) from baseline to 6 months compared with cDMARDs, as…
- Trial name
- HUMAN (NCT03264703)
- Where
- 15 sites in South Korea
- Volunteers
- 212 people
- Sponsor
- Eisai Korea Inc.
Patients at Risk for Melanoma
COPARIME: Pilot Study of a Target Detection of Malignant Melanoma
Melanoma is nowadays an important public health problem because its growing incidence. Mass screening for melanoma is not recommended worldwide because of its low cost-effectiveness.
- Trial name
- NCT01610531
- Testing
- SAMScore questionnaire
- Where
- France
- Volunteers
- 4,118 people
- Sponsor
- Nantes University Hospital
Lupus Nephritis (LN), Chronic Kidney Disease
Dapagliflozin to Reduce the Decline in Renal Function in Patients Newly Diagnosed With Lupus Nephritis
Lupus nephritis is one of the most serious complications of lupus, an autoimmune disease in which the immune system mistakenly attacks the body's own tissues.
- Conditions
- Lupus Nephritis (LN), Chronic Kidney Disease, SGLT 2 Inhibitors, Systemic Lupus Erythematosus
- Trial name
- DAPA-LN (NCT07678203)
- Testing
- Dapagliflozin (10Mg Tab) along with standard medical therapy, Proteinuria Quantification
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Hospital Civil Juan I. Menchaca
Rheumatoid Arthritis (RA)
Mechanistic Studies of B- and T-Cell Function in RA Patients Treated With TNF Antagonists, Tocilizumab, or Abatacept
An Agency for Healthcare Research and Quality executive summary indicated that better comparative effectiveness trial designs are needed to determine the relative merits of existing versus new and expensive biologic drug…
- Trial name
- MAZERATI (NCT02353780)
- Testing
- TNF Antagonist (enbrel, humire, remicade, cimzia, symponi), Abatacept, Tocilizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dr. Larry W. Moreland