Clinical trials: Skin Physiology
Breast Cancer Female
Lactobacillus Vaginalis Capsules for Treatment of Vulvovaginal Atrophy in Young Breast Cancer Patients
This study is a prospective, randomized controlled, phase II clinical study with a planned enrolment of 60 patients. The study focuses on the efficacy and safety of Lactobacillus vaginalis capsules for the prevention and/or…
- Trial name
- NCT05974449
- Testing
- Vaginal Lactobacillus capsules
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Systemic Sclerosis
Hand Function Impairment in Systemic Sclerosis: Outcomes, Mechanisms and Experience (HANDSOME)
Almost 90% of systemic sclerosis (SSc) patients experience hand function limitation, which leads to impaired daily functioning and work participation.
- Trial name
- NCT06133244
- Testing
- Imaging, blood samples, fuctional tests and physical examination
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- UMC Utrecht
Hypothalamus-Pituitary-Adrenal Axis Assessement, Topical Steroid Therapy in Chronic Skin Diseases
Does Topical Steroid Treatment Impair the Adrenal Function?
The purpose of this study is to determine if topical steroids treatment for different skin diseases suppress the adrenal cortisol production.
- Trial name
- NCT00476489
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- HaEmek Medical Center, Israel
Rheumatoid Arthritis, Hand Rheumatism
Magnetotherapy in Rheumatoid Arthritis Treatment
Participants with rheumatoid arthritis with recommendation to physiotherapy. Created 3 study groups: 1. Only kinesiotherapy 2. Kinesiotherapy with unipolar magnetic field 3.
- Trial name
- NCT04426513
- Testing
- Kinesiotherapy with magnetotherapy
- Where
- Poland
- Volunteers
- 62 people
- Sponsor
- Jolanta Zwolińska
Rheumatoid Arthritis
Initial Validation of PROMIS Physical Function/Disability Scales in Rheumatoid Arthritis (RA)
The Patient-Reported Outcomes Measurement Information System (PROMIS) is an NIH Roadmap initiative to develop a computerized system measuring patient-reported outcomes in respondents with a wide range of chronic diseases and…
- Trial name
- NCT00786227
- Where
- United States
- Volunteers
- 761 people
- Sponsor
- Stanford University
Breast Cancer, Gynecologic Cancers
Near Infrared Spectroscopy (NIRS) as a Method for Measuring Oxidative Capacity of Skeletal Muscle Mitochondria in Breast Cancer and All Gynecological Cancer Patients
Participants recruited for this study will be breast cancer or gynecological cancer patients who agree to participate in an exercise study examining the effects of chemotherapy on muscle mitochondrial oxidative capacity, a…
- Conditions
- Breast Cancer, Gynecologic Cancers, Mitochondrial Function
- Trial name
- NCT06672497
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of South Carolina
Melanoma, Non Small Cell Lung Cancer
Quality of Life and Physical Fitness After Immune Checkpoint Inhibitors
Rationale: Tremendous anti-tumor effects have been achieved using immune checkpoint inhibitors for melanoma and NSCLC with long lasting responses of more than 2 years in a substantial subgroup of patients.
- Trial name
- NCT03946007
- Where
- Netherlands
- Volunteers
- 134 people
- Sponsor
- University Medical Center Groningen
Breast Cancer, Muscle Strength
Effectiveness of PNF Training for Improving for Muscle Strength, Function, and Pain After Axillary Lymph Node Dissection
Breast cancer is the most common type of cancer affecting women of all ages worldwide. Advanced and comprehensive treatment options have increased survival rate and life expectancy, necessitating a focus on the complications of…
- Trial name
- NCT05288036
- Testing
- Proprioceptive Neuromuscular Rehabilitation group, Progressive Resistance Exercise Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Colorectal Cancer, Lung Cancer
The Effect of Monoclonal Vascular Endothelial Growth Factor (VEGF) Antibody (Bevacizumab) on Pituitary Function
The purpose of this research is to determine whether the drug, Bevacizumab (a monoclonal anti VEGF-A antibody), which is approved to treat patients with metastatic colon cancer induces hyperprolactinemia (increased prolactin…
- Conditions
- Colorectal Cancer, Lung Cancer, Breast Cancer, Glioblastoma
- Trial name
- NCT00973557
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cedars-Sinai Medical Center
Gut Microbiota, Skin Microbiota
Lactobacillus Rhamnosus GG: Interaction With Human Microbiota and Immunity
Hypothesis: Probiotics have been used as novel adjunct therapeutic approach in atopic dermatitis. In addition to balancing the gut microecology and promoting host immune defences, specific probiotics might further aid in…
- Conditions
- Gut Microbiota, Skin Microbiota, Humoral Immune Responses, Severity of Atopic Dermatitis
- Trial name
- NCT01148667
- Testing
- Casein hydrolysate added with LGG, Infants drink casein hydrolysate without LGG
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Turku University Hospital
Lacrimal Apparatus Disease, Salivary Gland Disease
DHEA Treatment for Sjogren's Syndrome
This study will evaluate the effectiveness of the male hormone dehydroepiandrosterone (DHEA) in treating Sjogren's syndrome. This autoimmune disorder, in which the immune system attacks the salivary glands and tear glands…
- Conditions
- Lacrimal Apparatus Disease, Salivary Gland Disease, Sjogren's Syndrome, Xerostomia
- Trial name
- NCT00001598
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Psoriatic Arthritis, Foot Arthritis
Effect of Custom Foot Orthoses in Patients With Psoriatic Arthritis
Foot involvement is a major concern in psoriatic arthritis (PsA). The patients could experience severe levels of foot pain and disability and reduced mobility and quality of life.
- Trial name
- NCT05075343
- Testing
- Custom foot orthoses
- Where
- 2 sites in Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Patrick Boissy
Atopic Dermatitis
Dupilumab Skin Barrier Function Study in Atopic Dermatitis
Primary Objective: Evaluate changes in skin barrier function with transepidermal water loss (TEWL) assessed after skin tape stripping (STS) in pre-defined lesional skin in participants with moderate to severe atopic dermatitis…
- Trial name
- BALISTAD (NCT04447417)
- Testing
- Dupilumab SAR231893
- Where
- 2 sites in United States, Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Sanofi
PAH
PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH)
This is a multicenter double-blind, placebo-controlled study to evaluate the safety, efficacy and pharmacokinetics of 2 doses of CXA-10 on stable background therapy in 96 subjects 18 to 80 years of age with PAH.
- Trial name
- PAH (NCT03449524)
- Testing
- 75mg CXA-10, 150mg CXA-10
- Where
- 46 sites in United States, United Kingdom
- Volunteers
- 69 people
- Sponsor
- Complexa, Inc.
Diabetes Mellitus, Type 2
Glucocorticoids and Skin Healing in Diabetes (GC-SHealD)
The study aims to investigate effects of inhibiting glucocorticoid activation on skin function and wound healing in patients with type 2 diabetes.
- Trial name
- GC-SHealD (NCT03313297)
- Testing
- AZD4017
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- University of Leeds
Osteogenesis Imperfecta (OI), Osteogenesis Imperfecta
Prospective Observational Cohort Study of Cardiac Structure and Function in Children and Adults With Osteogenesis Imperfecta
This prospective observational investigation will examine the incidence and progression of cardiologic findings in individuals with OI across different age groups.
- Trial name
- OI Cardio (NCT07287241)
- Testing
- Imaging evaluation, Echocardiography
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Ortopedico Rizzoli
Rheumatoid Arthritis
Cross-over Study to Investigate Retinal Function Following Administration of a Single Dose of AZD9056
The purpose of the study is to determine whether treatment with a single 800mg dose of AZD9056, a medication which has been developed as a possible treatment for Rheumatoid Arthritis, has an effect on the function of the retina
- Trial name
- NCT00700986
- Testing
- AZD9056
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Metastatic Breast Cancer
Mistletoe Extract in Early or Advanced Breast Cancer, A Feasibility Study
The purpose of this feasibility study is to identify appropriate surrogate parameters for a randomized study to examine the efficacy of a complementary therapy with an extract of viscum album (Iscador P) in patients with breast…
- Trial name
- NCT00176046
- Testing
- viscum album pini
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- Heidelberg University
Metastatic Melanoma
Whole Brain Radiotherapy Following Local Treatment of Intracranial Metastases of Melanoma
People with brain metastases from melanoma are offered different treatment options after local treatment of their brain metastases via surgery or stereotactic irradiation.
- Trial name
- WBRTMel (NCT01503827)
- Testing
- WBRT
- Where
- 23 sites in Australia, Norway and 1 more
- Volunteers
- 220 people
- Sponsor
- Melanoma and Skin Cancer Trials Limited
Rheumatoid Arthritis, Hand Rheumatism
Treatment of Rheumatoid Hand With Magnetotherapy
Brief Summary: Participants with rheumatoid arthritis with recommendation to physiotherapy. Created 2 study groups: 1. Kinesiotherapy with static magnetic field 2.
- Trial name
- NCT05920746
- Testing
- Kinesiotherapy with magnetotherapy
- Where
- Poland
- Volunteers
- 72 people
- Sponsor
- Jolanta Zwolińska