Clinical trials: Skin Pigmentation
Lentigo, Solar Lentigo
Evaluation of the Tolerance (Main Objective) and Performance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots (Solar and Senile Lentigines, Post-inflammatory Hyperpigmentation) on the Face
The goal of this clinical trial is to compare the 3 different prototype of cyto-selective cryotherapy devices (name of the devices : CRYONOVE) use in brown spots on the face of subject from different ethnicities.
- Conditions
- Lentigo, Solar Lentigo, Post Inflammatory Hyperpigmentation
- Trial name
- CS5_10B (NCT06305897)
- Testing
- CRYONOVE (EC14_4osc), CRYONOVE (EC+05_1osc), CRYONOVE (EC+05_2osc)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cryonove Pharma
Vitiligo, Generalized
Vitiligo, New Treatment and Serum s100B
vitiligo is an autoimmune depigmenting skin disorder characterized by milky white macules or patches, with 2% worldwide prevalence.
- Trial name
- NCT06768840
- Testing
- Baricitinib, oral mini pulse, Narrow Band UVB Treatment
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- South Valley University
Vitiligo, Generalized
Comparison of Efficacy and Safety Psoralen Combined With Ultraviolet A (PUVA) Vs Tofacitinib in the Treatment of Generalized Vitiligo.
This study aims to compare the efficacy and safety of PUVA versus Tofacitinib in the treatment of generalized vitiligo. Given the high prevalence of vitiligo in Pakistan and the significant psychosocial impact on patients…
- Trial name
- (PUVA) (NCT07055529)
- Testing
- Group A recieving PUVA therapy, Group B receiving Tablet Tofacitinib
- Where
- Pakistan
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hayat Abad Medical Complex, Peshawar
Accuracy of the SofTouch Device Measuring Blood Glucose and Other Parameters
A Comparative Study of the SoftTouch Non-Invasive Finger-Mounted Device
1. Aim: SoftTouch is a non-invasive device intending for use in the temporarily quantitative measurement of peripheral blood biomarkers.
- Trial name
- NCT00712361
- Testing
- Non Invasive peripheral blood screening (Cnoga Medical Ltd.,SofTouch,OnlyTouch, CM-CL-R-007, CMC 07015922,HT 4502, HTA 4502)
- Where
- 4 sites in Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Cnoga Medical Ltd.
Acne Scar, Wrinkle
Fractional CO2 Treatment of Acne Scars in Asians
The objective of this study is to investigate the efficacy and side effects of a fractional CO2 laser for treatment of acne scar in Asians.
- Trial name
- CO2 (NCT00748462)
- Testing
- Fractional CO2 Laser
- Where
- Thailand
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Vitiligo
Stress Response Pathways in Vitiligo
The purpose of this study is to investigate stress response pathways in tissues and melanocytes from patients with vitiligo. Investigators are collecting evidence of UPR and stress response activation in tissues and melanocytes…
- Trial name
- NCT02797574
- Testing
- Punch Biopsy at a Lesional Site, Punch Biopsy at a Non- Lesional site
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Hyperpigmentation, Melasma
Annurca Apple Peel Oleolite for the Treatment of Skin Hyperpigmentation
The aim of this cosmetic clinical trial is to learn if an oleolite derived from Annurca Apple peel (AAO) works to enhance skin tone and luminosity, by counteracting the visibility of skin hyperpigmentation and dark spots in adult…
- Conditions
- Hyperpigmentation, Melasma, Skin Spots, Photodamaged Skin
- Trial name
- EAAO22G01 (NCT07040345)
- Testing
- Annurca apple oleolite
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ritamaria Di Lorenzo
Melasma
Comparison of 30% Metformin and 2% Nicotinamide Lotion With Kligman Formula in the Treatment of Melasma
Comparison of 30% Metformin and 2% Nicotinamide lotion with kligman formula in the treatment of Melasma
- Trial name
- NCT05790577
- Testing
- Metformin and Nicotinamide vs Kligman Formula
- Where
- Pakistan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ishtiaq Ahmed
Gingival Hyperpigmentation, Oral Pigmentation
Comparison of Er-YAG Laser, Air Polishing, and Surgical Excision for Gingival Hyperpigmentation
This randomized controlled clinical trial aimed to compare the effectiveness of different treatment approaches for physiologic gingival hyperpigmentation.
- Trial name
- APGH (NCT07672587)
- Testing
- Er:YAG Laser Therapy, Air Polishing with Erythritol Powder, Air Polishing with Sodium Bicarbonate Powder
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Face and Neck Wrinkles, Texture, Pigmentation
Lutronic Infini and LaseMD Systems in Combination Treatment
This is a prospective, multi-site, non-randomized study evaluating the safety and effectiveness of the Infini and LaseMD Systems for combination treatment in wrinkles, texture, and pigmentation of the face and/or neck.
- Trial name
- NCT03409965
- Testing
- Lutronic Infini System, Lutronic LaseMD System
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- CynosureLutronic
Hyperpigmentation
Efficacy of Ceramic Soft Tissue Trimming Bur Versus Conventional Scalpel Technique in Ginigival Depigmentation Procedure
the investigator compares the clinical outcomes and pain levels after gingival depigmentation by ceramic soft tissue bur vs scalpel surgery
- Trial name
- NCT06031116
- Testing
- depigmentation
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Melasma
Curcuma Xanthorriza Roxb. 10% Cream for Melasma
Melasma is an acquired hyperpigmentation disorder with a multifactorial etiology and complex pathogenesis that can significantly diminish the quality of life for affected patients.
- Trial name
- NCT06153134
- Testing
- 10% Curcuma xanthorriza Roxb., 2% Kojic Acid
- Where
- Indonesia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Skin Cancer, Malignant Melanoma
Fast Track Diagnosis of Skin Cancer by Advanced Imaging Technologies and Tumour Tapestripping
In this clinical feasibility study the investigators will test and compare two advanced optical imaging technologies, lipid and RNA tape stripping with regards to diagnostic accuracies for fast bedside diagnosis of pigmented skin…
- Trial name
- NCT05389085
- Testing
- Reflectance confocal microscopy (RCM), Photoacoustic imaging (PAI) and tape-strippng of RNA and lipids
- Where
- Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Herpes Simplex, Herpes Zoster
Activation of Alternative Cellular Energy (ACE) Pathway in the Therapy of Herpes Virus Infections
The research question to be addressed is whether indirect phototherapy based activation of the body's alternative cellular energy (ACE) pathway will lead to expedited healing of active herpes simplex virus (HSV) and herpes zoster…
- Trial name
- NCT00642785
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Institute of Progressive Medicine
Wrinkle Appearance, Skin Pigment
Cosmetic Effects of Topical Acetyl Zingerone
Cosmeceuticals are an emerging market within dermatology and the growth of natural products and derivatives of natural products has accelerated in use within the field.
- Conditions
- Wrinkle Appearance, Skin Pigment, Erythema, Side Effect
- Trial name
- NCT03530787
- Testing
- Acetyl Zingerone Topical Cream, Topical cream
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Vitiligo
Enhanced Transcutaneous Delivery of Betamethasone for the Treatment of Vitiligo
Vitiligo is the commonest acquired depigmenting disorder characterized by loss of melanocytes from the basal layer of skin causing white patches which leads to great psychological distress in many patients.
- Trial name
- NCT05233735
- Testing
- Enhanced Transcutaneous Delivery of Topical Betamethasone after the treatment with Tixel, Topical treatment
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Skin Quality
Laser Treatment to Improve Skin Quality
To assess the efficacy of a 1064nm picosecond laser (PicoWay; Candela; Marlborough, MA) with diffractive lens array and a picosecond 755nm laser (PicoSure®; Cynosure®; Westford, MA) with diffractive lens array in subjects for the…
- Trial name
- NCT05595525
- Testing
- 1064NM pico Laser, 755NM pico Laser
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Acne, Melasma
The Use of Image-Based Computer Gradings in the Analysis of Acne, Rosacea, Melasma, and Seborrheic Dermatitis
The study is conducted to determine if image-based computer grading can of acne, melasma, rosacea and seborrheic dermatitis correlate well to expert based clinical severity grading.
- Conditions
- Acne, Melasma, Rosacea, Seborrheic Dermatitis
- Trial name
- NCT05942248
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Skin Pigmentation Over Contour Deformities of Face, Trauma, Rhomberg Disease
Long Term Effects on Skin Hyper Pigmentation With and Without Mesenchymal Stem Cell Enriched Adipose Tissue Grafting for "Contour Deformities With Pigmentary Changes on Face"
MSCs one injected along with fat, regulate pigmentation over the contour defects of face
- Trial name
- MSCs (NCT03564808)
- Testing
- MSC
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Edward Medical University
Hyperpigmentation
Efficacy and Tolerability of Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06253468
- Testing
- tested product
- Where
- Singapore
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International