Clinical trials: Skin Tone
Vitiligo, Mesenchymal Stem Cells
Study of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Vitiligo
This study evaluates whether exosomes derived from human umbilical cord mesenchymal stem cells (hUMSCs-Exo) are safe and effective for treating vitiligo in adults.
- Conditions
- Vitiligo, Mesenchymal Stem Cells, Exosomes
- Trial name
- hUMSCs-Exo-VIT (NCT07519031)
- Testing
- Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes (hUC-MSC-Exos) Intravenous Infusion, Oral Prednisone, Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes (hUC-MSC-Exos) Local Injection
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Xijing Hospital
Vitiligo
Thymic Stromal Lymphopoietin (TSLP) in Vitiligo
study \& verify the hypothesis of the involvement of TSLP in the pathogenesis of vitiligo in comparison to their levels in the healthy control persons.
- Trial name
- NCT03367273
- Testing
- skin biopsy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Laser-induced Hypopigmentation
Gingival Depigmentation by Diode Laser
Physiologic gingival pigmentation(PGP) is the most common type of gingival pigmentation and cosmetic concern particularly in gummy smile patients. Laser therapy is an effective and noninvasive treatment option.
- Trial name
- NCT02143375
- Testing
- 810 Diode Laser
- Where
- Iran
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Vitiligo
Effect of Procedural Variables on Outcome of Surgical Treatment of Vitiligo
ORSHFS grafts yielded lower cell counts than NCECS but the M-K ratio and resultant repigmentation did not show significant difference with better healing of the donor site.
- Trial name
- NCT02510651
- Testing
- Melanocyte-keratinocyte suspension
- Volunteers
- 40 people
- Sponsor
- Cairo University
Sentinel Lymph Node, Breast Cancer
Carbon Dye Tattooing of Biopsied Axillary Node in Breast Cancer
The primary aim of this prospective, multicentre study is to determine whether the involved node can be marked using black carbon dye and successfully identified at the time of surgery.
- Conditions
- Sentinel Lymph Node, Breast Cancer, Tattoo; Pigmentation, Axilla; Breast
- Trial name
- pre-ATNEC (NCT03640819)
- Testing
- Tattooing of biopsied node
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Psoriasis
Levels of Pigment Epithelium-derived Factor in Patients With Psoriasis.
Psoriasis is an immune-mediated chronic inflammatory skin disease associated with increase interaction of inflammatory mediators like adipokines.
- Trial name
- NCT05252741
- Testing
- serum samples and punch skin biopsies
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Sohag University
Non-segmental Vitiligo, Segmental Vitiligo
Punchgrafting Techniques for Vitiligo
Rationale: Punch grafting is a safe, simple and widely used technique for in vitiligo. However, no reliable data are available on the effect of punch depth and punch size.
- Conditions
- Non-segmental Vitiligo, Segmental Vitiligo, Piebaldism
- Trial name
- MiniSNIP (NCT01377077)
- Testing
- punchgrafting
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hyperpigmentation
Randomized and Open Label Study for Safety and Efficacy of DBI-102 vs. Vehicle vs. Hydroquinone on Skin Pigmentation and Lentigos
This is a randomized, observer-blinded, vehicle-controlled multi-dose trial that examines the effect of twice daily application of 0.8% DBI-102 Gel, 4% Hydroquinone cream, and Vehicle Gel for 12 weeks in adults with Fitzpatrick…
- Trial name
- NCT05511948
- Testing
- DBI-102, Vehicle gel, Hydroquinone Cream
- Where
- El Salvador
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- DermBiont, Inc.
Scar
Impact of Suture Type on Pigment Disturbances in Patients of Skin of Color
The present study assesses if dissolvable (fast gut) or non-dissolvable (polypropylene) epidermal sutures produce better cosmetic results in terms of dyspigmentation and scarring in patients of skin of color.
- Trial name
- NCT05408117
- Testing
- 5-0 Polypropylene epidermal suture, 5-0 Fast gut epidermal suture
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- Melissa Pugliano-Mauro
Cystinosis
Clinical and Biological Study of Sub-pigmentation During Infantile Cystinosis
The purpose of this study is to determine the molecular mechanism of this disease and to research the relationship between cystinosis and skin phenotype.
- Trial name
- NCT00822250
- Testing
- analysis of pigmentation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sunscreening Agents
Sun Protection Factor Assay (341/2016)
To evaluate the Sun Protection Factor efficacy on human skin.
- Trial name
- NCT02995135
- Testing
- BAY987517, SFP Control
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bayer
Age-related Macular Degeneration, Pigment Epithelial Detachment
Lucentis for Age-related Macular Degeneration Pigment Epithelial Detachments
Patients with neovascular Age-related macular degeneration (AMD) and the particular feature of pigment epithelial detachments (PEDs) were not studied in the Phase III trials for ranibizumab (Lucentis).
- Conditions
- Age-related Macular Degeneration, Pigment Epithelial Detachment, Neovascular Macular Degeneration, Wet Macular Degeneration
- Trial name
- DETAIL (NCT00590694)
- Testing
- ranibizumab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Pacific Eye Associates
Healthy
Performance of Masimo MightySat Pulse Oximeter in Differing Levels of Skin Pigmentation
Evaluation of the noninvasive oxygen saturation (SpO2) performance of the noninvasive Masimo MightySat against reference arterial blood samples analyzed by a laboratory CO-oximeter reference instrument.
- Trial name
- NCT05083351
- Testing
- MightySat
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Vitiligo
Efficacy and Safety of Apremilast in Combination with NBUVB and NBUVB Alone in Vitiligo Patients
Patients of non-segmental vitiligo, fulfilling the inclusion criteria will be selected from the OPD, dermatology department. It\'s an interventional study where Group A patient will be given NBUVB and Tab Apremilast 30 mg…
- Trial name
- NCT06593197
- Testing
- Apremilast with NB-UVB, NB-UVB
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Dow University of Health Sciences
Sunscreening Agents
18475 - Sun Protection Factor Assay
To evaluate the Sun Protection Factor efficacy on human skin.
- Trial name
- SPF Assay (NCT02774252)
- Testing
- BAY987521
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Bayer
Vitiligo Vulgaris
Possible Augmentation Of NB-UVB Induced Pigmentation In NSV By Carboxy.
Patients with stable vitiligo with 2 or more symmetric patches, 2 on acral sites and/or 2 on non acral sites will be recruited and assessed for eligibility for inclusion to receive NB-UVB on the whole body, and carboxytherapy on…
- Trial name
- NB-UVB (NCT07563049)
- Testing
- NB-UVB alone, NB-UVB combined with carboxy
- Where
- Egypt
- Volunteers
- 59 people
- Sponsor
- Kasr El Aini Hospital
Xeroderma Pigmentosum
A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum (XP)
The CUV156 study will evaluate the safety of afamelanotide in XP-C patients, as well as the drug's ability to assist reparative processes following ultraviolet (UV) provoked DNA damage of the skin.
- Trial name
- NCT05159752
- Testing
- Afamelanotide
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Clinuvel Europe Limited
Leber Congenital Amaurosis, Retinitis Pigmentosa
Treatment of RP and LCA by Primary RPE Transplantation
Early Phase I Study of the Safety and Preliminary Efficacy of Human primary Retinal Pigment Epithelial (HuRPE) Cells Subretinal Transplantation in Retinitis Pigmentosa (RP) and Leber Congenital Amaurosis (LCA) Patients
- Trial name
- NCT03566147
- Testing
- Human primary Retinal Pigment Epithelial (HuRPE) cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Eyecure Therapeutics Inc.
Xeroderma Pigmentosum
XPAND Trial: Enhancing XP Photoprotection Activities - New Directions
People with Xeroderma Pigmentosum (XP) have a genetic condition which stops their skin repairing damage from Ultraviolet Radiation (UVR). This means they are much more likely to develop potentially fatal skin cancers.
- Trial name
- XPAND (NCT03445052)
- Testing
- XPAND
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Pancreatic Ductal Adenocarcinoma, Pancreatic Cyst
The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics
The long-term goal of our PIC is to develop effective strategies that can be applied clinically at the point-of-care to prevent, intercept, or detect PDAC at an early stage, thereby reducing PDAC burden and saving lives.
- Conditions
- Pancreatic Ductal Adenocarcinoma, Pancreatic Cyst, Chronic Pancreatitis, Fatty Pancreas
- Trial name
- NCT05692596
- Testing
- Data collection
- Where
- United States
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute