Clinical trials: Skin Wrinkling
Wrinkle Reduction
Assessment of the Safety and Effectiveness of a Micro-RF Skin Treatment Device (nebulyft）
The objective of the study is to evaluate the safety, efficacy and usage compliance of the home-use device nebulyft for self-treatment of wrinkles appearance. The participants do treatment 5 time /week and last 4 weeks.
- Trial name
- ASEMRSTD (NCT06623214)
- Testing
- nebulyft
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Hangzhou Rebecca Medical Science and Technology Ltd.
Skin Quality
Laser Treatment to Improve Skin Quality
To assess the efficacy of a 1064nm picosecond laser (PicoWay; Candela; Marlborough, MA) with diffractive lens array and a picosecond 755nm laser (PicoSure®; Cynosure®; Westford, MA) with diffractive lens array in subjects for the…
- Trial name
- NCT05595525
- Testing
- 1064NM pico Laser, 755NM pico Laser
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Skin Laxity, Wrinkle
Evaluation of Efficacy and Safety of the triLift™ System
Single center, single-arm, prospective, open Label with Before \& After Study Design.
- Trial name
- LUM-triLift (NCT05773924)
- Testing
- triLift system
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Lumenis Be Ltd.
Intrinsic Aging of Skin, Skin Wrinkling
Study of Intradermal Injections of RCS-01 in Male and Female Subjects
The primary purpose of this study is to assess the safety profile of RCS-01 injections as compared to placebo injections. This study will also measure the impact these injections will have on skin markers related to aging through…
- Conditions
- Intrinsic Aging of Skin, Skin Wrinkling, Solar Degeneration of Skin
- Trial name
- NCT02391935
- Testing
- RCS-01
- Where
- Germany
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- RepliCel Life Sciences, Inc.
Wrinkles, Striae
Clinical Evaluation of M22 ResurFX 1565nm Module
At least thirty (30) subjects, Fitzpatrick-Goldman Skin Type I-IV will be enrolled in 2 clinical sites; each clinic will enroll at least 15 subjects. Subjects should present visible wrinkles and/or striae requiring treatment.
- Trial name
- NCT01796626
- Testing
- M22 ResurFX module
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Lumenis Be Ltd.
Laxity; Skin
Pivotal Study to Evaluate the Safety and Efficacy of a Micro-coring Device Treating Moderate to Severe Facial Wrinkles
Study evaluating the safety and efficacy of a micro-coring device for the treatment of moderate to severe cheek wrinkles.
- Trial name
- NCT03573271
- Testing
- MCD
- Where
- 5 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cytrellis Biosystems, Inc.
Skin Laxity, Wrinkle
Safety and Efficacy of SofWave Treatment to Lift Lax Tissue in the Submental and Neck Zones and to Lift the Eyebrow
This is a prospective, open label, multi-center, self-controlled clinical study to demonstrate the safety and efficacy of SofWave treatment to lift lax tissue in the submental and neck zones and to lift the eyebrow.
- Conditions
- Skin Laxity, Wrinkle, Brow Lifting
- Trial name
- NCT04146584
- Testing
- Sofwave Treatments
- Where
- 5 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Sofwave Medical LTD
Dermis Density, Wrinkles
The Effect of 12-week Dietary Intake of Food Supplements Containing Collagen on Dermis Density and Other Skin Parameters
The aim of the randomized, double-blind, placebo-controlled, one-period effectiveness study is to compare the effects of multiple-dose 12 weeks daily dietary supplementation with 10 g collagen alone or 5 g or 10 g of collagen in…
- Conditions
- Dermis Density, Wrinkles, Skin Hydration, Trans Epidermal Water Loss (TEWL)
- Trial name
- TO-COSKIN (NCT04988412)
- Testing
- Investigational product 1, Investigational product 2, Investigational product 3
- Where
- Slovenia
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- VIST - Faculty of Applied Sciences
Wrinkle
Robotic Mechanical Coring for the Treatment of Moderate to Severe Facial Wrinkles
This study is a prospective, up to 4 center study of the safety and efficacy of mechanical coring with skin closure of cored holes, intended for the improvement in the appearance of wrinkles of the cheeks in up to 70 subjects…
- Trial name
- NCT05091788
- Testing
- Venus Aime
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Venus Concept
Photoaging, Hyperpigmentation
Randomized, Double-Blind Evaluation of Maple Leaf Extract (Maplifa) for Photoaging
Recent research has reported that the maple leaf extract exhibits anti-aging effects by inhibiting elastase activity, thereby preventing the breakdown of elastin and interfering with the formation of wrinkles.
- Conditions
- Photoaging, Hyperpigmentation, Rhytides
- Trial name
- NCT04586816
- Testing
- 1% red maple leaf extract in cream base, 5% red maple leaf extract, vehicle
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Wrinkles
Silk'n HST for Wrinkle Reduction - Clinical Study Protocol
The objective of the study is to evaluate the safety, efficacy and usage compliance of the home-use device Silk'n HST for self-treatment of periorbital wrinkles and skin laxity and improvement of skin appearance.
- Trial name
- NCT02913547
- Testing
- Silk'n HST
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Home Skinovations Ltd.
Skin Aging, Elastosis Senilis
Comparison of Escalating Doses of IncobotulinumtoxinA (Xeomin®) in the Treatment of Glabellar Rhytids
The objective of the study is to compare the efficacy and duration of escalating doses of IncobotulinumtoxinA (Xeomin®) in the treatment of glabellar rhytids (frown lines between the eyes).
- Trial name
- NCT01583478
- Testing
- incobotulinumtoxinA
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Maas Clinic
Skin Rejuvenation, Laser
Comparative Effectiveness of Long-Pulsed 1064-nm Nd:YAG and Fractional CO₂ Laser in Skin Rejuvenation
Skin rejuvenation is an effort to improve skin condition from the signs of skin aging. Skin aging is a complex biological process influenced by intrinsic and extrinsic factors, leading to changes in the epidermis and dermis…
- Trial name
- NCT07467954
- Testing
- Fractional CO₂ laser, Long-pulsed 1064-nm Nd:YAG laser
- Where
- Indonesia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Wrinkle, Pigment Skin
A Clinical Study to Assess the Safety and Effectiveness of Anti-Ageing and Skin Brightening Gel
This is a Randomized, Interventional, Prospective, Double Blind, Two Arm, Comparative, Parallel, Placebo-Controlled, Safety and Efficacy Study of Anti-Ageing and Skin Brightening Gel.
- Conditions
- Wrinkle, Pigment Skin, Aging
- Trial name
- NCT06123572
- Testing
- Anti-Ageing and Skin Brightening Gel
- Where
- India
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Spot Pigmented, Wrinkle
Clinical Study for the Efficacy Evaluation of a Food Supplement
The primary aim of this in vivo clinical study is to evaluate the depigmenting effect of an active ingredient incorporated into a food supplement through the evaluation of the melanin variation parameter, assessed with the…
- Trial name
- NCT06453837
- Testing
- Mentha Suaveolens extract incorporated into a food supplement
- Where
- Portugal
- Volunteers
- 110 people
- Sponsor
- Mibelle Group Biochemistry
Skin Aging, Hyperpigmentation
Homocysteic Acid Biostimulator for Photoaged Facial Skin
This study evaluated whether a chemical skin biostimulator containing ammonium trichloroacetate, homocysteic acid, phytic acid and citric acid can improve signs of photoaged skin in women with mature skin.
- Trial name
- NCT07722351
- Testing
- Chemical skin biostimulation with ammonium trichloroacetate and homocysteic acid
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Medical University of Silesia
Improve Photoaging Signs
Skin Care Regimen for Improving Photoaging Signs on the Face
Compare the effectiveness of laser treatment using CE Ferulic versus vehicle pre/post laser.
- Trial name
- NCT06603857
- Testing
- CE Ferulic, 1927nm (Clear and Brilliant Perméa®)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Periorbital Hyperpigmentation, Periorbital Edema
A 12 Week Study to Evaluate the Efficacy of an Eye Cream
This single center, open-label clinical study was conducted to assess the efficacy and tolerance of a topical eye cream when used over the course of 12 weeks by healthy women with moderate to severe under-eye dark circles…
- Conditions
- Periorbital Hyperpigmentation, Periorbital Edema, Fine Lines, Wrinkle
- Trial name
- NCT05807620
- Testing
- Gentle Cleansing Lotion, Facial Moisturizer, Sunscreen SPF 30
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Wrinkle, Elastic Skin
Straberi Epistamp Needling Treatment For Skin Rejuvenation
This pilot study will expand knowledge and application needling using the Epistamp device for the improvement of a new vitalized epidermal layer with new vibrant active cells, supported by more robust collagen and elastin fine…
- Conditions
- Wrinkle, Elastic Skin, Collagen Degeneration
- Trial name
- ESAA (NCT04742803)
- Testing
- Straberi Epistamp Microneedling Treatment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universal Skincare Institute
Collagen Degeneration, Wrinkle
The Effects of Almond on Facial Skin Collagen and Wrinkles
Investigate the effects of almond consumption on collagen production, elastin levels, wrinkles, and pigmentation among premenopausal women and postmenopausal women belonging to all Fitzpatrick skin types.
- Conditions
- Collagen Degeneration, Wrinkle, Pigmentation, Elastic Skin
- Trial name
- NCT06074276
- Testing
- Food: whole almonds, Food: non-nut snack
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research