Clinical trials: Skin and Connective Tissue Diseases
Breast Cancer
PET Scans in Assessing Response To Treatment in Patients Receiving Hormone Therapy or Trastuzumab for Breast Cancer
RATIONALE: Diagnostic procedures, such as PET scans, may help in learning how well hormone therapy and trastuzumab work to kill breast cancer cells and allow doctors to plan better treatment.
- Trial name
- NCT00362973
- Testing
- laboratory biomarker analysis, needle biopsy, positron emission tomography
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of Washington
Leg Ulcer
SANGUINATE™ in Sickle Cell Disease Associated Leg Ulcer
SANGUINATE™ Sickle Cell Disease associated Leg Ulcers.
- Trial name
- LU (NCT02600390)
- Testing
- SANGUINATE
- Where
- 2 sites in Dominican Republic, Panama
- Volunteers
- 10 people
- Sponsor
- Prolong Pharmaceuticals
Breast Cancer
Long Term Cohort Study of Adding Ovarian Function Suppression to Tamoxifen in Young Women
This study evaluates the long-term effects of adding 2 years of ovarian function suppression (OFS) to tamoxifen therapy in young premenopausal women with hormone receptor-positive breast cancer after chemotherapy.
- Trial name
- ASTRRAIV (NCT07735897)
- Where
- South Korea
- Volunteers
- 1,483 people
- Sponsor
- MedicalExcellence
Breast Cancer
A Prospective Observational Study to Describe Clinical Outcomes, Treatment Patterns, Patients Characteristics Among Patients With HR+/HER2- Advanced BC Initiating Treatment With Risarg®, Piqray®, Endocrine Therapy or Chemotherapy in Routine Clinical Practice in Russia
This study was planned as a prospective multicenter NIS. This study was observational in nature and did not impose a therapy protocol, diagnostic/therapeutic interventions or a visit schedule.
- Trial name
- PROSPERITY (NCT04943497)
- Testing
- ribociclib, aplelicib, mono endocrine therapy
- Where
- 57 sites in Russia
- Volunteers
- 2,390 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer
Clinical Application of Dual Sentinel Lymph Node Staining Method in Breast Cancer Patients
This study aimed to compare detection rate between dual sentinel node staining method using mixture of indocyanine green (ICG) with radioisotope(RI), and RI only.
- Trial name
- NCT02479997
- Testing
- Indocyanine green, Radioisotope
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- National Cancer Center, Korea
Alopecia Areata
Evaluate the Efficacy and Safety of SHR0302 in Adult Patients With Severe Alopecia Areata
This is a multi-central, double-blind, randomized, parallel, placebo-controlled phase 3 study in adult subjects with severe alopecia areata (SALT≥50%). Approximately 330 adult patients will be enrolled into the study.
- Trial name
- NCT05470413
- Testing
- SHR0302
- Where
- 31 sites in China
- Volunteers
- 330 people
- Sponsor
- Reistone Biopharma Company Limited
Rheumatoid Arthritis
Clinical Outcomes, Compliance and Effectiveness of Switching From Infliximab or Etanercept to Adalimumab in Patients With Active Rheumatoid Arthritis (RA). A Multicenter Post-Marketing Observational Study in Routine Clinical Use
This is a prospective, single-arm, post marketing observational study in adult patients with active rheumatoid arthritis (RA) who are discontinuing treatment due to lack of efficacy, intolerance or to an incomplete response with…
- Trial name
- FALLA (NCT01083160)
- Where
- 12 sites in Mexico
- Volunteers
- 82 people
- Sponsor
- Abbott
Dermatitis, Atopic
A Single Dose Phase I Exploratory Study in Healthy Volunteers With GSK2894512 Cream
This will be an open-label, non-randomized, single-center study to assess the residency of GSK2894512 in the skin of healthy adult male volunteers with normal barrier function.
- Trial name
- NCT02411162
- Testing
- Combination therapy GSK2894512 Cream A + GSK2894512 Cream B, Combination therapy Vehicle Cream A + Vehicle Cream B
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Stiefel, a GSK Company
Effect of Drugs, Adverse Effects of Medical Drugs
Comparison of Efficacy of Tranexamic Acid Mesotherapy Versus 0.9% Normal Saline for Melasma
It is a randomized controlled trial in which investigators determine the efficacy of tranexamic acid (TA) by mesotherapy in comparison to normal saline on participants having Melasma.
- Trial name
- NCT04170088
- Testing
- Tranexamic Acid, 0.9% Normal Saline
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Breast Cancer, Menopause
Study to Assess Efficacy of Risedronate in Preventing Bone Loss in Postmenopausal Women Treated for Breast Cancer
Aromatase inhibitor therapy is in France the adjuvant reference treatment for postmenopausal women with early-stage breast cancer. This treatment induces bone loss and a higher risk of fractures.
- Conditions
- Breast Cancer, Menopause, Osteopenia
- Trial name
- RISAROS (NCT00859703)
- Testing
- Risedronate
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Erythema
Characterisation of the Time-course Response of UV-induced Erythema
Erythema is a physiological response to an insult on the skin. One such insult is ultraviolet (UV) radiation, with the resultant erythema also known as sunburn.
- Trial name
- CHERY (NCT04290273)
- Testing
- MED Test, Wearing device
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Dundee
Systemic Lupus Erythematosus
Examining Distinct Immunophenotypes to Validate and Enhance Rational Treatment in Systemic Lupus
The primary purpose of this study is to evaluate the potential effectiveness of 24 weeks of MMF within previously discovered immunologically defined subsets of SLE patients.
- Trial name
- DIVERT (NCT05306873)
- Testing
- Mycophenolate Mofetil, Voclosporin
- Where
- 10 sites in United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Breast Cancer
Xenogeneic HER2/Neu DNA Immunization for Patients With Metastatic and High Risk Breast Cancer: A Phase I Study to Assess Safety and Immunogenicity
The purpose of this study is to evaluate whether the injection of HER2/neu DNA is safe and stimulates an immune response. The immune system consists of different kinds of cells and substances which help fight against infections…
- Trial name
- NCT00393783
- Testing
- MAB HER 2 (HERCEPTIN)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Advanced Solid Tumor, Breast Cancer
Study of M4344 in Combination With Niraparib
Study will include 3 parts. Aim of Part 1 of this study is to establish the maximum tolerated dose (MTD) and recommended dose for expansion (RDE) for M4344 (is an Ataxia Telangiectasia Mutated and Rad3-related [ATR] inhibitors)…
- Trial name
- NCT04655183
- Testing
- Niraparib, M4344
- Sponsor
- EMD Serono Research & Development Institute, Inc.
HRD 100 Gene Expression High, Triple Negative Breast Cancer
Efficacy of Talazoparib in Asian Metastatic Breast Cancer Patients With a Homologous Recombinant Deficiency (HRD) Signature
This is an open label, non randomised, investigator-initiated Phase II study of single agent talazoparib (Talzenna®) in metastatic triple negative breast cancer patients with enriched HRD signature.
- Trial name
- NCT05288127
- Testing
- Talazoparib
- Where
- Malaysia
- Volunteers
- 55 people
- Sponsor
- University of Malaya
Breast Cancer, Sentinel Lymph Node
Tumor-Targeted-NIR-II Fluorescent Molecular Probes for the Identification of Breast Cancer Tissue and SLN Metastatic Status
Accurate evaluation of tumor boundaries in breast-conserving surgery is closely associated with reducing the second operation of patients.
- Conditions
- Breast Cancer, Sentinel Lymph Node, Metastases, Margin Assessment
- Trial name
- NIR-II (NCT06713161)
- Testing
- NIR-II Probe(i.e ICG-POL6326) incubation solution
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yunnan Cancer Hospital
n Ulcer, Scleroderma, Systemic
A Study to Evaluate the Efficacy of an Oral Medication in the Treatment and Prevention of Digital Ulcers in Patients With Systemic Sclerosis (Scleroderma).
This is a research study of an investigational drug called ambrisentan (Letairis) in the treatment and prevention of digital ulcers in patients with systemic sclerosis.
- Trial name
- NCT00725361
- Testing
- Ambrisentan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Melanoma
An Expanded Cohort Trial of Bortezomib and Sorafenib in Advanced Malignant Melanoma
This research study involves the use of two investigational drugs: sorafenib and bortezomib. Sorafenib is designed to stop the growth of cells caused by changes associated with cancer.
- Trial name
- NCT01078961
- Testing
- bortezomib, sorafenib
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Clonal Mast Cell Disease, KIT D816V Mutation
Screening Study for KIT D816V Mutated Mast Cell Disease in Select Populations
This is a multicenter screening study to characterize the prevalence of the KIT D816V mutation in participants with suspected clonal mast cell disease.
- Conditions
- Clonal Mast Cell Disease, KIT D816V Mutation, Suspected KITD816V Mutated Clonal Mast Cell Disease
- Trial name
- POLARIS (NCT07143669)
- Testing
- Screening
- Where
- 26 sites in United States, Belgium
- Volunteers
- 750 people
- Sponsor
- Blueprint Medicines Corporation
Osteoarthritis, Rheumatoid Arthritis
Vanguard Complete Knee Versus Vanguard High Flex Rotating Platform (RP) Knee Study
The purpose of this study is to compare Vanguard High Flex Rotating Platform to Vanguard Complete Knee System in Asian population in terms of early range of motion (ROM), clinical outcomes, and kinetic and kinematic…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- NCT01010269
- Testing
- Vanguard Complete Knee, Vanguard High Flex RP
- Where
- 4 sites in South Korea
- Volunteers
- 300 people
- Sponsor
- Zimmer Biomet