Clinical trials: Skull
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma
Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction
Phase I trial to study the effectiveness of erlotinib in treating patients who have metastatic or unresectable solid tumors and liver or kidney dysfunction.
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma, Adult Brain Stem Glioma
- Trial name
- NCT00030498
- Testing
- erlotinib hydrochloride, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute (NCI)
Bell Palsy, Vitamin D Deficiency
The Effect Vitamin D on the Recovery Rate of Bell Palsy
Patients aged between 18-65 who visit the Physical Medicine and Rehabilitation outpatient clinic diagnosed with Bell Palsy will be included in the study.
- Conditions
- Bell Palsy, Vitamin D Deficiency, Facial Paralysis
- Trial name
- NCT05997199
- Testing
- Vitamin D replacement
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Umraniye Education and Research Hospital
Vestibular Function Tests
Computerized Rotational Head Impulse Test-Vertical (crHIT-vertical)
The purpose of this research study is to test whether a Computerized Rotational Head Impulse Test-Vertical (crHIT-vertical) is able to reliably evaluate the vertical semicircular canals in patients with vestibular dysfunctions.
- Trial name
- NCT04087044
- Testing
- Computerized Rotational Head Impulse Test ( crHIT)-Vertical
- Where
- 3 sites in United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Neurolign
Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration
PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK
Progressive Supranuclear Palsy (PSP), Cortico-Basal Degeneration (CBD) and Multiple System Atrophy (MSA) are degenerative brain conditions for which there are currently no curative treatments.
- Conditions
- Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration, Multiple System Atrophy (MSA)
- Trial name
- PROSPECT-M (NCT02778607)
- Where
- United Kingdom
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University College, London
Pain, Procedural
SPI and Remifentanil in Skull Pin Fixation
Forty patients were enrolled, and all patients used total intravenous anesthesia (remifentanil-propofol based total intravenous analgesia) as anesthesia induction and maintenance.
- Trial name
- NCT06331663
- Testing
- Remifentanil
- Where
- Taiwan
- Volunteers
- 27 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
SCI - Spinal Cord Injury
tDCS and VI to Treat Neuropathic Pain and Function in SCI
Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) will be applied for patient who suffer from neuropathic pain following spinal cord injury The tDCS treatment will be coupled with a video of a man…
- Trial name
- NCT03052244
- Testing
- tDCS+VI
- Volunteers
- 100 people
- Sponsor
- Loewenstein Hospital
Neuropathy, Optic
OCT Angiography in Arteritic and Non Arteritic Anterior Ischemic Neuropathy
Anterior ischaemic optic neuropathy results from infarction of retrolaminar portion of the optic nerve head, caused by occlusion of the posterior ciliary artery.
- Trial name
- NOIA (NCT03642899)
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Esophageal Neoplasm, Anastomotic Leak
Prediction of Anastomotic Complications and Recurrent Laryngeal Nerve Injury Based on Postoperative Early Endoscopic Evaluation
Analyze the correlation between the conformity of the anatomy (based on endoscopic examination) and postoperative anastomotic fistula and anastomotic stenosis; establish an anastomotic classification; and construct a predictive…
- Conditions
- Esophageal Neoplasm, Anastomotic Leak, Recurrent Laryngeal Nerve Injuries, Anastomotic Stenosis
- Trial name
- NCT06348381
- Testing
- No intervention
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shanghai Chest Hospital
Skull Defect
Development of Three-dimensional Deep Learning for Automatic Design of Skull Implants
This project aims to develop an effective deep learning system to generate numerical implant geometry based on 3D defective skull models from CT scans.
- Trial name
- NCT05603949
- Testing
- 3D deep learning neural network system
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- Chang Gung Memorial Hospital
Humoral Rejection, Guillain-Barre Syndrome
Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation
Plasma exchange procedures remove procoagulant and anticoagulant factors. Every procedure increases the risk of bleeding and repeated procedures increase the risk of bleeding mostly because lower fibrinogen levels.
- Conditions
- Humoral Rejection, Guillain-Barre Syndrome, Miller Fisher Syndrome, CIDP
- Trial name
- NCT03801135
- Testing
- Fibrinogen concentrate, Fresh Frozen Plasma
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
Vestibular Schwannoma, Facial Nerve Paralysis
Steroids for Facial Nerve Function Protection in Post-surgical Vestibular Schwannoma Patients
The purpose of this study is to evaluate the efficacy and safety of steroids treatment compared with placebo in preserving facial nerve function after craniotomy in patients with vestibular schwannoma who have not received…
- Trial name
- SAF-NRVS (NCT07116811)
- Testing
- Steroids therapy
- Where
- China
- Volunteers
- 364 people
- Sponsor
- Beijing Tiantan Hospital
Progressive Supranuclear Palsy
Risk Factors for Progressive Supranuclear Palsy (PSP)
Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian movement disorder. This study will determine the role of specific genetic, occupational and environmental components in the development of PSP by…
- Trial name
- NCT00431301
- Where
- 10 sites in United States, Canada
- Volunteers
- 942 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Mandibular Tumor
Assessment of Accuracy and Aesthetics Following Automated Mandibular Defect Reconstruction Using AI
The Aim of the study is to evaluate Accuracy of automated mandibular defect reconstruction using Artificial intelligence and assessing impact on aesthetic and occlusion outcomes using patient-specific reconstruction plates.
- Trial name
- NCT06945692
- Testing
- patient specific reconstruction plates
- Volunteers
- 4 people
- Sponsor
- Cairo University
Head and Neck Cancer, Neck Dissection
Porcine Extracellular Matrix Nerve Wrap in Neck Dissection for Head and Neck Cancer
Perform a preliminary efficacy study using the porcine extracellular matrix nerve wrap (AxoGuard Nerve Protector™, AxoGen Inc., Alachua, FL) to wrap the spinal accessory nerve (SAN) during neck dissections for head and neck…
- Conditions
- Head and Neck Cancer, Neck Dissection, Postoperative Complications
- Trial name
- NCT07268092
- Testing
- Porcine Extracellular Matrix Nerve Wrap (AxoGuard Nerve Protector™)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Henry Ford Health System
Vocal Cord Paralysis Unilateral
Laryngeal Reinnervation Versus Thyroplasty in Patients With Vocal Fold Weakness.
The purpose of this study is to help determine the most effective treatment for participants with Unilateral Vocal Fold Paralysis. There are currently two types of operations used to treat this condition.
- Trial name
- VOCALIST (NCT02973152)
- Testing
- Thyroplasty, Reinnervation
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Royal National Throat, Nose and Ear Hospital
Progressive Supranuclear Palsy, Cortico Basal Degeneration
Utilisation of Health Services and Quality of Life in Patients With Atypical Parkinsonian Syndromes
The study will compare health care utilisation and quality of life for patients with progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy in different parts of the region that our specialist clinic…
- Conditions
- Progressive Supranuclear Palsy, Cortico Basal Degeneration, Multiple System Atrophy
- Trial name
- UHSQOLAPS (NCT06645626)
- Where
- United Kingdom
- Volunteers
- 198 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Progressive Supranuclear Palsy
GV1001 Subcutaneous(SC) for the Treatment of Progressive Supranuclear Palsy (PSP)
The study will be conducted by the Sponsor to evaluate the efficacy and safety of GV1001 (0.56 mg and 1.12 mg) administered subcutaneously as a treatment for Progressive Supranuclear Palsy, (PSP).
- Trial name
- NCT05819658
- Testing
- GV1001 0.56mg, GV1001 1.12mg
- Where
- 5 sites in South Korea
- Volunteers
- 78 people
- Sponsor
- GemVax & Kael
Mandibular Neoplasms, Maxillary Neoplasms
3D-Printed Patient-Specific Surgical Plates Versus Conventional Surgical Plates in Jaw Reconstruction
Objectives: The aim of this randomised controlled clinical trial is to evaluate surgical accuracy and efficiency of computer-assisted jaw reconstruction using 3D-printed patient-specific titanium surgical plates versus…
- Conditions
- Mandibular Neoplasms, Maxillary Neoplasms, Dentofacial Deformities
- Trial name
- NCT04635865
- Testing
- 3D-printed patient-specific plate, Conventional commercial reconstruction plate
- Where
- Hong Kong
- Volunteers
- 92 people
- Sponsor
- The University of Hong Kong
Unilateral Vocal Cord Paresis, Unilateral Vocal Cord Paralysis
Cough in Reduced True Vocal Fold Mobility
This project is a first attempt to assess cough airflow dynamics and true vocal fold (TVF) adduction and abduction angles during voluntary cough to examine the effects of changes in glottal closure due to reduced mobility of one…
- Trial name
- NCT02407301
- Testing
- cough airflow measure, vocal tasks, true vocal fold movement
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Florida
Trigeminal Neuralgia
Comparative Study inTreatment of Trigeminal Neuralgia
This study aims to evaluate the results of percutaneous radiofrequency rhizotomy and the effectiveness of microvascular decompression for the treatment of trigeminal neuralgia and Comparing between them according the different…
- Trial name
- NCT04801407
- Testing
- percutaneous radiofrequency trigeminal rhizotomy, Microvascular decompression of the trigeminal nerve
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
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