Clinical trials: Skull
Zygomaticomaxillary Complex Fracture, Zygomatic Fractures
BoneTape Feasibility Trial
This study aims to evaluate the safety, effectiveness, and usability of BoneTape, an innovative medical device designed to fix facial bone fractures, specifically in the zygomaticomaxillary (midface) region.
- Conditions
- Zygomaticomaxillary Complex Fracture, Zygomatic Fractures, Zygoma Fracture
- Trial name
- NCT06600854
- Testing
- BoneTape
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Cohesys Inc.
Low Back Pain, Mechanical, Hamstring Flexibility
Effect of Superficial Back Line Relaxation Technique on Hamstring Flexibility in Non Specific Low Back Pain Patients
Current study aim to evaluate the effect of Superficial back line relaxation techniques (SMIT along with CCFE) In Non Specific Low back Pain Patients in order to improve pain and hamstring flexibility.
- Trial name
- NCT06406894
- Testing
- Conventional physical therapy, Superficial back line relaxation (SMIT & CCFE)
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Ascending Colon Cancer, Ileocaecal Valve Carcinoma
A Study of Laparoscopic Right Hemicolectomy Using the Caudal-to-cranial Approach
To investigate the clinical application value of laparoscopic radical right hemicolectomy using the caudal-to-cranial approach versus the medial-to-lateral approach by prospective randomized controlled clinical study.
- Conditions
- Ascending Colon Cancer, Ileocaecal Valve Carcinoma, Cancer Flexure Hepatic, Adenocarcinoma of Hepatic Flexure (Diagnosis)
- Trial name
- LRHCTC-1 (NCT02949440)
- Testing
- the caudal-to-cranial approach, the medial-to-lateral approach
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Anxiety, Depression
Effectiveness of CES on Emotional and Cellular Wellbeing
The investigators aim to use a CES (cranial electrotherapy stimulation) intervention to improve emotional well-being by reducing symptoms of anxiety and depression and to assess for changes in markers of cellular health …
- Trial name
- NCT03369418
- Testing
- Alpha-Stim Active, Alpha-Stim Inactive
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Chronic Inflammatory Demyelinating Polyradiculoneuropathy, NMO Spectrum Disorder
Safety and Efficacy of BAFF-R CART for Refractory Neuroimmune Diseases
This study is a phase Ib/IIa dose-escalation study designed to evaluate the safety, tolerability, and preliminary efficacy of autologous T cells expressing chimeric antigen receptor (CAR)-targeted B-cell activating factor…
- Conditions
- Chronic Inflammatory Demyelinating Polyradiculoneuropathy, NMO Spectrum Disorder, Myasthenia Gravis, Idiopathic Inflammatory Myopathies
- Trial name
- NCT07022197
- Testing
- BAFF-R CART
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Tianjin Medical University General Hospital
Vestibular Schwannoma, Hearing Loss
Intraoperative EABR for Decision Making
In this study patients undergoing simultaneous translabyrinthine vestibular schwannoma resection and cochlear implantation are included. The goal of the study is to correlate the eABR results with postoperative hearing results.
- Trial name
- NCT03745560
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- Christoph Arnoldner
Progressive Supranuclear Palsy (PSP)
Efficacy of RIVAstigmine on Motor, Cognitive and Behavioural Impairment in Progressive Supranuclear Palsy
Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease from the parkinsonian syndrome group. It represents 5 to 10% of all parkinsonian syndromes and affects 3,000 to 10,000 persons in France.
- Trial name
- RIVA-PSP (NCT02839642)
- Testing
- Rivastigmine
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Neuromyelitis Optica Spectrum Disorder
Efficacy and Safety Study of Ravulizumab IV in Pediatric Participants With NMOSD
The primary purpose of this study is to evaluate the safety and efficacy of ravulizumab in pediatric participants with Neuromyelitis Optica Spectrum Disorder (NMOSD).
- Trial name
- NCT05346354
- Testing
- Ravulizumab
- Where
- 16 sites in United States, Canada and 5 more
- Volunteers
- 12 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Bell Palsy
Comparative Effects of Mime Therapy and Action Observation Therapy in Bell's Palsy
The aim of this study is to determine comparative effects of mime therapy and action observation therapy on facial symmetry and quality of life in Bell's palsy.
- Trial name
- NCT06308250
- Testing
- MIME THERAPY, ACTION OBSERVATION THERAPY
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- Riphah International University
Optic Neuropathy, Ischemic
A Study to Assess Whether PDE5 Inhibitors Increase the Chance of Triggering the Onset of Acute NAION
The objective of this non-interventional study is to examine whether use of Phosphodiesterase Inhibitors (PDE5s), including use of sildenafil, vardenafil, or tadalafil, triggers the onset of acute NAION.
- Trial name
- NCT00759174
- Testing
- No intervention
- Where
- 105 sites in United States, France and 4 more
- Volunteers
- 673 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Trigeminal Neuralgia
Intravenous Lacosamide for the Treatment of Acute Pain in Trigeminal Neuralgia
This prospective observational study evaluates the effectiveness and safety of intravenous lacosamide as a rescue treatment for acute pain in patients presenting to the emergency department with trigeminal neuralgia
- Trial name
- NCT06851910
- Testing
- Lacosamide
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Universitari de Bellvitge
Alzheimer's Disease (AD), Progressive Supranuclear Palsy (PSP)
Evaluation of [18F]MNI-815 as a Potential PET Radioligand for Imaging Tau Protein in the Brain of Patients With Tauopathies
The overall goal of this imaging trial is to characterize [18F]MNI-815, a PET radioligand for imaging Tau.
- Conditions
- Alzheimer's Disease (AD), Progressive Supranuclear Palsy (PSP), Cortical Basal Syndrome (CBS), Frontal Temporal Dementia (FTD)
- Trial name
- NCT02531360
- Testing
- [18F]MNI-815 (MNI-815)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Molecular NeuroImaging
Idiopathic Intracranial Hypertension (IIH)
VEHICLE Registry: Venous Stenting for IIH in the MENA Region
The VEHICLE Registry is a multicenter observational study aimed at evaluating the management and outcomes of patients with Idiopathic Intracranial Hypertension (IIH) undergoing venous sinus stenting in the Middle East and North…
- Trial name
- VEHICLE (NCT06692790)
- Testing
- Venous Sinus Stenting Procedure
- Where
- 2 sites in Egypt, Saudi Arabia
- Volunteers
- 150 people
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Cerebral Aneurysm
Acupoint Stimulation and Cranial Endovascular Treatment
In this prospective randomized controlled trial, the subjects will be assigned to group transcutaneous electrical acupoint stimulation (TEAS) and group control (no intervention).
- Trial name
- ASSET (NCT05413460)
- Testing
- transcutaneous electrical acupoint stimulation
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Zhihong LU
Bell Palsy
Intradermal Acupuncture and Self-rehabilitation Program in Patients With Severe Bell's Palsy
This study aims to assess the effect of intradermal acupuncture(IA) and guided self-rehabilitation management program(GRMP) (either single or combined) for patients with severe Bell's Palsy.
- Trial name
- NCT06778473
- Testing
- Active Intradermal Acupuncture, Guided self-rehabilitation management program, Health Education
- Where
- China
- Volunteers
- 552 people
- Sponsor
- Zhangjiagang First People's Hospital
Skull Base
Bed Rest Duration and Outcomes in Endoscopic Skull Base Reconstruction
This study is a randomized controlled trial conducted across multiple centers. Due to the anatomical and pathological complexity of endoscopic endonasal skull base surgery, the study scope was restricted to the midline anterior…
- Trial name
- BRO (NCT07465861)
- Testing
- non-bed-rest, 2-day bed-rest, 1-day bed-rest
- Volunteers
- 316 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Craniotomy
Safety and Effectiveness of TETRANITE Bone Adhesive for Cranial Flap Fixation Compared to Traditional Metal Hardware
The aim of this study is to demonstrate the safety and efficacy of TETRANITE, a bioresorbable bone adhesive, for Cranial Flap Fixation as compared to traditional metal hardware.
- Trial name
- NCT07452549
- Testing
- Tetranite for Cranial Flap Fixation, Standard of Care Plating System
- Volunteers
- 204 people
- Sponsor
- RevBio
Alternating Exotropia
Bil. LR Rec. Using Standard Tables VS Reduced Numbers in Intermittent Exo. in Children Under 6
comparing the motor alignment and the incidence of postoperative esotropia following the correction of intermittent exotropia in children below 7 years by bilateral lateral rectus recession using the standard recession tables…
- Trial name
- NCT04308538
- Testing
- Standard Recession, Reduced Recession
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Non-small Cell Lung Cancer
Prophylactic Cranial Irradiation in Erlotinib/Gefitinib-responders With Non-small Cell Lung Cancer (NSCLC) (RT1001)
RATIONALE: Radiation therapy to the brain may be effective in preventing brain metastases in patients with advanced non-small cell lung cancer.
- Trial name
- NCT01158170
- Testing
- Prophylactic cranial irradiation, Erlotinib /Gefitinib
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Zhejiang Cancer Hospital
Lung Cancer, Adenocarcinoma
HS-PCI in Locally Advanced Adenocarcinoma of the Lung
The primary aim of this study is evaluate the impact of hippocampal-sparing prophylactic cranial irradiation (HS-PCI) on survival status in patients with nodal-positive (locally advanced) adenocarcinoma by comparing overall…
- Conditions
- Lung Cancer, Adenocarcinoma, Lymphatic Metastasis
- Trial name
- HIPPO-S (NCT02341170)
- Testing
- HS-PCI
- Sponsor
- Universitätsmedizin Mannheim
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