Clinical trials: Skull Base Chordoma
Pituitary Tumor, Meningioma
Long-Term Longitudinal QoL in Patients Undergoing EEA
This is a prospective longitudinal study to access postoperative 2-year quality of life in patients who undergo endonasal endoscopic approach surgeries of the skull base.
- Conditions
- Pituitary Tumor, Meningioma, Rathke Cleft Cysts, Chordoma
- Trial name
- NCT04087902
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Ohio State University
Chordoma, Chondrosarcoma
Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine
The primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose.
- Trial name
- NCT00592748
- Testing
- Charged Particle Radiation Therapy
- Where
- United States
- Volunteers
- 381 people
- Sponsor
- Massachusetts General Hospital
Chordoma of Spine, Chordoma of Sacrum
High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull
There are two types of external radiation treatments; proton beam and photon beam radiation. What type of therapy participants will receive will depend upon the location of their tumor.
- Conditions
- Chordoma of Spine, Chordoma of Sacrum, Chordoma of Base of Skull, Chondrosarcoma of the Spine
- Trial name
- NCT01346124
- Testing
- High Dose Intensity Modulated Proton Radiation
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Massachusetts General Hospital
Chordoma, Tumor
Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base
This study is a prospective randomised clinical phase III trial. The primary objective of this study is to evaluate, if the innovative therapy (carbon ion irradiation) in chordomas is superior to the standard proton treatment…
- Conditions
- Chordoma, Tumor, Treatment
- Trial name
- HIT-1 (NCT01182779)
- Testing
- Carbon ion, Protons
- Where
- Germany
- Volunteers
- 319 people
- Sponsor
- Heidelberg University
Chordomas, Chondrosarcomas
Proton Therapy for Chordomas and/or Chondrosarcomas
The purpose of this study is to collect information from medical records to see what effects proton beam radiation has on cancer and analyze possible side effects.
- Trial name
- CH01 (NCT00797602)
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- University of Florida
Chordoma of Clivus
Study to Evaluate the Efficacy of Afatinib in Skull Base Chordoma
This is a single arm, open label, single center, and prospective, interventional study to explore clinical efficacy of afatinib in patients with chordoma of skull base.
- Trial name
- NCT05519917
- Testing
- Afatinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huashan Hospital
Skull Base Chordoma, Vertebral Chordoma
Improvement of Local Control in Skull Base, Spine and Sacral Chordomas Treated by Surgery and Protontherapy Targeting Hypoxic Cells Revealed by [18F]FAZA) PET/CT Tracers
Improved local control of chordoma initially treated with surgery or not, thanks to adjuvant radiotherapy oriented by conventional imaging Computed Tomography /Magnetic Resonance Imaging (CT / MRI) and guided by the [18Fluor]…
- Trial name
- PROTONCHORDE01 (NCT02802969)
- Testing
- Surgery, Protontherapy, 18F FAZA
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Institut Curie
Chordoma, Chondrosarcoma
Hypofractionated Protontherapy in Chordomas and Chondrosarcomas of the Skull Base
The project is planned as a phase II clinical trial with a low level of intervention, for the prospective evaluation of the clinical results of radical or adjuvant treatment by proton therapy in chordomas and chondrosarcomas of…
- Trial name
- NCT05861245
- Testing
- 5-fraction hipofractionated protontheray, 25-fraction hypofractionated proton therapy
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Quironsalud
Chordoma of Spine, Chordoma of Skull Base
Exploration of Personalized Biomarkers During Neoadjuvant Radiation Therapy for Spinal and Sacral Chordoma
In this study the investigators will study the effects of neoadjuvant radiation therapy (RT), in the form of either proton therapy or stereotactic body radiation therapy (SBRT), on the Circulating tumor DNA (ctDNA), radiographic…
- Conditions
- Chordoma of Spine, Chordoma of Skull Base, Chordoma of Sacrum
- Trial name
- Canon (NCT06463262)
- Testing
- ctDNA
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Skull Base Chordoma
Multi-parametric Imaging in Personalized Radiotherapy
The study consists in the retrospective and prospective collection of imaging data (along with clinical information related to treatment) of skull-base chordoma patients treated with particle therapy, to derive imaging biomarkers…
- Trial name
- NCT05888064
- Testing
- diffusion MRI sequences
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- CNAO National Center of Oncological Hadrontherapy
Chordoma
Proton Beam Therapy for Chordoma Patients
The goal of this clinical research study is to learn if proton beam therapy, with or without photon beam radiation therapy, is effective in the treatment of skull base chordoma. The safety of this treatment will also be studied.
- Trial name
- NCT00496119
- Testing
- Proton Beam Therapy, Photon Beam Therapy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- M.D. Anderson Cancer Center