Clinical trials: Sleep Apnea, Obstructive
Obstructive Sleep Apnea
Long-term Follow-up of Children With OSA Treated With AT
Objectives: To assess the cardiovascular outcomes of children with obstructive sleep apnoea (OSA) at a mean of 5 years after they had undergone adenotonsillectomy (AT), compared to OSA children who did not undergo AT, and normal…
- Trial name
- NCT04473066
- Testing
- Adenotonsillectomoy +/- turbinate reduction
- Where
- 2 sites in Hong Kong
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Stroke, Obstructive Sleep Apnea
Role of Obstructive Sleep Apnea in Stroke Appearance
Stroke is the third leading cause of death in industrialized countries and the first cause of handicap in adults. Several stroke risk factors were identified such as high blood pressure, diabetes mellitus, hypercholesterolemia or…
- Trial name
- AVSAS (NCT00613522)
- Testing
- polygraphic study
- Where
- France
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Obstructive Sleep Apnea
Sodium-Restricted Diet and Diuretic in the Treatment of Severe Sleep Apnea
This study evaluates the intervention of the 1) sodium-restricted diet, or 2) diuretic, or 3) placebo pill in the treatment of obstructive sleep apnea in adults.
- Trial name
- DESALT (NCT01945801)
- Testing
- Lasilactone, Sodium-Restricted Diet
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Obstructive Sleep Apnea, Orthodontic Tooth Movement
The Effect of Tooth Position During Orthodontic Treatment on the Apnea/ Hypopnea Index (AHI)
The study design of this research project involves orthodontic patients registered at the Harvard School of Dental Medicine who are deemed eligible to undergo orthodontic treatment and who have been provided with sufficient…
- Conditions
- Obstructive Sleep Apnea, Orthodontic Tooth Movement, Apnea, Sleep Disordered Breathing
- Trial name
- NCT03299023
- Testing
- Medibyte Portable Monitor
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Harvard School of Dental Medicine
Obstructive Sleep Apnea (OSA)
Level 3 Validation Study
This study will compare the output of a new Level 3 polysomnography system against in-laboratory polysomnography.
- Trial name
- NCT07688603
- Testing
- Comparison 1: Level 1 Polysomnography: Cadwell/Alice, Comparison 2: Level 3 Test: Berry Sleep Apnea Screening Monitor
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Windsor Sleep Disorders Clinic
Insulin Sensitivity, Obstructive Sleep Apnea
Obesity, Sleep Apnea, and Insulin Resistance
Obstructive sleep apnea (OSA) and type 2 diabetes confer increasing economic, social, and public health burdens in the United States.
- Trial name
- NCT02192684
- Testing
- Pioglitazone
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sleep Apnea
Comparison of RT in Patients With Sleep Apnea With and Without Complaints of Daytime Sleepiness
Not all patients with the Obstructive Sleep Apnea Syndrome (OSAS), mostly mild, have excessive daytime sleepiness. Sleep fragmentation provides the performance decrease with increasing reaction time to external stimuli and…
- Trial name
- NCT01562262
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Obstructive Sleep Apnea
Effects of Continuous Positive Airway Pressure (CPAP) in Heart Remodeling by Magnetic Resonance Imaging (MRI)
Obstructive sleep apnea (OSA) is independently associated with important heart remodeling that further contributes to overt heart failure.
- Trial name
- OSA-MRI (NCT00727454)
- Testing
- CPAP, No treatment
- Where
- 2 sites in Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Obstructive Sleep Apnea, Insomnia
Effect of Eszopiclone on Adherence to CPAP and Severity of Insomnia in Patients With COMISA
The comorbidity between obstructive sleep apnea (OSA) and insomnia (COMISA) is common, and associated with poorer sleep quality. CPAP adherence among COMISA patients is worst than among those with OSA only.
- Trial name
- NCT06017921
- Testing
- Eszopiclone 3 mg
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Obstructive Sleep Apnea
Non-invasive Device for the Screening and Diagnosis of Sleep Apnea Syndrome
This prospective study aims to establish and evaluate a predictive model to diagnose OSA with maxillofacial characteristics 3D acquisition.
- Trial name
- Episas (NCT03632382)
- Testing
- 3D acquisition of maxillofacial characteristics
- Where
- France
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea
Evaluation of Potential Biomarkers for Obstructive Sleep Apnea and the Effect of Positive Pressure Treatment
Potential biomarkers for obstructive sleep apnea (OSA), and full genomic screening will be evaluated and correlated to the degree of OSA and to effect of CPAP-treatment measured by polygraphy.
- Trial name
- NCT01976052
- Where
- Sweden
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Obstructive Sleep Apnoea, Obesity
Obstructive Sleep Apnoea and Adipose Tissue Dysfunction
Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea.
- Conditions
- Obstructive Sleep Apnoea, Obesity, Hypoxia
- Trial name
- NCT02518633
- Testing
- Continuous positive airway pressure devices
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Obstructive Sleep Apnea
The Effects of Nasal Airflow on Upper Airway Dilator Muscles During Sleep
Obstructive sleep apnea (OSA) is an increasingly prevalent disorder characterized by repeated upper airway collapse during sleep, resulting in oxygen desaturation and frequent arousals. The etiology of OSA remains unclear.
- Trial name
- NCT03506178
- Testing
- Oxymetazoline Nasal Spray, Menthol Nasal Spray, Normal saline Nasal Spray
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Obstructive Sleep Apnea
Derivation and Validation of a Combination of BOSTON Score and DES-OSA Score for Selection of OSA Patients.
Derivation and Validation of a combination of BOSTON score and DES-OSA score to exclude OSA or to confirm OSA in patients.
- Trial name
- NCT03983564
- Testing
- Cutoff Validation
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Astes
Pediatric Obstructive Sleep Apnea
Development of a Wearable Point of Care Monitoring Device for Pediatric Obstructive Sleep Apnea
Background: Obstructive sleep apnea (OSA) occurs when the blockage of the airway causes a person to stop breathing involuntarily for 10 seconds or more throughout the night during sleep.
- Trial name
- NCT05052216
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Obstructive Sleep Apnea, Postoperative Pain
Effect of Sleep Apnea on Pain After Dental Treatment
This observational study aims to investigate the effects of sleep quality and systemic health status on pain levels following endodontic treatment in adult patients.
- Conditions
- Obstructive Sleep Apnea, Postoperative Pain, Hypertension Complicated With Type 2 Diabetes
- Trial name
- OSA-EndoPain (NCT07581964)
- Testing
- Standard Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Harran University
Obstructive Sleep Apnea (OSA)
Assessing the Validity of the PAP Problems Triage Tool in Patients With PAP Treatment for Obstructive Sleep Apnea
The intended use of the Positive Airway Pressure (PAP) Problems Triaging Tool (TT) is to appropriately triage patients with a PAP-associated problem(s) to a specific intervention(s) based on patient responses.
- Trial name
- TriagingTool (NCT05530967)
- Testing
- TT, VE
- Where
- United States
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Obstructive Sleep Apnea, Healthy Subjects
Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Healthy Subjects and Adult and Elderly Subjects With Mild Obstructive Sleep Apnea
This study will be conducted to determine whether lemborexant as compared to placebo decreases the peripheral oxygen saturation during total sleep time in healthy adult and elderly participants after a single dose of treatment…
- Trial name
- NCT03471871
- Testing
- Lemborexant 10 mg, Lemborexant 25 mg
- Where
- 11 sites in United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Shift-Work Sleep Disorder, Insomnia
Fire Fighter Fatigue Management Program: Operation Healthy Sleep
Firefighters work some of the most demanding schedules known under highly stressful and demanding conditions. The need to work frequent extended shifts and long work weeks leads to acute and chronic partial sleep deprivation as…
- Conditions
- Shift-Work Sleep Disorder, Insomnia, Restless Leg Syndrome, Obstructive Sleep Apnea
- Trial name
- NCT01988129
- Testing
- Sleep disorders education and screening
- Where
- United States
- Volunteers
- 1,189 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Circadian Rhythms and Cardiovascular Risk
The purpose of this study is to understand how behaviors and the effects of the body's internal clock (called the circadian pacemaker) affect the control of the heart and blood pressure.
- Trial name
- NCT02202811
- Testing
- Forced Desynchrony
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University