Clinical trials: Sleep Disorder; Breathing-Related
Obstructive Sleep Apnea, Hypertension
Assessment of Heart Rate Variability for Predicting Obstructive Sleep Apnea in Patients With Hypertension
This study aims to investigate the relationship between hypertension and obstructive sleep apnea (OSA) using heart rate variability (HRV) as a non-invasive biomarker of autonomic nervous system function.
- Trial name
- HRV-OSA-HTN (NCT07603583)
- Testing
- Polysomnography
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Kaohsiung Armed Forces General Hospital
Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Sleep Related Breathing Disturbances in Patients With Respiratory Disease at Altitude
In this trial, the investigators will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on sleep related breathing disturbances at altitude in patients with COPD.
- Trial name
- NCT03177850
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 185 people
- Sponsor
- University of Zurich
Recurrent Tonsillitis, Obstructive Sleep Apnea
Post-operative Pain Control After Pediatric Adenotonsillectomy
Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in…
- Conditions
- Recurrent Tonsillitis, Obstructive Sleep Apnea, Sleep Disordered Breathing, Adverse Reaction to Drug
- Trial name
- NCT02296840
- Testing
- Ibuprofen, Hydrocodone-Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Emory University
Obesity Hypoventilation Syndrome (OHS)
Functional Capacity, Sleep Quality, and Cognitive Function in Obesity Hypoventilation Syndrome
Introduction: Obesity Hypoventilation Syndrome (OHS) is defined as the coexistence of obesity (BMI ≥ 30 kg/m²), daytime hypercapnia (PaCO₂ > 45 mmHg) in the absence of other causes of hypoventilation, and sleep-disordered…
- Trial name
- NCT07147153
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Bezmialem Vakif University
Transurethral Resection of Bladder Tumor, Transurethral Resection of the Prostate (TURP)
Effect of Cyclic Sighing Breathing Exercise on CRBD, Pain, and Sleep Quality in Patients Undergoing TUR
Transurethral resection (TUR) is a common minimally invasive surgical procedure for lower urinary tract diseases. However, postoperative urinary catheterization often causes catheter-related bladder discomfort (CRBD) and pain due…
- Conditions
- Transurethral Resection of Bladder Tumor, Transurethral Resection of the Prostate (TURP), Transurethral Resection of the Bladder
- Trial name
- NCT07843602
- Testing
- Cyclic Sighing Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Mersin University
Sleep Apnea Syndromes, Insomnia Disorder
Apnea and Insomnia Relief Study
The purpose of this study is to determine whether a behavioral sleep treatment improves functioning and sleep in Veterans with posttraumatic stress disorder (PTSD).
- Conditions
- Sleep Apnea Syndromes, Insomnia Disorder, Stress Disorders, Post-Traumatic
- Trial name
- AIR (NCT04007796)
- Testing
- Apnea and Insomnia Relief (AIR), Sleep Education (SE)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Sleep Apnea Syndrome, Obstructive, Bruxism, Sleep-Related
Bruxism Induced by Obstructive Sleep Apnoea.
The relationship between obstructive sleep apnea (OSA), sleep bruxism, and temporomandibular disorders is becoming clearer, but data on how upper airway volume affects bruxism due to OSA is limited.
- Conditions
- Sleep Apnea Syndrome, Obstructive, Bruxism, Sleep-Related, Upper Respiratory Tract Illness
- Trial name
- OSA Bruxism (NCT07511946)
- Testing
- Upper airway volume assessment using Cone-Beam Computed Tomography (CBCT) and Polysomnography, Upper airway volume assessment using Cone-Beam Computed Tomography (CBCT)
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Sleep Initiation and Maintenance Disorders, Sleep
Sleep Disturbances in the 2nd and 3rd Trimester
Sleep disorders and disturbances are mostly underestimated in clinical practice. Moreover, this problem is generally neglected by the pregnant themselves.
- Conditions
- Sleep Initiation and Maintenance Disorders, Sleep, Sleep Apnea, Sleep Disorder
- Trial name
- NCT03763071
- Testing
- Patient-reported scales to measure sleep disorders
- Where
- Turkey (Türkiye)
- Volunteers
- 683 people, healthy volunteers welcome
- Sponsor
- Bartin State Hospital
Sleep Apnea
Evaluation of the Noga System: Detecting of Respiratory Related Sleep Disorders in Cardiac Patients
Medical literature has shown that 1 out of 2 patients that are admitted to the hospital as a cardiac patient, will be found suffering from sleep breathing disorders.
- Trial name
- NCT00800397
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- WideMed LTD.
Asthma, Obstructive Sleep Apnea
Asthma and Obstructive Sleep Apnea (OSA)
Obstructive sleep apnea (OSA) is a common but under-diagnosed form of sleep disordered breathing (SDB). Asthma is a common disease with rising prevalence, which continues to pose significant morbidity and costs.
- Trial name
- NCT01026298
- Testing
- FDA-Approved Treatment
- Where
- United States
- Volunteers
- 744 people
- Sponsor
- University of Wisconsin, Madison
Diabetes Mellitus, Hypertension
Safety and Efficacy of Xenical in Children and Adolescents With Obesity-Related Diseases
Obesity is a condition affecting one-third off the U.S. population and is a major risk actor for the development of Type 2 diabetes, hyperlipidemia (increased levels of fat in the blood), hypertension (high blood pressure), and…
- Conditions
- Diabetes Mellitus, Hypertension, Metabolic Disease, Obesity
- Trial name
- NCT00001723
- Testing
- Orlistat
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jack Yanovski
Sleep Apnea, Obstructive, Pregnancy Related
Efficacy of Oral Appliances on Obstructive Sleep Apnea During Pregnancy
Issue: The prevalence and severity of sleep-disordered breathing increases during pregnancy due to weight gain, physiological and hormonal changes.
- Trial name
- OSApod (NCT03138291)
- Testing
- Somnodent
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Sleep Apnea Syndromes
Cloud Based Follow up of CPAP Treatment
Obstructive sleep apnea (OSA) is treated with a continuous positive airway pressure, so called CPAP. A new technology that enables telemetric monitoring of CPAP therapy.
- Trial name
- NCT03446560
- Testing
- CPAP, conventional follow up, CPAP, telemedicine based follow up
- Where
- Sweden
- Volunteers
- 403 people
- Sponsor
- Vastra Gotaland Region
Physical Activity, Sleep Apnea
Examining the Association Between Physical Activity and Sleep Quality in Children With Autism Spectrum Disorder
This study aims to investigate whether physical activity intervention would be effective to improve sleep quality in children with ASD, and investigate how physical activity impacts on sleep in children with ASD through…
- Conditions
- Physical Activity, Sleep Apnea, Autism Spectrum Disorder
- Trial name
- NCT03348982
- Testing
- Jogging program
- Volunteers
- 32 people
- Sponsor
- The Hong Kong Polytechnic University
Obstructive Sleep Apnea
Optimizing Treatment Effects on OSA-related Clinical and Patient-centered Outcomes Among Blacks
The study is to maximize efficacy of message delivery to achieve desired Obstructive sleep apnea (OSA) adherence goal. Newly diagnosed black patients (n=390, all genders) from participating sleep clinics will be randomly exposed…
- Trial name
- NCT03354520
- Testing
- Tailored Videos, OSA Treatment, Standard Videos
- Where
- United States
- Sponsor
- NYU Langone Health
Sleep Apnea, Insomnia
Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities.
Rural communities in the southern U.S. suffer a disproportionate burden of morbidity and mortality from cardiometabolic disease, with traditional risk factors explaining only a modest proportion of the excess burden of disease.
- Conditions
- Sleep Apnea, Insomnia, Sleep Deprivation, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT06336525
- Where
- United States
- Volunteers
- 3,680 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Assessing the Symptoms of Obstructive Sleep Apnea
The purpose of this study is to investigate the correlation between health outcomes associated with the severity of obstructive sleep apnea (OSA) symptomatology, the findings will guide the design of interventional studies.
- Trial name
- OSA (NCT01481636)
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- Bangor University
Obstructive Sleep Apnea, Postoperative Pain
Effect of Sleep Apnea on Pain After Dental Treatment
This observational study aims to investigate the effects of sleep quality and systemic health status on pain levels following endodontic treatment in adult patients.
- Conditions
- Obstructive Sleep Apnea, Postoperative Pain, Hypertension Complicated With Type 2 Diabetes
- Trial name
- OSA-EndoPain (NCT07581964)
- Testing
- Standard Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Harran University
Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Domiciliary Nasal High Flow and Patient Outcomes in Chronic Hypercapnic Respiratory Failure in the United Kingdom
Chronic hypercapnic respiratory failure (CHRF) in the context of Chronic Obstructive Pulmonary Disease (COPD) and Obesity Hypoventilation Syndrome (OHS) is associated with increased mortality.
- Conditions
- Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Obesity Hypoventilation Syndrome (OHS), Nasal High Flow
- Trial name
- NCT05167201
- Testing
- Nasal High Flow
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Obstructive Sleep Apnea of Adult, Mild Cognitive Impairment
The Relationship Between Obstructive Sleep Apnea and Alzheimer's Disease: Evidence and Effectiveness
The research plan to enroll 15 simple snoring patients (apnea/hypopnea <5, control group), 30 severe OSA patients (apnea/hypopnea >30, treatment group), and 15 mild cognitive impairment patients (comparative group).
- Trial name
- OSA (NCT05433883)
- Testing
- sleep surgery
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital