Clinical trials: Sleep Disorder (Disorder)
Positive Airway Pressure Therapy, Obstructive Sleep Apnea
F&P Toffee Full Face Mask Clinical Trial, NZ, 2020
This will be a prospective, multi-arm, randomized, and non-blinded clinical trial designed to evaluate the performance, comfort, and usability of the Toffee full face mask amongst participants who have been prescribed PAP therapy…
- Trial name
- NCT04615832
- Testing
- Toffee Full Face Mask
- Where
- 3 sites in New Zealand
- Volunteers
- 44 people
- Sponsor
- Fisher and Paykel Healthcare
Restless Legs Syndrome, Ekbom Syndrome
Switching From Oral Dopamine Agonists to Rotigotine
The primary objective is to demonstrate safety and tolerability of switching patients with Restless Legs Syndrome (RLS) from an oral dopamine agonist to rotigotine.
- Conditions
- Restless Legs Syndrome, Ekbom Syndrome, Willis-Ekbom Disease
- Trial name
- SWITCH (NCT01976871)
- Testing
- Rotigotine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- John Winkelman, MD, PhD
Heart Failures
Predicting Successful Sleep Apnea Treatment With Acetazolamide in Heart Failure Patients
The ultimate goal is to improve our understanding of the pathophysiology and resistance to effective treatment of sleep disordered breathing in patients with heart failure, with a focus on selecting patients that will benefit…
- Trial name
- HF-ACZ (NCT01377987)
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- David Andrew Wellman
Excessive Sleepiness, Shift-work Disorder
Clinical Trial of Solriamfetol for Excessive Sleepiness Related to Shift Work Disorder
In this research study the investigators want to learn more about whether the medication Solriamfetol improves daytime sleepiness in workers who start work at very early times (between 3 and 6am).
- Trial name
- NCT04788953
- Testing
- Solriamfetol Oral Tablet
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Charles A. Czeisler, PhD, MD
Anxiety, Sleep Disturbance
Targeting Worry to Improve Sleep
The purpose of this study is to test an app-based mindfulness training program for worry to see if it can help individuals decrease worry and improve sleep.
- Trial name
- NCT03684057
- Testing
- App-Delivered Mindfulness Training (MT)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Brown University
Obesity, Childhood, Overweight and Obesity
First Heroes: Engaging Fathers in the First 1000 Days
The First Heroes study plans to influence weight and health trajectories, modify disease risk, and improve health care services for mother-father-infant triads from racial/ethnic minority and health disparity populations.
- Conditions
- Obesity, Childhood, Overweight and Obesity, Social Determinants of Health, Physical Activity
- Trial name
- First Heroes (NCT04477577)
- Testing
- New Parent Intervention, Safety Control
- Where
- United States
- Volunteers
- 657 people
- Sponsor
- Massachusetts General Hospital
Obstructive Sleep Apnea
Trial of AD036 in Obstructive Sleep Apnea
This is a randomized, double blind, placebo-controlled, repeat-dose, parallel arm, outpatient and inpatient phase 2 clinical study to examine the efficacy and safety of three dose levels of AD036 versus placebo in patients with…
- Trial name
- NCT03845023
- Testing
- AD036 Dose 1, AD036 Dose 2, AD036 Dose 3
- Where
- 12 sites in United States
- Volunteers
- 140 people
- Sponsor
- Apnimed
Sleep Deprivation, Pain
Mechanisms of Sleep Disruption Hyperalgesia
Twenty percent of Americans suffer from chronic pain. Sleep disturbance is similarly prevalent and among the most common and disabling neurobehavioral problems associated with chronic pain.
- Trial name
- ESP2 (NCT01794689)
- Testing
- Morphine, Forced Awakenings, Uninterrupted Sleep
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sleep Disordered Breathing, Sleep Apnea, Central
Evaluation of Software Enhancements to the Respironics BiPAP Auto Servo Ventilation (AutoSV) Device
This study is being undertaken to collect data from Respironics Inc's BiPAP Auto Servo Ventilation 3 (autoSV3) and compare with data from Respironics, Inc's BiPAP autoSV2, to confirm that the algorithms in the BiPAP autoSV3…
- Trial name
- AUTOSV3 (NCT00720213)
- Testing
- Respironics BiPAP autoSV2, Respironics BiPAP autoSV3
- Where
- 5 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Philips Respironics
Epilepsy
Effects of Clobazam on Sleep and Daytime Function in Patients With Epilepsy
The purpose of this study is to monitor the effect of Clobazam on sleep and daytime alertness in people with Epilepsy.
- Trial name
- NCT02911025
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Brigham and Women's Hospital
Narcolepsy
An Interventional Safety Switch Study (Segue Study) of XYWAV in Narcolepsy
The rationale for the interventional, open-label, single-arm design of JZP258-401 is to evaluate the clinical experience in participants with narcolepsy transitioning treatment from Xyrem to XYWAV.
- Trial name
- NCT04794491
- Testing
- JZP-258
- Where
- 28 sites in United States
- Volunteers
- 62 people
- Sponsor
- Jazz Pharmaceuticals
Insomnia, Primary, Depression
Sleep to Prevent Evolving Affecting Disorders
The primary objective of the proposed research is to determine the efficacy of Digital Cognitive Behavior Therapy (dCBTI) in reducing severity of depression and also in preventing the incidence and relapse of depression among…
- Trial name
- SPREAD (NCT02988375)
- Testing
- dCBTI, Sleep Education
- Where
- United States
- Volunteers
- 1,385 people
- Sponsor
- Henry Ford Health System
Obstructive Sleep Apnea
A Development Study to Evaluate a Nasal Mask for the Treatment of Obstructive Sleep Apnea
This investigation is designed to evaluate the comfort, ease of use and performance of a trial nasal mask for the treatment of Obstructive Sleep Apnea (OSA) in the home environment.
- Trial name
- NCT03124069
- Testing
- F&P Saturn
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Fisher and Paykel Healthcare
Insomnia Chronic
Effectiveness of BBT-I and Zopiclone for Chronic Insomnia
Background: Importance of chronic insomnia (CI) problem is determined by its high prevalence rate, comorbidity and resistance to the treatment.
- Trial name
- NCT03339583
- Testing
- Brief behavioral therapy, Zopiclone
- Volunteers
- 42 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Insomnia
Pharmacokinetic and Safety of Ramelteon Between Adolescents With Insomnia and Healthy Adults
The purpose of this study is to determine the pharmacokinetic profile, safety, and tolerability of ramelteon in adolescents with insomnia, children with Attention Deficit Hyperactivity Disorder (ADHD) associated with insomnia and…
- Trial name
- NCT00914862
- Testing
- Ramelteon
- Where
- 2 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Takeda
Obstructive Sleep Apnea
Validation of Sleep Apnea Screening Device
Obstructive sleep apnea (OSA) is the most common type of sleep apnea. OSA affects an estimated 18-40 million adults and 0.7-3% of all children in the US.
- Trial name
- NCT02814227
- Testing
- Zansors® sleep screening device
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Michigan
Shift-Work Sleep Disorder
Effects of Daytime Eszopiclone Administration in Shift Workers
The purpose of this study is to test the effects of eszopiclone on daytime sleep and overnight wakefulness in shift workers.
- Trial name
- NCT00900159
- Testing
- eszopiclone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Comparison of High Flow Nasal Cannula Therapy to Nasal Oxygen as a Treatment for Obstructive Sleep Apnea in Infants
This is a small pilot study that will compare High Flow Nasal Cannula (HFNC) therapy to oxygen nasal cannula therapy on infants who have obstructive sleep apnea (OSA) and are scheduled for a clinically ordered sleep study called…
- Trial name
- NCT02858154
- Testing
- HFNC, Low flow oxygen by nasal cannula
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Autism Spectrum Disorder, Sleep Disturbance
Telehealth Delivery of Treatment for Sleep Disturbances in Young Children With Autism Spectrum Disorder
Study Design: Ninety children with Autism Spectrum Disorder (ASD), between the ages of 2 to less than 7 years, and their parents will be recruited for this 10 week randomized clinical trial.
- Trial name
- NCT03668873
- Testing
- Sleep Parent Training, Sleep Parent Education
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- The Cleveland Clinic
Sleep Apnea, Obstructive
Titration Pressures in Sleep Apnea Patients Using ThermoSmart® Versus Conventional Humidification
Patients who have Obstructive Sleep Apnea (OSA) may have different Continuous Positive Airway Pressure (CPAP)when titrated with different levels of humidification.
- Trial name
- NCT00681083
- Testing
- Heated breathing tube (CPAP with ThermoSmart), Non heated breathing tube (CPAP with conventional humidification)
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Fisher and Paykel Healthcare
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