Clinical trials: Sleep Disorder Rem Sleep Behavior
REM Behavior Disorder, Parkinson Disease
Quantification of Phosphorylated Alpha-synuclein in Cutaneous Biopsies as a Prospective Biomarker in Parkinson's Disease
This study aims to assess the levels of phosphorylated alpha-synuclein (P-SYN) in patients with Parkinson's disease and REM Behavior Disorder using a minimally invasive skin punch biopsy.
- Trial name
- Syn-Q (NCT06621602)
- Where
- 18 sites in United States
- Volunteers
- 100 people
- Sponsor
- CND Life Sciences
Insomnia Chronic, Narcolepsy
The Impact of Light, Electrical, and Magnetic Neuroregulation Interventions on Sleep-wake Disorders
Carry out precise and effective neuromodulation interventions, and develop new neuromodulation technologies for sleep disorders.
- Conditions
- Insomnia Chronic, Narcolepsy, REM Sleep Behavior Disorder
- Trial name
- NCT06797284
- Testing
- Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Premature Infant Sleep
Sleep Organization in Premature Infants With Feeding Difficulties
Babies born too soon, premature babies, can have complications following birth because their systems are immature. Hospitals help prevent deformities and delays in motor development by using therapeutic positioning to provide…
- Trial name
- NCT01946308
- Testing
- Conformational positioning system
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
REM Sleep Behavior Disorder, Pre-motor Parkinson's Disease
Terazosin Effect on Cardiac Changes in Early Parkinson's Disease
Parkinson's disease (PD) is characterized by many non-motor symptoms that occur several years before the diagnosis, in particular idiopathic REM behavior disorder (iRBD), which is associated with autonomic impairment.
- Conditions
- REM Sleep Behavior Disorder, Pre-motor Parkinson's Disease, Symptomatic Parkinson Disease
- Trial name
- NCT04386317
- Testing
- Terazosin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cedars-Sinai Medical Center
Mild Cognitive Impairment, Lewy Body Dementia, Parkinson's Disease Rapid Eye Movement Sleep Behavior Disorder, Parkinson's Disease Dementia
A Study of Clenbuterol (CST-103) Co-administered With Nadolol (CST-107) in Subjects With Neurodegenerative Disorders
This is a Phase II, randomized, placebo-controlled, double-blind, crossover study on the CNS and pharmacodynamic effects of clenbuterol (CST-103) co-administered with nadolol (CST-107) in 4 subject populations with…
- Trial name
- CLIN-011 (NCT04739423)
- Where
- 7 sites in Australia, New Zealand and 1 more
- Volunteers
- 41 people
- Sponsor
- CuraSen Therapeutics, Inc.
REM Sleep Behavior Disorder
Familial Aggregation and Biomarkers in REM Sleep Behaviour Disorder.
In this cohort study, the investigators aim to study the familial aggregation of REM sleep behavior disorder (RBD) and compare the differences in major biomarkers of neurodegeneration, including percentage of EMG activity during…
- Trial name
- NCT03660982
- Where
- Hong Kong
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Multiple Sclerosis, Parkinson Disease
Intestinal Immunity in Neurologic Disease
The purpose of this study is to ascertain the functional profiles of the immune cells within the gastrointestinal tract and to determine how these cells contribute to autoimmune and neurologic diseases.
- Conditions
- Multiple Sclerosis, Parkinson Disease, REM Sleep Behavior Disorder
- Trial name
- NCT06329453
- Testing
- Colon Tissue Biopsy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University
Parkinson Disease, REM Sleep Behavior Disorder
Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder
This is a prospective cohort study to evaluate degenerative changes in the brain by performing functional imaging analysis in patients with RBD and its correlations with clinical symptoms and dopaminergic degeneration.
- Trial name
- NCT02984137
- Testing
- testing, evaluation, sampling
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Parkinsonism, REM Sleep Behavior Disorder
A Multimodal Prospective Cohort Study of Parkinsonism
This is a single-center, prospective, observational cohort study designed to investigate the progression and differential diagnosis of Parkinsonism using a multimodal approach.
- Trial name
- NCT07553845
- Where
- China
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Parkinson Disease (PD)
L-THEANINE AND MEDITERRANEAN DIET ON RBD, GI FUNCTION, AND INFLAMMATION IN PARKINSON'S DISEASE
Parkinson's disease is a progressive neurological disorder associated with severe dopaminergic neuron loss in the substantia nigra pars compacta.
- Trial name
- NCT07682532
- Testing
- Dietary Supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Medipol University
REM Sleep Behavior Disorder
Gut Microbiota Across Early Stages of Synucleinopathy: From High-risk Relatives, REM Sleep Behavior Disorder to Early Parkinson's Disease
With the global ageing population, neurodegenerative disorders including synucleinopathy are major burdens to patients, carers and society.
- Trial name
- NCT03645226
- Testing
- Colonoscopy
- Where
- 2 sites in Hong Kong
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Autism Spectrum Disorders
A Trial of the Drug Donepezil for Sleep Enhancement and Behavioral Change in Children With Autism
Background: Some children with autism spectrum disorders (ASD) do not have normal sleep cycles. Some of these children spend very little time in the rapid eye movement (REM) stage of sleep.
- Trial name
- NCT01887132
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Mental Health (NIMH)
Autism, Cognition Disorder
The Effect of Donepezil (Aricept(Registered Trademark)) on REM Sleep in Children With Autism
This study will test whether donepezil (Aricept(Registered Trademark)), a drug that is approved by the Food and Drug Administration to treat Alzheimer's disease, can increase rapid eye movement (REM) sleep in children with autism…
- Trial name
- NCT00695136
- Testing
- Donepezil hydrochloride, Increase REM sleep percentage
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Institute of Mental Health (NIMH)
REM Sleep Behavior Disorder
DREAMER - IsolateD REM Sleep Without Atonia as a Risk Factor for REM Sleep Behavior disordER
This study aims at the constitution of a large cohort of adult subjects without Rapid eye movement (REM) sleep behavior disorder (RBD), among whom subjects with isolated REM sleep without atonia (RSWA) will be identified; their…
- Trial name
- DREAMER (NCT06140511)
- Testing
- Polysomnography
- Volunteers
- 600 people
- Sponsor
- Oasi Research Institute-IRCCS
Narcolepsy Type 1, Hypnagogic Hallucinations
Imagery Control Therapy and Lucid Dreaming for REM-Related Symptoms in Narcolepsy
This randomized controlled trial evaluated the efficacy of a cognitive behavioral intervention based on lucid dreaming training and imagery control therapy for reducing REM-related symptoms in patients with narcolepsy type 1.
- Conditions
- Narcolepsy Type 1, Hypnagogic Hallucinations, Sleep Paralysis, REM Sleep Intrusion Symptoms
- Trial name
- ICLDR-NAR Tria (NCT07609537)
- Testing
- Cognitive Behavioral Therapy for Narcolepsy (CBT-NAR) With Lucid Dreaming and Imagery Control Therapy, Sleep Hygiene Education and Structured Clinical Follow-up
- Where
- Colombia
- Volunteers
- 98 people
- Sponsor
- Institute of Behavioral Sleep Medicine, Colombia
Parkinson Disease, REM Sleep Behavior Disorder
Ultra High Field Magnetic Resonance Imaging as a Biomarker for Premotor Parkinson's Disease
This is a prospective observational study investigating the utility of 7 Tesla MRI to quantify nigrosome1 signal in a cohort of individuals with recent onset Parkinson's disease and in at-risk cohorts at a premotor state of…
- Trial name
- NCT03288909
- Testing
- MRI
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
REM Sleep Behavior Disorder
Effects of Tablet Computer-based Cognitive Training in Patients With Idiopathic REM Sleep Behavior Disorder
To evaluate the effectiveness of tablet computer-based cognitive training in patients with idiopathic REM sleep behavior disorder.
- Trial name
- NCT05256836
- Testing
- Tablet computer-based cognitive training program
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Sleep Paralysis, Narcolepsy Type 1
Meditation-Relaxation (MR Therapy) for Sleep Paralysis.
The aim of the study is to evaluate, with a small-scale pilot study, the efficacy of Meditation Relaxation therapy for Sleep Paralyses in patients with narcolepsy.
- Trial name
- MR_Therapy (NCT04483310)
- Testing
- MR therapy., breathing-distraction exercise
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Usl di Bologna
REM Sleep Behavior Disorder, Concussion, Brain
The COSP-RBD Study: Concussions and Contact Sports in RBD vs Controls
The goal of this observational study is to investigate concussions and contact sports practices in REM sleep behaviour disorder (RBD).
- Trial name
- COSP-RBD (NCT06270290)
- Testing
- Exposure to contact sports or history of concussions
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Parkinson Disease, Movement Disorders
Multimodal Image Technologies Investigate the Role and Mechanism of Probiotics in Improving RBD with Parkinson's Disease
Rapid eye movement sleep behavior disorder (RBD) is important non-movement feature, and also the important risk factor of Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Movement Disorders, Rapid Eye Movement Sleep Behavior Disorder, Gut Microbiomes
- Trial name
- NCT06710574
- Testing
- PD-RBD, iRBD
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital