Clinical trials: Sleep Disorder Rem Sleep Behavior
Parkinson Disease, REM Sleep Behavior Disorder
Implementing a National Biobank of PD With WGS and Functional Assessment of Polygenic Inheritance by iPSC Technology
The genetic complexity and heterogeneity of the sporadic forms of Parkinson's disease (PD) are posing a formidable challenge to disentangle their direct molecular causes.
- Trial name
- NCT05721911
- Testing
- whole genome sequencing
- Where
- Italy
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
REM Sleep Behavior Disorder
Gut Microbiota in the Progression of Alpha-synucleinopathies
The aim of this study is to correlate baseline gut microbiota features and the progression of neurodegeneration in the established cohort of patients with early Parkinson's disease.
- Trial name
- NCT05353868
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 490 people
- Sponsor
- Chinese University of Hong Kong
Rapid Eye Movement Sleep Behavior Disorder
Sleep Profiles in REM Sleep Behavior Disorder
Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disorder in which you act out dreams during REM sleep. Sleep disturbances are very common in RBD, where they negatively impact patients' quality of life and…
- Trial name
- NCT04886076
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
REM Sleep Behavior Disorder
Study to Determine Whether Ramelteon Helps People With REM Sleep Behavior Disorder
The purpose of this study is to determine whether the use of the drug ramelteon decreases the symptoms of REM Sleep Behavior Disorder.
- Trial name
- NCT01401413
- Testing
- ramelteon
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sleep Medicine Centers of WNY
REM Sleep Behavior Disorder, Parkinson s Disease
Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's Disease
This study will test whether taking ginger supplements can increase ghrelin, a hunger hormone that is decreased in the blood of people with Parkinson's disease (PD) and REM Sleep Behaviour disorder (RBD).
- Trial name
- Ginger-PD (NCT07882108)
- Testing
- Ginger
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Depressed Insomniac Co-morbid Patients
Trazodone on NREM Sleep Stage Ⅲ in Depressed Insomniac Co-morbid Patients
This study used polysomnographic technology and randomly selected 60 patients who met the diagnostic criteria for depression and non-organic insomnia as stipulated in DSM-5 into an intervention group (n=30) and a control group…
- Trial name
- n-REMSS (NCT06740188)
- Testing
- 5-hydroxytryptamine balanced antidepressants trazodone, Citalopram hydrobromide combined with zolpidem
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tongji University
Chronic Insomnia, Sleep Deprivation
Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia
This clinical trial aims to evaluate the safety and efficacy of PROSOMNIA Sleep Therapy (PSTx) for individuals suffering from chronic insomnia, sleep deprivation, and REM sleep disorders.
- Conditions
- Chronic Insomnia, Sleep Deprivation, REM Behavior Disorder, REM Sleep Behavior Disorder
- Trial name
- PSHW (NCT06644573)
- Testing
- PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nyree Penn
Parkinson Disease, Multiple System Atrophy
Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease
To determine whether retinal abnormalities, as measured by high definition optical coherence tomography (HD-OCT) and visual electrophysiology techniques can be used as a clinical biomarker to monitor disease progression overtime…
- Conditions
- Parkinson Disease, Multiple System Atrophy, REM Sleep Behavior Disorder, Pure Autonomic Failure
- Trial name
- NCT02640339
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
REM Sleep Behavior Disorder, Neurodegenerative Diseases
Striatal Dopamine Transmission in Individuals With Isolated Rapid Eye Movement Sleep With Atonia: a Search for Precursor Biomarker for Neurodegeneration
Background: Previous studies have confirmed that most patients with idiopathic REM sleep behaviour disorder (iRBD) eventually develop neurodegenerative diseases.
- Trial name
- NCT03353207
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Parkinson Disease
Exploration of the Mechanism of Movement Improvement During RBD in Parkinson's Disease Using NIRS
The purpose of this study is to confirm the improvement of movement during RBD in Parkinson's disease and to explore the neuronal network involved in this improvement using NIRS.
- Trial name
- NIRS-RBD (NCT03060239)
- Testing
- Near Infrared Spectroscopy
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Clinique Beau Soleil
REM Sleep Behavior Disorder
Neuroplasticity in RBD
REM sleep behavior disorder is a parasomnia that reflects the presence of alpha-synucleinopathy in the brain and is highly predictive of eventual phenoconversion to Parkinson's disease, dementia with Lewy bodies, or multiple…
- Trial name
- NCT05471960
- Testing
- Natural progression over time
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parkinson's Disease, REM Sleep Behavior Disorder
Gait and REM Sleep Behavior Disorder
Many people with idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) have an underlying synucleinopathy, the most common of which are Parkinson's disease (PD) and Lewy body disease.
- Trial name
- RBD-M2H (NCT02554331)
- Testing
- FP-CIT single-photon emission computed tomography, neuropsychological evaluation, Gait recording with sensors
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
REM Sleep Behavior Disorder
Establish a National Registry of REM Sleep Behavior Disorder
In this proposed study, the investigators aim to build up a large cohort of Rapid eye movement sleep behavior disorder (RBD) to study the etiology and risk factors of neurodegeneration.
- Trial name
- NCT03671798
- Where
- Hong Kong
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Nightmare, Nightmare Disorder With Associated Other Sleep Disorder
Behavioral Treatment for Nightmares in REM Sleep Behavior Disorder
The purpose of this clinical trial is learn whether a behavioral (non-medication) treatment can reduce nightmares in adults with Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD).
- Conditions
- Nightmare, Nightmare Disorder With Associated Other Sleep Disorder, REM Sleep Behavior Disorder
- Trial name
- NCT06441864
- Testing
- Cognitive Behavioral Therapy for Nightmares
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
REM Sleep Behavior Disorder, Parkinson Disease
A Study of Efficacy and Safety of Idebenone Vs. Placebo in Prodromal Parkinson Disease
To investigate whether 24 months of idebenone may reduce the progression from Prodromal Parkinson disease (PPD) to Parkinson disease (PD).
- Trial name
- SEASEiPPD (NCT04152655)
- Testing
- Idebenone
- Where
- China
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
REM Sleep Behavior Disorder, Parkinson Disease
Treatment of REM Sleep Behavior Disorder (RBD) With Sodium Oxybate
This study is the first clinical trial using sodium oxybate for the treatment of REM sleep behavior disorder (RBD). Sodium oxybate is a drug approved by FDA for the treatment of narcolepsy which has been used "off label" to treat…
- Trial name
- NCT04006925
- Testing
- Sodium Oxybate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stanford University
Parkinson Disease, REM Sleep Behavior Disorder
Artificial Intelligence in Molecular Imaging: Predicting Parkinson's Risk in REM Sleep Behavior Disorder
The study aims to systematically document the course of REM sleep behavior disorder (RBD) and investigate possible clinical and imaging biomarkers for disease progression and conversion risk to Parkinson's disease (PD), dementia…
- Conditions
- Parkinson Disease, REM Sleep Behavior Disorder, Dementia, Lewy Body
- Trial name
- NUK-RBD (NCT06629207)
- Testing
- PET/CT with 18-FDG, SPECT : 123 I-FP-CIT (DATSCAN), MRI
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Idiopathic REM Sleep Behavior Disorder, Parkinson Disease
Predicting Parkinson's Disease Before It Strikes: A Brain Imaging Study in At-Risk Individual
This study aims to characterize neurodegeneration progression in patients with polysomnography (PSG)-confirmed longstanding idiopathic REM sleep behavior disorder (iRBD) and to develop a prognostic model for clinical evolution…
- Conditions
- Idiopathic REM Sleep Behavior Disorder, Parkinson Disease, Neurodegeneration, Prodromal Parkinson Disease
- Trial name
- iRBD (NCT07729748)
- Testing
- Multiparametric clinical, neuropsychological, PSG and MRI assessment
- Where
- 2 sites in Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Parkinson Disease
Motor Control During Rapid Eye Movement (REM) Sleep Behaviour Disorder
To compare the electrical activity of SubThalamic Nuclei (STN), by mean of local field potentials recordings, during the phasic behaviours of RBD with the electrical activity recorded at this level during the execution of…
- Trial name
- RevesParkNST (NCT01886131)
- Testing
- Synchronised video-polysomnography
- Where
- 2 sites in France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Toulouse
Parkinson Disease, REM Sleep Behavior Disorder
Detecting Parkinson's Disease Through Speech Analysis
Speech is an important indicator of motor function and movement coordination and can be extremely sensitive to involvement in the course of neurologic diseases.
- Trial name
- NCT03133611
- Testing
- Speech assessment, Routine clinical assessment
- Where
- 7 sites in United States, Austria and 5 more
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague