Clinical trials: Sleep Disorders, Intrinsic
Sleep Apnea, Obstructive
Comparison Study of the ICON™ Auto Series With and Without SensAwake™ and ThermoSmart™ and Conventional Continuous Positive Airway Pressure in Obstructive Sleep Apnea Patients
A total of 216 patients will be randomized into a partially single blind, randomized, parallel-arm trial to determine whether the ICON™ AT with SensAwake™ and ThermoSmart™ can improve therapy adherence when compared to standard…
- Trial name
- NCT01517763
- Testing
- Conventional CPAP Therapy, Fixed pressure ICON™ without ThermoSmart™, Auto ICON™ with SensAwake™ and ThermoSmart™
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Fisher and Paykel Healthcare
Diabetes Mellitus Type 2
GLYCOSA Study:Effect of PAP Treatment on Glycemic Control in Patients With Type 2 Diabetes
Obstructive Sleep Apnea (OSA) and type 2 diabetes mellitus are two prevalent medical conditions with significant associated cardiovascular and cerebrovascular morbidity and mortality.
- Trial name
- NCT00509223
- Testing
- Positive Airway Pressure therapy, Lifestyle counseling
- Where
- 15 sites in United States, Australia and 1 more
- Volunteers
- 416 people
- Sponsor
- ResMed
Migraine With Aura, Patent Foramen Ovale
Comorbidities Associated With Migraine and Patent Foramen Ovale (CAMP)
The purpose of the study is to compare the rate of comorbidities associated with migraine aura (MA) between persons who have a large circulatory right-to-left shunt (RLS) and those who do not have RLS.
- Trial name
- CAMP (NCT01257880)
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Swedish Medical Center
Primary Insomnia
Sleep Loss and Mechanisms of Impaired Glucose Metabolism
The purpose of this study is to test the effects of sleep and eszopiclone, a drug that helps people sleep, on how the body processes glucose (sugar). Eszopiclone is approved by the U.S.
- Trial name
- NCT00555750
- Testing
- eszopiclone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Insomnia, Primary Insomnia
Long Term Treatment With Zolpidem: Nightly and Intermittent Dosing
We want to assess whether "how and when" one takes sleep medication results in similar or different outcomes with respect to symptom relief.
- Conditions
- Insomnia, Primary Insomnia, Psychophysiologic Insomnia
- Trial name
- NCT00156533
- Testing
- Zolpidem, Sugar Pill
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Rochester
Insomnia, Sleep-Disordered Breathing
CPAP vs ASV for Insomnia
The study will determine which of two different types of positive airway pressure (PAP therapy) modes are more effective in reducing sleep breathing events in chronic insomnia patients and in decreasing insomnia severity.
- Trial name
- P2P (NCT02365064)
- Testing
- AirCurve 10 ASV
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- ResMed
Sleep Apnea, Obstructive, Pregnancy
Obstructive Sleep Apnea in Pregnancy
Obstructive sleep apnea (OSA) is a risk factor for complications during pregnancy and current screening tools for OSA have not been shown to be reliable in pregnant women.
- Conditions
- Sleep Apnea, Obstructive, Pregnancy, Obesity, Morbid
- Trial name
- OSAinPreg (NCT02383706)
- Testing
- ApneaLink Air, Berlin Quesionnaire, Epworth Sleepiness Scale
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Duke University
Sleep Apnea Syndromes
Amara View Benchmark Study
This randomized crossover, benchmark clinical trial aims to compare the Philips Amara View and ResMed AirFit F40 minimal contact full face masks on patient preference of mask attributes and usage parameters.
- Trial name
- NCT06535932
- Testing
- Amara View Minimal Contact Full Face Mask, F40 Minimal Contact Full Face Mask
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Hypertension, Insomnia
Sleep Quality and Mechanisms of Cardiovascular Risks in Adults With Hypertension
The objective of this study is to elucidate the potential mechanisms responsible for the increased risk of cardiovascular disease among patients with hypertension and comorbid insomnia.
- Trial name
- NCT04009447
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Duke University
Myotonic Dystrophy, Type 1 (DM1), Myotonic Dystrophy
Safety, Tolerability and Pharmacokinetics of ERX-963 in Adults With Myotonic Dystrophy Type 1
Participants in this study will receive two treatments, placebo and ERX-963, on different days in a randomized fashion. The primary purpose of this study is to investigate the safety and tolerability of ERX-963 in participants…
- Trial name
- NCT03959189
- Testing
- ERX-963
- Where
- 4 sites in United States
- Volunteers
- 12 people
- Sponsor
- Expansion Therapeutics, Inc.
Sleep Initiation and Maintenance Disorders, Pain
Pilot Study of Cyclobenzaprine for Treatment of Sleep Disturbance in Aromatase Inhibitor-treated Breast Cancer Patients
Many women with breast cancer who are treated with aromatase inhibitor medications develop difficulty sleeping and fatigue during treatment.
- Trial name
- NCT01921296
- Testing
- Cyclobenzaprine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Lynn Henry
Obstructive Sleep Apnea
Remote Monitoring in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) among Veterans is a condition that imparts a great burden to the patient in terms of serious co-morbidities and results in a great cost to the VA Health Care System to treat the co-morbidities, which…
- Trial name
- NCT01678560
- Testing
- Monitoring every 3 months by face-to-face visits, Frequent remote monitoring
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Connecticut Healthcare System
Sleep Apnea, Obstructive
Feasibility of Unattended Home Polysomnography and Comparison to In-laboratory Polysomnography in Pediatric Patients
The purpose of the study is: 1) To assess the feasibility of unmonitored polysomnography and 2) to compare apnea hypopnea index (AHI), average SPO2, and SPO2 nadir between unmonitored polysomnography and in-laboratory…
- Trial name
- NCT03473548
- Testing
- Portable sleep monitor, In-laboratory Polysomnography
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Idiopathic Restless Legs Syndrome
Non-interventional Study (NIS) in Patients With Restless Legs Syndrome in Daily Practise
This non-interventional observational study is designed to gain data for Neupro® in restless legs syndrome (RLS) under real life conditions in line with the summary of product characteristics (SmPC) related to effectiveness…
- Trial name
- RLS-Practise (NCT01113710)
- Testing
- Neupro®
- Where
- 80 sites in Germany
- Volunteers
- 687 people
- Sponsor
- UCB Pharma
Sleep Apnea, Obstructive, Obesity
Propofol vs Propofol + Benzo/Opiates in High Risk Group
This will be a randomized controlled trial that compares the rates of sedation related complications in high risk patients (ASA greater or equal to 3, BMI greater or equal to 30, those at risk for OSA) undergoing advanced…
- Trial name
- NCT01315158
- Testing
- Propofol Alone, Propofol+Benzo/Opioids
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Washington University School of Medicine
Insomnia Disorder
Brief Behavioral Insomnia Treatment Study
The purpose of this study is to determine whether a brief, behavioral treatment for insomnia is effective in addressing social and occupational functioning and overall health among Veterans with insomnia disorder.
- Trial name
- BBTI (NCT02571452)
- Testing
- Brief Behavioral Treatment for Insomnia, Progressive Muscle Relaxation
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- VA Office of Research and Development
Insulin Sensitivity, Obstructive Sleep Apnea
Obesity, Sleep Apnea, and Insulin Resistance
Obstructive sleep apnea (OSA) and type 2 diabetes confer increasing economic, social, and public health burdens in the United States.
- Trial name
- NCT02192684
- Testing
- Pioglitazone
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sleep Apnea, Obstructive
Sleep Apnea Treatment With Expiratory Resistance(Provent™)
Continuous positive airway pressure (CPAP) continues to be the primary therapy prescribed for the treatment of obstructive sleep apnea (OSA).
- Trial name
- SATER (NCT01061476)
- Testing
- Treatment sleep study (Provent™ device used), Baseline sleep study (No device), Physiology sleep study (Provent™ on/off)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Obstructive Sleep Apnea-hypopnea Syndrome
Effects of Myofunctional Therapy With an Application in Severe Apnea/Hypopnea Sleep Obstructive Syndrome (MTASSAOS)
Background and study aims: Obstructive sleep apnea is a potentially serious sleep disorder. It causes breathing to stop and start repeatedly during sleep.
- Trial name
- MTASSAOS (NCT04438785)
- Testing
- The intervention consists of myofunctional therapy (MT) using the AirwayGym app.
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Quironsalud
Mental Health Issue, Alcohol Use Disorder
Acceptability and Feasibility of Cognitive Behavioral Therapy for Treatment-Seeking (CBT-TS) With Deaf Individuals
The current study aims to assess the acceptability and feasibility of an adapted version of Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS) for use with signing Deaf adults.
- Conditions
- Mental Health Issue, Alcohol Use Disorder, Depression, Anxiety
- Trial name
- NCT05520190
- Testing
- Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Rochester