Clinical trials: Sleep Impairment
Mild Cognitive Impairment Due to Alzheimer's Disease, Subjective Cognitive Decline (SCD)
Autophagy-Enhancers to Reduce Sleep Disturbances
This clinical trial investigates the effects of spermidine supplementation on sleep quality and sleep-dependent memory consolidation in older adults with Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI), two…
- Trial name
- SpSleep (NCT07383311)
- Testing
- Spermidine Supplementation
- Where
- Germany
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Dementia, Mild Cognitive Impairment (MCI)
Combating Alzheimer's Through Sleep and Exercise
The Combating Alzheimer's through Sleep and Exercise (CASE) study is an exploratory, hypothesis-generating trial designed to: (1) assess whether improvements in sleep are associated with improvements in cognitive performance and…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Cognitively Unimpaired, Alzheimer's Dementia (AD)
- Trial name
- CASE (NCT04855630)
- Testing
- Elemind Neuromodulation Headband, Exercise Routine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Miami
Mild Cognitive Impairment
Auditory Stimulation of Slow Wave Sleep and Memory in Mild Cognitive Impairment and Older Adults
This study will evaluate the ability of sounds played during slow wave sleep using a phase locked loop algorithm to enhance slow wave sleep and memory in cognitively healthy older adults and in those with amnestic mild cognitive…
- Trial name
- NCT02608840
- Testing
- Auditory stimulation during sleep
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Hypoparathyroidism, Hypoparathyroidism Postprocedural
Evaluation of iMmune Function in Post-surgical and AuToimmune HYpoparathyroidism (EMPATHY)
This is an observational pilot study for the evaluation of immune function, infectious diseases, psychometric status and quality of life in patients with hypoparathyroidism compared to healthy controls.
- Conditions
- Hypoparathyroidism, Hypoparathyroidism Postprocedural, Hypoparathyroidism Due to Impaired Parathormone Secretion
- Trial name
- EMPATHY (NCT04059380)
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Dementia, Alzheimer Disease
The Music, Sleep and Dementia Study
The specific aims of this studyare to examine the 1) feasibility; 2) acceptability; and 3) preliminary efficacy of a tailored music intervention in home-dwelling older adults with dementia suffering from sleep disruption.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT04157244
- Testing
- Tailored music listening intervention
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Excessive Daytime Sleepiness, Obstructive Sleep Apnea (OSA)
Validating a Novel Driving Simulation-based MWT Against the Standard MWT in an OSA-cohort Challenged by CPAP-withdrawal
In brief, the proposed study will evaluate a recently proposed naturalistic, driving simulation test to identify and measure sleepiness behind the wheel, one of the most underestimated causes of road accidents.
- Conditions
- Excessive Daytime Sleepiness, Obstructive Sleep Apnea (OSA), CPAP Treatment, Driving Simulator Performance
- Trial name
- DS-MWT2 (NCT06872593)
- Testing
- CPAP-withdrawal, Test Sequence
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Stefan Lakämper
Mild Cognitive Impairment, Cognitive Decline
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
The study will examine whether 5mg melatonin (over the counter, OTC) over a 9-month period improves Alzheimer's disease (AD) biomarkers and cognitive function in two groups of individuals: those with mild cognitive impairment…
- Conditions
- Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
- Trial name
- NCT03954899
- Testing
- melatonin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Natalie Denburg
Glucose Intolerance, Sleep Deprivation
Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
This project is designed to test for the first time whether glucose metabolism is differentially impaired by sleep restriction with and without additional exposure to artificial light at night (ALAN).
- Conditions
- Glucose Intolerance, Sleep Deprivation, Sleep
- Trial name
- NCT04868539
- Testing
- Sleep Restriction with ALAN first, then Sleep Restriction without ALAN, Sleep Restriction without ALAN first, then sleep restriction with ALAN
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Stroke, Hypertension
DELPHI in Subjects at Risk for Stroke and Dementia
The DELPhi system is a software device that is used for the noninvasive evaluation of brain plasticity and connectivity. The DELPhi software uses EEG and TMS devices as accessories.
- Conditions
- Stroke, Hypertension, Diabete Mellitus, Dyslipidemias
- Trial name
- NCT03884647
- Testing
- DELPhI system
- Where
- 4 sites in United States, Israel
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- QuantalX Neuroscience
Alzheimer Disease, Late Onset, Mild Cognitive Impairment
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease
Dementia caused by Alzheimer's disease affects approximately 5.6 million adults over age 65, with costs expected to rise from $307 billion to $1.5 trillion over the next 30 years.
- Conditions
- Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Sleep, Cognitive Change
- Trial name
- ALPS (NCT05138848)
- Testing
- Time in Bed Restriction, Sleep Schedule
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Brain Fog, Cognitive Impairment
Cognitive Task-Based Walking Effects on Cognition, Mood, Sleep, and Quality of Life in Older Adults With Brain Fog
This randomized controlled trial aims to investigate the effects of cognitive task-based walking exercise on cognitive function, depressive symptoms, sleep quality, and quality of life in older adults experiencing brain fog.
- Conditions
- Brain Fog, Cognitive Impairment, Geriatric Population
- Trial name
- NCT07396779
- Testing
- Cognitive Task-Based Walking Exercise, Walking-Only Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medipol University
Shift-Work Sleep Disorder, Insomnia
Fire Fighter Fatigue Management Program: Operation Healthy Sleep
Firefighters work some of the most demanding schedules known under highly stressful and demanding conditions. The need to work frequent extended shifts and long work weeks leads to acute and chronic partial sleep deprivation as…
- Conditions
- Shift-Work Sleep Disorder, Insomnia, Restless Leg Syndrome, Obstructive Sleep Apnea
- Trial name
- NCT01988129
- Testing
- Sleep disorders education and screening
- Where
- United States
- Volunteers
- 1,189 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Parkinson Disease
Gait, Physical Activity, and Sleep in Parkinson's Disease
This study aims to investigate the relationship between balance and gait impairments, physical activity levels, and sleep status in individuals with Parkinson's disease (PD).
- Trial name
- NCT07424924
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Biruni University
Breast Cancer, Fatigue
The Role of Circadian Rhythms in Cancer-Related Symptoms
Emerging evidence indicates that circadian rhythms may be disrupted following cancer and its treatment, and that circadian rhythm disruption may be an underlying pathophysiological mechanism of cancer- and cancer…
- Conditions
- Breast Cancer, Fatigue, Cognitive Impairment, Sleep
- Trial name
- CHRONO (NCT04401189)
- Where
- Denmark
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Dementia, Mild Cognitive Impairment
Dual-Task Training for People With Mild Cognitive Impairment and Mild Dementia
Evidence shows that people with dementia have a higher prevalence of sleep disturbance, cognitive decline, behavioral disturbance, and experience motor dysfunction. These symptoms are interrelated.
- Conditions
- Dementia, Mild Cognitive Impairment, Older Adult
- Trial name
- DTT (NCT06348810)
- Testing
- Dual-task training, Cognitive training, Motor training
- Where
- Indonesia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Insomnia, Renal Impairment
Pharmacokinetics and Safety Study of YZJ-1139 in Subjects With Severe Renal Impairment and Normal Renal Impairment
Objective： 1. To evaluate the pharmacokinetics of YZJ-1139 tablets in patients with severe renal impairment and in subjects with normal renal impairment. 2.
- Trial name
- NCT06671444
- Testing
- YZJ-1139
- Where
- 3 sites in China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Shanghai Haiyan Pharmaceutical Technology Co., Ltd.
PARKINSON DISEASE (Disorder), Parkinson
The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions
Gut problems, such as constipation, can have an important impact on quality of life of people who have them, and have been associated with higher risk of developing neurological diseases such as Parkinson's or Alzheimer's…
- Conditions
- PARKINSON DISEASE (Disorder), Parkinson, Parkinson Disease, Parkinson s Disease
- Trial name
- Met-Pro (NCT07786116)
- Testing
- Probiotic Supplementation with L. reuteri
- Where
- United Kingdom
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Insomnia
A Study to Evaluate the Pharmacokinetics of LY2624803 in Subjects With Hepatic Impairment
The purpose of this study is to evaluate the impact of hepatic dysfunction on the pharmacokinetics and safety of LY2624803 and its major metabolite, LSN2797276.
- Trial name
- NCT01257178
- Testing
- LY2624803
- Where
- 4 sites in Germany, Hungary and 1 more
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Sleep Deprivation, Feeding Behavior
Impaired Vigilance, and Its Effects on Cognition and Behavior
Fifty healthy, young participants (10 male, 40 female) completed two 3-hour study sessions that were at least five days apart. The first session was a baseline.
- Trial name
- NCT02484846
- Testing
- Time in bed
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stanford University
Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease
Countermeasures to Circadian Misalignment
Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable.
- Conditions
- Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity
- Trial name
- C2CM (NCT04966351)
- Testing
- Time-restricted feeding, Circadian Misalignment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Colorado State University