Clinical trials: Sleep Impairment
Mild Cognitive Impairment, Alzheimer Disease
Improving Sleep and AD Biomarkers
The purpose of this research is to learn whether a dietary citicoline supplement will impact sleep and cognition. Cognitive disorders include such things as memory disorders and mild cognitive impairment.
- Trial name
- NCT06029894
- Testing
- Citicoline Supplement
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Emory University
Post Surgical Pain and Sleep Impairment
Biomarker Signatures of the Sleep-pain Enigma
This is an observational, prospective study that will leverage existing Standard of Care (SOC) patient reported outcomes (PRO) and Electronic Medical Record (EMR) data and collect additional Pain Rating Scale (PRS) data and blood…
- Trial name
- NCT03850743
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Brain Tumors, Epilepsy
Quality Improvement and Practice Based Research in Neurology Using the EMR
The investigators will conduct at NorthShore University HealthSystem pragmatic trials using the EMR for 10 common neurological disorders.
- Conditions
- Brain Tumors, Epilepsy, Migraine, Mild Cognitive Impairment
- Trial name
- NCT02670161
- Testing
- Listed for each disorder below, up to three drugs per disorder (too many characters to list in this field; see Intervention Description)
- Where
- United States
- Volunteers
- 3,300 people
- Sponsor
- Endeavor Health
Mild Cognitive Impairment, Obstructive Sleep Apnea
Evaluation of Trazodone in OSA-MCI
Alzheimer's disease (AD) is a progressive and multifactorial neurodegenerative disease. Before progressing to AD, individuals may experience mild cognitive impairment (MCI).
- Trial name
- NCT05209035
- Testing
- Trazodone
- Where
- Hong Kong
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Sleep Deprivation
A Change in Diet May Decrease the Negative Consequences of Chronic Sleep Deprivation
The purpose of this study is to determine whether or not a low calorie, low glycemic index diet with omega-3 fatty acid supplements can prevent some of the negative consequences of sleep deprivation.
- Trial name
- NCT00123214
- Testing
- Controlled Dietary Intervention
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- St. Vincent's Medical Center
Insomnia, Renal Impairment
Pharmacokinetics and Safety Study of YZJ-1139 in Subjects With Severe Renal Impairment and Normal Renal Impairment
Objective： 1. To evaluate the pharmacokinetics of YZJ-1139 tablets in patients with severe renal impairment and in subjects with normal renal impairment. 2.
- Trial name
- NCT06671444
- Testing
- YZJ-1139
- Where
- 3 sites in China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Shanghai Haiyan Pharmaceutical Technology Co., Ltd.
Unipolar Depression, Bipolar Disorder
Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression
Depressed mood is the main symptom of depression, but other symptoms like cognitive impairment, anhedonia or sleep disorders may also contribute to patients suffering and are difficult to treat.
- Trial name
- NCT06363981
- Testing
- Active rTMS over the left DLPFC and over the left DMPFC, Active rTMS over the left DLPFC
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Jakub Antczak
Anorexia Nervosa, Sleep Disorders in Children
Pediatric Prolonged-Release Melatonin for Sleep Disturbances in Children and Adolescents With Anorexia Nervosa (MELSom-ANOREXIA)
Sleep disturbances are reported by more than 50% of patients with Anorexia Nervosa (AN) and are associated with increased AN severity, psychiatric comorbidities, and poorer quality of life.
- Trial name
- MELSomAnorexia (NCT07576764)
- Testing
- Pediatric Prolonged-Released Melatonin (PedPRM)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Sleep Disturbance, Stress
Yoga for Persons With Severe Visual Impairment
This study aims to provide novel information on the feasibility of yoga interventions for secondary symptoms related to severe vision loss, such as sleep disturbances, negative mood states, fall risk and balance.
- Conditions
- Sleep Disturbance, Stress, Anxiety, Depression
- Trial name
- RPY (NCT01366677)
- Testing
- Yoga Intervention
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Insomnia, Alcohol Use
Brief Interventions to Reduce Comorbid Alcohol and Cannabis Misuse and Sleep Impairment in Young Adults (Rest-Up RCT)
This study is designed to evaluate an integrated intervention to reduce alcohol and marijuana use and consequences and improve sleep among young adults with comorbid heavy episodic drinking, marijuana use, and sleep impairment.
- Conditions
- Insomnia, Alcohol Use, Marijuana Use
- Trial name
- NCT06736444
- Testing
- Brief Behavioral Therapy for Insomnia (BBTI), Brief Alcohol Screening and Intervention for College Students (BASICS), Attention Control
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Washington
Impaired Glucose Tolerance, Obstructive Sleep Apnea
Effects of Treatment of Sleep Apnea on Metabolic Syndrome
The investigators performed a randomized, cross-over controlled clinical trial comparing 8 weeks of Continuous Positive Airway Pressure (CPAP) to 8 weeks of sham-CPAP in patients with moderate to severe Sleep Disordered Breathing…
- Trial name
- NCT01385995
- Testing
- Continuous Positive Airway Pressure (CPAP) (Philips-Respironics RemStar Pro® CPAP)
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Sleep Disorders, Frailty
Impact of Sleep Disorders and Digital Support on Older People's Health
The goal of this observational study is to learn about the effects of sleep disorders on health and ageing in older people over the age of 65.
- Conditions
- Sleep Disorders, Frailty, Cognitive Impairment, Quality of Life
- Trial name
- SOMNUS-DARE (NCT06944600)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Parma
Mild Cognitive Impairment
A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos
This study is a randomized, single-blind, controlled trial that will test a multilevel intervention, Tiempo Juntos para la Salud, (Time Together for Health) designed to promote moderate-intensity physical activity; theoretically…
- Trial name
- NCT05030948
- Testing
- Tiempo Juntos Intervention
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- University of Pennsylvania
Mild Cognitive Impairment
Rhythmic Light Therapy for Alzheimer's Disease Patients
The investigator will investigate how light delivering 40 hertz (Hz) affects subjective sleep and cognition in a controlled laboratory study.
- Trial name
- NCT05015478
- Testing
- Tailored Rhythmic Lighting Intervention
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Conscious Sedation, Bronchoscopy
Incidence and Nature of Respiratory Impairment in Consecutive Patients Undergoing Bronchoscopy Under Conscious Sedation: A Pilot Study
This study aims to characterize airflow patterns during bronchoscopy under conscious sedation, and determine the incidence of obstructive and central respiratory events.
- Trial name
- NCT03886454
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Tufts Medical Center
Hematopoietic Stem Cell Transplantation, Breast Cancer
Treating Cancer-Related Fatigue Through Systematic Light Exposure
Cancer related fatigue (CRF) - a persistent sense of exhaustion related to cancer or cancer treatment - can severely interfere with activities of daily living, and has even been reported to be a factor in patient requests for…
- Conditions
- Hematopoietic Stem Cell Transplantation, Breast Cancer, Fatigue, Mild Cognitive Impairment
- Trial name
- NCT01873794
- Testing
- Bright white light, Dim red light
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
IDIOPATHIC PARKINSON'S DISEASE
A Trial to Evaluate the Effects of Rotigotine Transdermal Patch on Early Morning Motor Impairment and Sleep Disorders Idiopathic Parkinson's Disease
The objective of this trial is to assess the effect of rotigotine (SPM 962) on the control of early morning motor impairment and sleep disorders in subjects with idiopathic PD.
- Trial name
- NCT00243945
- Testing
- Rotigotine
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- UCB Pharma
Obstructive Sleep Apnea-Hypopnea Syndrome, Anxiety Disorders
EGR2 and NLRP3 Pathways in Obstructive Sleep Apnea-Related Cognitive and Mood Disorders
Obstructive sleep apnea-hypopnea syndrome (OSAS) is a common disorder in which repeated airway blockages during sleep lead to low oxygen levels, inflammation, and disrupted sleep.
- Conditions
- Obstructive Sleep Apnea-Hypopnea Syndrome, Anxiety Disorders, Depressive Disorders
- Trial name
- NCT07120711
- Testing
- EGR2/NLRP3 pathway activity, fatty tissue
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Spinal Cord Injuries, Spine Disease
Outcomes Post Treatment: Impact on Motor Impairment of Sleep Efficiency in SCI (OPTIMISE SCI Trial)
This randomized clinical trial will compare three groups of individuals with cervical/thoracic, complete or incomplete spinal cord injury (SCI) that will undergo: (i) early CPAP therapy in the management of moderate-to-severe…
- Trial name
- NCT05473689
- Testing
- Continuous positive airway pressure (CPAP) therapy
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University Health Network, Toronto
Visual Impairment and Blindness (Excl Colour Blindness)
A Trial of Tai Chi Intervention for Youngsters with Visual Impairments
Investigators conducted a single-blind, randomized trial of Taijiquan exercise as compared with a control intervention consisting of wellness education and jogging for youngsters with visual impairments.
- Trial name
- NCT06450340
- Testing
- Moderate-intensity aerobic exercise refers to rhythmic and long-lasting exercise with increased heart rate, slight sweating and slight wheezing.
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Yanyun Zhang