Clinical trials: Sleep Insufficiency
Obesity Hypoventilation Syndrome (OHS)
Functional Capacity, Sleep Quality, and Cognitive Function in Obesity Hypoventilation Syndrome
Introduction: Obesity Hypoventilation Syndrome (OHS) is defined as the coexistence of obesity (BMI ≥ 30 kg/m²), daytime hypercapnia (PaCO₂ > 45 mmHg) in the absence of other causes of hypoventilation, and sleep-disordered…
- Trial name
- NCT07147153
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Bezmialem Vakif University
Hypercapnic Respiratory Failure, Pulmonary Disease, Chronic Obstructive
Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor
The study is an open, prospective, single center clinical observational pilot investigation. The aim is to compare the carbon dioxide values measured by the IscAlert sensor, which is inserted in proximity to the nasal mucosa.
- Conditions
- Hypercapnic Respiratory Failure, Pulmonary Disease, Chronic Obstructive, Neuromuscular Diseases, Obesity Hypoventilation Syndrome (OHS)
- Trial name
- DISCO (NCT06367686)
- Testing
- IscAlert sensor
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- The Hospital of Vestfold
COVID-19, Sleep Disorder
Investigation of Respiratory Muscle Strength, Exercise Capacity, Physical Activity and Sleep Quality Level in Individuals With Covid-19 Infection
COVID-19 infection was identified in Wuhan, China at the end of 2019 and turned into a pandemic in a short time. In our country, the pandemic continues at full speed and patients are being treated in various clinical pictures.
- Conditions
- COVID-19, Sleep Disorder, Respiratory Failure
- Trial name
- NCT06008470
- Testing
- observational tests
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Restless Legs Syndrome, End Stage Renal Disease
Effectiveness of Ropinirole and Gabapentin for the Treatment of RLS in Patients on Maintenance HD
Restless legs syndrome (RLS) is a neurologic disorder characterized by 1) an urge to move the legs, 2) uncomfortable sensations in the legs, 3) symptoms that are often worse the evening or when at rest , and 4) may be temporarily…
- Trial name
- NCT03708237
- Testing
- Ropinirole, Gabapentin
- Where
- 4 sites in Canada
- Volunteers
- 3 people
- Sponsor
- University of Alberta
Chronic Kidney Disease
Sleep Disturbances as a Risk Factor in Chronic Kidney Disease
This study is designed to determine if either short night time sleep or poor night time sleep could be a risk factor for increasing the rate at which kidney function deteriorates in persons with mild to moderate kidney disease.
- Trial name
- CRIC (NCT00817427)
- Testing
- Controls Short sleep, CKD- sleep extension
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Airway Obstruction
Airflow Perturbation Device (APD) for the Evaluation of Pulmonary and Sleep Disorders
In a prospective, observational study the investigators compared resistance values measured using the airway perturbation device (APD) to impulse oscillometry and spirometry.
- Trial name
- NCT03054116
- Testing
- Airflow pertubation device
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Restless Legs Syndrome, Kidney Failure, Chronic
Study of Vitamin C, Vitamin E and Their Combination to Treat Restless Legs Syndrome in Hemodialysis Patients
The purpose of this study is to determine whether vitamin C, vitamin E and their combination are effective in the treatment of RLS in hemodialysis patients.
- Trial name
- ShirazUMS (NCT01125033)
- Testing
- Vitamin C & Vitamin E, Vitamin C, Vitamin E
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shiraz University of Medical Sciences
Sleep Apnea, Diabetic Nephropathy Type 2
Sleep Apnea, Coronary Atherosclerosis and Heart Failure in Diabetes Patients With Nephropathy
Background: Diabetes, and especially diabetic kidney disease is associated with the development of cardiovascular disease such as calcification in the coronary arteries and heart failure.
- Conditions
- Sleep Apnea, Diabetic Nephropathy Type 2, Coronary Atheroscleroses, Heart Insufficiency
- Trial name
- SLEEP (NCT04549324)
- Where
- Denmark
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypertension, Hypertension, Systolic
Treatment of Hypertension During Sleep
On the basis of new evidence on the relationship between achieved office blood pressure (BP) measurements (OBPM) and the risk of cardiovascular disease (CVD) morbidity and mortality documented in the SPRINT trial, the recent 2017…
- Trial name
- THADEUS (NCT03457168)
- Testing
- Treatment of elevated asleep SBP mean
- Where
- 9 sites in Spain
- Volunteers
- 5,320 people
- Sponsor
- University of Vigo
Bronchial Asthma, Bronchiectasis
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
Research is being conducted into chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease, and bronchiectasis.
- Conditions
- Bronchial Asthma, Bronchiectasis, ILD, COPD
- Trial name
- NCT07060079
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
ESRD, Sleep Apnea
Effect of NAC on Sleep Apnea
Sleep studies in ESRD patients have identified increased prevalence of Sleep Apnea. Based on current knowledge, treatment aimed at reducing oxidative stress might improve Sleep Apnea in HD patients.
- Trial name
- NCT00592618
- Testing
- Oral N-Acetylcysteine 1200 mg x 2/day for 4 weeks
- Where
- Israel
- Sponsor
- Assaf-Harofeh Medical Center
Obesity Hypoventilation Syndrome
A Trial of Rehabilitation in Obesity Hypoventilation Syndrome (OHS)
Obesity is an escalating problem in the UK and a proportion of these patients have a condition known as Obesity Hypoventilation Syndrome (OHS).
- Trial name
- NCT01483716
- Testing
- Rehabilitation
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Neurodegenerative Diseases, Leukodystrophy
Home Exercise for Individuals With Neurodegenerative Disease
The primary goal of this study is to address the need for targeted therapeutic interventions for impairments that impact walking in related neurodegenerative diseases.
- Conditions
- Neurodegenerative Diseases, Leukodystrophy, Ataxia, LBSL
- Trial name
- NCT05443906
- Testing
- Home exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Renal Failure, Pain
Effect of Foot Bath on the Severity of Pain, Fatigue and Insomnia in Patients With Acute Renal Failure
One of the non-pharmacological methods that is easily applied, tolerated by the patient, and has no significant side effects is the foot bath.
- Trial name
- Foot Bath (NCT06613087)
- Testing
- Foot bath
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Amasya University
Neuromuscular Diseases, Alveolar Hypoventilation
Impact of the Type of Interface in Neuromuscular Patients Treated With Nocturnal Noninvasive Ventilation
Nocturnal Non Invasive Ventilation (NIV) is the reference treatment for chronic alveolar hypoventilation in patients with neuro-muscular diseases.
- Trial name
- InterfaceNMD (NCT03458507)
- Testing
- Switch of nocturnal NIV interface
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Respiratory Insufficiency
Effect of Sleep Disruption on the Outcome of Weaning From Mechanical Ventilation
Mechanically ventilated patients in the Intensive Care Unit (ICU) are highly susceptible to sleep disruption. Several studies in the last 15 years have demonstrated an extremely poor sleep quality and abnormal sleep pattern…
- Trial name
- SLEEWE (NCT02464735)
- Testing
- Polysomnography
- Where
- 3 sites in Canada
- Volunteers
- 44 people
- Sponsor
- Unity Health Toronto
Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB)
Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries
Sleep-disordered breathing (SDB) is common in individuals with cervical spinal cord injuries, with studies suggesting prevalence rates ranging from 27% to 62%.
- Conditions
- Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB), Sleep Apnea, Cervical Spinal Cord Injruy
- Trial name
- NCT06818604
- Testing
- CPAP, BiPAP
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Obstructive Sleep Apnea Syndrome, Chronic Venous Insufficiency
SPA Therapy in the Treatment of Sleep Apnea Syndrome
The purpose of this study is to determine whether 3-week of SPA therapy improves sleep apnea in patients with chronic venous insufficiency and concomitant Obstructive Sleep Apnea Syndrome (OSAS).
- Trial name
- THERMA-SAS (NCT02559427)
- Testing
- 3-week immediate SPA treatment, 3-week late SPA treatment
- Where
- 9 sites in France
- Sponsor
- Association Francaise pour la Recherche Thermale
Hemodialysis, End Stage Chronic Renal Failure
Mindfulness for Saudi Hemodialysis Patients
This study aims to evaluate whether an MBI improves sleep quality, emotional symptoms (depression, anxiety, stress), emotion regulation, and trait mindfulness among adults with ESRD on HD.
- Trial name
- MSHP (NCT07816354)
- Testing
- Mindfulness-Based Intervention
- Where
- Saudi Arabia
- Volunteers
- 38 people
- Sponsor
- Jordan University of Science and Technology
Obstructive Sleep Apnea, Nasal Congestion
Effect of Heated Humidity With Thermosmart™ Compared to an Intranasal Steroid in Improving Compliance and Nasal Symptoms in Patients Using Continuous Positive Airway Pressure
1. CPAP compliance will be significantly higher in both the heated humidity with Thermosmart™ and the nasal steroid phases compared to the double placebo phase. 2.
- Conditions
- Obstructive Sleep Apnea, Nasal Congestion, Sinus Congestion
- Trial name
- Thermosmart (NCT00665977)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Clayton Sleep Insititute