Clinical trials: Sleep Obstructive Apnea
Stroke, Sleep Apnea Syndrome (OSAS)
Sleep and Stroke Rehabilitation Study
The study aims to map sleep disorders and their impact on the ability to engage in an active daily life among people who have had a stroke, with particular focus on how sleep apnea can be identified.
- Conditions
- Stroke, Sleep Apnea Syndrome (OSAS), Insomnia, Excessive Daytime Sleepiness
- Trial name
- SnSRehabS (NCT07579871)
- Where
- Sweden
- Volunteers
- 226 people
- Sponsor
- Malin Eleonora av Kák Gustafsson, MD, PhD
Type 1 Diabetes
Prevalence of Obstructive Sleep Apnea Syndrome in Type 1 Diabetic Patients Treated With Insulin Pump (At1Home)
Patients with type 1 diabetes have poorer glycemic control that could lead to macrovascular or neuropathic complications; in addition to an optimal treatment, prevention of diabetes complications requires to control associated…
- Trial name
- AT1Home (NCT02796534)
- Testing
- Diagnosis of sleep apnea by oxymetry
- Where
- France
- Volunteers
- 825 people
- Sponsor
- University Hospital, Grenoble
Lumbar Disc Herniation, Obstructive Sleep Apnea Risk Management
Daytime vs Evening Rehabilitation in Lumbar Disc Herniation Patients at High Risk for Obstructive Sleep Apnea
Lumbar disc herniation is a common musculoskeletal condition that negatively affects quality of life, physical function, and daily activities.
- Trial name
- REHAB-TIME (NCT07522021)
- Testing
- Physiotherapy and Exercise Program
- Volunteers
- 60 people
- Sponsor
- Mardin Artuklu University
Obstructive Sleep Apnea, Coronary Disease
Patients with Coronary Artery Disease or At High Cardiovascular Risk: Measuring Compliance with Treatment for Obstructive Sleep Apnea Syndrome
Obstructive sleep apnea (OSA) is a sleep disorder characterised by partial or total obstruction of the oro-pharyngeal carrefour during sleep.
- Conditions
- Obstructive Sleep Apnea, Coronary Disease, Cardiovascular Diseases
- Trial name
- PACOAM (NCT06568159)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Sleep Apnea, Obstructive
Relationship Between Vascular Endothelial Dysfunction and Beat-to-beat Blood Pressure Variability in Patients With OSAS
It is thought that intermittent hypoxia, poor tissue oxygenation, and perfusion in OSA can lead to eNOS uncoupling. Uncoupled eNOS can reduce nitric oxide (NO), which will result in an imbalance of contraction and diastole.
- Trial name
- NCT05548569
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huai'an No.1 People's Hospital
Sleep Apnea, Heart Failure
The Prevalence and Risk Factors of Sleep Disordered Breathing in a Heart Failure Program
The objective of this protocol is the evaluation of our clinical screening program for sleep disorders in patients with heart failure.
- Trial name
- NCT00679822
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Ohio State University
Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome
Postoperative Complications in Patients With Obesity Hypoventilation Syndrome
Obstructive sleep apnea (OSA) and Obesity-Hypoventilation Syndrome (OHS) are common conditions in obesity, which may influence the prognosis in patients undergoing surgery.
- Conditions
- Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome, Hypercapnia, Post-Op Complication
- Trial name
- OHBE (NCT02980770)
- Where
- Turkey (Türkiye)
- Volunteers
- 999 people
- Sponsor
- Marmara University
Type 2 Diabetes, Obstructive Sleep Apnea
Sleep Disordered Breathing and Diabetes
The hypothesis of this study is: sleep disordered breathing (SDB), specifically, obstructive sleep apnea, is associated with poorer glucose in the existing type 2 diabetic condition.
- Trial name
- NCT00901472
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Chicago
Obstructive Sleep Apnea
Intermittent Hypoxia-initiated Plasticity in Humans: A Multi-pronged Therapeutic Approach to Treat Sleep Apnea and Overlapping Co-morbidities
The prevalence of obstructive sleep apnea (OSA) is high in the United States and is a major health concern. This disorder is linked to numerous heart, blood vessel and nervous system abnormalities, along with increased tiredness…
- Trial name
- NCT05558501
- Testing
- Mild Intermittent Hypoxia
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea, Down Syndrome
Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea in Children With Down Syndrome
The goal of this observational study is to learn about the use of non-invasive ventilation for treatment of obstructive sleep apnoea syndrome in children with Down Syndrome.
- Conditions
- Obstructive Sleep Apnea, Down Syndrome, Quality of Life, Behavior
- Trial name
- REFRESHED (NCT06030349)
- Testing
- Non-invasive ventilation
- Where
- 6 sites in Ireland, United Kingdom
- Volunteers
- 200 people
- Sponsor
- Children's Health Ireland
Obstructive Sleep Apnea
Automated Graduated CPAP (AGPAP) for Improved Adherence in Newly Diagnosed Obstructive Sleep Apnea (OSA) Patients
Although positive airway pressure (PAP) is a highly effective treatment for sleep apnea, adherence to therapy remains an obstacle.
- Trial name
- NCT01450540
- Testing
- REMstar Auto A-Flex, modified REMstar Auto A-Flex with AGPAP
- Where
- 5 sites in United States
- Volunteers
- 241 people
- Sponsor
- Philips Respironics
Snoring, Obstructive Sleep Apnea
TranQuill™ Sling Snoreplasty for Snoring and Mild Obstructive Sleep Apnea:
The purpose of this study is to assess the safety and effectiveness of TranQuillTM Sling (a suture or thread used in surgery that is knotless) in snoreplasty (surgery procedure) for the treatment of snoring and mild OSA in adult…
- Trial name
- NCT02364518
- Testing
- Snoreplasty
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Obstructive Sleep Apnea
Neuromodulation Therapy Device for the Treatment of Sleep Apnea
We are looking to test a novel device in the treatment of Obstructive Sleep Apnea (OSA). Rather than using positive pressure to open the airways, we are testing a device that delivers an auditory tone to affect neuromodulation.
- Trial name
- NCT01117064
- Testing
- Neuromodulation Therapy Device (NMTD)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Excessive Daytime Sleepiness, Obstructive Sleep Apnea
Pitolisant (BF2.649) in the Treatment of EDS in Patients With OSA
The first objective of this study is to demonstrate the efficacy and safety of pitolisant given at 10, 20, or 40 mg per day versus placebo during 12 weeks of the Double Blind period, to treat the Excessive Daytime Sleepiness…
- Trial name
- HAROSA3 (NCT02739568)
- Testing
- Pitolisant (BF2.649)
- Where
- 6 sites in Bulgaria, North Macedonia
- Volunteers
- 389 people
- Sponsor
- Bioprojet
Obstructive Sleep Apnea, Pregnancy Induced Hypertension
Sleep Quality in Pregnancy and Its Impact on Pregnancy Outcomes
Hypothesis:Sleep Disorders are very common during pregnancy but the their exact role in causation of pregnancy related disorders is yet to be determined.
- Conditions
- Obstructive Sleep Apnea, Pregnancy Induced Hypertension, High-Risk Pregnancy, Restless Leg Syndrome
- Trial name
- NCT02016638
- Testing
- Polysomnography and ambulatory blood pressure recording
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Obstructive Sleep Apnea
The Taiwan OSA Study
We will prospectively recruit 7000 OSA patients referred to the sleep center or China Medical University Hospital between 2020 and 2027.
- Trial name
- TOSA (NCT07302685)
- Where
- Taiwan
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Obstructive Sleep Apnea (OSA) and Obesity
A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of HDM1005 Injection in Subjects With Obstructive Sleep Apnea (OSA) and Obesity Receiving Positive Airway Pressure (PAP) Therapy
This is a 56-week randomized, double blinded, parallel-controlled study evaluating the efficacy and safety of the HDM1005 in patients with obstructive sleep apnea (OSA) and obesity receiving positive airway pressure (PAP)…
- Trial name
- NCT07794397
- Testing
- HDM1005
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Coronary Artery Disease (CAD), Obstructive Sleep Apnea (OSA)
Chemoreflex Control of Sympathetic Activity in Patients With Coronary Artery Disease
The investigators hypothesize that chemoreflex response of muscle sympathetic nerve activity (MSNA) during hypoxia and hypercapnia will be increased in coronary artery disease (CAD) patients and that the presence of obstructive…
- Trial name
- NCT02624297
- Testing
- Aerobic exercise training
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Obstructive Sleep Apnea, Pregnancy
Incidence of Obstructive Sleep Apnea in Pregnancy
Obstructive sleep apnea is a condition characterized by obstruction of the upper airways and episodes of apnea and hypopnea during sleep. It is associated with significant adverse health effects.
- Trial name
- OSA (NCT00462306)
- Testing
- Survey: Berlin questionnaire
- Where
- United States
- Volunteers
- 4,577 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Obstructive Sleep Apnea
Pathophysiological Endotyping Using Baseline Polysomnography Data
The study is designed to develop models to predict site of collapse information using routine polysomnography. In an observational study, the investigators will study 1000 patients with obstructive sleep apnea (OSA) who have had…
- Trial name
- NCT05267808
- Testing
- Drug-induced sleep endoscopy
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Antwerp
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