Clinical trials: Sleep Obstructive Apnea
Obstructive Sleep Apnea
New Perspective on Exploring the Post-apneic BP Surge in Patients With OSA
The nocturnal short-term BPV induced by sleep-breathing events is affected by many factors. The purpose of the study is as follows: (1) to explore the relationship between nocturnal short-term BPV and vascular endothelial…
- Trial name
- NCT06172998
- Testing
- Phentolamine Injection
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Xu J
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Sleep Apnea, Obstructive
Mandibular Advancement Device on Sleep Quality in Obstructive Sleep Apnea Patients
Sleep is an important factor that influences long-term quality of life with known health consequences. Obstructive sleep apnea, the most prevalent disease that disturbs sleep, is considered a public health problem.
- Trial name
- DAMOSA (NCT06169228)
- Testing
- mandibular advancement
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Hypertension Secondary
Kynurenine/Tryptophan Ratio in Hypertension Associated to Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) is an independent risk factor for hypertension (HTN) and the most common cause of resistant HTN. The mechanisms underlying OSA-associated HTN are not completely understood.
- Trial name
- KYNTOSA (NCT04646902)
- Where
- 5 sites in Portugal
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Obstructive Sleep Apnea
Effect of CPAP Therapy on Molecular Breath Patterns in Patients With OSA
Determination of changes in molecular breath patterns in OSA patients, naïve for OSA treatment before and after one month of CPAP therapy by untargeted, secondary electrospray ionisation-high resolution mass spectrometry…
- Trial name
- BrOSA (NCT04638933)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 53 people
- Sponsor
- Malcolm Kohler
Obstructive Sleep Apnea
Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)
multi-center, randomized, double-blind, placebo-controlled, dose-finding, 4-arm, parallel assignment study to evaluate the efficacy of three different doses of sulthiame (STM) compared to placebo on sleep apnea activity in adult…
- Trial name
- NCT05236842
- Testing
- Sulthiame
- Where
- Belgium
- Volunteers
- 298 people
- Sponsor
- Desitin Arzneimittel GmbH
Obstructive Sleep Apnea
Effect of Upper Airway Stimulation in Patients With Obstructive Sleep Apnea
Upper Airway Stimulation is a new therapy, which is available for patients with obstructive sleep apnea, who are non-compliant to the standard treatment continuous positive airway pressure (CPAP) therapy.
- Trial name
- EFFECT (NCT03760328)
- Testing
- Upper Airway Stimulation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Hypertension
Long-term Cardiovascular Outcomes in Patients With RH and OSA With or Without Treatment With CPAP
Objectives: Main objective: To assess the impact of obstructive sleep apnea (OSA) and its treatment on cardiovascular outcomes (morbidity and mortality) in patients with resistant hypertension (RH).
- Trial name
- SARAH (NCT03002558)
- Where
- Spain
- Volunteers
- 591 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Normotensive, Obstructive Sleep Apnea
Normotensive OSA Patients With Nondipper Circadian Blood Pressure Pattern
The principal objective is to evaluate the effect of CPAP treatment on blood pressure (BP) in normotensive patients with nondipper circadian pattern with sleep apnea-hypopnea syndrome (SAHS).
- Trial name
- Nondipper-OSA (NCT03987425)
- Testing
- CPAP treatment
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Obstructive Sleep Apnea, Masked Hypertension
Masked Hypertensive Patients With Obstructive Sleep Apnea
The general objective is to evaluate the effect of continuous positive airway pressure (CPAP) treatment in patients with masked hypertension.
- Trial name
- Masked-OSA (NCT04251975)
- Testing
- CPAP treatment
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Influenza
Response to Live Attenuated Influenza Vaccine in Tonsillar Tissues and Blood
This is one project of a larger ongoing study related to the immune system's response to the flu virus. This study is designed to investigate the immune response to a nasal flu immunization in tonsillar tissue compared to what…
- Trial name
- FLU-Tonsil (NCT03884296)
- Testing
- FluMist
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Obstructive Sleep Apnea
Personal Therapy Comfort Settings Pilot Clinical Study
350 participants will be enrolled in this study. The target population are patients newly diagnosed with OSA and starting CPAP treatment.
- Trial name
- NCT05376137
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Australia
- Volunteers
- 66 people
- Sponsor
- ResMed
OSA, Obstructive Sleep Apnea
AD816 Crossover Study
The VicTor Study is a randomized, double blind, placebo-controlled, 3-period, multiple-dose crossover study in participants with OSA.
- Trial name
- VicTor (NCT05793684)
- Testing
- Period A, Period B, Period C
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Apnimed
Bariatric Surgery Candidate, Sleep Apnea, Obstructive
Using Digitalized Incentive Spirometers to Assist Postoperative Rehabilitation of Abdominal Surgery Patients
The purpose of this clinical trial is to use a digital recording device integrated with an incentive spirometer to record a patient's deep breathing lung training following abdominal surgery.
- Trial name
- NCT06132100
- Testing
- digitalized incentive spirometry, traditional incentive spirometry
- Volunteers
- 200 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Sleep Disordered Breathing, Obstructive Sleep Apnea
Adenotonsillectomy for Obstructive Sleep-Disordered Breathing in Childhood:The Chania Community Oximetry-Based Study
Obstructive sleep-disordered breathing (SDB) in childhood is a disorder of breathing during sleep characterized by intermittent upper airway obstruction.
- Conditions
- Sleep Disordered Breathing, Obstructive Sleep Apnea, Snoring, Obstructive Sleep Disordered Breathing
- Trial name
- NCT01918007
- Testing
- Adenotonsillectomy (AT)
- Where
- 2 sites in Greece
- Volunteers
- 186 people
- Sponsor
- Chania General Hospital "St. George"
Sleep Apnea, Obstructive
Enhanced Respiratory Polygraphy in Suspected OSA
Obstructive Sleep Apnea (OSA) remains underdiagnosed in 2022, as a result of the unawareness of its serious health-related consequences and the lack of diagnosis accessibility.
- Trial name
- PVa (NCT05949853)
- Testing
- the respiratory parameters (AHI) and time spent
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Upper Aerodigestive Tract Neoplasms, Obstructive Sleep Apnea-hypopnea Syndrome
Obstructive Sleep Apnea Syndrome In Patients Treated For Cancer Of The Upper Aerodigestive Tract
Prospective open-label, non-randomized, monocentric, cohort study, to assess the prevalence and severity of sleep apnea syndrome in patients treated for cancer of the upper aerodigestive tract.
- Trial name
- SAOS-K (NCT04262453)
- Where
- France
- Volunteers
- 142 people
- Sponsor
- Centre Hospitalier Sud Francilien
Sleep Apnea, Obstructive
AcuPebble to Remotely Monitor Patients With OSA on CPAP Therapy
Obstructive sleep apnoea (OSA) is a breathing problem that happens when you sleep. It is treated by a machine called continuous positive airway pressure (CPAP) therapy.
- Trial name
- NCT06097949
- Testing
- AcuPebble SA100
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Hypertensive Disorder of Pregnancy, Sleep Apnea, Obstructive
Positive Airway Pressure Treatment of Obstructive Sleep-disordered Breathing in Hypertensive Disorders of Pregnancy
The purpose of this study is to conduct a pilot randomized, controlled trial to evaluate the feasibility and obtain pilot outcome data for a subsequent definitive trial evaluating the effects of postitive airway pressure (PAP)…
- Trial name
- NCT03309826
- Testing
- Positive Airway Pressure, Nasal Dilator Strip
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Dr John Kimoff
Obstructive Sleep Apnea of Child
Endoscopic Classification and DISE-Guided Surgery in Pediatric Obstructive Sleep-Disordered Breathing.
Pediatric obstructive sleep apnea (OSA) can lead to severe health issues if untreated. While polysomnography is the gold standard for diagnosis, current surgical treatment in Denmark relies on caregiver reports and clinical…
- Trial name
- DISE (NCT06093802)
- Testing
- Drug-induced Sleep Endoscopy findings (identified obstruction sites)
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Regional Hospital West Jutland