Clinical trials: Sleep Restriction
Cardiometabolic Syndrome, Type 2 Diabetes
Circadian Intervention to Improve Cardiometabolic Health
The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD).
- Conditions
- Cardiometabolic Syndrome, Type 2 Diabetes, Sleep, Time Restricted Feeding
- Trial name
- TOCS (NCT05943626)
- Testing
- Circadian Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Utah
Alzheimer Disease, Late Onset, Mild Cognitive Impairment
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease
Dementia caused by Alzheimer's disease affects approximately 5.6 million adults over age 65, with costs expected to rise from $307 billion to $1.5 trillion over the next 30 years.
- Conditions
- Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Sleep, Cognitive Change
- Trial name
- ALPS (NCT05138848)
- Testing
- Time in Bed Restriction, Sleep Schedule
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Glucose Intolerance, Sleep Deprivation
Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
This project is designed to test for the first time whether glucose metabolism is differentially impaired by sleep restriction with and without additional exposure to artificial light at night (ALAN).
- Conditions
- Glucose Intolerance, Sleep Deprivation, Sleep
- Trial name
- NCT04868539
- Testing
- Sleep Restriction with ALAN first, then Sleep Restriction without ALAN, Sleep Restriction without ALAN first, then sleep restriction with ALAN
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Insomnia
Sleep Restriction Treatment for Insomnia
With a prevalence of about 10% chronic insomnia is a common problem. The standard treatment for insomnia is cognitive behavioral therapy. According to many, the core element within this treatment is sleep restriction.
- Trial name
- NCT05548907
- Testing
- sleep restriction treatment, sleep diary monitoring
- Where
- Netherlands
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- VU University of Amsterdam
Sleep Restriction, Impaired Glucose Metabolism
The Effects of Modafinil to Counteract the Adverse Metabolic Consequences of Sleep Restriction
The purpose of the study is to examine the effects of sleep and modafinil on how the body processes glucose.
- Trial name
- NCT00895570
- Testing
- modafinil
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Quality, Compliance
Changes in 24-hour Activity Cycle Behaviors During a Time-Restricted Eating Intervention in College-Aged Women
Time-restricted Eating (TRE) is a dietary approach that limits food intake to 4 - 12-hour windows without intentionally altering diet quality.
- Conditions
- Sleep Quality, Compliance, Physical Activity, Sedentary Behaviors
- Trial name
- DAWG-TREAT (NCT07520786)
- Testing
- Time Restricted Eating, Control
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Sleep Deprivation
Chronic Sleep Restriction and Driving
Young subjects and patients with nocturnal respiratory disorders are frequently involved in sleep-related accidents. This study assess the impact of chronic sleep restriction (4 hr of sleep during 5 days) or total sleep…
- Trial name
- PRIVASOM (NCT00560456)
- Testing
- Chronic sleep restriction and driving simulator
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Sleep Disordered Breathing
Pharmacological Intervention for Symptomatic Mild Sleep Disordered Breathing
Currently, there is no pharmacological intervention for mild symptomatic obstructive sleep disordered breathing (SDB) in the form of loud habitual snoring, inspiratory flow limitation (i.e.
- Trial name
- NCT04611750
- Testing
- AD036
- Where
- 2 sites in United States, Australia
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy
Repeating Patterns of Sleep Restriction and Recovery
Goal of this study is to test the hypothesis that repeated exposure to cycles of insufficient sleep increases susceptibility to a variety of disease states by progressively compromising the integrity of stress response systems.
- Trial name
- NCT01523691
- Testing
- Repeated sleep restriction and recovery, Control sleep
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Sleep Restriction
Decision-making After Sleep Restriction
The aim of this project is to investigate whether enhancing sleep intensity locally in the prefrontal cortex (PFC) can counteract a deterioration of cognitive control and therefore the previously described increase in risk…
- Trial name
- DM-SR (NCT03692962)
- Testing
- Sleep restriction, Acoustic stimulation
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Christian Baumann
Sleep Disturbance, Aging
Chronic Moderate Sleep Restriction in Older Adults
Higher rates of mortality have been found both in short sleepers (< 6 hr/night) and long sleepers (> 8 hr/night), but there has been little experimental investigation of the effects of chronic, moderate sleep loss in long or…
- Trial name
- MSSS (NCT01642719)
- Testing
- Sleep restriction, Non-sleep restriction
- Where
- 4 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Sleep Inertia, Caffeine
Delayed-release Bedtime Caffeine and Sleep Inertia Symptoms Immediately Upon Awakening
Sleep inertia (sometimes also referred to as sleep drunkenness) is a disabling state of increased sleepiness, impaired mood and reduced vigilance immediately upon awakening.
- Conditions
- Sleep Inertia, Caffeine, Placebo
- Trial name
- NCT04975360
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Sleep, Insomnia
The Effect of Sleep Loss on Emotion Regulation
The study is designed to investigate the impact of three nights of sleep restricted to 4 hours per night, on the processing and regulation of emotional information compared to Insomnia Disorder and control.
- Conditions
- Sleep, Insomnia, Sleep Deprivation
- Trial name
- NCT05393830
- Testing
- Sleep Restriction
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Obesity
Sleep Restriction and Energy Expenditure
Each 4-day period will follow the same protocol. Basically, for the entire study, we will prepare all of the subject's food and will require him or her to eat all of the food that we give at the times we tell them to eat.
- Trial name
- NCT01751581
- Testing
- Short Sleep, Habitual sleep
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Obstructive Sleep Apnea
Sodium-Restricted Diet and Diuretic in the Treatment of Severe Sleep Apnea
This study evaluates the intervention of the 1) sodium-restricted diet, or 2) diuretic, or 3) placebo pill in the treatment of obstructive sleep apnea in adults.
- Trial name
- DESALT (NCT01945801)
- Testing
- Lasilactone, Sodium-Restricted Diet
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Sleep Deprivation
Effect of Sleep Restriction on Decision Making and Inflammation
hypothesis: sleep restriction in healthy subject trigger alteration of decision making associated with immuno-inflammatory changes inclusion criterias: healthy subjects, men, under 35 years, BMI<26, no sleep troubles…
- Trial name
- NCT01989741
- Testing
- Sleep restriction
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche Biomedicale des Armees
Aging, Sleep Restriction
Impact of Chronic Circadian Disruption vs. Chronic Sleep Restriction on Metabolism
The overall objectives of the proposed study are to examine the consequences of chronic circadian disruption and chronic sleep restriction on metabolic function in healthy adults.
- Conditions
- Aging, Sleep Restriction, Circadian Disruption
- Trial name
- NCT02171273
- Testing
- Circadian Disruption, Sleep Restriction, Control
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Restriction Then Total Sleep Deprivation, Total Sleep Deprivation Then Sleep Restriction
Phenotypic and Genotypic Markers of Performance Vulnerability to Sleep Loss
Insufficient sleep is common, affecting 20-40% of adults, and resulting from sleep disorders, medical conditions, work demands, stress/emotional distress, and social/domestic responsibilities.
- Trial name
- NCT02130791
- Testing
- Sleep
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Sleep Deprivation, Sleep
Effects of Napping in Sleep-Restricted Adolescents
To examine the neurobehavioural responses to two successive cycles of sleep restriction and recovery in adolescents, and to determine the benefits of napping on cognitive performance, alertness, and mood.
- Trial name
- NCT02838095
- Testing
- Nap
- Where
- Singapore
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Sleep Deprivation
Physiologic Effects of Sleep Restriction
Evidence suggests a relationship between sleep deprivation and cardiovascular disease. The investigators wish to determine whether 9 nights of modest sleep restriction results in activation of cardiovascular disease mechanisms…
- Trial name
- NCT01433315
- Testing
- sleep restriction
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic