Clinical trials: Sleeplessness
Insomnia, Cognition
The Impact of Brief Behavioral Treatment for Insomnia Versus Brief Mindfulness Treatment on Cognition and Sleep Health in Adults (Age 50+) With HIV
The goal of this clinical trial is to examine the effects of a telephone-delivered Brief Behavioral Treatment Insomnia (BBTI) versus a Brief Mindfulness Treatment (BMT) on cognitive and sleep outcomes in older adults with HIV.
- Conditions
- Insomnia, Cognition, Aging, HIV
- Trial name
- NCT07272863
- Testing
- BBTI, BMT
- Where
- 2 sites in United States
- Volunteers
- 214 people
- Sponsor
- University of Alabama, Tuscaloosa
Insomnia, Stress Reaction
Neurexan - a Clinical Trial in Short-Term Insomnia Patients
This clinical study aims to understand the effects of a medication called Neurexan on sleep patterns and stress in people with short-term insomnia.
- Trial name
- NEUREXAN SLEEP (NCT06278077)
- Testing
- Neurexan
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Biologische Heilmittel Heel GmbH
Insomnia
Preventing the Inflammatory Response to Experimentally-induced Insomnia Symptoms
The main purpose of this study is to learn about the effects of sleep disruption (two days in a row where sleep is shortened and disrupted) on inflammation, mood (how you feel), and pain processing (your own…
- Trial name
- NCT02268565
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Autism Spectrum Disorder, Insomnia
Novel Adaptive Cognitive Training in Autistic Adults With Co-occurring Insomnia
The proposed study will test the usability and feasibility of a novel cognitive training (COGMUSE) for autistic adults with co-occurring insomnia (COGMUSE- AUT).
- Trial name
- NCT06291298
- Testing
- COGMUSE-AUT
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of South Florida
Insomnia
i-Sleep: Internet-based Treatment for Insomnia
In this study, people who suffer from insomnia will be randomized to one of three study conditions. The first group receives a multicomponent internet-based cognitive behavioral self-help intervention.
- Trial name
- i-Sleep (NCT03110263)
- Testing
- Multicomponent internet-based self-help, Internet-based sleep restriction
- Where
- Switzerland
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Bern
Primary Insomnia
Sleep Laboratory Study of MK0928 in Adult Patients With Primary Insomnia (0928-041)(TERMINATED)
A study to evaluate the efficacy, safety and tolerability of MK-0928 in Primary Insomnia.
- Trial name
- NCT00266357
- Testing
- MK0928, gaboxadol / Duration of Treatment: 6 days for treatment periods (2 days/dose)
- Volunteers
- 50 people
- Sponsor
- H. Lundbeck A/S
Insomnia
Bioequivalency Study of Zolpidem Tartrate Under Fed Conditions
The objective of this study was the bioequivalence of a Roxane Laboratories' Zolpidem Tablets, 10 mg, to Ambien® Tablets, 10 mg (Sanofi-Synthelabo Inc.) under fed conditions using a single-dose, randomized, 2-treatment, 2-period…
- Trial name
- NCT00602719
- Testing
- Zolpidem
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Primary Insomnia
Efficacy and Safety of 5 mg Sublingual Zolpidem vs 10mg Oral Zolpidem in the Induction and Maintenance of Sleep in Patients With Primary Insomnia
The purpose of this study is to evaluate the efficacy and safety of sublingual zolpidem presentation 5 mg in the induction of sleep in patients with primary insomnia.
- Trial name
- NCT01896336
- Testing
- Zolpidem Hemitartrate
- Where
- Brazil
- Volunteers
- 67 people
- Sponsor
- EMS
Diabetic Neuropathies, Insomnia Due to Medical Condition
To Assess the Efficacy of Investigational Product on the Neuropathic Pain in Individuals Suffering From Type II Diabetes Mellitus.
this study is to be carried out to examine the effect of Investigation product on diabetic individuals suffering from diabetic neuropathic pain.
- Trial name
- NCT04504305
- Testing
- NeuropAWAY, Microcystalline cellulose
- Where
- 2 sites in India
- Volunteers
- 64 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Primary Insomnia, Psychophysiological Insomnia
Improving Sleep Quality in People With Insomnia
Insomnia is a significant problem affecting 10 to 20% of US population. Long-term pharmacological treatments are not recommended due to side effects, with therapy and sleep hygiene education often employed as alternatives.
- Trial name
- NCT02443649
- Testing
- Sleep hygiene program, Sleep hypnosis
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Insomnia
Clinical Benefit of CBT for Insomnia in Primary Care
The purpose of this study is to evaluate using an RCT the potential benefits of CBT for insomnia in the community
- Trial name
- NCT00170417
- Testing
- Cognitive Behaviour Therapy
- Where
- United Kingdom
- Sponsor
- NHS Greater Glasgow and Clyde
Insomnia
An Open-label, Multicenter Study to Evaluate the Efficacy and Safety of Transitioning to Lemborexant in Japanese Subjects With Insomnia
This study will be conducted to evaluate whether the approach of direct transitioning to lemborexant (LEM) is supported for insomnia patients who are unsatisfied with current medication.
- Trial name
- NCT04742699
- Testing
- Lemborexant (LEM) 5 mg (Z-Drug-mono cohort), Lemborexant (LEM) 5 mg (SUV-mono cohort), Lemborexant (LEM) 5 mg (SUV-combination cohort)
- Where
- 9 sites in Japan
- Volunteers
- 97 people
- Sponsor
- Kurume University
Major Depressive Disorder, Insomnia
Combining Antidepressant Medication and Psychotherapy for Insomnia to Improve Depression Outcome
This study will examine the effectiveness of a combination of antidepressant medication and sleep-focused psychotherapy to simultaneously treat sleep difficulties and depression.
- Trial name
- NCT00149825
- Testing
- Escitalopram, CBTI, CTRL
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Nightmare, Insomnia
INSIGHT: Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention
The INSIGHT study is a multi-site clinical research program designed to examine how insomnia and symptoms of sympathetic hyperactivity impair sleep, cognition, and physiological restoration in warfighters, and to evaluate whether…
- Conditions
- Nightmare, Insomnia, PTSD, TBI
- Trial name
- INSIGHT (NCT07288593)
- Testing
- NightWare smartwatch configured to detect physiological signs of sympathetic activation during sleep, such as heart-rate spikes and movement patterns.
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Sleep Initiation and Maintenance Disorders
Traditional Chinese Medicine Herbal Sachet for Insomnia in Older Adults
The goal of this clinical trial was to determine whether nightly exposure to a Traditional Chinese Medicine herbal sachet could reduce insomnia symptoms and improve sleep quality in adults aged 60 years or older.
- Trial name
- NCT07788547
- Testing
- Traditional Chinese Medicine Herbal Sachet
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Macao Polytechnic University
Estazolam-dependent Insomnia
A Randomized Controlled Trial of Auricular Acupressure in Treating Estazolam-dependent Insomnia
Insomnia is a disorder characterized by difficulties in falling asleep, maintaining sleep or waking up too early, and impairment of daytime functioning.
- Trial name
- ESAAEDI (NCT06258226)
- Testing
- Conventional dosage reduction, Auricular acupressure
- Volunteers
- 108 people
- Sponsor
- Wenzhou Central Hospital
Insomnia, Cognitive Impairment
RESET-BRAIN: REhabilitation of SleEp and CogniTive Impairment in BReast Cancer Survivors Using an App-based Intervention
The goal of the study is to investigate whether treating insomnia using app-based cognitive behavioral therapy for insomnia (CBT-I) can improve cognitive impairment in breast cancer survivors compared to an active control group…
- Conditions
- Insomnia, Cognitive Impairment, Breast Cancer
- Trial name
- RESET-BRAIN (NCT06553235)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Sleep hygiene education
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Aarhus University Hospital
Opioid Use Disorder, Insomnia
Improving Insomnia in Patients With Opioid Use Disorder
This randomized, 35-day research study (n=20) explores the effects of a simplified mindfulness intervention in opioid use disorder patients stabilized on buprenorphine maintenance therapy (BMT), aiming to alleviate insomnia…
- Trial name
- OUDInsomnia (NCT05588726)
- Testing
- Sleep Hygiene, Mindfulness
- Where
- United States
- Sponsor
- University of Pennsylvania
Chronic Insomnia
Effects of Chronic Insomnia on the Neuroendocrine Regulation of Glucose and Lipid Metabolism
We aim to assess the influence of chronic insomnia on the neuroendocrine regulation of the glucose and lipid metabolism to more clearly define the metabolic derangements associated with chronic insomnia and to prove that chronic…
- Trial name
- NCT00442624
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Insomnia
Overcoming Insomnia: Impact on Sleep, Health and Work of Online CBT-I
Insomnia is a major public health concern. While cognitive behavior therapy for insomnia (CBT-I) is acknowledged as the best available intervention, there are unanswered questions about its wider dissemination, socio-economic…
- Trial name
- NORSE-3 (NCT02558647)
- Testing
- CBT for insomnia (CBT-I), Psycho-Education about Sleep (PE)
- Where
- 2 sites in Norway
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Norwegian Institute of Public Health