Clinical trials: Small Airway Disease
Chronic Lung Disease
Utility of Lung Clearance Index Score as a Noninvasive Marker of Small Airways Disease
To determine the utility and sensitivity of the lung clearance index (LCI) technique as a marker of small airways disease in adults with chronic lung conditions compared to healthy adults, adjusting for age, sex and smoking…
- Trial name
- NCT03241420
- Testing
- lung clearance index (LCI)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Asthma, Airway Hyperresponsiveness
Small Airways Disease in Asymptomatic and Symptomatic Subjects With Airway Hyperresponsiveness (AHR)
The purpose of this study is to study differences in small airways (<2mm) parameters in asthma patients, subjects with asymptomatic airway hyperresponsiveness and healthy controls.
- Trial name
- ABHR (NCT01549483)
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Obesity
Expiratory Airflow Limitation in Subjects With Obesity
The purpose of this study is to investigate posture dependent small airway obstruction in subjects with obesity, and to study the capacity of FOT as a measurement tool for small airways obstruction.
- Trial name
- EFL (NCT00865293)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical Center Alkmaar
COPD, Smoking
Defective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPD
Early changes associated with the development of smoking-induced diseases, e.g., COPD and lung cancer (the two commonest causes of death in U.S.) are often characterized by abnormal airway epithelial differentiation.
- Conditions
- COPD, Smoking, Lung Disorder
- Trial name
- NCT02341326
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Chronic Obstructive Pulmonary Disease, Lower Respiratory Disease
Small Airway Chronic Obstructive Disease Syndrome Following Exposure to WTC Dust
Many "Survivors" in the World Trade Center (WTC) clinical program have a clinical syndrome characterized by chronic obstruction in small airways and persistence of lower respiratory symptoms despite therapy.
- Trial name
- NCT03089515
- Testing
- Cardio-Pulmonary Exercise Testing (CPET)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Asthma, COPD
The Natural History of Small Airways Physiology in Diseased and Healthy States
Spirometry is a useful clinical tool for the assessment and monitoring of lung disease, however, it does not provide information on peripheral airways resistance.
- Conditions
- Asthma, COPD, Interstitial Lung Disease, Cystic Fibrosis
- Trial name
- NCT00677560
- Where
- United Kingdom
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Asthma
AssessmenT of smalL Airways involvemeNT In aSthma (ATLANTIS)
Multinational, multicentre, non-pharmacological intervention, cross-sectional and longitudinal study.
- Trial name
- ATLANTIS (NCT02123667)
- Where
- 26 sites in United States, Brazil and 6 more
- Volunteers
- 872 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Airway Disease, Interstitial Lung Disease
WTC Chest CT Imaging Archive
Dr. Rafael E de la Hoz and colleagues have performed standardized and computer-assisted readings of all chest CT scans received by WTC workers and volunteers at the Mount Sinai Medical Center between 2003 and 2016.
- Conditions
- Chronic Airway Disease, Interstitial Lung Disease, Lung Cancer
- Trial name
- NCT03295279
- Where
- United States
- Volunteers
- 2,122 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
COPD, Small Airway Disease
The Prevalence of Small Airways Dysfunction In COPD Patients and The Impact on COPD Control
Chronic obstructive pulmonary disease (COPD) is a worldwide prevalent disease. During recent years, increasing attention has been directed to the importance of the contribution of small airways in respiratory diseases.
- Trial name
- NCT04384133
- Testing
- Impulse oscillometry, Spirometric pulmonary function test, Fractional exhaled nitric oxide (FENO) test
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Sibel Naycı
Healthy, COPD
Closing Volume Interpretation and Bronchodilators Effect
The gold standard measures to evaluate small airways (SAW) "in vivo" is not well understood Two tests are today used to measure SAW but real results concordance is not clear These problems have a small evidence Data about real…
- Trial name
- NCT01437748
- Testing
- Indacaterol maleate, Tiotropium bromide
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Milan
Chronic Airway Disease
Impulse Oscillation to Evaluate Diagnostic Efficacy in Patients With Chronic Airway Disease
The aim of the research is to explore the diagnostic efficacy of impulse oscillation (IOS) before and after bronchial provocation test (BPT) and bronchial dilation test (BDT) in chronic airway disease.
- Trial name
- NCT04668027
- Testing
- impulse oscillation（IOS）, bronchial provocation test(BPT), bronchial dilation test(BDT)
- Where
- China
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA
Inhaler Lung Deposition in Chronic Obstructive Pulmonary Disease (COPD)
Patients with chronic obstructive pulmonary disease (COPD) experience breathing difficulties because the airways deep in their lungs become narrowed. COPD patients use inhaler drugs to provide relief from breathlessness.
- Conditions
- CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA, HEALTHY SUBJECTS
- Trial name
- NCT01721291
- Testing
- SALBUTAMOL
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Asthma
Small Airway Inflammation and Dysfunction in Different Asthma Phenotypes
Small airway inflammation and dysfunction will be measured in 40 children and 40 adults with asthma before and after 8 weeks of treatment with inhaled budesonide.
- Trial name
- NCT03718793
- Testing
- Peripheral exhaled nitric oxide
- Where
- Finland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
COPD, Healthy Controls
Supramaximal High-Intensity Interval Training in People With and Without Chronic Obstructive Pulmonary Disease
Beyond pulmonary complications, COPD presents with extrapulmonary manifestations including reduced cognitive, cardiovascular, and muscle function.
- Trial name
- COPD-HIIT (NCT06068322)
- Testing
- Exercise training on a stationary bicycle
- Where
- 2 sites in Belgium, Sweden
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Umeå University
Asthma, Reactive Airway Disease
Comparison of Asthma Programs for Schools
The purpose was to evaluate effectiveness and impact of an academic and counseling asthma health education program (SHARP) for fourth- and fifth-grade students diagnosed with asthma.
- Trial name
- CAPS (NCT01625364)
- Testing
- SHARP program, Open Airways for Schools
- Where
- United States
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Smoking, COPD
Canadian Cohort on the Origin and Progression of Airway Disease: Physiology Platform
The Canadian Respiratory Research Network (CRRN) has recently been established to study the origins and evolution of airways disease in the population.
- Trial name
- NCT02153684
- Where
- 3 sites in Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Dr. Denis O'Donnell
COPD, Asthma
Imaging Lung Function Using Oxygen Enhanced MRI
The goal of this study is to perform a pilot study to evaluate the utilization of oxygen as an inhaled contrast agent to image the airway spaces in normal and diseased human lungs to allow an effect size estimate to power future…
- Conditions
- COPD, Asthma, Cystic Fibrosis, Emphysema
- Trial name
- NCT01731015
- Testing
- Medical Grade Oxygen
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hal C Charles
Asthma, Reactive Airway Disease
Comparison of Oral Dexamethasone Doses in Asthma Exacerbation
Hypothesis: A 2-day course of oral dexamethasone is the superior option for the resolution of symptoms and prevention of relapse in the emergency department (ED) management of mild-moderate asthma exacerbations.
- Trial name
- NCT00942201
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Rady Children's Hospital, San Diego
Early Adult Lung Function, Small Airway Disease
Factors Affecting Early Adult Lung Function
Attainment of peak healthy lung function during the 18-26 yr window is a strong determinant of the rate of lung function decline during the later years of life.
- Conditions
- Early Adult Lung Function, Small Airway Disease, Metabolic Syndrome
- Trial name
- FEAL (NCT03187158)
- Testing
- Forced Oscillation Technique
- Where
- India
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Council of Scientific and Industrial Research, India
Asthma, Allergy
The Leaky Lung Test
This is a clinical trial designed to test the hypothesis that measuring the absorption and excretion of inhaled mannitol will provide a clinically useful marker of airway epithelial permeability in asthma.
- Conditions
- Asthma, Allergy, Reactive Airway Disease, Lung Diseases, Obstructive
- Trial name
- NCT02306473
- Testing
- Mannitol
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Rochester